& Translation Mutation
Intro (2006, Ch. 14:355-363; 2002, Ch. 6:138-146) Proteins Genetic code Mutations at nucleotide level
(2006, Ch. 15:377-382; 2002, Ch. 19:541-548)
General Background Direct Consequences of Mutation Translation Process
(2006, Ch. 14:363-370; 2002, Ch. 6:147-154)
Fig. 19.3a-d Types of base-pair substitution mutations
purines A
pyrimidines C transistion tranversion
G
T
Peter J. Russell, iGenetics: Copyright Pearson Education, Inc., publishing as Benjamin Cummings.
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Fig. 19.3c-d Types of base-pair substitution mutations
Sequence from normal gene
Sequence from mutated gene
Peter J. Russell, iGenetics: Copyright Pearson Education, Inc., publishing as Benjamin Cummings.
Fig. 19.3e-g Types of base-pair substitution mutations
Sequence from normal gene
sequence from mutated gene
Peter J. Russell, iGenetics: Copyright Pearson Education, Inc., publishing as Benjamin Cummings.
2
Translation & Mutation
Intro (2006, Ch. 14:355-363; 2002, Ch. 6:138-146) Proteins Genetic code Mutations at nucleotide level
(2006, Ch. 15:377-382; 2002, Ch. 19:541-548)
General Background Direct Consequences of Mutation Translation Process
(2006, Ch. 14:363-370; 2002, Ch. 6:147-154)
tRNA's & Ribosomes process: initiation, elongation, termination
Fig. 6.9 Example of base-pairing wobble
Peter Russell, J. iGenetics: Copyright Pearson Education, Inc., publishing as Benjamin Cummings.
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Overview of Gene Expression (see also Fig. 5.8/13.9) after Fig. 5.2 / 13.3
5' DNA 3' promoter transcription start RNA-coding sequence 5' terminator transcription stop +1 3'
Fig. 5.7 / 13.8
polypeptide
N-terminus
Peter J. Russell, iGenetics: Copyright Pearson Education, Inc., publishing as Benjamin Cummings.
C-terminus
Fig. 6.12 Initiation of protein synthesis in prokaryotes
Peter J. Russell, iGenetics: Copyright Pearson Education, Inc., publishing as Benjamin Cummings.
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Fig. 6.16 The formation of a peptide bond between the first two amino acids of a polypeptide chain is catalyzed on the ribosome by peptidyl transferase
Peter J. Russell, iGenetics: Copyright Pearson Education, Inc., publishing as Benjamin Cummings.
Fig. Elongation stage of translation in prokaryotes
Peter J. Russell, iGenetics: Copyright Pearson Education, Inc., publishing as Benjamin Cummings.
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Fig. 6.18 Termination of translation
Peter J. Russell, iGenetics: Copyright Pearson Education, Inc., publishing as Benjamin Cummings.
Fig. 6.17 Diagram of a polysome, a number of ribosomes each translating the same mRNA sequentially
Peter J. Russell, iGenetics: Copyright Pearson Education, Inc., publishing as Benjamin Cummings.
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