Safety Material Data Sheet
Ethyl Acetate/Ethanol Solution, 50/50 mix
ACC# 91851 Section 1 - Chemical Product and Company Identification
MSDS Name: Ethyl Acetate/Ethanol Solution, 50/50 mix Catalog Numbers: NC9052640, NC9821113, XXETHL50%RS50, XXETHYL50%RS Synonyms: None Known. Company Identification: Fisher Scientific 1 Reagent Lane Fair Lawn, NJ 07410 For information, call: 201-796-7100 Emergency Number: 201-796-7100 For CHEMTREC assistance, call: 800-424-9300 For International CHEMTREC assistance, call: 703-527-3887
Section 2 - Composition, Information on Ingredients
CAS# 64-17-5 141-78-6
Chemical Name Ethyl alcohol Ethylacetate
Percent 50 50
EINECS/ELINCS 200-578-6 205-500-4
Section 3 - Hazards Identification
EMERGENCY OVERVIEW
Appearance: Clear liquid. Warning! Causes severe eye irritation. Flammable liquid and vapor. Causes respiratory tract irritation. This substance has caused adverse reproductive and fetal effects in humans. May cause central nervous system depression. May cause liver, kidney and heart damage. Causes moderate skin irritation. Target Organs: Kidneys, heart, central nervous system, liver. Potential Health Effects Eye: Causes severe eye irritation. May cause painful sensitization to light. May cause chemical conjunctivitis and corneal damage. Skin: Causes moderate skin irritation. May cause cyanosis of the extremities. Ingestion: May cause gastrointestinal irritation with nausea, vomiting and diarrhea. May cause systemic toxicity with acidosis. May cause liver and kidney damage. May cause central nervous system depression, characterized by excitement, followed by headache, dizziness, drowsiness,
and nausea. Advanced stages may cause collapse, unconsciousness, coma and possible death due to respiratory failure. Inhalation: Inhalation of high concentrations may cause central nervous system effects characterized by nausea, headache, dizziness, unconsciousness and coma. Causes respiratory tract irritation. May cause narcotic effects in high concentration. Vapors may cause dizziness or suffocation. Chronic: May cause reproductive and fetal effects. Laboratory experiments have resulted in mutagenic effects. Chronic exposure may produce anemia, leukocytosis, cloudy swelling, and fatty degeneration of the viscera. Animal studies have reported the development of tumors. Prolonged exposure may cause liver, kidney, and heart damage.
Section 4 - First Aid Measures
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Immediately flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse. Ingestion: Do not induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Never give anything by mouth to an unconscious person. Get medical aid. Inhalation: Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation. Notes to Physician: Treat symptomatically and supportively. Persons with skin or eye disorders or liver, kidney, chronic respiratory diseases, or central and peripheral nervous sytem diseases may be at increased risk from exposure to this substance. Antidote: Replace fluid and electrolytes.
Section 5 - Fire Fighting Measures
General Information: Containers can build up pressure if exposed to heat and/or fire. As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. Vapors may form an explosive mixture with air. Vapors can travel to a source of ignition and flash back. Will burn if involved in a fire. Flammable Liquid. Can release vapors that form explosive mixtures at temperatures above the flashpoint. Use water spray to keep fire-exposed containers cool. Containers may explode in the heat of a fire. Extinguishing Media: For small fires, use dry chemical, carbon dioxide, water spray or alcohol-resistant foam. For large fires, use water spray, fog, or alcohol-resistant foam. Use water spray to cool fire-exposed containers. Water may be ineffective. Do NOT use straight streams of water. Flash Point: 45-55 deg F Autoignition Temperature: Not available. Explosion Limits, Lower:Not available. Upper: Not available. NFPA Rating: (estimated) Health: 2; Flammability: 3; Instability: 0
Section 6 - Accidental Release Measures
General Information: Use proper personal protective equipment as indicated in Section 8. Spills/Leaks: Absorb spill with inert material (e.g. vermiculite, sand or earth), then place in suitable container. Remove all sources of ignition. Use a spark-proof tool. Provide ventilation. A vapor suppressing foam may be used to reduce vapors.
Section 7 - Handling and Storage
Handling: Wash thoroughly after handling. Use only in a well-ventilated area. Ground and bond containers when transferring material. Use spark-proof tools and explosion proof equipment. Avoid contact with eyes, skin, and clothing. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep container tightly closed. Keep away from heat, sparks and flame. Avoid ingestion and inhalation. Do not pressurize, cut, weld, braze, solder, drill, grind, or expose empty containers to heat, sparks or open flames. Storage: Keep away from heat, sparks, and flame. Keep away from sources of ignition. Store in a tightly closed container. Keep from contact with oxidizing materials. Store in a cool, dry, well-ventilated area away from incompatible substances. Flammables-area. Do not store near perchlorates, peroxides, chromic acid or nitric acid.
Section 8 - Exposure Controls, Personal Protection
Engineering Controls: Use explosion-proof ventilation equipment. Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate general or local exhaust ventilation to keep airborne concentrations below the permissible exposure limits. Exposure Limits
Chemical Name Ethyl alcohol
ACGIH 1000 ppm TWA
Ethylacetate
400 ppm TWA
NIOSH 1000 ppm TWA; 1900 mg/m3 TWA 3300 ppm IDLH 400 ppm TWA; 1400 mg/m3 TWA 2000 ppm IDLH
OSHA - Final PELs 1000 ppm TWA; 1900 mg/m3 TWA 400 ppm TWA; 1400 mg/m3 TWA
OSHA Vacated PELs: Ethyl alcohol: 1000 ppm TWA; 1900 mg/m3 TWA Ethylacetate: 400 ppm TWA; 1400 mg/m3 TWA Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166. Skin: Wear appropriate protective gloves to prevent skin exposure. Clothing: Wear appropriate protective clothing to prevent skin exposure. Respirators: A respiratory protection program that meets OSHA's 29 CFR 1910.134 and ANSI Z88.2 requirements or European Standard EN 149 must be followed whenever workplace conditions warrant respirator use.
Section 9 - Physical and Chemical Properties
Physical State: Liquid Appearance: Clear Odor: alcohol-like pH: Not available. Vapor Pressure: Not available. Vapor Density: Not available. Evaporation Rate:Not available. Viscosity: Not available. Boiling Point: Not available. Freezing/Melting Point:Not available. Decomposition Temperature:Not available. Solubility: Not available. Specific Gravity/Density:Not available. Molecular Formula:Solution Molecular Weight:Not available.
Section 10 - Stability and Reactivity
Chemical Stability: Stable under normal temperatures and pressures. Conditions to Avoid: Incompatible materials, ignition sources, excess heat, oxidizers. Incompatibilities with Other Materials: Strong oxidizing agents, peroxides, acids, acid chlorides, acid anhydrides, alkali metals, ammonia, permanganic ruthenium acid, (VIII) oxide, bromine pentafluoride, nitrosyl perchlorate, chromyl chloride, uranium hexafluoride, iodine heptafluoride, uranyl perchlorate, acetyl bromide, silver nitrate, disulfuryl difluoride, magnesium perchlorate, platinum, potassium-tert-butoxide, silver oxide, hydrazine, tetrachlorosilane + water, acetyl chloride, calcium hypochlorite, mercuric nitrate, perchloric acid, potassium dioxide, sodium, chlorosulfonic acid, lithium aluminum hydride, lithium tetrahydroaluminate, oleum. Hazardous Decomposition Products: Carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. Hazardous Polymerization: Will not occur.
Section 11 - Toxicological Information
RTECS#: CAS# 64-17-5: KQ6300000 CAS# 141-78-6: AH5425000 LD50/LC50: CAS# 64-17-5: Draize test, rabbit, eye: 500 mg Severe; Draize test, rabbit, eye: 500 mg/24H Mild; Draize test, rabbit, skin: 20 mg/24H Moderate; Inhalation, mouse: LC50 = 39 gm/m3/4H; Inhalation, rat: LC50 = 20000 ppm/10H; Oral, mouse: LD50 = 3450 mg/kg; Oral, rabbit: LD50 = 6300 mg/kg; Oral, rat: LD50 = 7060 mg/kg; Oral, rat: LD50 = 9000 mg/kg; .
CAS# 141-78-6: Inhalation, mouse: LC50 = 45 gm/m3/2H; Inhalation, rat: LC50 = 200 gm/m3; Oral, mouse: LD50 = 4100 mg/kg; Oral, rabbit: LD50 = 4935 mg/kg; Oral, rat: LD50 = 5620 mg/kg; Skin, rabbit: LD50 = >20 mL/kg; . Carcinogenicity: CAS# 64-17-5: Not listed by ACGIH, IARC, NTP, or CA Prop 65. CAS# 141-78-6: Not listed by ACGIH, IARC, NTP, or CA Prop 65. Epidemiology: Ethanol has been shown to produce fetotoxicity in the embryo or fetus of laboratory animals.Prenatal exposure to ethanol is associated with a distinct pattern of congenital malformations that have collectively been termed the "fetal alcohol syndrome". Teratogenicity: Oral, Human - woman: TDLo = 41 gm/kg (female 41 week(s) after conception) Effects on Newborn - Apgar score (human only) and Effects on Newborn - other neonatal measures or effects and Effects on Newborn - drug dependence. Reproductive Effects: Intrauterine, Human - woman: TDLo = 200 mg/kg (female 5 day(s) pre-mating) Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated). Mutagenicity: DNA Inhibition: Human, Lymphocyte = 220 mmol/L.; Cytogenetic Analysis: Human, Lymphocyte = 1160 gm/L.; Cytogenetic Analysis: Human, Fibroblast = 12000 ppm.; Cytogenetic Analysis: Human, Leukocyte = 1 pph/72H (Continuous).; Sister Chromatid Exchange: Human, Lymphocyte = 500 ppm/72H (Continuous). Neurotoxicity: No information found Other Studies:
Section 12 - Ecological Information
Ecotoxicity: Fish: Rainbow trout: LC50 = 12900-15300 mg/L; 96 Hr; Flow-through @ 24-24.3CFish: Rainbow trout: LC50 = 11200 mg/L; 24 Hr; Fingerling (Unspecified)Bacteria: Phytobacterium phosphoreum: EC50 = 34900 mg/L; 5-30 min; Microtox test When spilled on land it is apt to volatilize, biodegrade, and leach into the ground water, but no data on the rates of these processes could be found. Its fate in ground water is unknown. When released into water it will volatilize and probably biodegrade. It would not be expected to adsorb to sediment or bioconcentrate in fish. Environmental: When released to the atmosphere it will photodegrade in hours (polluted urban atmosphere) to an estimated range of 4 to 6 days in less polluted areas. Rainout should be significant. Physical: No information available. Other: No information available.
Section 13 - Disposal Considerations
Chemical waste generators must determine whether a discarded chemical is classified as a hazardous waste. US EPA guidelines for the classification determination are listed in 40 CFR Parts 261.3. Additionally, waste generators must consult state and local hazardous waste regulations to ensure complete and accurate classification.
RCRA P-Series: None listed. RCRA U-Series: CAS# 141-78-6: waste number U112 (Ignitable waste).
Section 14 - Transport Information
Shipping Name: Hazard Class: UN Number: Packing Group:
US DOT FLAMMABLE LIQUIDS, N.O.S. 3 UN1993 II
Canada TDG No information available.
Section 15 - Regulatory Information US FEDERAL
TSCA CAS# 64-17-5 is listed on the TSCA inventory. CAS# 141-78-6 is listed on the TSCA inventory. Health & Safety Reporting List None of the chemicals are on the Health & Safety Reporting List. Chemical Test Rules CAS# 141-78-6: Test for Health Effects Section 12b None of the chemicals are listed under TSCA Section 12b. TSCA Significant New Use Rule None of the chemicals in this material have a SNUR under TSCA. CERCLA Hazardous Substances and corresponding RQs CAS# 141-78-6: 5000 lb final RQ; 2270 kg final RQ SARA Section 302 Extremely Hazardous Substances None of the chemicals...