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L&S C30T Lec21 Berkeley L&S C30T
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  • Title: L&S C30T Lec21
  • Type: Notes
  • School: Berkeley
  • Course: L&S C30T
  • Term: Spring

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C30T L&S Drugs in the Brain Lecture 21: Midterm Exam: Thursday November 15 Midterm Exam Review: Monday November 12 at 4:30 PM, 2050 VLSB Updated list of key concepts on website COCA Difference between plant and chemical Pharmaceuticals mislead that plants and chemicals similar There are similarities, but chemicals and plants different Nowhere is difference seen more than in coca plant and cocaine When plant taken out of place of use and chemical extracted as purified substance, is different Analogy of sugar--comes from lots of fruits Don't hear people get into health problems, addiction from fruits like peaches But if sugar extracted, bought cheaply, then get into abuse problem Corn syrup subsidized by government, pushed to be put in processed foods Huge awareness of marijuana abuse, nothing seen on sugar use and toxicity of food supply Difference between cocaine and coca "The Ally: She can bewitch. She can seduce..." ~(Parmako p163) Cocaine around in 17th century Primarily as local anesthetic Vin Mariani wine (with cocaine) Stimulant effect plus alcohol's sedative effect Coca-Cola Introduction through pharmaceutical company in 1890's in Georgia Invented by pharmacist, wanted to serve population wanting coca without alcohol Advertised as a temperance beverage Big market for stimulating beverage without alcohol "The Intellectual Beverage and Temperance Drink contains the valuable Tonic and Nerve Stimulant properties of the coca plant..." ~Coca Cola ad, 1980 Coca (cocaine), and cola (caffeine) 1903 Cocaine removed from company, but left in coca leaf extract Chemically remove cocaine molecule from that All of coca leaf extract may now be removed from Coca Cola Coca cola recipe as trade secret Coca Leaf Injection in Peru, taking roasted coca leaf with ground up limestone Figured out bigger stimulant effect by eating it with ground up rock, or seashell Chemistry of it Cocaine is alkaloid, pick up positive charge, forms a salt Cocaine hydrochloride salt Easily formed with salt by picking up Hydrogen and Chloride Water-soluble, like NaCl Mouth has a lot of positive charges Positive charge related to acidity Cocaine picks up positive charge, doesn't cross membranes as easily because need to be hydrophobic, so isn't as easily absorbed from mouth to bloodstream Still will be absorbed because no mouth-blood barrier, and mouth has holes between cells But absorption smaller Inonized form of cocaine at acidic pH CaCO3 calcium carbonate "lime" neutral "free base" form at basic pH, improved oral/buccal absorption Routes of entry for cocaine Oral/digestive Nasal insufflations Oral/buccal Smoking Injection Risks of toxic effects greater for more rapid routes of entry Nasal insufflation Injection Smoking All routes of administration can be dangerous Oral: body-packer overdoses Len Bias (1963-1986) Controlled Substance Cocaine and coca leaf are Schedule 2 Cocaine hydrochloride--less volatile/vaporizable baking soda NaHCO3 Cocaine "free base" +NaCl + H2O + CO2--more volatile/vaporizable "smoking cocaine" Vaporizing freebase/ crack cocaine Rapid onset Very high addictive potential Greater toxicity Based on pharmacology "Stealing from Tommorrow" (p178-183 Dynamis) "Pure taste..trace of metallic...trace of bitter...maybe it's what sweet would be like without sugar" Addiction Inability to control one's use Often associated with withdrawal effects Usually associated with adverse consequences A behavioral condition Bio-psycho-social conditions Has different components Biological aspects Genetic predispositions Drug pharmacology Drug-induced changes Psychological aspects Preferred coping with stress Numb anxiety and dysphoria Social / environmental aspects Learned behavior from others Supported by peer group Adverse socio-economic conditions Social sanction / availability Brain James Olds 1954, study rats learning in mazes Found place in brain where stimulated brain better Rat would always go back there, as if positive connection with that region of the place Speculated that rat experienced pleasure there, improving its ability to learn Published 1954 article Hooked rat up in cage in which rat could push lever to receive electrical brain stimulation Called the Pleasure center for years Sex, water, food all secondary to stimulation Rats choose stimulation over food Painful electrified grid Will cross to receive brain stimulation Reward-reinforcement pathway In area called ventral tegmentum (VTA) Sends axons to nucleus accumbens Sends axons to frontal cortex Neurotransmitter used is dopamine Pushing lever gives injection of drug Animals will self-administer cocaine, amphetamine, morphine, heroin, nicotine, and other euphorigenic chemicals Drugs having abuse potential facilitate increased dopamine activity in the reward pathway Increase presence of dopamine in synapse Cocaine blocks reuptake transmitter for dopamine Amphetamine causes it to leak out Cannabanoids, alcohol, interact with GABBA, other receptors, activation through other receptors make dopamine receptor more active Resulting changes in synaptic strength Physical changes in reward-reinforcement pathway People can recover, but brain never fully fixed, may be possible to reactivate

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Path: Berkeley >> L&S >> C30T Spring, 2008

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