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chol

Course: BAHS 501, Fall 2009
School: Emory
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Word Count: 283

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Cholesterol Metabolism November 19, 2001 (Only three more days to Thanksgiving) lecture topics Overview of cholesterol Cholesterol synthesis Regulation Cholesterol degradation and elimination Bile acids and bile salts Cholesterol/lipid trafficking/delivery Steroid hormones Top four reasons we need cholesterol??????? 1 Top four reasons we need cholesterol??????? 1) 2) 3) 4) Membrane component- controls fluidity...

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Cholesterol Metabolism November 19, 2001 (Only three more days to Thanksgiving) lecture topics Overview of cholesterol Cholesterol synthesis Regulation Cholesterol degradation and elimination Bile acids and bile salts Cholesterol/lipid trafficking/delivery Steroid hormones Top four reasons we need cholesterol??????? 1 Top four reasons we need cholesterol??????? 1) 2) 3) 4) Membrane component- controls fluidity Precursor of bile acids and bile salts Precursor of steroid hormones Precursor of vitamin D major sources of liver cholesterol Diet De novo synthesis Cholesterol synthesized in extrahepatic tissues Liver Cholesterol Pool Conversion to Secretion of HDL bile acids/salts and VLDL Free cholesterol secreted in bile major routes by which cholesterol exits liver structure of cholesterol site of attachment of fatty acid in cholesterol ester 2 lecture topics Overview of cholesterol Cholesterol synthesis Regulation Cholesterol degradation and elimination Bile acids and bile salts Cholesterol/lipid trafficking/delivery Steroid hormones <a href="/keyword/cholesterol-biosynthesis/" >cholesterol biosynthesis</a> ~50% results from de novo synthesis IQ &gt; 200 intestine &amp; adrenal cortex liver ovaries/ reproductive tissues <a href="/keyword/cholesterol-biosynthesis/" >cholesterol biosynthesis</a> ______-___ CATEGORY: Precursor for <a href="/keyword/cholesterol-biosynthesis/" >cholesterol biosynthesis</a> Also requires NADPH and ATP Highly regulated process Occurs in the cytoplasm Cytosol Endoplasmic reticulum 3 LIPIDS POLYSACCHARIDES (COMPLEX CARBO S) PROTEINS fatty acids glucose Glycolysis amino acids ATP pyruvate acetyl-CoA Fatty acid biosynthesis <a href="/keyword/cholesterol-biosynthesis/" >cholesterol biosynthesis</a> O2 FADH 2 and NADH (reducing power) oxidative phosphorylation ATP ATP ATP ATP ATP tricarboxylic acid (TCA) cycle...

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