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- Title: bios213lecture 14
- Type: Notes
- School: N. Illinois
- Course: BIOS 231
- Term: Spring
Coursehero >> Illinois >> N. Illinois >> BIOS 231
Path: N. Illinois >> BIOS >> 231 Spring, 2008
Path: University of Alberta >> STAT >> 151 Fall, 2007
Path: LSU >> GEOG >> 2050 Spring, 2008
Path: University of Alberta >> STAT >> 151 Fall, 2007
Path: Brandeis >> COSI >> 31a Spring, 2008
Path: Old Dominion >> ECI >> 301 Fall, 2007
Path: LSU >> BLAW >> 3201 Spring, 2008
Path: Brandeis >> MATH >> 15a Spring, 2008
Path: University of Alberta >> STAT >> 151 Fall, 2007
Path: LSU >> GEOG >> 2050 Spring, 2008
Path: Old Dominion >> ECI >> 301 Fall, 2007
Path: New Mexico >> CHNE >> 525 Fall, 2008
Path: Brandeis >> MATH >> 15a Spring, 2008
Path: University of Alberta >> STAT >> 151 Fall, 2007
Path: New Mexico >> CHNE >> 525 Fall, 2008
Path: Brandeis >> MATH >> 15a Spring, 2008
Path: Brandeis >> MATH >> 15a Spring, 2008
Path: Brandeis >> COSI >> 30a Spring, 2008
Path: Brandeis >> MATH >> 15a Spring, 2008
Path: Brandeis >> MATH >> 15a Spring, 2008
Path: Brandeis >> MATH >> 15a Spring, 2008
Path: Brandeis >> MATH >> 15a Spring, 2008
Path: New Mexico >> CHNE >> 525 Fall, 2008
Path: New Mexico >> CHNE >> 525 Fall, 2008
Path: University of Alberta >> STAT >> 151 Fall, 2007
Path: New Mexico >> CHNE >> 524 Fall, 2008
Path: New Mexico >> CHNE >> 525 Fall, 2008
Path: New Mexico >> CHNE >> 524 Fall, 2008
Path: New Mexico >> CHNE >> 524 Fall, 2008
Path: New Mexico >> CHNE >> 515 Fall, 2006
Path: New Mexico >> CHNE >> 515 Fall, 2006
Path: New Mexico >> CHNE >> 515 Fall, 2006
Path: New Mexico >> CHNE >> 515 Fall, 2006
Path: New Mexico >> CHNE >> 515 Fall, 2006
Path: Maryland >> ENES >> 102 Spring, 2008
Path: UCSB >> HIST >> 80 Spring, 2008
Path: Maryland >> ENES >> 102 Spring, 2008
Path: Maryland >> ENES >> 102 Spring, 2008
Path: Maryland >> ENES >> 102 Spring, 2008
Path: Maryland >> ENES >> 102 Spring, 2008
Path: Syracuse >> CSD >> 315/615 Spring, 2008
Path: Old Dominion >> ECI >> 301 Fall, 2007
Path: UCSB >> HIST >> 80 Spring, 2008
Path: CUNY City >> ECONOMICS >> 290 Spring, 2007
Path: Texas >> BIO >> 325 Spring, 2008
Path: Syracuse >> CSD >> 315/615 Spring, 2008
Path: CUNY City >> ECONOMICS >> 290 Spring, 2007
Path: Texas >> BIO >> 325 Spring, 2008
Path: CUNY City >> ECONOMICS >> 290 Spring, 2007
Path: Texas >> BIO >> 325 Spring, 2008
Path: Texas >> BIO >> 325 Spring, 2008
Path: CUNY City >> ECONOMICS >> 290 Spring, 2007
Path: CUNY City >> CHEM >> 103 Spring, 2007
Path: Texas >> BIO >> 325 Spring, 2008
Path: Texas >> BIO >> 325 Spring, 2008
Path: Texas >> BIO >> 325 Spring, 2008
Path: Texas >> BIO >> 325 Spring, 2008
Path: Bucknell >> EDUC >> 243 Winter, 2008
Path: Bucknell >> EDUC >> 243 Winter, 2008
Path: Bucknell >> EDUC >> 243 Winter, 2008
Path: Bucknell >> EDUC >> 243 Winter, 2008
Path: Bucknell >> ANTHRO >> 290 Winter, 2008
Path: UCSB >> ECE >> 162c Spring, 2008
Path: LSU Shreveport >> CHEM >> 121 Fall, 2008
Path: Syracuse >> CSD >> 315/615 Spring, 2008
Path: LSU Shreveport >> CHEM >> 121 Fall, 2008
Path: LSU Shreveport >> CHEM >> 121 Fall, 2008
Path: LSU Shreveport >> CHEM >> 121 Fall, 2008
Path: Kutztown >> CRJ >> 221 Spring, 2008
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Drugs Antimicrobial Chemotherapy The use of drugs to treat a disease Antimicrobial drugs Interfere with the growth of microbes within a host Antibiotic Substance produced by a microbe that, in small amounts,inhibits another microbe Selective toxicity A drug that kills harmful microbes without damaging the host 1928 Fleming discovered penicillin, produced by Penicillium. 1940 Howard Florey and Ernst Chain performed first clinical trials of penicillin. Figure 20.1 Table 20.1 Table 20.2 The Action of Antimicrobial Drugs Broad-spectrum - may kill normal microbiota Superinfection - opportunistic infections Bactericidal Bacteriostatic Figure 20.2 Antibacterial Antibiotics Inhibitors of Cell Wall Synthesis Penicillin Natural penicillins Semisynthetic penicillins Penicillins Figure 20.6 Antibacterial Antibiotics Inhibitors of Cell Wall Synthesis Penicillin derivatives Penicilinase-resistant penicillins Extended-spectrum penicillins Penicillins + -lactamase inhibitors Carbapenems Monobactam Penicillinase or beta-lactamase Figure 20.8 Antibacterial Antibiotics Inhibitors of Cell Wall Synthesis Cephalosporins 2nd, 3rd, and 4th generations more effective against gramnegatives Figure 20.9 Antibacterial Antibiotics Inhibitors of Cell Wall Synthesis Polypeptide antibiotics Bacitracin Topical application Against gram-positives Vancomycin Glycopeptide Important "last line" against antibiotic resistant MRSA S. aureus Antibacterial Antibiotics Inhibitors of Cell Wall Synthesis Antimycobacterium antibiotics (i.e., TB) Isoniazid (INH) Inhibits mycolic acid synthesis Ethambutol Inhibits incorporation of mycolic acid Antibacterial Antibiotics Inhibitors of Protein Synthesis Chloramphenicol Broad spectrum Binds 50S subunit, inhibits peptide bond formation Aminoglycosides Streptomycin, neomycin, gentamycin Broad spectrum shape Changes of 30S subunit Figure 20.4 Antibacterial Antibiotics Injury to the Plasma Membrane Polymyxin B Topical Combined with bacitracin and neomycin in overthe-counter preparation Antibacterial Antibiotics Inhibitors of Nucleic Acid Synthesis Quinolones and fluoroquinolones Ciprofloxacin Inhibits DNA gyrase Urinary tract infections Antibacterial Antibiotics Competitive Inhibitors Sulfonamides (Sulfa drugs) Inhibit folic acid synthesis Broad spectrum Figure 5.7 Figure 20.13 Antiviral Drugs Nucleoside and Nucleotide Analogs Figure 20.16a Antiviral Drugs Nucleoside and Nucleotide Analogs Figure 20.16b, c Antiviral Drugs Enzyme Inhibitors Protease inhibitors Indinavir HIV Inhibit attachment Zanamivir Influenza Inhibit uncoating Amantadine Influenza Interferons prevent spread of viruses to new cells Viral hepatitis Antibiotic Resistance A variety of mutations can lead to antibiotic resistance. Mechanisms of antibiotic resistance 1. 2. 3. 4. Enzymatic destruction of drug Prevention of penetration of drug Alteration of drug's target site Rapid ejection of the drug (efflux pumps) Resistance genes are often on plasmids or transposons that can be transferred between bacteria. Antibiotic Resistance Misuse of antibiotics selects for resistance mutants. Misuse includes: Using outdated, weakened antibiotics Using antibiotics for the common cold and other inappropriate conditions Use of antibiotics in animal feed Failure to complete the prescribed regimen Using someone else's leftover prescription The Future of Chemotherapeutic Agents Antimicrobial peptides Broad spectrum antibiotics from plants and animals Squalamine (sharks) Protegrin (pigs) Magainin (frogs) Antisense agents Complementary DNA or peptide nucleic acids that binds to a pathogen's virulence gene(s) and prevents transcription
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bios 213 lecture 11
Path: N. Illinois >> BIOS >> 231 Spring, 2008
Description: Specific Defenses of the Host: The Immune Response Innate (nonspecific) Defenses against any pathogen Immunity Specific antibody and lymphocyte response to an antigen Antigen (Ag) A substances that causes the body to produce specific antibodies o...
bios 213 lecture 12Path: N. Illinois >> BIOS >> 231 Spring, 2008
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Description: CHAPTER 2: DISPLAYING AND DESCRIBING DATA 2.1 Variables Consider a class of 30 students: . . Gender (male, female) Hair color (blond, brown, black,.) Height (in feet, inches) Weight (in pounds) Age (in years) Variable any characteristic of a pers...
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chapter5Path: University of Alberta >> STAT >> 151 Fall, 2007
Description: CHAPTER 5: PROBABILITY 5.1 What is probability? Random experiment results in one of a number of possible outcomes. The outcome that occurs cannot be predicted with certainty. Examples: Tossing a coin, rolling a die. Sample Space (S) - the list of a...
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Description: Otto Bretscher Linear Algebra with Applications 3rd Edition Section 6.1 10. By Sarrus\'s rule, is invertible. 24. is not invertible when , which is when . 32. By Fact 6.1.6, 44. For an matrix , : For any : For any matrix . , , , so . , so Th...
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Description: NE-524 Interaction of radiation with Matter Problem Set #5 (Complete by 11/13/2005) 1) A beam of 0.52 MeV electrons pass into a large reservoir of He at 3 atm pressure, 20 oC (electrons are totally absorbed). a) What is the range of the electrons? b)...
04terminology_ideal_rocket07Path: New Mexico >> CHNE >> 515 Fall, 2006
Description: Rocket Terminology Total Impulse: The integral of thrust over time tb IT 0 Fdt where t b is the burn time. I T Ft b Constant thrust Specific Impulse: Total impulse divided by the weight of propellant burned tb Fdt Is g0 0 0 tb m dt Constant thr...
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03fluid_eqns07part2Path: New Mexico >> CHNE >> 515 Fall, 2006
Description: FLUID MODELS: Part 2 Reduced Equations Splitting the energy equation: We can use the momentum equation and the continuity equation to write the energy equation in a shorter form. First take the dot product of u with the Du u p differential form o...
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Description: Thrust Equation - Momentum Transfer Consider a vehicle made up of mass m m moving at velocity v at time t. At time t t mass m has been ejected from the vehicle with a relative velocity v 2 so that m has a velocity v v 2 . The velocity of mass ...
05quasi1d_thrust_eqn_cv07Path: New Mexico >> CHNE >> 515 Fall, 2006
Description: Steady Quasi-One Dimensional Flow Consider the control volume shown below. We will consider steady quasi-one-dimensional flow through the volume. Material enters the control volume at the inlet of area A1 with velocity v1 at pressure p1 , mass densit...
ENES102 hw 1Path: Maryland >> ENES >> 102 Spring, 2008
Description: Problem 1.2: Problem 1.3: Problem 1.14: - Problem 1.16: Problem 1.21(a,f): -- Problem 1.22: Problem 1.27: Problem 1.28(a,d): ...
History_80_fullsyllabus[1]Path: UCSB >> HIST >> 80 Spring, 2008
Description: History 80: East Asian Civilization Spring Quarter 2008 T-TH 9:30-10:45, Buchanan Hall, 1910 Sections as assigned. Instructor: Anthony Barbieri-Low HSSB 4225 805-893-4065 (no msg.) barbieri-low@history.ucsb.edu Office Hours: Tues. 12:30-2:30 TA\'s: ...
ENES102 hw 2Path: Maryland >> ENES >> 102 Spring, 2008
Description: Problem 2.16: Problem 2.17: Problem 2.18: - Problem 2.19: Problem 2.21: Problem 2.22: Problem 2.25: Problem 2.26: Problem 2.33: - Problem 2.34: Problem 2.37(a): Problem 2.37(b): Problem 2.38(a): Problem 2.39(b): Problem 2.39(d): Prob...
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Description: Problem 3.6: Problem 3.7: Problem 3.9: Alternate Method: Problem 3.10: Problem 3.11: Problem 3.16: Problem 3.18: Problem 3.18 - Alternate Method: Problem 3.19: Problem 3.19 - Alternate Method: Problem 3.21: Problem 3.22: Problem 3.23: P...
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Description: Problem 6.8: Problem 6.10: Problem 6.12: Problem 6.13: Problem 6.13: (con\'t) Problem 6.17: Problem 6.20: Problem 6.23: Problem 6.23: (con\'t) Problem 6.25: Problem 6.26: Problem 6.27: Problem 6.30: Problem 6.31: Problem 6.35: ...
ENES102 hw 4Path: Maryland >> ENES >> 102 Spring, 2008
Description: Problem 4.1: Problem 4.4: Problem 4.6: Problem 4.7: Problem 4.9: Problem 4.13: Problem 4.18: -- Problem 4.19: Problem 4.22: Problem 4.25: Problem 4.27: Problem 4.27: (con\'t) Problem 4.28: Problem 4.31: Problem 4.32: Problem 4.35: Pro...
CSDL1P1Path: Syracuse >> CSD >> 315/615 Spring, 2008
Description: Anatomy 615 Index cards: Why did you enroll in this course? What do you expect to gain from this course? What are your concerns about the course? 1 CSD 315 ...
06. Obsolescence Kidd VersionPath: Old Dominion >> ECI >> 301 Fall, 2007
Description: Are dinosaurs cold-blooded or warm? What did you learn in school? From books? Dinosaur ectothermy (cold-bloodedness) remained a prevalent view until Robert T. \"Bob\" Bakker, an early proponent of dinosaur endothermy (warmbloodedness), published...
history80Essay1[1]Path: UCSB >> HIST >> 80 Spring, 2008
Description: History 80: East Asian Civilization Spring 2008 Essay no. 1: DUE IN LECTURE: TUESDAY, APRIL 22, 2008 Your first essay will be an exercise in creative historical fiction, drawing from the lecture on the Warring States\' philosophers and from the passag...
Principles_of_Statistics_-_Exam_1Path: CUNY City >> ECONOMICS >> 290 Spring, 2007
Description: Principles of Statistics First Examination Fall 2007 Name: Date: Instructions: Answer ALL the questions in the blue book. There is no need to write an explanation for the true or false questions or for the multiple-choice questions. For the problems...
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CSDL1P2Path: Syracuse >> CSD >> 315/615 Spring, 2008
Description: Anatomy Of Respiration Respiration Respiration Inspiration Inhalation Breathing in Brings oxygen to the body\'s cells Expiration Exhalation Breathing out Eliminates waste products 1 Boyle\'s Law Pressure =force distributed over area P=F/A An incre...
Principles_of_Statistics_-_Exam_2Path: CUNY City >> ECONOMICS >> 290 Spring, 2007
Description: Principles of Statistics Second Examination Fall 2007 Name: Date: Instructions: Answer ALL the questions in the blue book. There is no need to write an explanation for the true or false questions or for the multiple-choice questions. For the problem...
212655Path: Texas >> BIO >> 325 Spring, 2008
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PStats_-_H3_-_GHPath: CUNY City >> ECONOMICS >> 290 Spring, 2007
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212717Path: Texas >> BIO >> 325 Spring, 2008
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PStats_-_H4_-_GHPath: CUNY City >> ECONOMICS >> 290 Spring, 2007
Description: Homework PRINCIPLES OF STATISTICS 4 Spring 2008, Homework 4 Name 1: Name 2: Name 3: Name 4: Name 5: Instructions This homework consists of 7 questions. You must provide interpretations of your answers, not just calculations. The homework is due ...
103EX2-practice_ansPath: CUNY City >> CHEM >> 103 Spring, 2007
Description: THE CITY COLLEGE Department of Chemistry Chemistry 103 ANSWERS TO PRACTICE EXAMINATION II Work problems out to the correct number of significant figures! 1. (8 pts) a) In the SI system , the derived units for pressure in Pascals are kg/m .s2 . b) Ch...
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urban anthro study guide 2Path: Bucknell >> EDUC >> 243 Winter, 2008
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Description: Learning Log 2 Knowledge It is necessary to understand how children grow and develop to realize how to effectively teach, and in the second chapter of the text, the Piaget, Vygotsky, and Erikson views of cognitive, personal and social development are...
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Description: Learning Log 10 Knowledge The main idea of chapter 10 is that motivation, which is an internal process that activates, guides, and maintains behavior over time, is critically important for students and teachers in the classroom. Theories of motivatio...
learning log 3Path: Bucknell >> EDUC >> 243 Winter, 2008
Description: Learning Log: Chapter 3 Knowledge The main idea is that children develop physically through changes in muscle development at early ages and later in life through puberty, mentally by becoming fully literate, socially with peer interaction and cogniti...
urban anthropolgy study guide 1Path: Bucknell >> ANTHRO >> 290 Winter, 2008
Description: URBAN ANTHROPOLOGY-STUDY GUIDE EXAM 1 Urban Danger: Life in a Neighborhood of Strangers Sally Engle Merry pp.115-126 Ethnographic study of a multiethnic housing project in a high-crime neighborhood shows how the boundaries between social groups cont...
162C HW_2Path: UCSB >> ECE >> 162c Spring, 2008
Description: ECE 162C: PROBLEM SET #2 DUE WEDNESDAY, APRIL 16, 2008 PROBLEMS: 1. Derive an expression for the confinement factor of single mode fibers defined as the fraction of the total mode power contained inside the core . Use the Gaussian approximation for...
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Description: ...
CSDL3Path: Syracuse >> CSD >> 315/615 Spring, 2008
Description: Anatomy Of Respiration Structures of Respiration Bony thorax Visceral thorax Muscles 1 The Rib Cage Forms the front, sides, and back of the bony thorax Mobility Consists of 12 thoracic vertebrae Sternum 12 pairs of ribs The Rib Cage 2 The Ribs ...
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jjjournal1Path: Kutztown >> CRJ >> 221 Spring, 2008
Description: Dr. Khondaker Juvenile Justice System Journal Entry #1 1. Having a separate justice system for juveniles can be traced back all the way to common law in England. They stated that children under seven should not face legal punishments. However, in the...