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& Heart Systemic Circulation Acute Exercise Fick Equation Cardiac Output Blood Flow (a-v)O2 difference Training Adaptations Fick Equation VO2 = Q x (a-v)O2 Diff HR x SV Local Blood Flow Shift in O2 -Hb Dissociation curve Mito O2 use PO2 cell Cardiac Output Cardiac Output (Q) = HR x Stroke Volume Heart Rate Response to Exercise Regulation Regulation of Heart Rate Intrinsic Extrinsic Intrinsic SA Node AV Node Purkinje Fibers Atria Stretch Reflex Extrinsic Sympathetic & Parasympathetic Nervous System Circulating Catecholamines TABLE 15 1 Stroke Volume Response to Exercise Regulation Regulation of Stroke Volume Intrinsic Extrinsic Intrinsic Stretching of Myocardium (preload) Frank-Starling Curve Venous Return Frank-Starling Curve Length-tension relationship Extrinsic Sympathetic & Parasympathetic Nervous System Circulating * Catecholamines * * * TABLE 15 1 VO2 = Q x (a-v)O2 Diff HR x SV Local Blood Flow Shift in O2 -Hb Dissociation curve Mito O2 use PO2 cell Ways to increase blood flow to active muscle Cardiac Output Vasodilation of bloods vessels in active muscles Vasoconstriction of blood vessels in less essential tissues (Shunting) TABLE 15 1 * * * * Local autoregulation of blood flow during exercise [PO2] [PCO2] [H+] TABLE 15 2 5.2 L/min 21.0 L/min VO2 = Q x (a-v)O2 Diff HR x SV Local Blood Flow Shift in O2 -Hb Dissociation curve Mito O2 use PO2 cell O2 Uptake & Utilization O2-Hb dissociation curve Cell PO2 Mitochondria 2 exercise can to 15-20 mm Hg Training Adaptations TABLE 16 2 TABLE 14 1 (a-v)O2 difference Capillary/Fiber ratio Red blood cell number Mitochondria number
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