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23 MCDB Summer 2008 Slideset #1 MCDB 23 Biology of Cancer Dr. David Kohl kohl@lifesci.ucsb.edu LSB RM 2322 893-2162 General Education Area C Why Study Science? Science allows us to act as educated members of society Policy makers cannot be afraid of science Voters cannot be afraid of science Science important to economy, education and society Need better communication between scientists and...
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23 MCDB Summer 2008 Slideset #1
MCDB 23
Biology of Cancer
Dr. David Kohl kohl@lifesci.ucsb.edu LSB RM 2322 893-2162
General Education Area C
Why Study Science?
Science allows us to act as educated members of society Policy makers cannot be afraid of science Voters cannot be afraid of science Science important to economy, education and society Need better communication between scientists and non-scientists
If you are a Bio Major who has competed MCDB 1A or above your time can be better spent.
What is Cancer Anyway??
Cancer refers to a group of more than 100 different diseases Characterized by abnormal and unregulated growth of cells Destroys surrounding tissues May spread to other parts of body
1
Origin
Word cancer Greek Hippocrates (460370 B.C.) Refers to non-ulcer forming and ulcer forming growths More specifically to finger like spreading of disease and blood vessels which are akin to crab shape
Traditional view of cancer
Genes Environment Diet
(20th century):
Cancer (or not)
An individual's genes, environment, and diet have long been acknowledged contributors to cancer; however, the underlying mechanisms have been unclear and "black boxed" in the past.
Current view of cancer:
Genes Environment Diet Genes
Future of cancer Research Cancer (or not) Cancer (or not)
Diet
Finally, a real understanding of the underlying causes of cancer. Innovations in the understand of cancer have opened the door to exciting new opportunities for cancer technology in fields such as: Drug design Prediction of susceptibility Tumor detection (and monitoring) New technologies for canc...
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UCSB - MCDB - 023
MCDB 23Biology of CancerDr. David Kohl kohl@lifesci.ucsb.edu LSB RM 2322 893-2162Tumor Classification by Cell Type Benign and MalignantBenign TumorsBased on parenchymal component Mesenchymal tumors add oma to cell of origin Fibroblasts = fib
UCSB - MCDB - 024
MCDB 24 Genetics and Human DiseaseDr. David Kohl kohl@lifesci.ucsb.eduPurpose of this Course This course is offered as a general education course in the College of Letters and Science. Its target audience is the non biology, non science major who
Georgia Tech - ETD - 09252006
ANALYSIS AND SYNTHESIS OF FIXTURING DYNAMIC STABILITY IN MACHINING ACCOUNTING FOR MATERIAL REMOVAL EFFECTA Dissertation Presented to The Academic Facultyby Haiyan DengIn Partial Fulfillment of the Requirements for the Degree Doctor of Philosoph
Georgia Tech - ETD - 03282005
Resource Modeling and Allocation in Competitive SystemsA Dissertation Presented to The Academic Faculty byNa AnIn Partial Fulllment of the Requirements for the Degree Doctor of PhilosophySchool of Industrial and System Engineering Georgia Ins
Georgia Tech - ETD - 01052005
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Georgia Tech - IPSTETD - 188
The Institute of Paper ChemistryAppleton, WisconsinDoctor's DissertationAn Investigation of the Time-Dependent Structural and Mechanical Behavior of Individual Pulp Fibers When Subjected to an Applied StressRichard L. HillJanuary, 1967AN I
Georgia Tech - AE - 1350
Designing Human Exploration MissionsJoyce Carpenter Manager, Advanced Design Office Johnson Space Center Fall 2003Presentation Outline Human Space Exploration - Example Studies First Lunar Outpost Mars Missions Earth's Neighborhood What's t
UCSB - ECE - 125
1836IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES, VOL. 45, NO. 10, OCTOBER 1997When are Transmission-Line Effects Important for On-Chip Interconnections?Alina Deutsch, Senior Member, IEEE, Gerard V. Kopcsay, Member, IEEE, Phillip J. Rest
UCSB - ECE - 125
Logic and Logical Efforta) A three-input XNORT gate (see insert above) works like a two-input NOR as long as input A is high; otherwise, the output is stuck high. Implement the XNORT gate in complementary CMOS, and size all transistors such that th
UCSB - ECE - 125
ECE 225, Hw#1, Winter 2009Prof. Kaustav BanerjeeUNIVERSITY OF CALIFORNIA, SANTA BARBARA Department of Electrical and Computer Engineering ECE225 High-Speed Digital IC DesignHomework #1Due Date: Feb 4 by 5:00pm 1. Reading Assignment: Chapter 5
UCSB - ECE - 125
MOS Scaling: Transistor Challenges for the 21st CenturyScott Thompson, Portland Technology Development, Intel Corp. Paul Packan, Technology Computer Aided Design, Intel Corp. Mark Bohr, Portland Technology Development, Intel Corp. Index words: SDE,
UCSB - ECE - 125
ECE 225 High-Speed Digital IC DesignLecture 10CMOS Devices: Alpha-power Model, Sub-micron Effects, Leakage Mechanisms, Parasitic Effects Prof. Kaustav Banerjee Electrical and Computer Engineering E-mail: kaustav@ece.ucsb.eduLecture 10, ECE 225K
UCSB - ECE - 125
A. E. RuehiiInductance Calculations in a Complex Integrated Circuit Environmentby complicated interconnection conductors. Knowledge of these inductances leads to useful information concerning the design such systems. In the approach pursued here,
UCSB - ECE - 125
IEEE JOURNAL OF SOLID-STATECIRCUITS, VOL. SC-17, NO. 2, APRIL 1982281A Transmission Line Model for Silicided Diffusions: Impact on the Performance of VLSI CircuitsDAVID B. SCOTT, MEMBER,lEEE , WILLIAM R. HUNTER, AND HISASHI SHICHIJO, MEMBER,lEEE
UCSB - ECE - 125
5 84IELE J O ~ J R N A L SOLID-STATE CIRCUITS. VOL. ot25, NO. 2, APRIL 1990Alpha-Power Law MOSFET Model and its Applications to CMOS Inverter Delay and Other FormulasAbstract -A simple yet realistic MOS model, namely the a-power law MOS model
UCSB - ECE - 125
UCSB - ECE - 125
ECE 225, Hw#1, Winter 2008Prof. Kaustav BanerjeeUNIVERSITY OF CALIFORNIA, SANTA BARBARA Department of Electrical and Computer Engineering ECE225 High-Speed Digital IC DesignHomework #1Due Date: Feb 1 by 5:00pm 1. Reading Assignment: Chapter 5
UCSB - ECE - 125
ECE 225 High-Speed Digital IC DesignLecture 8CMOS Devices: Basic Operation, Sub-micron Effects, Parasitic Effects, Emerging Structures Prof. Kaustav Banerjee Electrical and Computer Engineering E-mail: kaustav@ece.ucsb.eduLecture 8, ECE 225Kaus
UCSB - ECE - 125
ECE 225 High Speed Integrated Circuit DesignLecture 14Prof. Kaustav Banerjee Electrical and Computer Engineering E-mail: kaustav@ece.ucsb.eduLecture 14, ECE 225Kaustav BanerjeeSemiconductor MemoriesLecture 14, ECE 225Kaustav BanerjeeMem
UCSB - ECE - 125
ECE 225 High Speed Digital IC Design Lecture 5Interconnect Technology and Scaling Issues-II (Thermal, Reliability and Power) Prof. Kaustav Banerjee Electrical and Computer Engineering E-mail: kaustav@ece.ucsb.edu1ECE 225, Lecture 5Interconnect
UCSB - ECE - 253
A PLATFORM FOR THE TESTING OF RECONFIGURABLE SECURITY PRIMITIVES Brett Brotherton, Nick Callegari Department of Electrical and Computer Engineering University of California, Santa Barbara email: brotherton, nick callegari@umail.ucsb.eduABSTRACT Embe
UCSB - ECE - 156
University of California Department of Electrical and Computer Engineering ECE 156A FALL 2004 Homework 6 Due:December 9thThis exercise is to practice the synthesis process from RTL code to the gate level simulation. It involves writing and simul
UCSB - ECE - 156
Logic SynthesisPreliminaryBorrow from slides made by Professor R. K. Brayton, UCB1 B = { 0,1} B2 = {0,1} X {0,1} = {00, 01, 10, 11} B0 B1 B3The Boolean n-cube BB2nB4Borrow from slides made by Professor R. K. Brayton, UCB21
UCSB - CHEM - 109
Cofactors: Additional Practice problems:Textbook 24(2,31) 1) Perform literature search about the mechanism of glucose oxidase (1.1.3.4). Draw a detailed catalytic mechanism for this enzyme. 2) Many, but not all, NAD+/NADP+-dependent enzymes catalyz
UCSB - CHEM - 109
UCSB CHEM 109C Dr. Kalju KahnCatalysisLearning goals:To have some understanding about:The fundamentals of chemical catalysis Different ways that enzymes carry out catalysis The concept of transition state stabilizationImages: active sites of c
UCSB - CHEM - 116
Using Solver in Excel for non-linear curve fitting Create a spreadsheet similar to the one pictured below. Import your kinetics data into columns A and B. Column A should be the time values and B the absorbance values. A 1 2 3 4 5 6 7 8 90 5 10 15 2
UCSB - CHEM - 116
Synthesis and Characterization of CdSe NanocrystalsSynthesis Add 75 mg of Li4[Cd10Se4(SPh)16] to a crimp top vial containing a magnetic stir bar. Seal the vial and purge with argon for 2-5 minutes. Transfer 5 mL of molten hexadecylamine1 that is st
UCSB - CHEM - 110
Chem 110LDepartment of Chemistry and Biochemistry University of California, Santa Barbara Fall 2004Syllabus and general course information for Chem110L, INTRODUCTORY BIOCHEMISTRY LABORATORYLecturer:Kalju Kahn kalju@chem.ucsb.edu Office: PSB-N
UCSB - CHEM - 110
Chem 110LDepartment of Chemistry and Biochemistry University of California, Santa Barbara Fall 2008Syllabus and general course information for Chem110L, INTRODUCTORY BIOCHEMISTRY LABORATORYLecturer:Kalju Kahn kalju@chem.ucsb.edu Office: PSB-N
UCSB - CHEM - 110
Chem 110LDepartment of Chemistry and Biochemistry University of California, Santa Barbara Fall 2007Syllabus and general course information for Chem110L, INTRODUCTORY BIOCHEMISTRY LABORATORYLecturer:Kalju Kahn kalju@chem.ucsb.edu Office: PSB-N
UCSB - CHEM - 110
November 2008Section II: TR 2-5:50 Section III: TR 6-9:50Hints of the month: - write up your lab reports as soon possible. The last week is very busy - talk with your TA/prof about how to improve your lab reports - a good way to prepare for the ex
UCSB - CHEM - 110
November 2008Section I: MW 6-9:50Hints of the month: - write up your lab reports as soon possible. The last week is very busy - talk with your TA/prof about how to improve your lab reports - a good way to prepare for the exam is to review all lab
UCSB - CHEM - 107
Course syllabus for Summer 2002Chemistry 107A Organic ChemistryClass meets: Mon, Tue, Wed, Thu 11:00 12:05 AM Instructor:Chem 1179Professor Kalju Kahn, Office: Chem 1005A, E-mail: kalju@chem.ucsb.edu Phone: (805) 893-6157 (not installed yet)
UCSB - CHEM - 107
Preparation guide for the final exam: Chem107AForeword: My goal in teaching this class has been to ensure that you learn as much organic chemistry as well as possible. I have deliberately prepared rather hard mid-terms to communicate to you that or
UCSB - CHEM - 126
Course syllabus for Chemistry 126 / 226Computational ChemistryClass meets: Mon, Wed 11:00 11:50 AMstPhelps 1420 Chem 1153 (Comp Lab)Fri (except 1 week) Instructor:11:00 11:50 AMDr. Kalju Kahn, Office: PSB-N 2623,E-mail: kalju@chem.ucsb.
UCSB - CHEM - 142
Suggested practice problems, Summer 2008 Week 1: 1) Visit http:/www.emc.maricopa.edu/faculty/farabee/BIOBK/BioBookCELL2.html and supplement your notes about cell structure and function with the information from this page. Then answer all 18 review qu
UCSB - CHEM - 142
Course syllabus for Chemistry 142ABiochemistry Class meets: Instructor: Mon, Tue, Wed, Thu 11:00 12:20 AM North Hall 1006Professor Kalju Kahn, Office: PSB-N 1511 E-mail: kalju@chem.ucsb.edu Phone: (805) 893-6157 Office Hours: Mon and Wed (1:00-2:
UCSB - CHEM - 162
Chem 162/262 Exam GuideWinter 2007 (Kahn)The exam takes 50 minutes and is given on March 5th. The exam will test your knowledge and your understanding of the material that was covered in the lectures, tutorials, and in the required literature. Yo
UCSB - CHEM - 142
Course syllabus for Chemistry 142ABiochemistry Class meets: Instructor: Mon, Tue, Wed, Thu 11:00 12:20 AM North Hall 1111Professor Kalju Kahn, Office: PSB-N 2623 E-mail: kalju@chem.ucsb.edu Phone: (805) 893-6157 Office Hours: Mon and Wed (1:00-2:
UCSB - CHEM - 142
Topics for the final exam: Chem142A (Kahn, Fall 2007) Thursday Dec 13, 4 7 PM Large portion of questions on the final will test your understanding of material from all the chapters covered in this course. Below are topics that you should study well
UCSB - CHEM - 162
Course syllabus for Chemistry 162A / 262ADrug Design (Winter 2009)Class meets: Mon, Wed, Fri 12:00 12:50 AM Phelps 1444Instructor:Teaching Assistant: Lecture Textbook: The Course:Professor Kalju Kahn, Office: PSB-N 2623 Phone: (805) 893-6157
UCSB - CHEM - 162
Chem 162/262 Midterm Exam Guide:Winter 2005 (Kahn)The exam in Chem 162/262 will test your understanding of topics covered up to, and including the structure-based drug design. You can demonstrate your understanding by explaining concepts and tech
UCSB - CHEM - 142
Topics for the first midterm: Chem142A (Kahn, Summer 2006) You are expected to know all the material that was covered in the lecture. The following list, organized by textbook chapters, list concepts that I think are especially important. Chapter 1.
UCSB - CHEM - 109
Midterm II Guide for Chem109C (Kahn, Spring 2005) Midterm II will be held on Tuesday, May 24th, 56:20 PM in Chem1179. In general, exam questions are based on topics that we covered in the lectures since the first midterm. However, in some cases the t
UCSB - CHEM - 126
Midterm Preparation Guide for Computational Chemistry 126 / 226 Kahn, Winter 2006 The Chem 126/226 midterm on Feb 22 may cover the following topics: 1) Optimization Methods a. Basic math: functions, derivatives, and the Hessian matrix b. Mathematical
UCSB - CHEM - 110
October 2006Section I: TR 2-5:50 Section II: TR 6-9:50Hints of the month: - trust your lab manuals. They are designed to give the best results - do not plan on writing lab reports up a day before they are due - know that we grade on the quality, n
UCSB - CHEM - 110
October 2006Section III: WF 2-5:50Hints of the month: - trust your lab manuals. They are designed to give the best results - do not plan on writing lab reports up a day before they are due - know that we grade on the quality, not on the quantity o
UCSB - CHEM - 110
September 2005Section III: WF 2-5:50Hints of the month: - be prepared to work hard - get used to seeing lots of new stuff - enjoy the cool experiments we are doing!21Prepare yourself for Biochem LabsMichaelis-Menten kinetics: GAPDH reaction 2
UCSB - CHEM - 110
October 2008Section I: MW 6-9:50Hints of the month: - trust your lab manuals. They are designed to give the best results - do not plan on writing lab reports up a day before they are due - know that we grade on the quality, not on the quantity of
UCSB - CHEM - 110
September 2005Section II: TR 6-9:50Hints of the month: - be prepared to work hard - get used to seeing lots of new stuff - enjoy the cool experiments we are doing!20Prepare yourself for Biochem LabsLecture 1: Intro to the course Experiment de
UCSB - CHEM - 110
Chem 110LDepartment of Chemistry and Biochemistry University of California, Santa Barbara Fall 2005Syllabus and general course information for Chem110L, INTRODUCTORY BIOCHEMISTRY LABORATORYLecturer:Kalju Kahn kalju@chem.ucsb.edu Office: PSB-N
UCSB - CHEM - 110
October 2006Section IV: MW 6-9:50Hints of the month: - trust your lab manuals. They are designed to give the best results - do not plan on writing lab reports up a day before they are due - know that we grade on the quality, not on the quantity of
UCSB - CHEM - 110
September 2005Section IV: MW 6-9:50Hints of the month: - be prepared to work hard - get used to seeing lots of new stuff - enjoy the cool experiments we are doing!Lecture Schedule (Monday) Lab Schedule (Monday) Lab Schedule (Wednesday)23Prepa
UCSB - CHEM - 110
October 2008Section II: TR 2-5:50 Section III: TR 6-9:50Hints of the month: - trust your lab manuals. They are designed to give the best results - do not plan on writing lab reports up a day before they are due - know that we grade on the quality,
UCSB - CHEM - 162
Chem 162/262 (2005)Assignment #3-MakeUp:Enzymes: Mechanisms & Inhibition (Make-up: 5 pts total)1. Transition state analogs are potent inhibitors of enzymes. Consider the following hypothetical enzymatic reactions and draw (using IsisDraw or a si
UCSB - CHEM - 162
Dr. Kalju KahnDepartment of Chemistry and Biochemistry University of California, Santa BarbaraCurrent Approaches to Drug DiscoveryDISEASE Biological ConceptUCSB Chem 162 Dr. Kalju KahnValidated TargetLead CompoundModificationsTestsDRU
UCSB - CHEM - 109
Final Exam Guide for Chem109C (Kahn, Spring 2007) The final will be held on Monday, June 11th, 811 AM in Chem1179. In general, the final exam questions are based on all the topics that we covered in the course. The focus will be on the material prese
UCSB - CHEM - 112
Conformational Analysis of Allantoin Biophysical and Bioanalytical Laboratory UC Santa Barbara Chem 112L Name: Group: Points earned Prelabs Prelab corrections (25% back of wrong answer points) Publication-style integrated introduction with rationale
UCSB - CHEM - 109
Midterm I Study Guide for Chemistry 109C(Kahn, Spring 2007) In general, exam questions are based on topics that we covered in the lectures. However, in some cases the textbook provides more detailed examples of these topics and you are expected to b
UCSB - CHEM - 110
Rape Prevention Education Program- Statistics1 in 4 women have been survivors of rape orattempted rape. 84% of those raped knew their attacker. 57% of the rapes happened on dates. 42% of the rape survivors told no one about the assault Only 5% rep
UCSB - CHEM - 109
Vitamin Problems for Week 5: A) Sex pheromone sequence determination Male newts use decapeptide pheromone X to attract females. When this decapeptide was treated with Edmans reagent, a serine derivative of hydantoin was obtained along with nonapeptid