Animal Use Exam
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Animal Use Exam

Course Number: BIO 302, Spring 2009

College/University: Washington

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The IACUC's activities to ensure compliance benefit whom? The institution, the investigators, and the animals. Which is not a function of the IACUC? Assist with writing the basic science portions of a grant application. Which PHS organization is responsible for monitoring institutional compliance with PHS Policy? The Office of Laboratory Animal Welfare (OLAW, formerly OPRR). Which of the following institutions...

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IACUC's The activities to ensure compliance benefit whom? The institution, the investigators, and the animals. Which is not a function of the IACUC? Assist with writing the basic science portions of a grant application. Which PHS organization is responsible for monitoring institutional compliance with PHS Policy? The Office of Laboratory Animal Welfare (OLAW, formerly OPRR). Which of the following institutions must follow PHS guidelines for animal research, teaching and testing? All institutions that accept PHS funding. Unlike the USDA AWA regulations, PHS Policy applies to which animals? All vertebrate species used in research, teaching or testing at institutions receiving PHS funds. Which of the following is a role of AAALAC? Sponsors a voluntary accreditation program for animal care and use programs. The USDA AWA regulations do not currently apply to which of the following animals? Non-vertebrates, laboratory mice and laboratory rats. Prior to beginning any work involving vertebrate animals, an investigator must do which of the following? Submit a fully completed animal protocol form to the IACUC and receive written confirmation of IACUC approval. Prior to IACUC review of animal protocol forms that describe procedures that may cause more than momentary pain or distress, which of the following is mandated by the USDA Animal Welfare Act Regulations? A consultation with a laboratory animal veterinarian. Explaining the potential value of proposed animal research to human and animal health is: Important to convey so that the lay member on the IACUC, or members of the public can understand. Which of the following are helpful to the IACUC when reviewing an animal protocol? Flowcharts to help illustrate complex experimental designs. Which of the following statements concerning selection of species for research is false? Cost of the animals should be a primary factor in determining which species to use. Which of the following statements about using a statistical analysis to justify animal numbers is true? A statistical analysis should be used whenever possible. Which of the following justifications for using a particular species would probably not be accepted by the IACUC? Reluctance to learn about another species. The three Rs of Russell and Burch stand for what? Replacement, reduction, and refinement. What are the primary purposes of the 3 Rs concept of Russell and Burch? Urge scientists to minimize use of animals and to minimize pain and distress to animals that are used. Which of the following is not an example of replacement? The use of a new analgesic that provides better postoperative pain relief. Which of the following is not an example of reduction? The use of a new anesthetic that provides better induction and a shorter recovery period. Which of the following is not an example of refinement? The use of computer modeling software to substitute for animal experiments. The USDA AWA Regulations require the IACUC to do what two things regarding alternatives? Ensure that the principal investigator has considered alternatives to painful or distressing procedures, and review a written assurance that alternatives are not available. Which of the following is not true regarding the information provided by an investigator to the IACUC to verify that alternatives to painful or stressful procedures are not available? If an alternative is available, it may be ignored as long as personnel have experience with the current technique. What is a primary mission of the Animal Welfare Information Center (AWIC)? Provides assistance with alternatives and database searches. The Johns Hopkins Center for Alternatives to Animal Testing (CAAT), the Institute for In Vitro Sciences, and the European Center for Validation of Alternative Methods (ECVAM) are primarily interested in what area? Performing or sponsoring research into alternatives to animal use for research and testing. Which of the following is true regarding the USDA Animal Welfare Act regulations and duplication of experiments? Unnecessary duplication of experiments is not allowed. Annually, the University of Washington must report the number of animals used by pain/distress category to what agency? United States Department of Agriculture (USDA). An investigator wishes to use animals in a study that involves category B, C, and D activities performed on the same animal. How should the animal be categorized? D. Category Which of the following activities would disqualify an animal from USDA category B? Blood collection for research. Which of the following activities would disqualify an animal from USDA category C? Terminal Surgery. Which of the following activities would disqualify an animal from USDA category D? Studies in which animals are allowed to die without pain relief. Which of the following activities would place an animal in category E? Lethal dose experiments in which animals are allowed to die without intervention. Studies placed in which USDA pain/distress category receive increased IACUC scrutiny and must be reported and described annually to the USDA? Category E. Endpoint criteria describe when it is time to do what? Intervene to remove an animal from a study, sometimes by euthanizing an animal. Which parameter would not likely be part of an endpoint policy? The number of animals approved by the IACUC for a particular protocol. Which of the following is a reasonable definition of euthanasia? The act of killing animals by methods that induce rapid unconsciousness and death without pain or distress. What is the main reason that proper training in euthanasia techniques is so important? Improper technique can cause unnecessary pain and distress in animals. Which reference document contains detailed guidelines for performing euthanasia on a variety of animals? The AVMA Guidelines on Euthanasia. Which of the following is not considered a physical method of euthanasia? Pentobarbital overdose. Which of the following concerning euthanasia is not true? Physical methods of euthanasia are most desirable when used on conscious animals. Which of the following euthanasia agents is recommended for use by itself on a conscious animal? Pentobarbital. Injections of euthanasia agents into the heart may be performed in what group of animals below? Anesthetized, heavily sedated, or comatose animals only. Which of the following is a false statement concerning cervical dislocation? Because it is a non-physical method, it can be approved by the IACUC without a scientific justification. Which of the following is an advantage of cervical dislocation as a method of euthanasia? It does not result in chemical contamination of tissues. Cervical dislocation performed by hand can be performed on which of the following animals? Rats weighing less than 200 grams and rabbits weighing less than 1 kg. Which of the following is a false statement concerning euthanasia of animals? Physical methods are generally preferred over non-physical methods. Which of the following is true concerning exsanguination? It is a technique that should not be used on conscious animals because loss of large blood volumes produces anxiety. Which of the following statements about the use of carbon dioxide for euthanasia is false? It is the preferred method of euthanizing rabbits, dogs, cats, and primates. Which of the following statements concerning the use of carbon dioxide to euthanize rodents is true? Compared to adults, neonates are resistant to low oxygen levels, and are therefore less susceptible to death by carbon dioxide inhalation. Which of the following statements about euthanasia of cold-blooded animals like reptiles and amphibians is true? According to the AVMA Panel on Euthanasia report, they can often be euthanized with barbiturates or gas anesthetics. Which of the following statements about pithing as a method of euthanasia is false? It is a simple technique readily performed by untrained students. Which of the following statements about preferred methods of euthanasia is false? Cervical dislocation is always the preferred method of euthanasia on conscious rodents. Who is generally given institutional responsibility for deciding if an individual researcher is properly trained to perform animal procedures, as required by law? The IACUC. USDA requires institutions to provide training in all of the following areas except which one? Names of high ranking USDA officials. All personnel performing animal procedures must be properly trained to do so when? Before any procedures are performed. Which statement about the Occupational Health and Safety Program is false? You may not decline medical treatments provided as part of the Occupational Health and Safety Program. Prior to making any significant changes in your use of animals, what must you do? Obtain IACUC approval.

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