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bios 213 lecture 11 N. Illinois BIOS 231
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  • Title: bios 213 lecture 11
  • Type: Notes
  • School: N. Illinois
  • Course: BIOS 231
  • Term: Spring

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Defenses Specific of the Host: The Immune Response Innate (nonspecific) Defenses against any pathogen Immunity Specific antibody and lymphocyte response to an antigen Antigen (Ag) A substances that causes the body to produce specific antibodies or sensitized T cells Antibody (Ab) Proteins made in response to an antigen Terminology Serology Study of reactions between antibodies and antigens Generic term for serum because it contains Ab Serum proteins Antiserum Globulins The Immune Response Immunity - state of resistance to foreign material that is characterized by specificity and memory The Immune Response Acquired immunity Developed during an individual's lifetime Involves Ab produced by B cells Involves T cells Humoral immunity Cell-mediated immunity Acquired Immunity Naturally acquired active immunity Resulting from infection Artificially acquired active immunity Injection of Ag (vaccination) Acquired Immunity Each set of lymphocytes react to an insult by: 1) Proliferating (i.e. divide) 2) Differentiating (i.e. specializing) Passive Immunity Naturally acquired passive immunity Transplacental or via colostrum Artificially acquired passive immunity Injection of Ab Antigenic Determinants Antibodies recognize and react with antigenic determinants or epitopes. Figure 17.3 Five Classes of Antibody IgG IgM IgA IgD IgE Antibody Structure: IgG Figure 17.5a-c IgM antibodies Pentamer 5-10% of serum antibodies Fix complement In blood, lymph, on B cells Agglutinates microbes; first Ab produced in response to infection Half-life = 5 days IgA antibodies Dimer 10-15% of serum antibodies In secretions Mucosal protection Half-life = 6 days IgD antibodies Monomer 0.2% of serum antibodies In blood, lymph, on B cells On B cells, initiate immune response Half-life = 3 days IgE antibodies Monomer 0.002% of serum antibodies On mast cells and basophils, in blood Allergic reactions; lysis of parasitic worms Half-life = 2 days Primary and Secondary Immune Response Figure 17.10 Clonal Selection Bone marrow gives rise to B cells. Mature B cells migrate to lymphoid organs. A mature B cells recognizes epitopes. Clonal Selection Figure 17.8 Apoptosis: programmed cell death - human body makes 100 miilion lymphocytes per day - need to turn them over or else develop leukemia The of Results Ag-Ab Binding Figure 17.9 Cell-Mediated Immunity Specialized lymphocytes, mostly T cells, respond to intracellular Ags After differentiating in the thymus, T cells migrate to lymphoid tissue T cells differentiate into effector T cells when stimulated by an Ag Some effector T cells become memory cells T Cells Helper T Cells (CD4, TH) TH1 Activate cells related to cell-mediated immunity (e.g., macs, CD8 cells, natural killer cells) Activate B cells to produce eosinophils, IgM, and IgE TH2 Cytotoxic T Cells (CD8, TC) Destroy target cells with perforin Minor T Cell populations Delayed Hypersensitivity T Cells (TD) Associated with allergic reaction, transplant rejection, and tuberculin skin test Suppressor T cells (TS) Turn off immune response when Ag no longer present Immune system communication 1) Lymphocyte populations need to be able to talk to one another 2) Humoral branch (B-cells) needs to interact with the Cell-mediated branch (T-cells) Cytokines Interleukin-1 Stimulates TH cells Interleukin-2 Activates TH, B, TC, and NK cells Interleukin-12 Differentiation of CD4 cells -Interferon Increase activity of macrophages Chemokines Cause leukocytes to move to an infection Major Histocompatability Ags Two types: Type 1 - found on all somatic cells Type 2 - restricted to B-cells,macs dendritic cells Dendritic cells present antigens Figure 17.12 Helper T Cells Figure 17.13 Abs against T-dependent Ags Figure 17.16 Cell-mediated Cytotoxicity Figure 17.14 Nonspecific Cells Activated macrophages: stimulated by ingesting Ag or by cytokines Natural killer cells: Lymphocytes that destroy virus-infected cells, tumor Figure 17.15 Antibody-Dependent CellMediated Cytotoxicity Figure 17.18 Self-tolerance Body doesn't make Ab against self Clonal deletion The process of destroying B and T cells that react to self antigens Monoclonal Antibodies Hybridomas are produced by fusing a cancer cell with an Ab-secreting plasma cells The hybridoma cell culture is immortal and produces monoclonal Abs (Mabs) Monoclonal Antibodies Figure 17.11 Monoclonal Antibodies Immunotoxins: Mabs conjugated with a toxin to target cancer cells Chimeric Mabs: Genetically modified mice that produce Ab with a human constant region Humanized Mabs: Mabs that are mostly human, except for mouse antigen-binding

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bios 213 lecture 12
Path: N. Illinois >> BIOS >> 231 Spring, 2008

Description: Disorders Associated with the Immune System Infection and immunosuppression are failures of the immune system. Superantigens cause release of cytokines that cause adverse host responses. Allergies and transplant rejection are harmful immune reacti...
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Path: University of Alberta >> STAT >> 151 Fall, 2007
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Path: Syracuse >> CSD >> 315/615 Spring, 2008
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Path: Old Dominion >> ECI >> 301 Fall, 2007
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Path: UCSB >> HIST >> 80 Spring, 2008
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Path: Bucknell >> EDUC >> 243 Winter, 2008
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Path: LSU Shreveport >> CHEM >> 121 Fall, 2008
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Path: LSU Shreveport >> CHEM >> 121 Fall, 2008
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Path: LSU Shreveport >> CHEM >> 121 Fall, 2008
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Path: Kutztown >> CRJ >> 221 Spring, 2008
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Path: Syracuse >> CSD >> 315/615 Spring, 2008
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