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301 BME World Health & Biotechnology Unique No. 13835 Spring 2009 Professor: Dept. of Biomedical Engineering University of Texas at Austin Dr. Christine E. Schmidt Professor of Biomedical Engineering and Chemical Engineering BME 4.202I, 471 1690 schmidt@che.utexas.edu T 2:00 PM 3:00 PM W 9:30 AM 10:30 AM or by appointment BME 4.202I BME 4.202I Office Hours: Teaching Assistant: Office/Phone Office Hours E-mail Class Hours/Location: Unique Number 13835 Prerequisites: Text (required): Black Board: None. Leandro (Leo) Forciniti BME 4.410, 471 1986 M 2:30 - 3:30 PM TH 12:00 - 1:00 PM or by appointment lf2563@che.utexas.edu Class Days TTH Class Hours 12:30 2:00 PM Class Location CBA 4.328 "Essentials of Global Health" by Richard Skolnik Jones and Bartlett Publishers, 2008, ISBN # 978 0 7637 3421 3 Blackboard will be used to post all class materials Grading System: Homework* Quizzes* Three In-Class Exams** Team Project Written Report Team Project Oral Report 15% 10% 45% 20% 10% 100% *drop lowest HW and quiz grade; **lowest exam counts 5%, other two count 20% each Note: There is no final exam for this course; the project is in lieu of a final exam. Final course grades will be assigned according to the "gap system". In other words, the final grade distribution for all students will be plotted and cut offs for grades will be determined based on breaks in the distribution. Thus, a student s performance in the class is measured relative to the performance of the remainder of the class. If exam and final exam class averages are significantly different BME 301, Spring 2009 C. Schmidt , p. 2 from each other, then a student s performance on a given exam will be relative to the class average for that particular exam. Students with a 90+ course average will receive an A, an 80+ average will receive at least a B, 70+ at least a C, and a 60+ at least a D. For students whose final course scores are borderline between two letter grades, the higher or lower grade will be selected based on participation in class, visits in office hours, and whether quiz and exam performance has improved or declined during the semester. BME 301, Spring 2009 C. Schmidt , p. 3 Course Objectives: This course provides an overview of global health concerns and how technological advances can improve human health. We will compare and contrast health concerns and technology advances for different parts of the world, including developed and developing countries. We will also consider legal and ethical issues associated with developing new medical technologies. During the semester, we will examine a number of diseases and healthcare issues and technologies. The course stresses active learning with interactive and group activities. The course is organized in parallel to the textbook: Principles, Measurements, and the Health Development Link Cross Cutting Global Health Themes The Burden of Disease Working Together to Improve Global Health Course Resources: In addition to the required textbook, lecture notes and other articles and handouts will be distributed via Blackboard or in class. In particular, chapters will be distributed from the draft form of "Bioengineering for World Health" by Rebecca Richards Kortum and Michele Follen at Rice University and MD Anderson Cancer Center. If you are interested in learning more about Biotechnology and Biomedical Engineering beyond this course, several good resources are recommended: Topic Biology Background Physiology Background General BME & Devices Biomaterials Tissue Engineering Book Title Molecular Biology of the Cell** Human Physiology: An Integrated Approach* The Biomedical Engineering Handbook* Biomaterials Science Frontiers in Tissue Engineering Editors/Authors Alberts, Bray, Lewis, Silverthorn Bronzino Ratner, Hoffman, Patrick, Mikos, McIntire Publisher Garland Prentice Hall CRC Press Academic Press Pergamon *Available in the Engineering Library in ECJ. **Available in the Life Science Library in the Main Building. Course Format & Learning Activities: The textbook is one of the newest texts in the "Essential Public Health" series. The book is an introduction to the most critical issues in global health and provides case studies, examples, and the latest data and statistics. In addition, copies of chapters from other texts or journal articles will be distributed in class or via Blackboard to supplement the textbook material. Lectures will complement readings from your textbook and class handouts. Classes will combine lectures by the professor with in class small group problem solving exercises, chalk board problem analyses, etc. Open BME 301, Spring 2009 C. Schmidt , p. 4 ended questions will provide you with opportunities to enhance your problem formulation/solving skills. Guest speakers have been invited to present their expertise and perspectives on biomedical engineering and global health issues. Homework assignments will provide practice at applying the concepts covered in lecture. Group discussion of the homework (but not copying) is encouraged. It is important for quizzes and exams that each student knows how to independently work the problems on his/her own. Short, in class quizzes (~10 minutes) will be given as scheduled or announced. Quiz problems will be similar to those on the homework or to problems and ideas discussed in class, and will evaluate your working understanding of the material. Quiz problems will test problem solving skills, retention of facts, and/or your conceptual understanding of the "big picture". A team project will be assigned to teams composed of about 3 4 students. Interim written progress reports (1 page typed memos), and a final written project report will be required from each team and one grade will be given for the report. In addition, each team will make an oral presentation to the class (details of the report and grading criteria will be provided later). The team project is a key component of the class, and will reflect your comprehensive knowledge gained from the entire course. The project is in lieu of a final exam. Three in class exams will test both retention of concepts and facts, and the ability to apply problem solving skills. Material tested will be from the readings (textbook and any additional readying), homework, lectures, projects, and quizzes. Extra Credit: student Any can receive extra credit that will be applied to any exam (up to 5 total points per exam). To receive extra credit, a student must submit a sample exam problem(s) (with detailed solution) for either the Exam I, Exam II or the Final Exam (must be turned in at least 3 days prior to the exam day). The number of points credited for a problem will depend on originality, applicability (does it really test what we learned in class?), length/detail, and the accuracy of the solution. Also, if your sample exam problem is selected for the exam, then your work on the exam will be that much easier. A student may turn in more than one sample problem per exam, but only the grade for the best problem will count for extra credit. However, all submissions will be considered as possible problems for the exam. Course Policies: Class Communication and Performance Feedback -- In addition to written feedback on quizzes, exams and projects, you will receive input through in class group activities. Solutions to exams and quizzes will be posted in the glass case outside Dr. Schmidt's office. Feedback is also encouraged through visits to the Professor and the TA in office hours or by appointment. Messages to the class will be announced in class, sent via e mail, and/or posted on Blackboard. Attendance -- Attendance at lectures is critical for your mastery of the subject material. In addition, in-class quizzes require your attendance for credit and important announcements are often made in class (students are responsible for any changes announced in class). BME 301, Spring 2009 C. Schmidt , p. 5 Homework -- Homework assignments must be turned in at the beginning of the class (first five minutes) in which they are due, and the next assignment will be available at this time or via Blackboard. Exceptions, especially closer to exams, will be announced in class or by e-mail. No late homework assignments will be accepted. Homework must adhere to the following guidelines: assignments must be neatly written or typed, the problem statement must be defined, your thought process must be clearly defined and easily followed, and any sources of information must be identified. Illegible papers will not be graded. Solutions to all problems must include adequate steps, and explanations where necessary. Graded problem sets will generally be returned within two lecture periods. Each homework assignment will be equally weighted in the computation of the final course grade, and the lowest homework score will be dropped. Quizzes -- Quizzes will typically be given weekly as scheduled or announced. Ten minutes at the beginning of class will be allotted for each quiz, and problems will usually be similar to homework problems or to ideas discussed and problems posed in class. Each quiz will be worth 10 points. Students not in class for quizzes will not receive credit (there are no make-up quizzes). Each quiz will be equally weighted in the computation of the final course grade, and the lowest quiz score will be dropped. Solutions to Quizzes and Homework These will be posted in hard copy form, unless required in another format for a special need/disability, in glass cases in the 4th floor elevator lobby of the BME building (Building hours: M-Th: 7 am - 10 pm, F: 7 am 8 pm). Team Project -- Typed progress reports and the final typed project report must be received at the beginning of the class period in which they are due. Assignments not turned in within the first 5 minutes of class are considered late and will not receive credit. Each team will also make an oral presentation to the professor, TA, and class during the class lecture period. More details on the requirements for the written and oral project report will be distributed in class. Grading Policies -- Grades for problems on homework, quizzes, and exams will take into account the following: Accurately defining the problem (defining and/or drawing a correct schematic/interpretation of the system) Making accurate assumptions, adequately explaining how you reached your conclusion, justifying your approach Correctness and completeness Neatness, organization (logical flow), and identifying the final solution Late Assignments No late assignments are accepted. Grading Disputes For HW disputes, see the TAs first. For quiz and exam disputes, see Dr. Schmidt. Only oversights will be considered valid reasons for dispute. If your work is not clear or the specific question involves subjectivity, then there is no justification for re grading. Grades will not be discussed after one week from the date the assignment is returned. Exams There will be three in class exams. The exams will be closed book and closed notes. Review sessions for the exams will either be held in class or during discussion sessions prior to the exam. Requests for re grading must be presented to the professor within 1 week after the graded exam has been returned. If re grading is desired, then the entire exam is subject to re grading. If your work is not clear or the specific question involves subjectivity, then there is no justification for re grading. Missed Exam No make up exams will be given. However, a student can have one of the exams count for two exams, if and only if, he or she has a valid reason (usually, medical or a required school function; BME 301, Spring 2009 C. Schmidt , p. 6 appropriate documentation required) to miss a particular exam and if the professor is notified before the exam is missed. Final Exam There is no final exam for this course. The team project is in lieu of a final exam. Cheating and Plagiarism Anyone found cheating will be dealt with according to University policy. Cheating includes, but is not limited to, plagiarism, copying other students' homework, copying other students' exams, and obtaining copies of exams before they are given. Collaboration on assignments is encouraged and not considered cheating, however, all final submitted documents must be each student's original work in his/her own words. Plagiarism on any written assignment is strictly forbidden. More information on plagiarism will be distributed in class. Drop Date The fourth class day is the last day of the official add/drop period. After this date, changes require approval by your Dean's office. Disabilities The University of Texas at Austin provides upon request appropriate academic adjustments for qualified students with disabilities. For more information, contact the Office of the Dean of Students at 471 6259, 471 4241 TTD or the College of Engineering Director of Students with Disabilities at 471 4382.
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Path: Texas >> BME >> 301 Spring, 2009
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Path: Texas >> BME >> 301 Spring, 2009
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Path: Texas >> SOC >> 308 Spring, 2009
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Path: Texas >> SOC >> 308 Spring, 2009
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Path: Texas >> SOC >> 308 Spring, 2009
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Path: Texas >> SOC >> 308 Spring, 2009
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Path: Texas >> SOC >> 308 Spring, 2009
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Path: Yakima Valley Community College >> MASS COMM >> MCOM 4653 Spring, 2004
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Path: USC >> HIST >> 104 Spring, 2009
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Path: USC >> HIST >> 104 Spring, 2009
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Path: USC >> HIST >> 104 Spring, 2009
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Path: USC >> HIST >> 104 Spring, 2009
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Path: USC >> HIST >> 104 Spring, 2009
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Path: USC >> HIST >> 104 Spring, 2009
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Path: USC >> HIST >> 104 Spring, 2009
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Path: USC >> HIST >> 104 Spring, 2009
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Path: USC >> HIST >> 104 Spring, 2009
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Path: USC >> HIST >> 104 Spring, 2009
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Path: USC >> HIST >> 104 Spring, 2009
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Path: USC >> HIST >> 104 Spring, 2009
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Path: USC >> HIST >> 104 Spring, 2009
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Path: USC >> HIST >> 104 Spring, 2009
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Path: USC >> HIST >> 104 Spring, 2009
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Path: USC >> HIST >> 104 Spring, 2009
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Path: USC >> HIST >> 104 Spring, 2009
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Path: USC >> HIST >> 104 Spring, 2009
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Path: USC >> HIST >> 104 Spring, 2009
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1. Introduction_Ch1_2_BB
Path: USC >> BISC >> 220 Spring, 2009
Description: BISC 220L Albert Herrera, lecturer William McClure, lecturer Gorjana Bezmalinovich, lab director Teaching assistants Supplemental Instruction leaders Mechanics of the course Lecture is important Use of Blackboard Streaming video copies of e...
2. Water_Ch3
Path: USC >> BISC >> 220 Spring, 2009
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Path: USC >> BISC >> 220 Spring, 2009
Description: Chapter 4 C, H, O, and N can combine in many ways Vitalism Hydrocarbons Isomers Structural, geometric, enantiomeric Rings (often not isomers at all) Functional groups contribute to the molecular diversity of life 6 groups are of primary value ...
4. Biomolecules_Ch5
Path: USC >> BISC >> 220 Spring, 2009
Description: Chapter 5: biomolecules 5 major classes Carbohydrates Proteins Nucleic acids Lipids Small molecules Formation of polymers Polymers Monomers; dimers, etc. Condensation reactions (in biochemistry) coupling (synthesis) by dehydration can be ...
5. Cell Structure_Ch6
Path: USC >> BISC >> 220 Spring, 2009
Description: Chapter 6. The structure of the cell. Smallest living unit. Generates own energy. Takes in nutrients, gives off wastes. Compartmentalized. Defined by membranes, intracellular organelles. Maintains genetic information. 0 0 0 0 0 0 0 0...
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Path: USC >> BISC >> 220 Spring, 2009
Description: 0 On to chapter 7: Membranes Phospholipid bilayer Fluid mosaic model Lateral diffusion Associated proteins Osmosis Transport across membranes Passive Active 0 0 0 ...
7. Metabolism_Ch8
Path: USC >> BISC >> 220 Spring, 2009
Description: CHAPTER8:METABOLISM The chemistry of life is organized into metabolic pathways Organisms transform energy The energy transformations of life are subject to two laws of thermodynamics Organisms live at the expense of free energy ATP powers cellul...
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Path: USC >> BISC >> 220 Spring, 2009
Description: 0 Chapter 9: Respiration Redox reactions Glycolysis Glucose to pyruvate Oxidative phosphorylation Acetyl-CoA to CO2 & H2O Proton gradients as a form of energy Alternative pathways Regulation Inorganic (directly electrons): Oxidation comes...
9. Photosynthesis_Ch10
Path: USC >> BISC >> 220 Spring, 2009
Description: 0 0 Photosynthesis Light energy into synthesis of glucose Two phases: Light reactions Lysis of water Electron transport NADPH Oxidative phosphorylation ATP Dark reactions NADPH & ATP drive CO2 Alternative pathways glucose 0 0 0 0 0 ...
10. Cell Communication_Ch11
Path: USC >> BISC >> 220 Spring, 2009
Description: Cell Communication Cell surface receptors G-linked proteins Tyrosine kinase receptors Intracellular actions Second messengers Cyclic AMP Calcium ions Lipophilic agents (steroid hormones, others) Amplification Calcium can also be a second...
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Path: USC >> BISC >> 220 Spring, 2009
Description: Mitosis: cell division Growth Development Prokaryotes vs. eukaryotes Reproduction (in prokaryotes) Division Six major phases Cell cycle Prokaryotes Ctyokinesis Regulation of division And on to cancer, and then meiosis ...
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Path: USC >> BISC >> 220 Spring, 2009
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Path: USC >> BISC >> 220 Spring, 2009
Description: Meiosis: reduction division Diploid haploid Two divisions Great genetic diversity Segregation of chromosomes Crossing over ...
36323
Path: Cornell >> MS&E >> 111 Fall, 2007
Description: August 2004 NREL/CP-520-36323 Conductive Atomic Force Microscopy Applied to CdTe/CdS Solar Cells H.R. Moutinho, R.G. Dhere, C.-S. Jiang, M.M. Al-Jassim, and L.L. Kazmerski Prepared for the 19th European PV Solar Energy Conference and Exhibit...
APL_paper
Path: Cornell >> MS&E >> 111 Fall, 2007
Description: APPLIED PHYSICS LETTERS 86, 034106 2005 A mechanical microscope: High-speed atomic force microscopy A. D. L. Humphris,a M. J. Miles, and J. K. Hobbsb University of Bristol, H.H. Wills Physics Laboratory, Tyndall Avenue, Bristol, BS8 1TL, United King...
Appendix_A
Path: Cornell >> PSYCH >> 101 Spring, 2008
Description: APPENDIX A Dimensions Microscopes are designed to create highly magnied views of very, very small objects. It is often helpful to have an idea of the sizes of the objects viewed with the microscope compared to the sizes of known objects. Dimensions...
Appendix_B
Path: Cornell >> MS&E >> 111 Fall, 2007
Description: APPENDIX B Scanner Qualications Certication of an AFM scanner to assure that it meets specications requires that several tests be made. This document oers the test protocol used for assuring that a scanner meets its specications. An example of a sp...
Appendix_C
Path: Cornell >> MS&E >> 111 Fall, 2007
Description: APPENDIX C AFM Standards and References Introduction Standards and references are required for proper operation of an AFM and to verify optimal operating conditions and calibration of the instrument. Standards are used to assure that the absolute ...
Appendix_D
Path: Cornell >> MS&E >> 111 Fall, 2007
Description: APPENDIX D Important Websites The following websites also provide information about Atomic Force Microscopy: probestore.com pacicnanotech.com nanoparticles.pacicnanotech.com afmuniversity.org 159 ...
C-AFM_Slides[1]
Path: Cornell >> MS&E >> 111 Fall, 2007
Description: Conductive Atomic-Force Microscopy Applied to CdTe/CdS Solar Cells Purpose: Measure the current between the tip and sample surface, and obtain high resolution images of polycrystalline materials Materials: Glass/SnO2/CdS/CdTe Procedure: Scann...
Chapter_1_
Path: Cornell >> MS&E >> 111 Fall, 2007
Description: CHAPTER 1 Introduction Typically, when we think of microscopes, we think of optical or electron microscopes. Such microscopes create a magnied image of an object by focusing electromagnetic radiation, such as photons or electrons, on its surface. ...
Chapter_2_
Path: Cornell >> MS&E >> 111 Fall, 2007
Description: CHAPTER 2 AFM Instrumentation An AFM is a deceptively simple instrument that requires a considerable amount of engineering construct such that the AFM is capable of measuring images with nanometer resolution. The basic components of an AFM are a c...
Chapter_3_
Path: Cornell >> MS&E >> 111 Fall, 2007
Description: CHAPTER 3 Measuring AFM Images Learning to operate an AFM well enough to get an image usually takes a few hours of instruction and practice. It takes 5 to 10 minutes to measure an image if the sample is properly prepared. However, if it is an unkn...
Chapter_4_
Path: Cornell >> MS&E >> 111 Fall, 2007
Description: CHAPTER 4 Imaging Modes The Atomic Force Microscope is a member of the family of scanning probe microscopes that includes the scanning tunneling microscope and the near eld optical microscope, see Figure 4-1. Scanning Probe Microscope Family Air, ...
Chapter_5_
Path: Cornell >> MS&E >> 111 Fall, 2007
Description: CHAPTER 5 Process, Display, Analyze Software AFM images are stored in a computer as a three dimensional array of numbers. The array of numbers can be processed, displayed, analyzed and then reported by specialized image processing software. AFM ima...
Chapter_6_
Path: Cornell >> MS&E >> 111 Fall, 2007
Description: CHAPTER 6 AFM Image Artifacts All measurement instrumentation used by scientists and engineers for research, development and quality control generates results that may have artifacts. This chapter serves as a guide to identifying common artifacts t...
Chapter_7_
Path: Cornell >> MS&E >> 111 Fall, 2007
Description: CHAPTER 7 AFM Applications Because the AFM is capable of measuring nanometer scale images of insulating surfaces with little or no sample preparation, it has a vast number of applications in many areas of science and technology. This chapter serves...
GetPDFServlet
Path: Cornell >> MS&E >> 111 Fall, 2007
Description: Calibration of atomic-force microscope tips Jeffrey L. Hutter and John Bechhoefer Department of Physics, Simon Fraser University, Burnaby, British Columbia, VSA 235, Canada (Received 29 March 1993; accepted for publication 12 April 1993) Imag...
Nano
Path: Cornell >> MS&E >> 111 Fall, 2007
Description: Conductive AFM Applied to CdTe/CdS Solar Cells Apply a voltage between a tip and the sample surface, and measure the current Conventional topographic image Current image for a constant voltage I- V image of any Figure 1: Set-up for the CAFM meas...
Nano
Path: Cornell >> MS&E >> 111 Fall, 2007
Description: Conductive AFM Applied to Apply a voltage between a tip and the sample surface, and measure the current Conventional topographic image Current image for a constant voltage I- V image of any Figure 1: Set-up for the CAFM measurements. The shaded ...
Nanotechnology presentation
Path: Cornell >> MS&E >> 111 Fall, 2007
Description: Nanotechnology presentation Atomic Force Microscopy The atomic force microscope (AFM) or scanning force microscope (SFM) is a very high-resolution type of scanning probe microscope, with demonstrated resolution of fractions of a nanometer, more tha...
Presentation_Notes
Path: Cornell >> MS&E >> 111 Fall, 2007
Description: Conductive Atomic Force Microscopy Applied to CdTe/CdS Solar Cells: Purpose: use an AFM to apply a voltage between a conductive tip and the sample surface, and to measure the current o Learn about the electrical properties of the sample o Obtain hig...
Presentation_Notes[1]
Path: Cornell >> MS&E >> 111 Fall, 2007
Description: Conductive Atomic Force Microscopy Applied to CdTe/CdS Solar Cells: Purpose: use an AFM to apply a voltage between a conductive tip and the sample surface, and to measure the current o Learn about the electrical properties of the sample through the ...
ENGRI111_1
Path: Cornell >> MS&E >> 111 Fall, 2007
Description: ENGRI 111 Nanotechnology Overview WHAT IS NANO? nano prefix means one billionth Human hair ~ 50,000 nm across Smallest features on a commercial microchip are 100 nm Smallest things seeable with unaided eye are 10,000 nm Ten hydrogen atoms m...
ENGRI111_2
Path: Cornell >> MS&E >> 111 Fall, 2007
Description: Nanotechnology: Electronics If a device uses electricity and you can tell it what to do by programming, there is a chip inside The most sophisticated chip is a microprocessor whose transistors can perform millions of instructions per second A microp...
ENGRI111_3
Path: Cornell >> MS&E >> 111 Fall, 2007
Description: Nanotechnology: Electronics -II Si Technology Si is a semiconductor Electrical conductivity is between a metal conductor (Cu) and an insulator (diamond) Material whose electrical properties can be influenced in a variety of subtle ways Some...
ENGRI111_4
Path: Cornell >> MS&E >> 111 Fall, 2007
Description: Nanotechnology: Electronics -III Junction Transistor p-n-p junction transistor Emitter + + + + + + + + Base -+ + Collector + + + + + + + + + + + + + + + - + + + + + + + + - Forward Bias - + Reverse Bias n-p-n junction transistor ...
