Course New Request
Check Appropriate Boxes:
1. School/Division
Indiana University
Undergraduate credit Graduate credit
IUPUT.
Campus
Professional credit
2. Academic Subject Code
GRAD
3. Course Number 5. CourseTitle
G'I \ 7
(must be cleared with University Enrollment Services) 4. Instructor Bidwell/Pavalko
.
Biomedical Science I11
-
Cellular Basis of Systems Bioloas
(Limited to 32 Characters including spaces)
Recommended Abbreviation (Optional)
R i W TTI
6. First time this course is to be offered (Semester/Year): 7. Credit Hours: Fixed at
Fall 2007
to
3
or Variable from No
8. Is this course to be graded S F (only)?Yes 9. Is variable title approval being requested? Yes
X
No
X
10. Course description (not to exceed 50 words) for Bulletin publication:
Third of a group of three biomedical
science core courses intended for incoming doctoral graduate students in School of Organization and function of cells, propra.ms or other graduate students. musculoskeletal. renal, cardiovascular, gastrointestinal, endocrine and pulmonary
11. Lecture Contact Hours: Fixed at 12. Non-Lecture Contact Hours: Fixed at 13. Estimated enrollment: 14. Frequency of scheduling:
36
0
or Variable from or Variable fiom
to to
40 Annually
ofwhich 100
percent are expected to be graduate students.
Will this course be required for majors?
YES YES
15. Justification for new course:
Restructuring of graduate program requirements.
16. Are the necessary reading materials currently available in the appropriate library?
17. Please append a complete outline of the proposed course, and indicate instructor (if known), textbooks, and other materials.
Attached
18. If this course overlaps with existing courses, please explain with which courses it overlaps and whether this overlap is necessary, desirable, or unimportant.
None
19. A copy of every new course proposal must be submitted to departments, schools, or divisions in which there may be overlap of the new course with existing courses or areas of strong concern, with instructions that they send comments directly to the originating Curriculum Committee. Please append a list of departments, schools, or divisions thus
Date Date
*
Approved by:
Dean
Date Date
Chancellor/Vice-President
Date
University Enrollment Services After School/Division approval, forward the last copy (without attachments) to University Enrollment Services for initial processing, and the remaining four copies and attachments to the Campus Chancellor or Vice-President. UPS 724 University Enrollment Services Final-White; Chancellor/VicePresident-Blue; School/Division-Yellow; Department/Division-Pink; University Enrollment Services AdvanceWhite
New Course Request
I. Title: Biomedical Science Ill - Cellular Basis of Systems Biology Course number: G717 Instructors: Joseph Bidwell & Fredrick Pavalko Prerequisites: none
II. COURSE DESCRIPTION AND RATIONALE Third of a group of three introductory biomedical science, lecture-based, core courses intended for all incoming basic science doctoral graduate students in the School of Medicine programs or other interested graduate or GCND students. Covers organization and function of cells, tissues and physiologic systems using disease-based examples. The course will explore topics including the organization of cells, neurophysiology, musculoskeletal biology, renal, cardiovascular and pulmonary systems, gastrointestinal and endocrine biology, and cancer biology. The course will emphasize the role of cells and molecules in regulating the function of tissues and physiologic systems. Course presentations will include Powerpoint computer presentations, overhead presentations, as well as web-based exercises. Ill. EDUCA'TIONAL OBJEC'TIVES Know the function of cellular str~~ctures I-~nderstand they are organized in and how the cell. Know the types of cytoskeletal structures in cells and understand how they function in cell-cell and cell-niatl-ix interactions. Understanding basic concepts about the cell biology of cancer. Understand how tissues develop and how they form organs. Understand the cellular cor~trol the nervous system. of Understand how cells control the function of systems in the body including bone, muscle, heart, kidney and lung. Know the cells and molecules that affect function of the gastrointestinal tract. Know how glucose homeostasis is controlled. Understand fundamental aspects of cancer biology and intervention treatments. IV. COURSE CONTENT:
Cellular Structures and Organization Topic 1. Organelles-structure/function Topic 2. Cytoskeleton-actin, microtubules, microfilaments Topic 3. Cell cycle, meiosis/mitosis, regulation of cell growth in cancer Topic 4. Extracellular matrix (cell-matrix interaction) Topic 5. Cell-cell interaction (adherens, tight junctions etc) Topic 6. Cells of the immune system. Topic 7. Cellular inflammatory response Topic 8. Development- Movements of cells to form tissue layers & organs Systems: Musculoskeletal biology Topic 9. lVlusculoskeletal system: skeletal, smooth, cardiac muscle cell structure. Topic 10. Organization and regulation of cardiac muscle ,function
Topic 11. Regulation of smooth muscle function. Topic 12. Control of Muscle Function: excitation-contraction coupling and mechanics Topic 13. Bone: growth and maintenance of the skeleton. Topic 14. Bone: cellular regulation of bone. Topic 15. Musculoskeletal disease: Myasthenia gravis; osteoporosis, MDlinterventions Systems: Neurobiology Topic 16. Neurophysiology: autonomic nervous system, reflex actions Topic 17. Neurophysiology: sensorylsomatosensory Topic 18. Integrative neurophysiology: painlreflex pathway, interventions Topic 19. Synaptic transmission. Systems: Renal Topic 20. Renal biology: renal cell structurelfunction, organizationlrenal function Topic 21. Renal biology: kidney nephron & tubules, glomerular filtration Topic 22. Renal regulation: Na+/K+ balance, acid-base balance interventions Topic 23. Renal disease: glomerulonephritis, polycystic kidney disease I Systems: Cardiovascular and Respiratory Topic 24. Organization of the cardiovascular system Topic 25. Cardiovascular biology: circulation, anatomy I structure I function Topic 26. Cardiovascular biology: regulation of blood pressure. Topic 27. Respiratory biology: organization of the respiratory system, ventilationlmechanics Topic 28. Respiratory biology: alveolar functionlgas exchange Topic 29. Cystic fibrosislinterventions Systems: GI and Endocrine Biology Topic 30. Gastrointestinal physiology, basic functional gross & microscopic anatomy of the digestive Topic 31. Microbiology of GI tract-H. pylori, digestion and absorption in the intestine Topic 32. Glucose homeostasis, disr~~ptions homeostasis (e.g. diabetes) I of Interventions Cancer Biology Topic 33. Cell Biology of Cancer Topic 34. Effects of cellular microenvironment on cancer progression Topic 35. Cancerlinterventions and treatments V. REQUIRED AND RECOMMENDED TEXTS:
Recommended: Molecular Cell Biology (5th edition) by Harvey Lodish, publisher W. H. Freeman. Recommended: Rhoades and Tanner, Medical Physiology, Second Edition, Lippincott, Williams and Wilkins, Baltimore, MD. VI. EVALUATION AND GRADING: Student grades the in course will be determined by three examinations, each covering approximately one-third of the material with no comprehensive final. 2
Exam will be a combination of short answerlfill in the blank questions and short essay questions. Each exam will contribute one-third of the final grade. Objectives covered in the lectures will be the source of all examination questions. Grading Scale:
1 Letter grade
I Percentage
1
F 1 c50 Note that grades of C and lower are not passing grades in graduate level courses.
VII. BIBLIOGRAPHY:
1
Representative sample of the selected readings related to the course: Srivastava, D. and Yu, S. (2006) Stretching to meet needs: integrirl-linked kinase and the cardiac pump. Genes Dev. 20: 2327-2331. Rosen, C.J. and Bouxsein, M. L. (2006) Mechanisms of disease: is osteoporosis the obesity of bone? Nature Clinical Practice Rheumatology 2: 35-43.
VIII. CHEATING AND PLAGIARISM:
Students are instructed to make themselves aware of University regulations concerning plagiarism, the maintenance of academic honesty and the definitions of unacceptable behavior and cheating. Academic misconduct of any sort will not be tolerated and will be dealt with as outlined in the IU/IUPUI Code o f Student Rights, Responsibilities, a n d Conduct, which can be viewed at: http://www.life.iupui.edu/help/docs/Part 3all.html Examples of misconduct include but are not lirr~ited to: 1. Cheating A student must not use or attempt to use unauthorized assistance, materials, information, or study aids in any academic exercise 2. Fabrication A student must not falsify or invent any information or data in an academic exercise including, but not limited to, records or reports, laboratory results, and citations to the sources of information. 3. Plagiarism A student must not adopt or reproduce ideas, words, or statements of another person without appropriate acknowledgment. A student must give credit to the originality of others and acknowledge an indebtedness whenever he or she does any of the following: a. Quotes another person's actual words, either oral or written
b. Paraphrases another person's words, either oral or written c. Uses another person's idea, opinion, or theory; or d. Borrows facts, statistics, or other illustrative material, urlless the information is common knowledge. 4. Interference a. A student must not steal, change, destroy, or impede another student's work. b. A student must not give or offer a bribe, promise favors, or make threats with the intention of affecting a grade or the evaluation of academic performance. Potential consequences for academic misconduct: If the instructor has information that one of I-~islher students corr~rr~itted act of an academic misconduct, the faculty member will hold an informal conference with the student. The conference will be prompt and private. If the faculty member concludes that the student is responsible for the misconduct, then the faculty member will impose an appropriate academic sanction (i.e., lower or failing grade on the assignment, assessing a lower or failing grade for the course).
IX. AMERICANS WITH DISABLITIES ACT:
If you need any special accommodations due to a disability, please contact Adaptive Educational Services at (3 17)-274-3241. The ofice is located in CA 001E.
From: Lees, Norman D Sent: Monday, October 23,2006 5:46 PM To: Rhodes, Simon J Subject: Re: new course requests
Simon,
I see no significant overlap among the courses you are proposing and the ones we offer in Biology.
Doug
.................................................................................... Dear Doug and Frank,
Please find attached a Word file that outlines three proposed graduate level courses in biomedical sciences. These three courses will be the core series that incoming IUSM PhD students will take in their first semester when we switch to a common entry system for our PhD programs. They are each three credits. I expect that the typical enrollment will be mostly the incoming PhD student class (-35-40 students) plus perhaps a few All prospective students that might be "sampling" the curric~.~lum. of the classes will be open to any IUPUl student that wants to take them but I do not really expect a significant enrollment from non-IUSM students. I do not think that the courses conflict with you...