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419 Chemistry Midterm Paper* (Grad students) Your paper should include references, figures, and Tables (if needed). It should be ~fifteen pages in length, including references and figures, and be approximately in the format of a journal review article (J. Chem. Ed. format would be acceptable). The purpose of the paper is to provide evidence for the involvement of a metal ion, its proposed role, and proposed mechanism of action, in the protein or enzyme you've selected to research. It may be that further work needs to be done in order to answer these questions. For example, it may be that mechanistic details are lacking, or that the structure of the active site has not been definitively elucidated. In that case, provide a brief paragraph or two which discusses these remaining questions and how you would go about answering them. A rough guideline for your paper is given below. I. Intro. (3 5 pages) Where is the metallobiomolecule found? What metal ion is involved? How do they know this? Function? Protein structure (a2_2, MW, etc)? Proposed role of the metal ion. mechanism? Proposed II. Past work. (9 - 11pages) Has the system been characterized by X-ray crystallography? Has the protein been sequenced. What physical techniques have been used to characterize the metal site? How was the physical data interpreted to create a "picture" of the active site (provide supporting data such as g-values (EPR), isomer shifts (Mossbauer), EXAFS....etc)? Is there more than one state (resting, active, etc) of the enzyme? What is the local structure of the metal ion (geometry, oxidation state, spin state, etc) in each of its known states? Is there any experiemental evidence to support a particular mechanism? Have any model compounds been synthesized? How have they been used to characterize the site and/or imply any relationship between structure and function? III. Future work. (1-3 paragraphs) Describe any further work needed to elucidate the structure and/or function , or provide evidence to support a particular mechanism. This could include physical methods, and/or synthetic modeling studies. *Due Date: Fri, June 7, 2001

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