Innocenti
TJD Paolo Group
November 2006
As usual, provide mechanisms, missing reagents and structures... a)
O 1) 2) O O methyl acetoacetate, NaH Pd(PPh3)4, THF, 55 C MeO
A
F F F F O F
1) 2) 3)
N
O
1) N
1) 2)
1) 2) N Boc 3) 4) N Boc
NBoc
1) CAN, CHCl3/DME/H2O
H N
B
O
1)
C
2)
MeO
, NaOH, DMSO
(HO)2B
Boc N
NH Pd(PPh3)4, LiCl, Na2CO3 (aq.) 80 DME, C MeO butylcycloheptylprodigiosin N H N
b)
S Et NH carbon suboxide
O2N
D
toluene, 120 C
O2N O S N - COS O
H2N
E
1) H2, Pd/C 2) LiAlH4 Et N
Et
1) N H N
Et isoschizozygane core
c)
O EtO I
(1 eq...