Metabolism
Objectives
Lipid Students will
Articulate the rxns of -oxidation of fatty acids Describe the steps used by organisms to catabolize monounsaturated, polyunsaturated, and odd-number fatty acids in their diets Articulate the coordinated regulation of fatty acid anabolism and catabolism and the misregulation of these processes in Type I diabetes mellitus Articulate the process of 16:0 fatty acid synthesis
Notes
Digestion of Fats
Chylomicrons
Mobilization of Stored Fats
Transport FA into Mitochondrion
Esterify to CoA in cytosol Transesterify to carnitine and transport
Rate limiting Regulation point Commits FA to -oxidation
Transesterify back to CoA
-oxidation
Wrinkles: < 12 C, soluble enzymes Rather than TFP complex
Where about to?
What unsaturation?
Recall that activated transFAs are produced during -oxidation. Most naturally occurring Unsaturated FAs are cis Isomerase: QED
Polyunsaturated FAs
Odd number of C atoms?
Regulation
Ketone Bodies
Convert acetyl-CoA and export from liver for use as fuel in other tissues Acetone exhaled
Used to diagnose diabetes
Starvation gluconeogenesis depletes TCA intermediates Diverts acetyl-CoA to ketone bo...