Clinical Laboratory Sciences 1113 Introduction to Clinical Laboratory Practices UNIT 7: IMMUNOLOGY OF INFECTIOUS DISEASE LEARNING OBJECTIVES: 1. Outline the characteristics of the antibodies produced in response to an infection of the human body by Treponema Palladium. 2. Compare and contrast the RPR and FTA tests in regard to which antibody they are detecting, sensitivity, specificity, and test procedure. 3. Identify the immunological mechanisms which gives rise to anti-streptolysin O, antistreptokinase, anti-NADase, anti-hyaluronidase, etc. 4. Compare and contrast the test methodologies used for detection of Cytomegalovirus (CMV). Epstein-Barr virus, Hepatitis A, B, C; and HIV. 5. Identify the mode of transmission and common characteristics of CMV. 6. Identify the common serological methods used in the diagnosis of CMV. 7. Identify the antibody, antigen, and common serological methods used in the diagnosis of the Epstein-Barr virus. 8. Compare and contrast the antibodies of the native Foresman type to that of infectious mononucleosis and serum sickness. 9. Compare and contrast direct methods and what they detect for CMV infection. 10. Identify the common name, the mode of transmission, and the serological methods used in the diagnosis of the Rubella virus. 11. Compare and contrast Hepatitis A, B and C with regard to the transmission route, length of incubation, acute and/or chronic states and <a href="/keyword/causative-agent/" >causative agent</a> . 12. Correlate test results for HbsAg and anti-HBc antibody to disease phase. 13. Explain the process by which immunity to hepatitis A &amp; B can be obtained. 14. Describe the <a href="/keyword/causative-agent/" >causative agent</a> , etiology and pathogenicity of AIDS. 15. Describe the clinical and laboratory findings in a patient with acquired immunodeficiency syndrome (AIDS). 16. Identify the common serological methods used in the diagnosis of the <a href="/keyword/human-immunodeficiency-virus/" >human <a href="/keyword/immunodeficiency-virus/" >immunodeficiency virus</a> </a> (HIV) 17. Define the current confirmatory testing for HIV infections. 18. Explain what the P24 antigen test is and how it is more useful in the detection of HIV. LEARNING ACTIVITIES: 1. Read Stevens, Chapters 15-18 as guided by course objectives. Chapter review highlights. 2. Attend lecture and discussions of objectives. 3. Compile reading and lecture notes to answer each objective.