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IPRO 345 ABSTRACT
Course: IPRO 345, Fall 2009School: Illinois Tech
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PRODUCTIONOFIFN OBJECTIVES: IPRO345 TheObjectiveofIPRO345wastodesignaprocessforthelargescaleproductionof InterferonAlpha(IFN)tomeetthegrowingdemandofthisbiotherapeuticproduct.We alsohadtoperformanEconomicAnalysisontheprocesswedesigned. IPRO BACKGROUND: Interferon(IFN)isaproteinproducedbytheanimalcellwhentheyareinvadedbyviruses, thenreleasedintothebloodstreamorintercellularfluidtoinducemanufactureofenzymes...
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PRODUCTIONOFIFN
OBJECTIVES: IPRO345 TheObjectiveofIPRO345wastodesignaprocessforthelargescaleproductionof InterferonAlpha(IFN)tomeetthegrowingdemandofthisbiotherapeuticproduct.We alsohadtoperformanEconomicAnalysisontheprocesswedesigned.
IPRO
BACKGROUND: Interferon(IFN)isaproteinproducedbytheanimalcellwhentheyareinvadedbyviruses, thenreleasedintothebloodstreamorintercellularfluidtoinducemanufactureofenzymes thatcounteracttheinfection.IFNcanbeproducedbygeneticengineering.IFNAlpha hasbeenapprovedforuseasatherapeuticagainsthairycellLeukemia,HepatitisC, chronicHepatitisB.Ithasalsobeenfoundasthetreatmentforgenitalwartsandsome rarecasesofcancersofthebloodandbonemarrow. ORGANIZATION: OurTeamssplitintothreesubteams:adesignteamandtworesearchteams.Thethree groupscollaboratedtomeettheoverallteamgoals. OurTeamdesignedaprocesstoisolateIFNfromChineseHamsterOvaryCells(CHO ACCOMPLISHMENTS: cells).Ourprocessincludesthegrowthofcellsandsecretionofproductsinabatch reactorsystem,recoverysystemtoobtainahighpurityproductfromcellbroth. TheprocessDesignedwasextremelyprofitablebasedonthepriceonIFN.Weputin considerationtosubsidizethepriceofourproduct,thisstillprovedprofitable.
345
RobertRivera RachidAmine MinhTran PhoungBui AlanBabjak VuChu ShanIqbalHus...
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