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Chemistry Second Organic Edition The INSTANT NOTES series Series Editor: B.D. Hames School of Biochemistry and Molecular Biology, University of Leeds, Leeds, UK Animal Biology 2nd edition Biochemistry 2nd edition Bioinformatics Chemistry for Biologists 2nd edition Developmental Biology Ecology 2nd edition Immunology 2nd edition Genetics 2nd edition Microbiology 2nd edition Molecular Biology 2nd edition Neuroscience Plant Biology Chemistry series Consulting Editor: Howard Stanbury Analytical Chemistry Inorganic Chemistry 2nd edition Medicinal Chemistry Organic Chemistry 2nd edition Physical Chemistry Psychology series Sub-series Editor: Hugh Wagner Dept of Psychology, University of Central Lancashire, Preston, UK Psychology Forthcoming titles Cognitive Psychology Physiological Psychology Organic Chemistry Second Edition G. L. Patrick Department of Chemistry and Chemical Engineering, Paisley University, Paisley, Scotland This edition published in the Taylor & Francis e-Library, 2005. "To purchase your own copy of this or any of Taylor & Francis or Routledge's collection of thousands of eBooks please go to www.eBookstore. tandf.co.uk. Garland Science/BIOS Scientic Publishers, 2004 First published 2000 Second edition published 2004 All rights reserved. No part of this book may be reproduced or transmitted, in any form or by any means, without permission. A CIP catalogue record for this book is available from the British Library. ISBN 0-203-42761-0 Master e-book ISBN ISBN 0-203-44168-0 (Adobe eReader Format) ISBN 1 85996 264 5 (Print Edition) Garland Science/BIOS Scientic Publishers 4 Park Square, Milton Park, Abingdon, Oxon OX14 4RN, UK and 29 West 35th Street, New York, NY 100012299, USA World Wide Web home page: www.bios.co.uk Garland Science/BIOS Scientic Publishers is a member of the Taylor & Francis Group Distributed in the USA by Fullment Center Taylor & Francis 10650 Toebben Drive Independence, KY 41051, USA Toll Free Tel.: +1 800 634 7064; E-mail: taylorandfrancis@thomsonlearning.com Distributed in Canada by Taylor & Francis 74 Rolark Drive Scarborough, Ontario M1R 4G2, Canada Toll Free Tel.: +1 877 226 2237; E-mail: tal_fran@istar.ca Distributed in the rest of the world by Thomson Publishing Services Cheriton House North Way Andover, Hampshire SP10 5BE, UK Tel.: +44 (0)1264 332424; E-mail: salesorder.tandf@thomsonpublishingservices.co.uk Library of Congress Cataloging-in-Publication Data Patrick, Graham L. Organic chemistry / G.L. Patrick.2nd ed. p. cm. (Instant notes series) Includes bibliographical references and index. ISBN 1-85996-264-5 (alk. paper) 1. Chemistry, OrganicOutlines, syllabi, etc. I. Title: Instant notes organic chemistry. II. Title. III. Series. QD256.5.P37 2003 547dc22 Production Editor: Andrew Watts C ONTENTS Preface Section A Structure and bonding A1 Atomic structure of carbon A2 Covalent bonding and hybridization A3 sp3 Hybridization A4 sp2 Hybridization A5 sp Hybridization A6 Bonds and hybridized centers Section B Alkanes and cycloalkanes B1 Denition B2 Drawing structures B3 Nomenclature Section C Functional groups C1 Recognition of functional groups C2 Aliphatic and aromatic functional groups C3 Intermolecular bonding C4 Properties and reactions C5 Nomenclature of compounds with functional groups C6 Primary, secondary, tertiary and quaternary nomenclature Section D Stereochemistry D1 Constitutional isomers D2 Congurational isomers alkenes and cycloalkanes D3 Congurational isomers optical isomers D4 Conformational isomers Section E Nucleophiles and electrophiles E1 Denition E2 Charged species E3 Neutral inorganic species E4 Organic structures Section F Reactions and mechanisms F1 Reactions F2 Mechanisms Section G Acidbase reactions G1 BrnstedLowry acids and bases G2 Acid strength G3 Base strength G4 Lewis acids and bases G5 Enolates ix 1 1 3 5 8 14 17 19 19 20 22 27 27 29 30 33 35 43 45 45 46 49 56 63 63 64 66 69 73 73 75 79 79 82 88 94 95 vi Contents Section H Alkenes and alkynes H1 Preparation of alkenes and alkynes H2 Properties of alkenes and alkynes H3 Electrophilic addition to symmetrical alkenes H4 Electrophilic addition to unsymmetrical alkenes H5 Carbocation stabilization H6 Reduction and oxidation of alkenes H7 Hydroboration of alkenes H8 Electrophilic additions to alkynes H9 Reduction of alkynes H10 Alkylation of terminal alkynes H11 Conjugated dienes Section I Aromatic chemistry I1 Aromaticity I2 Preparation and properties I3 Electrophilic substitutions of benzene I4 Synthesis of mono-substituted benzenes I5 Electrophilic substitutions of mono-substituted aromatic rings I6 Synthesis of di- and tri-substituted benzenes I7 Oxidation and reduction Section J Aldehydes and ketones J1 Preparation J2 Properties J3 Nucleophilic addition J4 Nucleophilic addition charged nucleophiles J5 Electronic and steric effects J6 Nucleophilic addition nitrogen nucleophiles J7 Nucleophilic addition oxygen and sulfur nucleophiles J8 Reactions of enolate ions J9 -Halogenation J10 Reduction and oxidation J11 ,-Unsaturated aldehydes and ketones Section K Carboxylic acids and carboxylic acid derivatives K1 Structure and properties K2 Nucleophilic substitution K3 Reactivity K4 Preparations of carboxylic acids K5 Preparations of carboxylic acid derivatives K6 Reactions K7 Enolate reactions Section L Alkyl halides L1 Preparation and physical properties of alkyl halides L2 Nucleophilic substitution L3 Factors affecting SN2 versus SN1 reactions L4 Elimination L5 Elimination versus substitution L6 Reactions of alkyl halides L7 Organometallic reactions 99 99 101 105 112 115 117 121 124 127 129 131 135 135 137 139 147 150 160 164 167 167 169 173 175 181 184 187 191 198 200 202 205 205 209 213 217 219 224 234 239 239 242 247 252 256 258 261 Contents vii Section M Alcohols, phenols, and thiols M1 Preparation of alcohols M2 Preparation of phenols M3 Properties of alcohols and phenols M4 Reactions of alcohols M5 Reactions of phenols M6 Chemistry of thiols Section N Ethers, epoxides, and thioethers N1 Preparation of ethers, epoxides, and thioethers N2 Properties of ethers, epoxides, and thioethers N3 Reactions of ethers, epoxides, and thioethers Section O Amines and nitriles O1 Preparation of amines O2 Properties of amines O3 Reactions of amines O4 Chemistry of nitriles Section P Organic spectroscopy and analysis P1 Spectroscopy P2 Visible and ultra violet spectroscopy P3 Infra-red spectroscopy P4 Proton nuclear magnetic resonance spectroscopy 13 P5 C nuclear magnetic resonance spectroscopy P6 Mass spectroscopy Further reading Index 263 263 264 266 270 277 281 283 283 286 289 295 295 299 305 311 315 315 317 322 324 339 342 347 349 P REFACE This textbook aims to provide a comprehensive set of basic notes in organic chemistry, which will be suitable for undergraduate students taking chemistry, chemistry-related courses, or courses which involve organic chemistry as an ancillary subject. The book concentrates on core topics which are most likely to be common to those organic chemistry courses which follow on from a foundation or introductory general chemistry course. Organic chemistry is a subject which can lead some students to the heights of ecstasy, yet drive others up the wall. Some students switch on to it immediately, while others can make neither head nor tail of it, no matter how hard they try. Certainly, one of the major problems in studying the subject is the vast amount of material which often has to be covered. Many students blanche at the prospect of having to learn a seemingly endless number of reactions, and when it comes to drawing mechanisms and curly arrows, they see only a confusing maze of squiggly lines going everywhere yet nowhere. The concepts of organic reaction mechanisms are often the most difcult to master. These difculties are often compounded by the fact that current textbooks in organic chemistry are typically over 1200 pages long and can be quite expensive to buy. This book attempts to condense the essentials of organic chemistry into a manageable text of 310 pages which is student friendly and which does not cost an arm and a leg. It does this by concentrating purely on the basics of the subject without going into exhaustive detail or repetitive examples. Furthermore, key notes at the start of each topic summarize the essential facts covered and help focus the mind on the essentials. Organic chemistry is a peculiar subject in that it becomes easier as you go along! This might seem an outrageous statement to make, especially to a rstyear student who is struggling to come to terms with the rules of nomenclature, trying to memorize a couple of dozen reactions and making sense of mechanisms at the same time. However, these topics are the basics of the subject and once they have been grasped, the overall picture becomes clear. Understanding the mechanism of how a reaction takes place is particularly crucial in this. It brings a logic to the reactions of the different functional groups. This in turn transforms a list of apparently unrelated facts into a sensible theme which makes remembering the reactions a piece of cake (well, nearly). Once this happy state of affairs has been reached, the relevance of organic chemistry to other subjects such as genetics and biochemistry suddenly leaps off the page. Understanding organic chemistry leads to a better understanding of life chemistry and how the body works at the molecular level. It also helps in the understanding of the molecular mechanisms involved in disease and bodily malfunction, leading in turn to an understanding of how drugs can be designed to cure these disease states the science of medicinal chemistry. And thats not all. An understanding of organic chemistry will help the industrial chemist or chemical engineer faced with unexpected side-reactions in a chemical process, and the agro-scientist trying to understand the molecular processes taking place within plants and crops; and it will assist in the design and synthesis of new herbicides and fungicides which will be eco-friendly. It x Preface will aid the forensic scientist wishing to analyze a nondescript white powder is it heroin or our? The list of scientic subject areas involving organic chemistry is endless designing spacesuits, developing new photographic dyes, inventing new molecular technology in microelectronics one could go on and on. Organic chemistry is an exciting subject since it leads to an essential understanding of molecules and their properties. The order in which the early topics of this book are presented is important. The rst two sections cover structure and bonding, which are crucial to later sections. Just why does carbon form four bonds? What is hybridization? The third section on functional groups is equally crucial if students are to be capable of categorizing the apparent maze of reactions which organic compounds can undergo. It is followed by section D on stereochemistry, then sections E and F, in which the basic theory of reactions and mechanisms is covered. What are nucleophiles and electrophiles? What does a mechanism represent? What does a curly arrow mean? The remaining sections can be used in any order. These look at the reactions and mechanisms of the common functional groups which are important in chemistry and biochemistry. It is hoped that students will nd this textbook useful in their studies and that once they have grasped what organic chemistry is all about they will read more widely and enter a truly exciting world of molecular science. Section A Structure and bonding A1 ATOMIC STRUCTURE OF CARBON Key Notes Atomic orbitals The atomic orbitals available for the six electrons of carbon are the s orbital in the rst shell, the s orbital in the second shell and the three p orbitals in the second shell. The 1s and 2s orbitals are spherical in shape. The 2p orbitals are dumbbell in shape and can be assigned 2px, 2py or 2pz depending on the axis along which they are aligned. The 1s orbital has a lower energy than the 2s orbital which has a lower energy than the 2p orbitals. The 2p orbitals have equal energy (i.e. they are degenerate). Carbon is in the second row of the periodic table and has six electrons which will ll up lower energy atomic orbitals before entering higher energy orbitals (aufbau principle). Each orbital is allowed a maximum of two electrons of opposite spin (Pauli exclusion principle). When orbitals of equal energy are available, electrons will occupy separate orbitals before pairing 2 up (Hunds rule). Thus, the electronic conguration of a carbon atom is 1s 2 1 1 2s 2px 2py . Covalent bonding and hybridization (A2) Energy levels Electronic conguration Related topic Atomic orbitals Carbon has six electrons and is in row 2 of the periodic table. This means that there are two shells of atomic orbitals available for these electrons. The rst shell closest to the nucleus has a single s orbital the 1s orbital. The second shell has a single s orbital (the 2s orbital) and three p orbitals (3 2p). Therefore, there are a total of ve atomic orbitals into which these six electrons can t. The s orbitals are spherical in shape with the 2s orbital being much larger then the 1s orbital. The p orbitals are dumbbell-shaped and are aligned along the x, y and z axes. Therefore, they are assigned the 2px, 2py and 2pz atomic orbitals (Fig. 1). y y y y y z x z x z 2px x z x z x 1s Fig. 1. Atomic orbitals. 2s 2py 2pz 2 Section A Structure and bonding Energy levels The atomic orbitals described above are not of equal energy (Fig. 2). The 1s orbital has the lowest energy. The 2s orbital is next in energy and the 2p orbitals have the highest energies. The three 2p orbitals have the same energy, meaning that they are degenerate. Energy 2px 2s 2py 2pz 1s Fig. 2. Energy levels of atomic orbitals. Electronic conguration Carbon is in the second row of the periodic table and has six electrons which will ll up the lower energy atomic orbitals rst. This is known as the aufbau principle. The 1s orbital is lled up before the 2s orbital, which is lled up before the 2p orbitals. The Pauli exclusion principle states that each orbital is allowed a maximum of two electrons and that these electrons must have opposite spins. Therefore, the rst four electrons ll up the 1s and 2s orbitals. The electrons in each orbital have opposite spins and this is represented in Fig. 3 by drawing the arrows pointing up or down. There are two electrons left to t into the remaining 2p orbitals. These go into separate orbitals such that there are two half-lled orbitals and one empty orbital. Whenever there are orbitals of equal energy, electrons will only start to pair up once all the degenerate orbitals are half lled. This is known as Hunds rule. Energy 2px 2s 2py 2pz 1s Fig. 3. Electronic conguration for carbon. 2 2 1 1 The electronic conguration for carbon is 1s 2s 2px 2py . The numbers in superscript refer to the numbers of electrons in each orbital. The letters refer to the types of atomic orbital involved and the numbers in front refer to which shell the orbital belongs. Section A Structure and bonding A2 COVALENT BONDING AND HYBRIDIZATION Key Notes Covalent bonding When two hydrogen atoms approach each other, their 1s atomic orbitals interact to form a bonding and an antibonding molecular orbital (MO). A stable covalent bond is formed when the bonding MO is lled with a pair of electrons and the antibonding MO is empty. Sigma () bonds are strong bonds with a circular cross-section formed by the head-on overlap of two atomic orbitals. The electronic conguration of atomic carbon implies that carbon should form two bonds. However, it is known that carbon forms four bonds. When carbon is part of an organic structure, it can mix the 2s and 2p orbitals of the valence shell in a process known as hybridization. There are three 3 2 possible types of hybridization sp , sp and sp hybridization. Atomic structure of carbon (A1) 3 sp Hybridization (A3) sp Hybridization (A4) sp Hybridization (A5) 2 Sigma bonds Hybridization Related topics Covalent bonding A covalent bond binds two atoms together in a molecular structure and is formed when atomic orbitals overlap to produce a molecular orbital so called because the orbital belongs to the molecule as a whole rather than to one specic atom. A simple example is the formation of a hydrogen molecule (H2) from two hydrogen atoms. Each hydrogen atom has a half-lled 1s atomic orbital and when the atoms approach each other, the atomic orbitals interact to produce two MOs (the number of resulting MOs must equal the number of original atomic orbitals, Fig. 1). H H Antibonding molecular orbital (empty) Energy H 1s atomic orbital + H 1s atomic orbital H H = H H Bonding molecular orbital (full) Fig. 1. Molecular orbitals for hydrogen (H2 ). The MOs are of different energies. One is more stable than the original atomic orbitals and is called the bonding MO. The other is less stable and is called the antibonding MO. The bonding MO is shaped like a rugby ball and results from 4 Section A Structure and bonding the combination of the 1s atomic orbitals. Since this is the more stable MO, the valence electrons (one from each hydrogen) enter this orbital and pair up. The antibonding MO is of higher energy and consists of two deformed spheres. This remains empty. Since the electrons end up in a bonding MO which is more stable than the original atomic orbitals, energy is released and bond formation is favored. In the subsequent discussions, we shall concentrate solely on the bonding MOs to describe bonding and molecular shape, but it is important to realize that antibonding molecular orbitals also exist. Sigma bonds The bonding molecular orbital of hydrogen is an example of a sigma () bond: bonds have a circular cross-section and are formed by the head-on overlap of two atomic orbitals. This is a strong interaction and so sigma bonds are strong bonds. In future discussions, we shall see other examples of bonds formed by the interaction of atomic orbitals other than the 1s orbital. Atoms can form bonds with each other by sharing unpaired electrons such that each bond contains two electrons. In Topic A1, we identied that a carbon atom has two unpaired electrons and so we would expect carbon to form two bonds. However, carbon forms four bonds! How does a carbon atom form four bonds with only two unpaired electrons? So far, we have described the electronic conguration of an isolated carbon atom. However, when a carbon atom forms bonds and is part of a molecular structure, it can mix the s and p orbitals of its second shell (the valence shell). This is known as hybridization and it allows carbon to form the four bonds which we observe in reality. There are three ways in which this mixing process can take place. Hybridization the 2s orbital is mixed with all three 2p orbitals. This is known as sp hybridization; 2 the 2s orbital is mixed with two of the 2p orbitals. This is known as sp hybridization; the 2s orbital is mixed with one of the 2p orbitals. This is known as sp hybridization. 3 Section A Structure and bonding A3 SP 3 HYBRIDIZATION Key Notes Denition In sp hybridization, the s and the p orbitals of the second shell are mixed 3 to form four hybridized sp orbitals of equal energy. Each hybridized orbital contains a single unpaired electron and so four bonds are possible. Each sp orbital is shaped like a deformed dumbbell with one lobe much larger than the other. The hybridized orbitals arrange themselves as far apart from each other as possible such that the major lobes point to the cor3 ners of a tetrahedron. sp Hybridization explains the tetrahedral carbon in saturated hydrocarbon structures. Sigma () bonds are strong bonds formed between two sp hybridized car3 bons or between an sp hybridized carbon and a hydrogen atom. A bond 3 formed between two sp hybridized carbon atoms involves the overlap of 3 half lled sp hybridized orbitals from each carbon atom. A bond formed 3 between an sp hybridized carbon and a hydrogen atom involves a half3 lled sp orbital from carbon and a half-lled 1s orbital from hydrogen. Nitrogen, oxygen, and chlorine atoms can also be sp hybridized in organic 3 molecules. This means that nitrogen has three half-lled sp orbitals and can form three bonds which are pyramidal in shape. Oxygen has two half-lled 3 sp orbitals and can form two bonds which are angled with respect to each 3 other. Chlorine has a single half-lled sp orbital and can only form a single bond. All the bonds which are formed are bonds. Covalent bonding and hybridization (A2) Bonds and hybridized centers (A6) 3 3 3 3 Electronic conguration Geometry Sigma bonds Nitrogen, oxygen and chlorine Related topics Denition In sp hybridization, the 2s orbital is mixed with all three of the 2p orbitals to give a 3 set of four sp hybrid orbitals. (The number of hybrid orbitals must equal the number of original atomic orbitals used for mixing.) The hybrid orbitals will each have the same energy but will be different in energy from the original atomic orbitals. That energy difference will reect the mixing of the respective atomic orbitals. The energy of each hybrid orbital is greater than the original s orbital but less than the original p orbitals (Fig. 1). The valence electrons for carbon can now be tted into the sp hybridized orbitals (Fig. 1). There was a total of four electrons in the original 2s and 2p orbitals. The s orbital was lled and two of the p orbitals were half lled. After hybridization, 3 there is a total of four hybridized sp orbitals all of equal energy. By Hunds rule, 3 3 Electronic conguration 6 Section A Structure and bonding they are all half lled with electrons which means that there are four unpaired electrons. Four bonds are now possible. Energy 2px 2py 2pz 2s Original atomic orbitals Fig. 1. sp Hybridization. 3 3 sp3 hybridized orbitals Geometry Each of the sp hybridized orbitals has the same shape a rather deformed looking dumbbell (Fig. 2). This deformed dumbbell looks more like a p orbital than an s orbital since more p orbitals were involved in the mixing process. Minor lobe Fig. 2. sp Hybridized orbital. 3 3 Major lobe Each sp orbital will occupy a space as far apart from each other as possible by pointing to the corners of a tetrahedron (Fig. 3). Here, only the major lobe of each hybridized orbital has been shown and the angle between each of these lobes is 109.5 . This is what is meant by the expression tetrahedral carbon. The threedimensional shape of the tetrahedral carbon can be represented by drawing a normal line for bonds in the plane of the page. Bonds going behind the page are represented by a hatched wedge, and bonds coming out the page are represented by a solid wedge. H 109 .5 o C H Tetrahedral shape Fig. 3. Tetrahedral shape of an sp hybridized carbon 3 Bond in the plane of the page H H Bond going behind the page Bond coming out of the page C Sigma bonds A half-lled sp hybridized orbital from one carbon atom can be used to form a 3 bond with a half-lled sp hybridized orbital from another carbon atom. In Fig. 4a, 3 the major lobes of the two sp orbitals overlap directly leading to a strong bond. It is the ability of hybridized orbitals to form strong bonds that explains why hybridization takes place in the rst place. The deformed dumbbell shapes allow a much better orbital overlap than would be obtained from a pure s orbital or a 3 pure p orbital. A bond between an sp hybridized carbon atom and a hydrogen 3 atom involves the carbon atom using one of its half-lled sp orbitals and the hydrogen atom using its half-lled 1s orbital (Fig. 4b). 3 A3 sp Hybridization 3 7 a) C + C sp3 sp3 C + C sigma bond H C sigma bond 3 C b) H sp3 1s Fig. 4. (a) Bond between two sp hybridized carbons; (b) bond between an sp hybridized carbon and hydrogen 3 3 Nitrogen, oxygen, and chlorine Nitrogen, oxygen and chlorine atoms can also be sp hybridized in organic structures. Nitrogen has ve valence electrons in its second shell. After 3 hybridization, it will have three half-lled sp orbitals and can form three bonds. Oxygen has six valence electrons. After hybridization, it will have two 3 half-lled sp orbitals and will form two bonds. Chlorine has seven valence 3 electrons. After hybridization, it will have one half-lled sp orbital and will form one bond. 3 The four sp orbitals for these three atoms form a tetrahedral arrangement with one or more of the orbitals occupied by a lone pair of electrons. Considering the atoms alone, nitrogen forms a pyramidal shape where the bond angles are slightly less than 109.5 (c. 107 ) (Fig. 5a). This compression of the bond angles is due to the orbital containing the lone pair of electrons, which demands a slightly greater amount of space than a bond. Oxygen forms an angled or bent shape where two lone pairs of electrons compress the bond angle from 109.5 to c. 104 (Fig. 5b). Alcohols, amines, alkyl halides, and ethers all contain sigma bonds involving nitrogen, oxygen, or chlorine. Bonds between these atoms and carbon are formed 3 by the overlap of half-lled sp hybridized orbitals from each atom. Bonds involving hydrogen atoms (e.g. OH and NH) are formed by the overlap of the half3 lled 1s orbital from hydrogen and a half-lled sp orbital from oxygen or nitrogen. a) N H H 107o b) O O H H3C 104o Angled molecule Fig. 5. (a) Geometry of sp hybridized nitrogen; (b) geometry of sp hybridized oxygen. 3 3 = CH3 H H N CH3 Pyramidal = H CH3 Section A Structure and bonding A4 SP 2 HYBRIDIZATION In sp hybridization, a 2s orbital is mixed with two of the 2p orbitals to 2 form three hybridized sp orbitals of equal energy. A single 2p orbital is left over which has a slightly higher energy than the hybridized orbitals. For carbon, each sp hybridized orbital contains a single unpaired electron. There is also a half-lled 2p orbital. Therefore, four bonds are possible. Each sp orbital is shaped like a deformed dumbbell with one lobe much larger than the other. The remaining 2p orbital is a symmetrical dumbbell. 2 The major lobes of the three sp hybridized orbitals point to the corners of a triangle, with the 2p orbital perpendicular to the plane. Each sp hybridized carbon forms three bonds using three sp hybridized orbitals. The remaining 2p orbital overlaps side on with a neighboring 2p orbital to form a pi () bond. The bond is weaker than the bond, but is strong enough to prevent rotation of the C C bond. Therefore, alkenes are planar, with each carbon being trigonal planar. The oxygen and carbon atoms are both sp hybridized. The carbon has three 2 sp hybridized orbitals and can form three bonds, one of which is to the 2 oxygen. The oxygen has one sp orbital which is used in the bond with carbon. The p orbitals on carbon and oxygen are used to form a bond. Aromatic rings are made up of six sp hybridized carbons. Each carbon forms three bonds which results in a planar ring. The remaining 2p orbital on each carbon is perpendicular to the plane and can overlap with a neighboring 2p orbital on either side. This means that a molecular orbital is formed round the whole ring such that the six electrons are delocalized around the ring. This results in increased stability such that aromatic rings are less reactive than alkenes. Conjugated systems such as conjugated alkenes and ,-unsaturated carbonyl compounds involve alternating single and double bonds. In such systems, the p lobes of one bond are able to overlap with the p lobes of a neighboring bond, and thus give a small level of double bond character to the connecting bond. This partial delocalization gives increased stability to the conjugated system. Properties of alkenes and alkynes (H2) Conjugated dienes (H11) Aromaticity (I1) Properties (J2) ,-Unsaturated aldehydes and ketones (J11) Structure and properties (K1) 2 2 2 2 2 2 2 Key Notes Denition Electronic conguration Geometry Alkenes Carbonyl groups Aromatic rings Conjugated systems Related topics A4 sp Hybridization 2 9 Denition In sp hybridization, the s orbital is mixed with two of the 2p orbitals (e.g. 2px and 2 2pz) to give three sp hybridized orbitals of equal energy. The remaining 2py orbital is unaffected. The energy of each hybridized orbital is greater than the original s orbital but less than the original p orbitals. The remaining 2p orbital (in this case the 2py orbital) remains at its original energy level (Fig. 1). Energy 2px 2py 2pz 2py sp2 2s Original atomic orbitals Fig. 1. sp Hybridization. 2 2 2 sp2 hybridized orbitals Electronic conguration For carbon, there are four valence electrons to t into the three hybridized sp orbitals and the remaining 2p orbital. The rst three electrons are tted into each of the hybridized orbitals according to Hunds rule such that they are all halflled. This leaves one electron still to place. There is a choice between pairing it 2 up in a half-lled sp orbital or placing it into the vacant 2py orbital. The usual principle is to ll up orbitals of equal energy before moving to an orbital of higher energy. However, if the energy difference between orbitals is small (as here) it is easier for the electron to t into the higher energy 2py orbital resulting in three 2 half-lled sp orbitals and one half-lled p orbital (Fig. 1). Four bonds are possible. The 2py orbital has the usual dumbbell shape. Each of the sp hybridized orbitals 3 has a deformed dumbbell shape similar to an sp hybridized orbital. However, 2 the difference between the sizes of the major and minor lobes is larger for the sp hybridized orbital. The hybridized orbitals and the 2py orbital occupy spaces as far apart from each other as possible. The lobes of the 2py orbital occupy the space above and below 2 the plane of the x and z axes (Fig. 2a). The three sp orbitals (major lobes shown only) will then occupy the remaining space such that they are as far apart from the 2py orbital and from each other as possible. As a result, they are all placed in the xz plane pointing toward the corner of a triangle (trigonal planar shape; Fig. 2b). The angle between each of these lobes is 120 . We are now ready to look at the 2 bonding of an sp hybridized carbon. y a) b) 120o x x y 2 Geometry z z 2 Fig. 2. (a) Geometry of the 2 py orbital; (b) geometry of the 2 py orbital and the sp hybridized orbitals. 10 Section A Structure and bonding Alkenes sp Hybridization results in three half-lled sp hybridized orbitals which form a trigonal planar shape. The use of these three orbitals in bonding explains the shape of an alkene, for example ethene (H2C CH2). As far as the CH bonds are concerned, the hydrogen atom uses a half-lled 1s orbital to form a strong bond 2 with a half lled sp orbital from carbon (Fig. 3a). A strong bond is also possible 2 between the two carbon atoms of ethene due to the overlap of sp hybridized orbitals from each carbon (Fig. 3b). H C + sp C + sp2 Fig. 3. 2 2 2 C H 1s C sp2 (a) Formation of a CH bond; (b) formation of a CC bond. C C The full bonding diagram for ethene is shown in Fig. 4a and can be simplied as shown in Fig. 4b. Ethene is a at, rigid molecule where each carbon is trigonal pla2 nar. We have seen how sp hybridization explains the trigonal planar carbons but we have not explained why the molecule is rigid and planar. If the bonds were the only bonds present in ethene, the molecule would not remain planar since rotation could occur round the CC bond (Fig. 5). Therefore, there must be further bonding which locks the alkene into this planar shape. This bond involves H C H C H H H H C C H H Fig. 4. (a) Bonding diagram for ethene; (b) simple representation of bonds for ethene. H H H C C H H Bond rotation H H H C C Fig. 5. Bond rotation around a bond. the remaining half-lled 2py orbitals on each carbon which overlap side-on to produce a pi (p) bond), with one lobe above and one lobe below the plane of the molecule (Fig. 6). This bond prevents rotation round the CC bond since the bond would have to be broken to allow rotation. A bond is weaker than a bond since the 2py orbitals overlap side-on, resulting in a weaker overlap. The presence of a bond also explains why alkenes are more reactive than alkanes, since a bond is more easily broken and is more likely to take part in reactions. A4 sp Hybridization 2 11 2py 2py H H H C O H H H Bond Fig. 6. Formation of a bond. Carbonyl groups The same theory explains the bonding within a carbonyl group (C O) where 2 both the carbon and oxygen atoms are sp hybridized. The following energy level 2 diagram (Fig. 7) shows how the valence electrons of oxygen are arranged after sp 2 hybridization. Two of the sp hybridized orbitals are lled with lone pairs of 2 electrons, which leaves two half-lled orbitals available for bonding. The sp orbital can be used to form a strong bond, while the 2py orbital can be used for the weaker bond. Figure 8 shows how the and bonds are formed in the carbonyl group and explains why carbonyl groups are planar with the carbon atom having a trigonal planar shape. It also explains the reactivity of carbonyl groups since the bond is weaker than the bond and is more likely to be involved in reactions. Energy 2px 2py 2pz 2py sp2 2s Original atomic orbitals Fig. 7. a) H H H H 2 sp2 hybridized orbitals Energy level diagram for sp hybridized oxygen. C O C O sp2 2py sp 2 sigma bond 2py b) H H C O Fig. 8. (a) Formation of the carbonyl bond; (b) formation of the carbonyl bond. 12 Section A Structure and bonding Aromatic rings All the carbons in an aromatic ring are sp hybridized which means that each carbon can form three bonds and one bond. In Fig. 9a, all the single bonds are while each double bond consists of one bond and one bond. However, this is an oversimplication of the aromatic ring. For example, double bonds are shorter than single bonds and if benzene had this exact structure, the ring would be deformed with longer single bonds than double bonds (Fig. 9b). a) H H H b) 2 = H H Fig. 9. (a) Representation of the aromatic ring; (b) deformed structure resulting from xed bonds. H In fact, the CC bonds in benzene are all the same length. In order to understand this, we need to look more closely at the bonding which takes place. Figure 10a shows benzene with all its bonds and is drawn such that we are looking into the 2 plane of the benzene ring. Since all the carbons are sp hybridized, there is a 2py orbital left over on each carbon which can overlap with a 2py orbital on either side of it (Fig. 10b). From this, it is clear that each 2py orbital can overlap with its neighbors right round the ring. This leads to a molecular orbital which involves all the 2py orbitals where the upper and lower lobes merge to give two doughnut-like lobes above and below the plane of the ring (Fig. 11a). The molecular orbital is symmetrical and the six electrons are said to be delocalized around the aromatic ring since they are not localized between any two particular carbon atoms. The aromatic ring is often represented as shown in Fig. 11b to represent this delocalization of the a) b) H H H H H H Fig. 10. (a) Bonding diagram for benzene, (b) Bonding diagram for benzene. a) a) H H b) b) C C C C C H H = H H C = Fig. 11. Bonding molecular orbital for benzene; (b) representation of benzene to illustrate delocalization. A4 sp Hybridization 2 13 electrons. Delocalization increases the stability of aromatic rings such that they are less reactive than alkenes (i.e. it requires more energy to disrupt the delocalized system of an aromatic ring than it does to break the isolated bond of an alkene). Conjugated systems Aromatic rings are not the only structures where delocalization of electrons can take place. Delocalization occurs in conjugated systems where there are alternating single and double bonds (e.g. 1,3-butadiene). All four carbons in 1,3-butadiene 2 are sp hybridized and so each of these carbons has a half-lled p orbital which can interact to give two bonds (Fig. 12a). However, a certain amount of overlap is also possible between the p orbitals of the middle two carbon atoms and so the bond connecting the two alkenes has some double bond character (Fig. 12b) borne out by the observation that this bond is shorter in length than a typical single bond. This delocalization also results in increased stability. However, it is important to realize that the conjugation in a conjugated alkene is not as great as in the aromatic system. In the latter system, the electrons are completely delocalized round the ring and all the bonds are equal in length. In 1,3-butadiene, the electrons are not fully delocalized and are more likely to be found in the terminal CC bonds. Although there is a certain amount of character in the middle bond, the latter is more like a single bond than a double bond. Other examples of conjugated systems include ,-unsaturated ketones and ,unsaturated esters (Fig. 13). These too have increased stability due to conjugation. a) 2py H H 2py CH H 2py 2py H CH C CH H 1,3-Butadiene CH C C H H C H b) H H 2py 2py CH H 2py 2py CH C C H Fig. 12. (a) Bonding in 1,3-butadiene; (b) delocalization in 1,3-butadiene. a) H3C C H O C H b) H3C C C H C CH3 H O C OCH3 Fig. 13. (a) ,-Unsaturated ketone; (b) ,-unsaturated ester. Section A Structure and bonding A5 SP HYBRIDIZATION Key Notes Denition In sp hybridization, the 2s orbital and one of the three 2p orbitals are mixed to form two hybridized sp orbitals of equal energy. Two 2p orbitals are left over and have slightly higher energy than the unhybridized orbitals. For carbon, each sp hybridized orbital contains a single unpaired electron. There are also two half-lled 2p orbitals. Therefore, four bonds are possible. Each sp orbital is shaped like a deformed dumbbell with one lobe much larger than the other. The remaining 2p orbitals are symmetrical dumbbells. If we dene the 2p orbitals as being aligned along the y and the z axes, the two sp hybridized orbitals point in opposite directions along the x axis. Each sp hybridized carbon of an alkyne can form two bonds using sp hybridized orbitals. The remaining 2p orbitals can overlap side-on to form two bonds. Alkynes are linear molecules and are reactive due to the bonds. The nitrogen and carbon atoms of a nitrile group (C N) are both sp hybridized. The carbon has two sp hybridized orbitals and can form two bonds, one of which is to nitrogen. The nitrogen has one sp orbital which is used in the bond with carbon. Both the carbon and the nitrogen have two 2p orbitals which can be used to form two bonds. Properties of alkenes and alkynes (H2) Chemistry of nitriles (O4) Electronic conguration Geometry Alkynes Nitrile groups Related topics Denition In sp hybridization, the 2s orbital is mixed with one of the 2p orbitals (e.g. 2px) to give two sp hybrid orbitals of equal energy. This leaves two 2p orbitals unaffected (2py and 2pz) with slightly higher energy than the hybridized orbitals (Fig. 1). Energy 2px 2py 2pz 2py sp 2s Original atomic orbitals Fig. 1. sp Hybridization of carbon. sp hybridized orbitals 2pz A5 sp Hybridization 15 Electronic conguration For carbon, the rst two electrons t into each sp orbital according to Hunds rule such that each orbital has a single unpaired electron. This leaves two electrons which can be paired up in the half-lled sp orbitals or placed in the vacant 2py and 2pz orbitals. The energy difference between the orbitals is small and so it is easier for the electrons to t into the higher energy orbitals than to pair up. This leads to two half-lled sp orbitals and two half-lled 2p orbitals (Fig. 1), and so four bonds are possible. The 2p orbitals are dumbbell in shape while the sp hybridized orbitals are deformed dumbbells with one lobe much larger than the other. The 2py and 2pz orbitals are at right angles to each other (Fig. 2a). The sp hybridized orbitals occupy the space left over and are in the x axis pointing in opposite directions (only the major lobe of the sp orbitals are shown in black; Fig. 2b). a) y 2py 2p z z x z b) sp 2p z sp x y 2py Geometry Fig. 2. (a) 2py and 2pz orbitals of an sp hybridized carbon; (b) 2py, 2pz and sp hybridized orbitals of an sp hybridized carbon. A molecule using the two sp orbitals for bonding will be linear in shape. There are two common functional groups where such bonding takes place alkynes and nitriles. Alkynes Let us consider the bonding in ethyne (Fig. 3) where each carbon is sp hybridized. The CH bonds are strong bonds where each hydrogen atom uses its half-lled H Fig. 3. C Ethyne. C H 1s orbital to bond with a half-lled sp orbital on carbon. The remaining sp orbital on each carbon is used to form a strong carboncarbon bond. The full bonding diagram for ethyne is linear (Fig. 4a) and can be simplied as shown (Fig. 4b). a) H C C H b) H C C H Fig. 4. (a) Bonding for ethyne; (b) representation of bonding. Further bonding is possible since each carbon has half-lled p orbitals. Thus, the 2py and 2pz orbitals of each carbon atom can overlap side-on to form two bonds (Fig. 5). The bond formed by the overlap of the 2py orbitals is represented in dark 16 Section A Structure and bonding gray. The bond resulting from the overlap of the 2pz orbitals is represented in light gray. Alkynes are linear molecules and are reactive due to the relatively weak bonds. Nitrile groups Exactly the same theory can be used to explain the bonding within a nitrile group (C N) where both the carbon and the nitrogen are sp hybridized. The energy level diagram in Fig. 6 shows how the valence electrons of nitrogen are arranged after sp hybridization. A lone pair of electrons occupies one of the sp orbitals, but the other sp orbital can be used for a strong bond. The 2py and 2pz orbitals can be used for two bonds. Figure 7 represents the bonds of HCN as lines and how the remaining 2p orbitals are used to form two bonds. 2py 2py H 2pz C 2pz C H Pi Bond () C C Fig. 5. -Bonding in ethyne. Energy 2px 2py 2pz 2py sp 2s Original atomic orbitals Fig. 6. sp Hybridization of nitrogen. 2py sp hybridized orbitals 2pz 2py H 2pz C 2pz C N N N Pi Bond () Fig. 7. -Bonding in HCN. Section A Structure and bonding A6 BONDS AND HYBRIDIZED CENTERS Key Notes and bonds Every bond in an organic structure is a bond or a bond. Every atom in a structure is linked to another by a single bond. If there is more than one bond between any two atoms, the remaining bonds are bonds. All atoms in an organic structure (except hydrogen) are either sp, sp or sp 3 hybridized. Atoms linked by single bonds are sp hybridized, atoms linked 2 by double bonds are sp hybridized* and atoms linked by triple bonds are sp hybridized.* sp Hybridized centers are tetrahedral, sp hybridized centers are trigonal planar and sp centers are linear. This determines the shape of functional 2 groups. Functional groups containing sp hybridized centers are planar while functional groups containing sp hybridized centers are linear. Functional groups containing bonds tend to be reactive since the bond is weaker than a bond and is more easily broken. sp Hybridization (A3) 2 sp Hybridization (A4) 3 Hybridized centers 2 3 Shape 3 2 Reactivity Related topics sp Hybridization (A5) (* with the exception of allenes R2C C CR2) and bonds Identifying and bonds in a molecule (Fig. 1) is quite easy as long as you remember the following rules: all bonds in organic structures are either sigma () or pi () bonds; all single bonds are bonds; all double bonds are made up of one bond and one bond; all triple bonds are made up of one bond and two bonds. O H CH3 CH2 H3C C C H Cl CH H3C CH2 CH3 C H3C CH3 H3C O C O C C H Fig. 1. Examples all the bonds shown are bonds except those labelled as . 2 3 Hybridized centers All the atoms in an organic structure (except hydrogen) are either sp, sp or sp hybridized (Fig. 2). 18 Section A Structure and bonding 3 Cl sp O sp2 CH3 sp3 C sp2 CH3 CH2 sp3 sp3 H3C sp3 H C CH3 3 sp 2 C 2 sp sp H CH H3C sp3 sp2 O sp3 CH2 sp3 H3C sp3 H C H3C sp3 Fig. 2. C C sp2 O sp sp3 sp Examples of sp, sp and sp hybridized centers. 2 3 2 3 The identication of sp, sp and sp centers is simple if you remember the following rules: all atoms linked by a single bond are sp hybridized (except hydrogen). 2 both carbon atoms involved in the double bond of an alkene (C C) must be sp hybridized.* 2 both the carbon and the oxygen of a carbonyl group (C O) must be sp hybridized. 2 all aromatic carbons must be sp hybridized. both atoms involved in a triple bond must be sp hybridized. hydrogen uses a 1s orbital for bonding and is not hybridized. 3 Hydrogen atoms cannot be hybridized. They can only bond by using an s orbital since there are no p orbitals in the rst electron shell. It is therefore impossible for a hydrogen to take part in bonding. Oxygen, nitrogen and halogens on the other hand can form hybridized orbitals which are either involved in bonding or in holding lone pairs of electrons. Shape The shape of organic molecules and the functional groups within them is determined by the hybridization of the atoms present. For example, functional 2 groups containing trigonal planar sp centers are planar while functional groups containing sp centers are linear: planar functional groups aldehyde, ketone, alkene, carboxylic acid, acid chloride, acid anhydride, ester, amide, aromatic. linear functional groups alkyne, nitrile. functional groups with tetrahedral carbons alcohol, ether, alkyl halide. Reactivity Functional groups which contain bonds are reactive since the bond is weaker than a bond and can be broken more easily. Common functional groups which contain bonds are aromatic rings, alkenes, alkynes, aldehydes, ketones, carboxylic acids, esters, amides, acid chlorides, acid anhydrides, and nitriles. * Functional groups known as allenes (R2C C CR2) have an sp hybridized carbon located at the center of two double bonds, but these functional groups are beyond the scope of this text. Section B Alkanes and cycloalkanes B1 DEFINITION Key Notes Alkanes Alkanes are organic molecules consisting solely of carbon and hydrogen 3 atoms linked by single bonds. All the carbon atoms are tetrahedral and sp hybridized. Alkanes are stable molecules and unreactive to most chemical reagents. They have the general formula CnH2n 2 Cycloalkanes are cyclic alkane structures. They have the general formula CnH2n. Most cycloalkanes are unreactive to chemical reagents. However, three- and four-membered rings are reactive due to ring strain and behave like alkenes. sp Hybridization (A3) 3 Cycloalkanes Related topics Conformational isomers (D4) Alkanes Alkanes are organic molecules with the general formula CnH2n 2, which consist of carbon and hydrogen atoms linked together by CC and CH single bonds. They are often referred to as saturated hydrocarbons saturated because all the bonds are single bonds, hydrocarbons because the only atoms present are carbon and 3 hydrogen. All the carbon atoms in an alkane are sp hybridized and tetrahedral in shape. The CC and CH bonds are strong bonds, and so alkanes are unreactive to most chemical reagents. Alkanes are sometimes referred to as straight chain or acyclic alkanes to distinguish them from cycloalkanes or alicyclic compounds. Cycloalkanes are cyclic alkanes (alicyclic compounds) having the general formula CnH2n where the carbon atoms have been linked together to form a ring. All sizes of ring are possible. However, the most commonly encountered cycloalkane in organic chemistry is the six-membered ring (cyclohexane). Most cycloalkanes are unreactive to chemical reagents. However, small three- and four-membered rings are reactive and behave like alkenes. Such cyclic structures are highly strained since it is impossible for the carbon atoms to adopt their preferred tetrahedral shape. Cycloalkanes Section B Alkanes and cycloalkanes B2 DRAWING STRUCTURES Key Notes CH Bond omission Alkanes can be drawn more quickly and efciently if the CH bonds are omitted. Skeletal drawings show only the CC bonds. Each bond junction is assumed to have a carbon atom with sufcient hydrogens present to make up four bonds. Alkyl groups (CnH2n 1) are alkane portions of a more complicated structure. They can be drawn as a skeletal drawing, or as CH3, CH2CH3, et cetera Denition (B1) Skeletal drawings Alkyl groups Related topic CH Bond omission There are several ways of drawing organic molecules. A molecule such as ethane can be drawn showing every CC and CH bond. However, this becomes tedious, especially with more complex molecules, and it is much easier to miss out the CH bonds (Fig. 1). A further simplication is often used where only the carboncarbon bonds are shown. This is a skeletal drawing of the molecule (Fig. 2). With such drawings, it is understood that a carbon atom is present at every bond junction and that every carbon has sufcient hydrogens attached to make up four bonds. Straight chain alkanes can also be represented by drawing the CC bonds in a zigzag fashion (Fig. 3). Skeletal drawings H H C H Fig. 1. H C H Ethane. H = H3C CH3 H H H H H Fig. 2. Skeletal drawing of cyclohexane. C C C H C H C C H H H H H B2 Drawing structures 21 H H C H Fig. 3. H C H H C H H C H H Skeletal drawing of butane. a) or b) CH3 CH2CH2CH3 H3C Fig. 4. a) Drawings of an alkyl substituted cyclohexane. b) CH2CH2CH3 CH3 CH2CH2CH3 CH3 H3C CH3 Fig. 5. (a) Correct depiction of methyl group; (b) wrong depiction of methyl group. Alkyl groups Alkyl groups (CnH2n 1) are alkane substituents of a complex molecule. Simple alkyl groups can be indicated in skeletal form (Fig. 4a), or as CH3, CH2CH3, CH2CH2CH3, et cetera. (Fig. 4b). Notice how the CH3 groups have been written in Fig. 5. The structure in Fig. 5a is more correct than the structure in Fig. 5b since the bond shown is between the carbons. Section B Alkanes and cycloalkanes B3 NOMENCLATURE Key Notes Simple alkanes The names of the rst 10 simple alkanes are methane, ethane, propane, butane, pentane, hexane, heptane, octane, nonane, and decane. Branched alkanes have alkyl substituents branching off from the main chain. When naming a branched alkane, identify the longest chain and number it from the end nearest the branch point. Identify the substituent and its position on the longest chain. The name is n-alkylalkane where n is the position of the substituent, alkyl is the substituent and alkane is the longest chain. If there is more than one substituent present, the substituents are named in alphabetical order. Identical substituents are identied by prexing them with di-, tri-, tetra-, etc., but the order of naming still depends on the alphabetical order of the substituents themselves. If there are two different substituents at equal distances from either end of the chain, the substituent with alphabetical priority has the lowest numbering. This rule may be supplanted if there are several substituents so placed. Cycloalkanes are named according to the number of carbon atoms making up the ring, that is, cyclopropane (C3H6), cyclobutane (C4H8), cyclopentane (C5H10), cyclohexane (C6H12), etc. Cycloalkanes linked to an alkane are usually named such that the cycloalkane is considered the parent system and the alkane group is an alkyl substituent (i.e. alkylcycloalkane). However, the opposite holds true if the alkane portion has more carbon atoms than the cycloalkane in which case the cycloalkane is considered a substituent of the alkane portion (i.e. n-cycloalkylalkane). Cycloalkanes having several substituents are numbered such that the substituent with alphabetical priority is at position 1. Numbering is then carried out such that the total obtained from the substituent positions is a minimum. Denition (B1) Branched alkanes Multi-branched alkanes Cycloalkanes Branched cycloalkanes Multi-branched cycloalkanes Related topic Simple alkanes The names of the simplest straight chain alkanes are shown in Fig. 1. Branched alkanes Branched alkanes are alkanes with alkyl substituents branching off from the main chain. They are named by the following procedure: B3 Nomenclature 23 CH4 Methane H3C Ethane CH3 Propane Butane Pentane Hexane Heptane Octane Nonane Decane Fig. 1. Nomenclature of simple alkanes. CH3 CH2 H3C Fig. 2. a) CH2 b) CH3 H3C 5 CH2 4 CH2 3 CH3 CH 2 CH CH3 1 (a) identify the longest chain; (b) number the longest chain. identify the longest chain of carbon atoms. In the example shown (Fig. 2a), the longest chain consists of ve carbon atoms and a pentane chain; number the longest chain of carbons, starting from the end nearest the branch point (Fig. 2b); identify the carbon with the branching group (number 2 in Fig. 2b); identify and name the branching group. (In this example it is CH3. Branching groups (or substituents) are referred to as alkyl groups (CnH2n 1) rather than alkanes (CnH2n 2). Therefore, CH3 is called methyl and not methane.) name the structure by rst identifying the substituent and its position in the chain, then naming the longest chain. The structure in Fig. 1 is called 2methylpentane. Notice that the substituent and the main chain is one complete word, that is, 2-methylpentane rather than 2-methyl pentane. Multi-branched alkanes If there is more than one alkyl substituent present in the structure then the substituents are named in alphabetical order, numbering again from the end of the chain nearest the substituents. The structure in Fig. 3 is 4-ethyl-3-methyloctane and not 3-methyl-4-ethyloctane. If a structure has identical substituents, then the prexes di-, tri-, tetra-, et cetera are used to represent the number of substituents. For example, the structure in Fig. 4 is called 2,2-dimethylpentane and not 2-methyl-2-methylpentane. CH3 H3C CH3 CH3 Fig. 3. H3C 4-Ethyl-3-methyloctane. CH3 Methyl 1 7 2 3 4 5 8 Ethyl 6 H3C 2 1 CH3 3 4 5 Fig. 4. 2,2-Dimethylpentane. 24 Section B Alkanes and cycloalkanes H3C CH3 H3C 2 1 CH2CH3 CH3 5 10 CH2CH3 Fig. 5. H3C 5-Ethyl-2,2-dimethyldecane. CH3 CH3 H3C 2 CH2CH3 CH3 5 1 CH2CH3 CH3 10 Fig. 6. 5-Ethyl-2,2,6-trimethyldecane. The prexes di-, tri-, tetra- etc. are used for identical substituents, but the order in which they are written is still dependent on the alphabetical order of the substituents themselves (i.e. ignore the di-, tri-, tetra-, et cetera). For example, the structure in Fig. 5 is called 5-ethyl-2,2-dimethyldecane and not 2,2-dimethyl-5-ethyldecane. Identical substituents can be in different positions on the chain, but the same rules apply. For example, the structure in Fig. 6 is called 5-ethyl-2,2,6-trimethyldecane. In some structures, it is difcult to decide which end of the chain to number from. For example, two different substituents might be placed at equal distances from either end of the chain. If that is the case, the group with alphabetical priority should be given the lowest numbering. For example, the structure in Fig. 7a is 3-ethyl-5-methylheptane and not 5-ethyl-3-methylheptane. However, there is another rule which might take precedence over the above rule. The structure (Fig. 7c) has ethyl and methyl groups equally placed from each end of the chain, but there are two methyl groups to one ethyl group. Numbering should be chosen such that the smallest total is obtained. In this example, the structure is called 5-ethyl-3,3-dimethylheptane (Fig. 7c) rather than 3-ethyl5,5-dimethylheptane (Fig. 7b) since 5 3 3 = 11 is less than 3 5 5 = 13. Cycloalkanes Cycloalkanes are simply named by identifying the number of carbons in the ring and prexing the alkane name with cyclo (Fig. 8). 7 5 CH3 Methyl 3 CH2CH3 Ethyl 1 b) 7 H3C 5 CH3 Methyl 3 CH2CH3 Ethyl 1 c) 1 H3C 3 CH3 Methyl 5 CH2CH3 Ethyl 7 Fig. 7. (a) 3-Ethyl-5-methylheptane; (b) incorrect numbering; (c) 5-ethyl-3,3-dimethylheptane. a) b) c) d) Fig. 8. (a) Cyclopropane; (b) cyclobutane; (c) cyclopentane; (d) cyclohexane. B3 Nomenclature 25 a) CH3 b) 1 8 c) 3 5 1 Fig. 9. (a) Methylcyclohexane; (b) 1-cyclohexyloctane; (c) 1-ethyl-3-methylcyclohexane. Branched cyclohexanes Cycloalkanes consisting of a cycloalkane moiety linked to an alkane moiety are usually named such that the cycloalkane is the parent system and the alkane moiety is considered to be an alkyl substituent. Therefore, the structure in Fig. 9a is methylcyclohexane and not cyclohexylmethane. Note that there is no need to number the cycloalkane ring when only one substituent is present. If the alkane moiety contains more carbon atoms than the ring, the alkane moiety becomes the parent system and the cycloalkane group becomes the substituent. For example, the structure in Fig. 9b is called 1-cyclohexyloctane and not octylcyclohexane. In this case, numbering is necessary to identify the position of the cycloalkane on the alkane chain. Branched cycloalkanes having different substituents are numbered such that the alkyl substituent having alphabetical priority is at position 1. The numbering of the rest of the ring is then carried out such that the substituent positions add up to a minimum. For example, the structure in Fig. 9c is called 1-ethyl-3-methylcyclohexane rather than 1-methyl-3-ethylcyclohexane or 1-ethyl-5-methylcyclohexane. The last name is incorrect since the total obtained by adding the substituent positions together is 5 1 6 which is higher than the total obtained from the correct name (i.e. 1 3 4). Multi-branched cycloalkanes Section C Functional groups C1 RECOGNITION OF FUNCTIONAL GROUPS Key Notes Denition Functional groups are portions of a molecule which contain atoms other than carbon and hydrogen, or which contain bonds other than CC and CH. Some of the most common functional groups in organic chemistry are alkenes, alkynes, aromatics, nitriles, amines, amides, nitro compounds, alcohols, phenols, ethers, aldehydes, ketones, carboxylic acids, acid chlorides, acid anhydrides, esters, alkyl halides, thiols, and thioethers. Denition (B1) Drawing structures (B2) Aliphatic and aromatic functional groups (C2) Common functional groups Related topics Denition A functional group is a portion of an organic molecule which consists of atoms other than carbon and hydrogen, or which contains bonds other than CC and CH bonds. For example, ethane (Fig. 1a) is an alkane and has no functional group. All the atoms are carbon and hydrogen and all the bonds are CC and CH. Ethanoic acid on the other hand (Fig. 1b), has a portion of the molecule (boxed portion) which contains atoms other than carbon and hydrogen, and bonds other than CH and CC. This portion of the molecule is called a functional group in this case a carboxylic acid. O C H3C Fig. 1. CH3 H3C OH Carboxylic acid functional group a) b) (a) Ethane; (b) ethanoic acid. Common functional groups The following are some of the more common functional groups in organic chemistry. functional groups which contain carbon and hydrogen only (Fig. 2); R C R C R R b) R C C R c) a) Fig. 2. (a) Alkene; (b) alkyne; (c) aromatic. 28 Section C Functional groups functional groups which contain nitrogen (Fig. 3); O a) R Fig. 3. b) C N R R N R c) C R NR2 d) R NO2 (a) Nitrile; (b) amine; (c) amide; (d) nitro. functional groups involving single bonds and which contain oxygen (Fig. 4); b) R OH R a) O R Fig. 4. (a) Alcohol or alkanol; (b) ether. functional groups involving double bonds and which contain oxygen (Fig. 5); O C R H O C R OR R R O g) C NR2 b) O C R h) R c) O C OH O H R d) O C Cl R e) O C O O C R a) f) Fig. 5. (a) Aldehyde or alkanal; (b) ketone or alkanone; (c) carboxylic acid; (d) carboxylic acid chloride; (e) carboxylic acid anhydride; (f) ester; (g) amide; (h) phenol. functional groups which contain a halogen atom (Fig. 6); X b) R X R c) O C Cl a) Fig. 6. (a) Aryl halide (X F, Cl, Br, I); (b) alkyl halide or halogenoalkane (X = F, Cl, Br, I); (c) carboxylic acid chloride. functional groups which contain sulfur (Fig. 7). b) a) R SH R S R Fig. 7. (a) Thiol; (b) thioether. Section C Functional groups C2 ALIPHATIC AND AROMATIC FUNCTIONAL GROUPS Key Notes Aliphatic functional groups Functional groups are dened as aliphatic if there is no aromatic ring directly attached to them. It is possible to have an aromatic molecule containing an aliphatic functional group if the aromatic ring is not directly attached to the functional group. Functional groups are dened as aromatic if they have an aromatic ring directly attached to them. In the case of esters and amides, the aromatic ring must be attached to the carbonyl side of the functional group. If the aromatic ring is attached to the heteroatom, the functional groups are dened as aliphatic. Recognition of functional groups (C1) Aromatic functional groups Related topic Aliphatic functional groups Functional groups can be classed as aliphatic or aromatic. An aliphatic functional group is one where there is no aromatic ring directly attached to the functional group (Fig. 1a and b). O a) O C H3C CH CH3 CH3 b) c) CO2CH2CH3 CO2H d) C CH3 Fig. 1. (a) Aliphatic ketone; (b) aliphatic ester; (c) aromatic carboxylic acid; (d) aromatic ketone. Aromatic functional groups An aromatic functional group is one where an aromatic ring is directly attached to the functional group (Fig. 1c and d). There is one complication involving esters and amides. These functional groups are dened as aromatic or aliphatic depending on whether the aryl group is directly attached to the carbonyl end of the functional group, that is, ArCOX. If the aromatic ring is attached to the heteroatom instead, then the ester or amide is classed as an aliphatic amide (Fig. 2). b) O C H3C O c) O C N CH3 CH3 H3C d) O C NH a) O C O CH3 Fig. 2. (a) Aromatic ester; (b) aliphatic ester; (c) aromatic amide; (d) aliphatic amide. Section C Functional groups C3 INTERMOLECULAR BONDING Key Notes Denition Intermolecular bonding takes place between different molecules. This can take the form of ionic bonding, hydrogen bonding, dipoledipole interactions and van der Waals interactions. The type of bonding involved depends on the functional groups present. Ionic bonds are possible between ionized functional groups such as carboxylic acids and amines. Intermolecular hydrogen bonding is possible for alcohols, carboxylic acids, amides, amines, and phenols. These functional groups contain a hydrogen atom bonded to nitrogen or oxygen. Hydrogen bonding involves the interaction of the partially positive hydrogen on one molecule and the partially negative heteroatom on another molecule. Hydrogen bonding is also possible with elements other than nitrogen or oxygen. Dipoledipole interactions are possible between molecules having polarizable bonds, in particular the carbonyl group (C O). Such bonds have a dipole moment and molecules can align themselves such that their dipole moments are parallel and in opposite directions. Ketones and aldehydes are capable of interacting through dipoledipole interactions. van der Waals interactions are weak intermolecular bonds between regions of different molecules bearing transient positive and negative charges. These transient charges are caused by the random uctuation of electrons. Alkanes, alkenes, alkynes and aromatic rings interact through van der Waals interactions. Recognition of functional groups (C1) Ionic bonding Hydrogen bonding Dipoledipole interactions van der Waals interactions Related topic Denition Intermolecular bonding is the bonding interaction which takes place between different molecules. This can take the form of ionic bonding, hydrogen bonding, dipoledipole interactions or van der Waals interactions. These bonding forces are weaker than the covalent bonds, but they have an important inuence on the physical and biological properties of a compound. C3 Intermolecular bonding 31 Ionic bonding Ionic bonding takes place between molecules having opposite charges and involves an electrostatic interaction between the two opposite charges. The functional groups which most easily ionize are amines and carboxylic acids (Fig. 1). H R N H Ammonium ion H b) R C OH +H O -H R C O Carboxylate ion O a) R N H +H H Amine Fig. 1. -H Carboxylic acid (a) Ionization of an amine; (b) ionization of a carboxylic acid. Ionic bonding is possible between a molecule containing an ammonium ion and a molecule containing a carboxylate ion. Some important naturally occurring molecules contain both groups the amino acids. Both these functional groups are ionized to form a structure known as a zwitterion (a neutral molecule bearing both a positive and a negative charge) and intermolecular ionic bonding can take place (Fig. 2). O H3N R Fig. 2. C O R H3N O C O H3N R O C O Intermolecular ionic bonding of amino acids. Hydrogen bonding Hydrogen bonding can take place when molecules have a hydrogen atom attached to a heteroatom such as nitrogen or oxygen. The common functional groups which can participate in hydrogen bonding are alcohols, phenols, carboxylic acids, amides, and amines. Hydrogen bonding is possible due to the polar nature of the NH or OH bond. Nitrogen and oxygen are more electronegative than hydrogen. As a result, the heteroatom gains a slightly negative charge and the hydrogen gains a slightly positive charge. Hydrogen bonding involves the partially charged hydrogen of one molecule (the H bond donor) interacting with the partially charged heteroatom of another molecule (the H bond acceptor) (Fig. 3). R O H + O + H Fig. 3. H + O R R Intermolecular hydrogen bonding between alcohols. Dipoledipole interactions Dipoledipole interactions are possible between polarized bonds other than NH or OH bonds. The most likely functional groups which can interact in this way are those containing a carbonyl group (C O). The electrons in the carbonyl bond are polarized towards the more electronegative oxygen such that the oxygen gains 32 Section C Functional groups a slight negative charge and the carbon gains a slight positive charge. This results in a dipole moment which can be represented by the arrow shown in Fig. 4. The arrow points to the negative end of the dipole moment. Molecules containing dipole moments can align themselves with each other such that the dipole moments are pointing in opposite directions (Fig. 4b). a) - O + C R R b) O C R R R C O R Fig. 4. (a) Dipole moment of a ketone; (b) intermolecular dipoledipole interaction between ketones. van der Waals interactions van der Waals interactions are the weakest of the intermolecular bonding forces and involve the transient existence of partial charges in a molecule. Electrons are continually moving in an unpredictable fashion around any molecule. At any moment of time, there is a slight excess of electrons in one part of the molecule and a slight decit in another part. Although the charges are very weak and uctuate around the molecule, they are sufciently strong to allow a weak interaction between molecules, where regions of opposite charge in different molecules attract each other. Alkane molecules can interact in this way and the strength of the interaction increases with the size of the alkane molecule. van der Waals interactions are also important for alkenes, alkynes and aromatic rings. The types of molecules involved in this form of intermolecular bonding are fatty molecules which do not dissolve easily in water and such molecules are termed hydrophobic (waterhating). Hydrophobic molecules can dissolve in nonpolar, hydrophobic solvents due to van der Waals interactions and so this form of intermolecular bonding is sometimes referred to as a hydrophobic interaction. Section C Functional groups C4 PROPERTIES AND REACTIONS Key Notes Properties The presence of functional groups affect such properties as melting points, boiling points, polarity, dipole moments, and solubility. Molecules with strongly polar functional groups tend to have higher melting points and boiling points than molecules with nonpolar functional groups, and prefer to dissolve in polar solvents rather than nonpolar solvents. The sorts of reactions which compounds undergo are determined by the sorts of functional groups which are present. Functional groups undergo characteristic reactions, but the rates of these reactions are affected by stereoelectronic factors and conjugation. Recognition of functional groups (C1) Acid strength (G2) Base strength (G3) Conjugated dienes (H11) ,-Unsaturated aldehydes and ketones (J11) Reactions Related topics Properties The chemical and physical properties of an organic compound are determined by the sort of intermolecular bonding forces present, which in turn depends on the functional group present. A molecule such as ethane has a low boiling point and is a gas at room temperature because its molecules are bound together by weak van der Waals forces (Fig. 1a). In contrast, methanol is a liquid at room temperature since hydrogen bonding is possible between the alcoholic functional groups (Fig. 1b). van der Waals bonding H H C O H H H a) H CH3 H C H3C H C H H b) H C H H O Hydrogen bonding H Fig. 1. (a) Intermolecular van der Waals (methane); (b) intermolecular hydrogen bonding (methanol). The polarity of molecules depends on which functional groups are present. A molecule will be polar and have a dipole moment if it contains polar functional groups such as an alcohol, amine, or ketone. Polarity also determines solubility in different solvents. Polar molecules prefer to dissolve in polar solvents such as water or alcohols, whereas nonpolar molecules prefer to dissolve in nonpolar solvents such as ether and chloroform. Polar molecules which can dissolve in water are termed hydrophilic (water-loving) while nonpolar molecules are termed hydrophobic (water-hating). 34 Section C Functional groups In most cases, the presence of a polar functional group will determine the physical properties of the molecule. However, this is not always true. If a molecule has a polar group such as a carboxylic acid, but has a long hydrophobic alkane chain, then the molecule will tend to be hydrophobic. Reactions The vast majority of organic reactions take place at functional groups and are characteristic of that functional group. However, the reactivity of the functional group is affected by stereoelectronic effects. For example, a functional group may be surrounded by bulky groups which hinder the approach of a reagent and slow down the rate of reaction. This is referred to as steric shielding. Electronic effects can also inuence the rate of a reaction. Neighboring groups can inuence the reactivity of a functional group if they are electron-withdrawing or electrondonating and inuence the electronic density within the functional group. Conjugation and aromaticity also has an important effect on the reactivity of functional groups. For example, an aromatic ketone reacts at a different rate from an aliphatic ketone. The aromatic ring is in conjugation with the carbonyl group and this increases the stability of the overall system, making it less reactive. Section C Functional groups C5 NOMENCLATURE OF COMPOUNDS WITH FUNCTIONAL GROUPS Key Notes General rules The main chain (or parent chain) must include the functional group. The presence of functional groups is indicated by adding the relevant sufx for that functional group. The position of the functional group must be dened and other substituents are identied as described for alkanes. Alkenes and alkynes are dened by adding the sufxes -ene and -yne respectively. The stereochemistry of alkenes may need to be dened. The simplest aromatic ring is benzene. Other important aromatic molecules include toluene, phenol, aniline, benzoic acid, and benzaldehyde.Any of these names can be used as parent names if other substituents are present. The position of substituents is determined by numbering round the ring, or in the case of disubstituted aromatic rings, the ortho, meta, para nomenclature. Alcohols (or alkanols) are given the sufx -anol. Ethers and alkyl halides are not identied with sufxes. Instead, these functional groups are considered to be substituents of the main alkane chain. The halogen of an alkyl halide is a halo substituent, while the ether is an alkoxy substituent. Aldehydes (or alkanals) are identied by the sufx -anal. Ketones (or alkanones) are identied by the sufx -anone. Aldehydes must always be at position 1 of the main chain and do not need to be numbered. Carboxylic acids and acid chlorides are identied by adding the sufx -anoic acid and -anoyl chloride respectively. Both these functional groups are always at the end of the main chain and do not need to be numbered. Esters are named from the parent carboxylic acid and alcohol. The alkanoic acid is renamed alkanoate and the alkanol is treated as an alkyl substituent. The combined name is alkyl alkanoate. There must be a space between both parts of the name. Amides are termed as alkanamides based on the parent carboxylic acid. If the amide nitrogen has alkyl groups, then these are considered as alkyl substituents. The symbol N is used to show that the substituents are on the nitrogen and not some other part of the alkanamide skeleton. Simple amines can be named by placing the sufx -ylamine after the root name. Other amines are named by considering the amino group as a substituent of the main chain in the same way as alkyl halides and ethers. Alkenes and alkynes Aromatics Alcohols Ethers and alkyl halides Aldehydes and ketones Carboxylic acids and acid chlorides Esters Amides Amines 36 Section C Functional groups Thiols and thioethers Thiols are named by adding the sufx thiol to the name of the main alkane chain. Thioethers are named in the same way as ethers where the major alkyl substituent is considered to be the main chain with an alkylthio substituent. Simple thioethers can be identied as dialkylsuldes. Nomenclature (B3) Congurational isomers alkenes and cycloalkanes (D2) Related topics General rules Many of the nomenclature rules for alkanes (Topic B3) hold true for molecules containing a functional group, but extra rules are needed in order to dene the type of functional group present and its position within the molecule. The main rules are as follows: (i) The main (or parent) chain must include the functional group, and so may not necessarily be the longest chain (Fig. 1); H O CH3 CH3 Fig. 1. Identication of the main chain. O Main chain = 4C Correct H CH3 CH3 Main chain = 5C Wrong (ii) The presence of some functional groups is indicated by replacing -ane for the parent alkane chain with the following sufxes: functional group alkene alcohol ketone acid chloride sufx -ene -anol -anone -anoyl chloride functional group alkyne aldehyde carboxylic acid amine sufx -yne -anal -anoic acid -ylamine. The example in Fig. 1 is a butanol. (iii) Numbering must start from the end of the main chain nearest the functional group. Therefore, the numbering should place the alcohol (Fig. 2) at position 1 and not position 4. H O 1 Fig. 2. 3 2 H 4 CH3 Correct CH3 Numbering of the longest chain. O 4 3 2 1 CH3 CH3 Wrong (iv) The position of the functional group must be dened in the name. Therefore, the alcohol (Fig. 2) is a 1-butanol. (v) Other substituents are named and ordered in the same way as for alkanes. The alcohol (Fig. 2) has an ethyl group at position 2 and so the full name for the structure is 2-ethyl-1-butanol. C5 Nomenclature of functional groups 37 There are other rules designed for specic situations. For example, if the functional group is an equal distance from either end of the main chain, the numbering starts from the end of the chain nearest to any substituents. For example, the alcohol (Fig. 3) is 2-methyl-3-pentanol and not 4-methyl-3-pentanol. 4 H O 3 2 5 CH3 1 CH3 Correct 2 H O 3 1 CH3 Wrong H3C Fig. 3. 2-Methyl-3-pentanol. CH3 4 5 H3C Alkenes and alkynes Alkenes and alkynes have the sufxes -ene and -yne respectively (Fig. 4). With some alkenes it is necessary to dene the stereochemistry of the double bond (Topic D2). 2 C CH3 34 5 C C CH3 CH3 1 a) H3C 2 CH 3 CH 4 CH3 1 b) H3C 2 CH 3 C(CH3) 45 CH2CH3 c) 1 H3C Fig. 4. (a) 2-Butene; (b) 3-methyl-2-pentene; (c) 4,4-dimethyl-2-pentyne. Aromatics The best known aromatic structure is benzene. If an alkane chain is linked to a benzene molecule, then the alkane chain is usually considered to be an alkyl substituent of the benzene ring. However, if the alkane chain contains more than six carbons, then the benzene molecule is considered to be a phenyl substituent of the alkane chain (Fig. 5). Note that a benzyl group consists of an aromatic ring and a methylene group (Fig. 6). Benzene is not the only parent name which can be used for aromatic compounds (Fig. 7). CH3 a) CH3 b) 1 2 CH3 Fig. 5. (a) Ethylbenzene; (b) 1-phenyl-2,3-dimethylpentane. 3 4 CH3 5 CH2 Fig. 6. Benzyl group. 38 Section C Functional groups a) CH3 b) OH c) NH2 d) CO2H O e) CHO f) C CH3 Fig 7. (a) Toluene; (b) phenol; (c) aniline; (d) benzoic acid; (e) benzaldehyde; (f) acetophenone. With disubstituted aromatic rings, the position of substituents must be dened by numbering around the ring such that the substituents are positioned at the lowest numbers possible, for example, the structure (Fig. 8) is 1,3-dichlorobenzene and not 1,5-dichlorobenzene. Cl 1 6 5 4 Fig. 8. 1,3-Dichlorobenzene 2 3 Cl Correct 3 4 5 Cl 2 Cl 1 6 Wrong Alternatively, the terms ortho, meta, and para can be used. These terms dene the relative position of one substituent to another (Fig. 9). Thus, 1,3dichlorobenzene can also be called meta-dichlorobenzene. This can be shortened to m-dichlorobenzene. The examples in Fig. 10 illustrate how different parent names may be used. Notice that the substituent which denes the parent name is dened as position 1. For example, if the parent name is toluene, the methyl group must be at position 1. X ortho position ortho position meta position meta position para position Fig. 9. ortho, meta and para positions of an aromatic ring. When more than two substituents are present on the aromatic ring, the ortho, meta, para nomenclature is no longer valid and numbering has to be used (Fig. 11). Once again, the relevant substituent has to be placed at position 1 if the C5 Nomenclature of functional groups 39 Br a) CH3 b) OH c) Cl NH2 Br Fig. 10. (a) 2-Bromotoluene or o-bromotoluene; (b) 4-bromophenol or p-bromophenol; (c) 3-chloroaniline or mchloroaniline. NO2 b) NO2 2 3 4 NO2 Fig. 11. 6 5 4 NO2 1 2 3 Cl a) O2N 6 5 CH3 1 (a) 2,4,6-Trinitrotoluene; (b) 2-chloro-1,4-dinitrobenzene. parent name is toluene, aniline, et cetera. If the parent name is benzene, the numbering is chosen such that the lowest possible numbers are used. In the example shown, any other numbering would result in the substituents having higher numbers (Fig. 12). NO2 1 6 5 4 NO2 2 3 Correct Substituent total = 1+2+4 = 7 4 5 2 Cl 3 NO2 1 Cl 5 6 NO2 Wrong Substituent total = 1+2+5 = 8 6 NO2 4 3 2 1 NO2 Wrong Substituent total = 1+3+4 = 8 Cl Fig. 12. Possible numbering systems of tri-substituted aromatic ring. Alcohols Alcohols or alkanols are identied by using the sufx -anol. The general rules described earlier can be used to name alcohols (Fig. 13). CH3 CH H3C CH2 OH CH CH3 main chain 5 CH3 OH CH3 1 4 3 2 Substituent suffix for functional group 4-Methyl-2-pentanol Position Fig. 13. Position 4-Methyl-2-pentanol. 40 Section C Functional groups Ethers and alkyl halides The nomenclature for these compounds is slightly different from previous examples in that the functional group is considered to be a substituent of the main alkane chain. The functional group is numbered and named as a substituent (Fig. 14). (a) H3C 3 Fig. 14. CH2 2 Cl CH2 1 (b) H3C 3 CH2 2 O CH2 1 CH3 (a) 1-Chloropropane; (b) 1-methoxypropane. Note that ethers have two alkyl groups on either side of the oxygen. The larger alkyl group is the parent alkane. The smaller alkyl group along with the oxygen is the substituent and is known as an alkoxy group. Aldehydes and ketones The sufx for an aldehyde (or alkanal) is -anal, while the sufx for a ketone (or alkanone) is -anone. The main chain must include the functional group and the numbering is such that the functional group is at the lowest number possible. If the functional group is in the center of the main chain, the numbering is chosen to ensure that other substituents have the lowest numbers possible (e.g. 2,2dimethyl-3-pentanone and not 4,4-dimethyl-3-pentanone; Fig. 15). 3-Methyl2-butanone can in fact be simplied to 3-methylbutanone. There is only one possible place for the ketone functional group in this molecule. If the carbonyl C O group was at the end of the chain, it would be an aldehyde and not a ketone. Numbering is also not necessary in locating an aldehyde group since it can only be at the end of a chain (Fig. 16). a) 4 CH3 2 3 O O 1 b) H3C 1 2 CH3 3 O O 5 4 c) 3 2 1 CH3 CH2CH3 6 4 5 d) 6 5 4 1 2 3 CH3 Fig. 15. (a) 3-Methyl-2-butanone; (b) 2,2-dimethyl-3-pentanone; (c) 4-ethyl-3-methyl-2hexanone; (d) 3-methylcyclohexanone. O a) 4 2 3 1 H 4 5 Fig. 16. (a) Butanal; (b) 2-ethylpentanal. O b) H 12 3 CH3 CH2 C5 Nomenclature of functional groups 41 Carboxylic acids Carboxylic acids and acid chlorides are identied by adding the sufx -anoic acid and acid chlorides and -anoyl chloride respectively. Both these functional groups are always at the end of the main chain and do not need to be numbered (Fig. 17). O 4 2 3 CH3 Fig. 17. 1 OH CH3 5 3 4 CH3 2 O 1 Cl a) b) (a) 2-Methylbutanoic acid; (b) 2,3-dimethylpentanoyl chloride. Esters To name an ester, the following procedure is carried out: (i) identify the carboxylic acid (alkanoic acid) from which it was derived; (ii) change the name to an alkanoate rather than an alkanoic acid; (iii) identify the alcohol from which the ester was derived and consider this as an alkyl substituent; (iv) the name becomes an alkyl alkanoate. For example, the ester (Fig. 18) is derived from ethanoic acid and methanol (Topic K5). The ester would be an alkyl ethanoate since it is derived from ethanoic acid. The alkyl group comes from methanol and is a methyl group. Therefore, the full name is methyl ethanoate. (Note that there is a space between both parts of the name.) O C H3C OH Ethanoic acid CH3 O + C H3C O H O CH3 Methyl group Methanol Fig. 18 Ester formation Ethanoate portion Fig. 18. Ester formation. Amides Amides are also derivatives of carboxylic acids. This time the carboxylic acid is linked with ammonia or an amine. As with esters, the parent carboxylic acid is identied. This is then termed an alkanamide and includes the nitrogen atom. For example, linking ethanoic acid with ammonia gives ethanamide (Fig. 19). O C H3C Fig. 19. OH O + -H2O NH3 H3C C NH2 Formation of ethanamide. If the carboxylic acid is linked with an amine, then the amide will have alkyl groups on the nitrogen. These are considered as alkyl substituents and come at the beginning of the name. The symbol N is used to show that the substituents are on the nitrogen and not some other part of the alkanamide skeleton. For example, the structure in Fig. 20 is called N-ethylethanamide. 42 Section C Functional groups O C H3 C N H CH2 CH3 H3C O C N H Ethanamide CH2 CH3 Ethyl substituent on nitrogen Fig. 20. N-Ethylethanamide. Amines The nomenclature for amines is similar to alkyl halides and ethers in that the main part (or root) of the name is an alkane and the amino group is considered to be a substituent (Fig. 21). Simple amines are sometimes named by placing the sufx -ylamine after the main part of the name (Fig. 22). NH2 H3C CH3 H3C CH3 NH2 H3C NH2 CH3 CH3 CH3 Fig. 21. (a) 2-Aminopropane; (b) 1-amino-3-methylbutane; (c) 2-amino-3,3-dimethylbutane; (d) 3-aminohexane. a) H3C NH2 b) CH2 H3C NH2 H3C NH2 CH3 Fig. 22. (a) Methylamine; (b) ethylamine. Amines having more than one alkyl group attached are named by identifying the longest carbon chain attached to the nitrogen. In the example (Fig. 23), that is an ethane chain and so this molecule is an aminoethane (N,N-dimethylaminoethane). CH3 N H3C Fig. 23. CH2CH3 N,N-Dimethylaminoethane. H3C CH3 N CH2 Ethane CH3 Some simple secondary and tertiary amines have common names (Fig. 24). a) H3C Fig. 24. CH3 N H b) H3C CH3 N CH3 CH3CH2 c) CH2CH3 N CH2CH3 (a) Dimethylamine; (b) trimethylamine; (c) triethylamine. Thiols and thioethers Thiols are named by adding the sufx thiol to the name of the parent alkane (Fig. 25a). Thioethers are named in the same way as ethers using the prex alkylthio, for example, 1-(methylthio)propane (Fig. 25c). Simple thioethers can be named by identifying the thioether as a sulde and prexing this term with the alkyl substituents, for example, dimethyl sulde (Fig. 25b). a) CH3CH2 SH b) H3C S CH3 c) H3C S CH2CH2CH3 Fig. 25. (a) Ethanethiol; (b) dimethylsulde; (c) 1-(methylthio)propane. Section C Functional groups C6 PRIMARY, SECONDARY, TERTIARY AND QUATERNARY NOMENCLATURE Key Notes Denition Carbon centers, as well as some functional groups (alcohols, alkyl halides, amines and amides), can be dened as primary (1 ), secondary (2 ), tertiary (3 ) or quaternary (4 ). Carbon centers can be identied as primary, secondary, tertiary, or quaternary depending on the number of bonds leading to other carbon atoms. A methyl group contains a primary carbon center. A methylene group (CH2) contains a secondary carbon center. The methine group (CH) contains a tertiary carbon center while a carbon atom having four substituents is a quaternary center. Amines and amides can be dened as being primary, secondary, tertiary, or quaternary depending on the number of bonds leading from nitrogen to carbon. Alcohols and alkyl halides are dened as primary, secondary, or tertiary depending on the carbon to which the alcohol or halide is attached. The assignment depends on the number of bonds from that carbon to other carbon atoms. It is not possible to get quaternary alcohols or quaternary alkyl halides. Recognition of functional groups (C1) Carbon centers Amines and amides Alcohols and alkyl halides Related topic Denition The primary (1 ), secondary (2 ), tertiary (3 ) and quaternary (4 ) nomenclature is used in a variety of situations: to dene a carbon center, or to dene functional groups such as alcohols, halides, amines and amides. Identifying functional groups in this way can be important since the properties and reactivities of these groups may vary depending on whether they are primary, secondary, tertiary, or quaternary. One of the easiest ways of determining whether a carbon center is 1 , 2 , 3 or 4 is to count the number of bonds leading from that carbon center to another carbon atom (Fig. 1). A methyl group (CH3) is a primary carbon center, a methylene group (CH2) is a secondary carbon center, a methine group (CH) is a tertiary carbon center, and a carbon center with four alkyl substituents (C) is a quaternary carbon center (Fig. 2). Carbon centers 44 Section C Functional groups R R C R R a) R H C H H b) R R C H H c) R R C R H d) Fig. 1. Carbon centers; (a) primary; (b) secondary; (c) tertiary; (d) quaternary. CH3 3o 1o 2o 2o 2o 2o 1o CH3 o CH3 1 4o o CH3 1 1o H3C Fig. 2. Primary, secondary, tertiary, and quaternary carbon centers. Amines and amides Amines and amides can be dened as being primary, secondary, tertiary, or quaternary depending on the number of bonds from nitrogen to carbon (Fig. 3). Note that a quaternary amine is positively charged and is therefore called a quaternary ammonium ion. Note also that it is not possible to get a quaternary amide. a) H N R b) O 1o H 1o C R Fig. 3. N H R R H R N 2o H O C R 2o N H R R R N 3o R O C R R 4o N R 3o N R R + R (a) Amines; (b) amides. Alcohols and alkyl halides Alcohols and alkyl halides can also be dened as being primary, secondary, or tertiary (Fig. 4). However, the denition depends on the carbon to which the alcohol or halide is attached and it ignores the bond to the functional group. Thus, quaternary alcohols or alkyl halides are not possible. a) R H C H Fig. 4. X b) R R C H X c) R R C R X Alcohols and alkyl halides; (a) primary; (b) secondary; (c) tertiary. The following examples (Fig. 5) illustrate different types of alcohols and alkyl halides. a) H3C H3C d) CH3 OH H3C Br b) Br c) Br 3o 1o H3C e) OH 2o CH3 H3C f) CH3 CH3 CH3 OH 3o H3C CH3 CH3 1o H3C 2o Fig. 5. (a) 1 alkyl bromide; (b) 2 alkyl bromide; (c) 3 alkyl bromide; (d) 1 alcohol; (e) 2 alcohol; (f) 3 alcohol. Section D Stereochemistry D1 CONSTITUTIONAL ISOMERS Key Notes Introduction Isomers are compounds which have the same molecular formula, but differ in the way the atoms are arranged. There are three types of isomers constitutional, congurational, and conformational. Constitutional isomers are compounds which have the same molecular formula but have the atoms joined together in a different way. Constitutional isomers have different physical and chemical properties. Alkanes of a particular molecular formula can have various constitutional isomers. The larger the alkane, the more isomers which are possible. Nomenclature (B3) Nomenclature of functional groups (C5) Congurational isomers alkenes and cycloalkanes (D2) Congurational isomers optical isomers (D3) Conformational isomers (D4) Denition Alkanes Related topics Introduction Isomers are compounds which have the same molecular formula (i.e. they have the same atoms), but differ in the way these atoms are arranged. There are three types of isomers constitutional isomers, configurational isomers, and conformational isomers. Constitutional isomers are isomers where the atoms are linked together in a different skeletal framework and are different compounds. Congurational isomers are structures having the same atoms and bonds, but which have different geometrical shapes which cannot be interconverted without breaking covalent bonds. Congurational isomers can be separated and are different compounds with different properties. Conformational isomers are different shapes of the same molecule and cannot be separated. Constitutional isomers are compounds which have the same molecular formula but have the atoms joined together in a different way. In other words, they have different carbon skeletons. Constitutional isomers have different physical and chemical properties. Alkanes of a particular molecular formula can exist as different constitutional isomers. For example, the alkane having the molecular formula C4H10 can exist as two constitutional isomers the straight chain alkane (butane) or the branched alkane (2-methylpropane; Fig. 1). These are different compounds with different physical and chemical properties. a) H3C Fig. 1. CH2 CH2 CH3 b) H3C CH H 3C CH3 Denition Alkanes (a) Butane (C4H10 ); (b) 2-methylpropane (C4H10 ). Section D Stereochemistry D2 CONFIGURATIONAL ISOMERS ALKENES AND CYCLOALKANES Key Notes Denition Congurational isomers have the same molecular formula and the same bonds. However, some of the atoms are arranged differently in space with respect to each other, and the isomers cannot be interconverted without breaking a covalent bond. Substituted alkenes and cycloalkanes can exist as congurational isomers. Alkenes having two different substituents at each end of the double bond can exist as two congurational isomers. Simple alkenes can be dened as cis or trans depending on whether substituents at different ends of the alkene are on the same side of the alkene (i.e. cis) or on opposite sides (i.e. trans). Alkenes can be assigned as Z or E depending on the relative positions of priority groups. If the priority groups at each end of the alkene are on the same side of the double bond, the alkene is the Z isomer. If they are on opposite sides, the alkene is dened as the E isomer. Priority groups are determined by the atomic numbers of the atoms directly attached to the alkene. If there is no distinction between these atoms, the next atom of each substituent is compared. Substituted cycloalkanes can exist as congurational isomers where the substituents are cis or trans with respect to each other. Nomenclature (B3) Nomenclature of functional groups (C5) Properties of alkenes and alkynes (H2) Alkenes cis and trans isomerism Alkenes Z and E nomenclature Cycloalkanes Related topics Denition Congurational isomers are isomers which have the same molecular formula and the same molecular structure. In other words, they have the same atoms and the same bonds. However, the isomers are different because some of the atoms are arranged differently in space, and the isomers cannot be interconverted without breaking and remaking covalent bonds. As a result, congurational isomers are different compounds having different properties. Common examples of congurational isomers are substituted alkenes and substituted cycloalkanes where the substituents are arranged differently with respect to each other. D2 Congurational isomers alkenes and cycloalkanes 47 Alkenes cis and trans isomerism Alkenes having identical substituents at either end of the double bond can only exist as one molecule. However, alkenes having different substituents at both ends of the double bond can exist as two possible isomers. For example, 1-butene (Fig. 1a) has two hydrogens at one end of the double bond and there is only one way of constructing it. On the other hand, 2-butene has different substituents at both ends of the double bond (H and CH3) and can be constructed in two ways. The methyl groups can be on the same side of the double bond (the cis isomer; Fig. 1b), or on opposite sides (the trans isomer; Fig. 1c). The cis and trans isomers of an alkene are congurational isomers (also called geometric isomers) because they have different shapes and cannot interconvert since the double bond of an alkene cannot rotate. Therefore, the substituents are xed in space relative to each other. The structures are different compounds with different chemical and physical properties. H b) H H Fig. 1. CH3 H3C H C C CH3 H c) H CH3 C C CH3 H a) (a) 1-Butene; (b) cis-2-butene; (c) trans-2-butene. Alkenes Z and E nomenclature The cis and trans nomenclature for alkenes is an old method of classifying the congurational isomers of alkenes and is still commonly used. However, it is only suitable for simple 1,2-disubstituted alkenes where one can compare the relative position of the two substituents with respect to each other. When it comes to trisubstituted and tetrasubstituted alkenes, a different nomenclature is required. The Z/E nomenclature allows a clear, unambiguous denition of the conguration of alkenes. The method by which alkenes are classied as Z or E is illustrated in Fig. 2. First of all, the atoms directly attached to the double bond are identied and given their atomic number (Fig. 2b). The next stage is to compare the two atoms at each end of the alkene. The one with the highest atomic number takes priority over the other (Fig. 2c). At the left hand side, oxygen has a higher atomic number than hydrogen and takes priority. At the right hand side, both atoms are the same (carbon) and we cannot choose between them. Therefore, we now need to identify the atom of highest atomic number attached to each of these identical carbons. These correspond to a hydrogen for the methyl substituent and a carbon for the ethyl substituent. These are now different and so a priority can be made (Fig. 3a). Having identied which groups have priority, we can now see whether the priority groups are on the same side of the double bond or on opposite sides. If the two priority groups are on the same side of the double bond, the alkene is designated as Z (from the German word zusammen meaning together). If the two priority groups are on opposite sides of the double bond, the a) CH3O C H C CH3 CH2CH3 b) 8 1 O C H C C C 6 6 c) Priority 8 1 6 O C H C C C No difference 6 Fig. 2. (a) Alkene; (b) atomic numbers; (c) priority groups. 48 Section D Stereochemistry Priority 8 1 1 O C H C C C C H 6 Priority b) CH3O C H C CH3 CH2CH3 Fig. 3. a) (a) Choosing priority groups; (b) (E)-1-methoxy-2-methyl-1-butene. b) H H3C H CH3 H H3C CH3 H Fig. 4. (a) cis-1,2-Dimethylcyclopropane; (b) trans-1,2-dimethylcyclopropane. alkene is designated as E (from the German word entgegen meaning across). In this example, the alkene is E (Fig. 3b). Cycloalkanes Substituted cycloalkanes can also exist as congurational isomers. For example, there are two congurational isomers of 1,2-dimethylcyclopropane depending on whether the methyl groups are on the same side of the ring or on opposite sides (Fig. 4). The relative positions of the methyl groups can be dened by the bonds. A solid wedge indicates that the methyl group is coming out the page towards you, whereas a hatched wedge indicates that the methyl group is pointing into the page away from you. If the substituents are on the same side of the ring, the structure is dened as cis. If they are on opposite sides, the structure is dened as trans. Section D Stereochemistry D3 CONFIGURATIONAL ISOMERS OPTICAL ISOMERS Key Notes Denition Optical isomers are congurational isomers which have the ability to rotate plane-polarized light clockwise or counterclockwise. They have identical chemical and physical properties (apart from their effects on plane-polarized light), but can have different biological properties. Asymmetric molecules are molecules which lack symmetry. Such molecules can also be termed as chiral molecules and as such can exist as two nonsuperimposable mirror images. These mirror images are optical isomers and are a form of congurational isomerism. Complete asymmetry is not required for a molecule to be chiral and some chiral molecules can have a single axis of symmetry. Asymmetric carbon centers are carbon atoms having four different substituents. Molecules having asymmetric centers will usually be chiral. However, there are special cases where molecules can have asymmetric centers and be achiral, or where molecules are chiral but have no asymmetric centers. Nonsuperimposable mirror images of a molecule are called enantiomers. An equal mixture of two enantiomers is called a racemate and does not rotate plane polarized light. Asymmetric carbon centers are only possi3 ble on sp carbons. Fischer diagrams are used to represent chiral molecules. The vertical bonds in a Fischer diagram represent bonds pointing into the page while the horizontal bonds represent bonds coming out of the page. The R and S nomenclature is used to determine the absolute conguration at asymmetric centers. The groups attached to the asymmetric center are given priorities based on the atomic weights of the atoms directly attached to the center. The group of lowest priority is placed behind the page and an arc is drawn connecting the top three priority groups. If the arc is clockwise, the assignment is R. If the arc is anticlockwise, the assignment is S. The symbols ( ) and ( ) are used to show which direction an enantiomer rotates plane-polarized light. The direction of rotation can only be determined by experimentation. Asymmetric molecules Asymmetric carbon centers Fischer diagrams R and S nomenclature (+) and () 50 Section D Stereochemistry Optical purity Optical purity is quoted in terms of enantiomeric excess. This indicates the excess of pure enantiomer over racemate. Some substituted allenes and spiro compounds are chiral molecules despite the lack of an asymmetric center. Molecules are chiral if they are asymmetric overall or contain only one axis of symmetry. A meso structure has two identical asymmetric centers which effectively cancel each other out. Such a molecule has a plane of symmetry and cannot be chiral. The mirror images are superimposable and optical isomers are not possible. Molecules containing more than one asymmetric center can have several stereoisomers, that is, different congurational isomers. For each asymmetn ric center present (n) in a molecule, there are 2 possible stereoisomers. n1 Every stereoisomer has a mirror image and so there are 2 sets of enantiomers. Each set of enantiomers is called a diastereomer. Diastereomers are different molecules having different chemical and physical properties. Congurational isomers alkenes and cycloalkanes (D2) Allenes and spiro compounds meso structures Diastereomers Related topic Denition Optical isomerism is another example of congurational isomerism and is so named because of the ability of optical isomers to rotate plane-polarized light clockwise or counterclockwise. The existence of optical isomers has very important consequences for life, since optical isomers often have signicant differences in their biological activity. Apart from their biological activity and their effects on plane-polarized light, optical isomers have identical chemical and physical properties. A molecule such as chloroform (CHCl3) is tetrahedral and there is only one way of tting the atoms together. This is not the case for a molecule such as lactic acid. There are two ways of constructing a model of lactic acid, such that the two structures obtained are nonsuperimposable and cannot be interconverted without breaking covalent bonds. As such, they represent two different molecules which are congurational isomers. The difference between the two possible molecules lies in the way the substituents are attached to the central carbon. This can be represented by the following drawings (Fig. 1) where the bond to the hydroxyl group comes out of the page in one isomer but goes into the page in the other isomer. The two isomers of lactic acid are mirror images (Fig. 2). A molecule which exists as two nonsuperimposable mirror images has optical activity if only one of the mirror images is present. HO C H3C Fig. 1. CO2H Lactic acid. H3C H H C CO2H OH Asymmetric molecules D3 Congurational isomers optical isomers 51 HO C H3C H CO2H H C HO2C OH CH3 Mirror Fig. 2. Nonsuperimposable mirror images of lactic acid. Lactic acid exists as two nonsuperimposable mirror images because it is asymmetric in other words it lacks symmetry. Asymmetric molecules can also be termed as chiral, and the ability of molecules to exist as two optical isomers is called chirality. In fact, a molecule does not have to be totally asymmetric to be chiral. Molecules containing a single axis of symmetry can also be chiral. Asymmetric carbon centers A simple method of identifying most chiral molecules involves identifying what are known as asymmetric carbon centers. This works for most chiral molecules, but it is important to realize that it is not foolproof and that there are several cases where it will not work. For example, some chiral molecules have no asymmetric carbon centers, and some molecules having more than one asymmetric carbon center are not chiral. Usually, a compound will have optical isomers if there are four different substituents attached to a central carbon (Fig. 3). In such cases, the mirror images are nonsuperimposable and the structure will exist as two congurational isomers called enantiomers. The carbon center which contains these four different substituents is known as a stereogenic or an asymmetric center. A solution of each enantiomer or optical isomer is capable of rotating plane-polarized light. One enantiomer will rotate plane-polarized light clockwise while the other (the mirror image) will rotate it counterclockwise by the same amount. A mixture of the two isomers (a racemate) will not rotate plane-polarized light at all. In all other respects, the two isomers are identical in physical and chemical properties and are therefore indistinguishable. The asymmetric centers in the molecules shown (Fig. 4) have been identied with an asterisk. The structure lacking the asymmetric center is symmetric or achiral and does not have optical isomers. A structure can also have more than one asymmetric center. 1 HO 3 C H3C H 2 CO2H 4 Fig. 3. (a) Four different substituents of lactic acid. Cl (b) CH3 H3C Cl CH3 (c) OH H3C Fig. 4. * * * Cl Chiral and achiral structures: (a) chiral; (b) achiral; (c) chiral. 52 3 Section D Stereochemistry 2 Asymmetric centers are only possible on sp carbons. An sp center is planar and cannot be asymmetric. Similarly, an sp center cannot be asymmetric. Fischer diagrams A chiral molecule can be represented by a Fischer diagram (Fig. 5). The molecule is drawn such that the carbon chain is vertical with the functional group positioned at the top. The vertical CC bonds from the asymmetric center point into the page while the horizontal bonds from the asymmetric center come out of the page. This is usually drawn without specifying the wedged and hatched bonds. The Fischer diagrams of alanine allow the structures to be dened as L- or Dfrom the position of the amino group. If the amino group is to the left, then it is the L- enantiomer. If it is positioned to the right, it is the D-enantiomer. This is an old fashioned nomenclature which is only used for amino acids and sugars. The L- and D- nomenclature depends on the absolute conguration at the asymmetric center and not the direction in which the enantiomer rotates plane-polarized light. It is not possible to predict which way a molecule will rotate plane-polarized light and this can only be found out by experimentation. The structure of an enantiomer can be specied by the R and S nomenclature, determined by the CahnIngoldPrelog rules. The example (Fig. 6) shows how the nomenclature is worked out. First of all, the atoms directly attached to the asymmetric center and their atomic numbers are identied. Next, you give the attached atoms a priority based on their atomic numbers. In this example, there are two carbon atoms with the same atomic numbers and so they cannot be given a priority. When this happens, the next stage is to move to the next atom of highest atomic number (Fig. 7a). This means moving to an oxygen for one of the carbons and to a hydrogen for the other. The oxygen has the higher priority and so this substituent takes priority over the other. Once the priorities have been settled, the structure is redrawn such that the group of lowest priority is positioned behind the page. In this example (Fig. 7b), R and S nomenclature mirror CO2H H2N * C CH3 L-Alanine CO2H H H * C CH3 D-Alanine CO2H NH2 H * C CH3 NH2 CO2H = H * C CH3 NH2 Fig. 5. Fischer diagrams of L-alanine and D-alanine. HO C H3C H 8 O 6 C C H 1 6 Highest priority Lowest priority O 6 C 8 H C 1 6 C ? * CO2H * C ? * Asymmetric centre Fig. 6. Assigning priorities to substituents of an asymmetric center. * D3 Congurational isomers optical isomers 53 a) Highest priority 1 6 8 O C C 1 H 6 C 8 O Lowest priority b) 1 O C H 4 Numbers refer to priorities. Arrow is drawn as an arc from 1 2 3 H * Third priority Second priority H C 3 C2 O Fig. 7. (a) Assigning priorities to substituents; (b) assigning an asymmetric center as R or S. the group of lowest priority (the hydrogen) is already positioned behind the page (note the hatched bond indicating the bond going away from you). An arc is now drawn connecting the remaining groups, starting from the group of highest priority and nishing at the group of third priority. If the arc is drawn clockwise, the assignment is R (rectus). If the arc is drawn counterclockwise, the assignment is S (sinister). In this example the arrow is drawn clockwise. Therefore, the molecule is (R)-lactic acid. A second example (Fig. 8) illustrates another rule involving substituents with double bonds. The asymmetric center is marked with an asterisk. The atoms directly attached to the asymmetric center are shown on the right with their atomic numbers. At this stage, it is possible to dene the group of highest priority (the oxygen) and the group of lowest priority (the hydrogen). There are two identical carbons attached to the asymmetric center so we have to move to the next stage and identify the atom with the highest atomic number joined to each of the identical carbons (Fig. 9). This still does not distinguish between the CHO and CH2OH groups since both carbon atoms have an oxygen atom attached. The next stage is to look at the second most important atom attached to the two carbon atoms. However, if there is a double bond present, you are allowed to visit the same atom twice. The next most important atom in the CH2OH group is the hydrogen. In the CHO group, the oxygen can be revisited since there is a double bond. Therefore, this group takes priority over the CH2OH group. The priorities H C HO CH2 Lowest priority 6 C ? 1 H C C 8 O 6 Highest priority OH * C O H ? Fig. 8. Assigning priority to substituents of an asymmetric center. Lowest 1 priority H 8 Highest O priority C 6 C O Lowest 1 priority H 8 O C C Highest priority 6 Second priority 8 O 6 C 8 8 6 C O Third priority H 1 O 8,8 Fig. 9. Assigning priority to substituents of an asymmetric center. 54 Section D Stereochemistry 4 H C HO CH2 3 OH 1 1 HO C 4 H * C O 2 H Place group of lowest priority behind page H 2 C O * CH2 3 OH Anti-clockwise (S ) Fig. 10. Assigning an asymmetric center as R or S. have been determined, and so the group of lowest priority is placed behind the page and the three most important groups are connected to see if they are clockwise or counterclockwise (Fig. 10). (+) and () The assignment of an asymmetric center as R or S has nothing to do with whichever direction the molecule rotates plane-polarized light. Optical rotation can only be determined experimentally. By convention, molecules which rotate plane-polarized light clockwise are defined as ( ) or d. Molecules which rotate plane-polarized light counterclockwise are defined as ( ) or l. The R enantiomer of lactic acid is found to rotate plane-polarized light counterclockwise and so this molecule is dened as (R)-( )-lactic acid. The optical purity of a compound is a measure of its enantiomeric purity and is given in terms of its enantiomeric excess (ee). A pure enantiomer would have an optical purity and enantiomeric excess of 100%. A fully racemized compound would have an optical purity of 0%. If the enantiomeric excess is 90%, it signies that 90% of the sample is pure enantiomer and the remaining 10% is a racemate containing equal amounts of each enantiomer (i.e. 5% 5%). Therefore the ratio of enantiomers in a sample having 90% optical purity is 95:5. Not all chiral molecules have asymmetric centers. For example, some substituted allenes and spiro structures have no asymmetric center but are still chiral (Fig. 11). The substituents at either end of the allene are in different planes, and the rings in the spiro structure are at right angles to each other. The mirror images of the allene and the spiro structures are nonsuperimposable and are enantiomers. A better rule for determining whether a molecule is chiral or not is to study the symmetry of the molecule. A molecule will be chiral if it is asymmetric (i.e. has no elements of symmetry) or if it has no more than one axis of symmetry. The molecule in Fig. 12a has two identical asymmetric centers but is not chiral. The mirror images of this structure are superimposable and so the compound cannot be chiral. This is because the molecule contains a plane of symmetry as CH3 Optical purity Allenes and spiro compounds meso structures a) H3C C H C C b) H CH3 H3C Fig. 11. (a) Allene; (b) spiro structure. D3 Congurational isomers optical isomers 55 a) HO H CO2H HO b) HO H H * H OH * HO2C CO2H HO2C Plane of symmetry * Asymmetric centres Fig. 12. (a) Meso structure showing asymmetric centers; (b) plane of symmetry in meso structure. Mirror CO2H H2N C* C* H CH3 2S,3R Enantiomers H H CO2H C CO2H NH2 H2 N C* C* H CH3 2R,3S HO CH3 2S,3S H H Mirror CO2H C * * NH2 OH C* HO H C* H CH3 2R,3R Enantiomers OH Diastereomers Fig. 13. Stereoisomers of threonine. demonstrated in Fig. 12b where the molecule has been rotated around the central CC bond. A structure such as this is called a meso structure. Diastereomers Whenever a molecule has two or more asymmetric centers, there are several possible structures which are possible and we need to use terms such as stereoisomers, diastereomers and enantiomers in order to discuss them. To illustrate the relative meaning of these terms, we shall look at the possible structures of the amino acid threonine (Fig. 13). This molecule has two asymmetric centers. As a result, four different structures are possible arising from the two different possible congurations at each center. These are demonstrated with the asymmetric centers at positions 2 and 3 dened as R or S. The four different structures are referred to as stereoisomers. The (2S,3R) stereoisomer is a nonsuperimposable mirror image of the (2R,3S) stereoisomer and so these structures are enantiomers having the same chemical and physical properties. The (2S,3S) stereoisomer is the nonsuperimposable mirror image of the (2R,3R) stereoisomer and so these structures are also enantiomers having the same chemical and physical properties. Each set of enantiomers is called a diastereomer. Diastereomers are not mirror images of each other and are completely different compounds having different physical and chemical properties. To conclude, threonine has two asymmetric centers which means that there are two possible diastereomers consisting of two enantiomers each, making a total of four stereoisomers. As the number of asymmetric centers increases, the number of possible stereoisomers and diastereomers increases. For a molecule having n asymmetric centers, the number n n1 of possible stereoisomers is 2 and the number of diastereomers is 2 . Section D Stereochemistry D4 CONFORMATIONAL ISOMERS Key Notes Denition Conformational isomers are different shapes of the same molecule resulting from rotation round CC single bonds. Conformational isomers are not different compounds and are freely interconvertable. Alkanes can take up different shapes or conformations due to rotation around the CC bonds. The most stable conformations are those where the bonds are staggered, rather than eclipsed. The torsional angle in butane is the angle between the rst and third CC bonds when viewed along the middle CC bond. The most stable conformation of butane has a torsional angle of 180 where the carbon atoms and the CC bonds are as far apart from each other as possible. The other possible staggered conformation has a torsional angle of 60 which results in some steric and electronic strain called a gauche interaction. The most stable conformation for a straight chain alkane is zigzag shaped where all the torsional angles are at 180 . Cycloalkanes can adopt different conformations or shapes. The most stable conformation for cyclohexane is the chair. Each carbon in the chair has two CH bonds, one of which is equatorial and one of which is axial. A chair structure can invert through a high energy boat intermediate such that the equatorial bonds become axial and the axial bonds become equatorial. If a substituent is present, the most stable chair conformation is where the substituent is equatorial. In the axial position, the substituent experiences two gauche interactions with CC bonds in the ring. Alkanes Cycloalkanes Denition Conformational isomers are essentially different shapes of the same molecule resulting from rotation round CC single bonds. Since rotation round a single bond normally occurs easily at room temperature, conformational isomers are not different compounds and are freely interconvertable. Unlike constitutional and congurational isomers, conformational isomers cannot be separated. Conformational isomers arise from the rotation of CC single bonds. There are many different shapes which a molecule like ethane could adopt by rotation around the CC bond. However, it is useful to concentrate on the most distinctive ones (Fig. 1). The two conformations I and II are called staggered and eclipsed respectively. In conformation I, the CH bonds on carbon 1 are staggered with respect to the CH bonds on carbon 2. In conformation II, they are eclipsed. Newman projections (Fig. 2) represent the view along the C1C2 bond and emphasize the difference. Carbon 1 is represented by the small black circle and carbon 2 is represented by the larger Alkanes D4 Conformational isomers 57 H a) H 1 C H C 2 H b) H H H 2 C 1 CH H H H H Fig. 1. H H 1 H H Fig. 2. (a) Staggered conformation of ethane ; (b) eclipsed conformation of ethane. H H 1 I H HH II HH H Newman projections of the staggered (I) and eclipsed (II) conformations of ethane. sphere. Viewed in this way, it can be seen that the CH bonds on carbon 1 are eclipsed with the CH bonds on carbon 2 in conformation II. Of these two conformations, the staggered conformation is the more stable since the CH bonds and hydrogen atoms are as far apart from each other as possible. In the eclipsed conformation, both the bonds and the atoms are closer together and this can cause strain due to electron repulsion between the eclipsed bonds and between the eclipsed atoms. Therefore, the vast majority of ethane molecules are in the staggered conformation at any one time. However, it is important to realize that the energy difference between the staggered and eclipsed conformations is still small enough to allow each ethane molecule to pass through an eclipsed conformation (Fig. 3) otherwise CC bond rotation would not occur. Ethane has only one type of staggered conformation, but different staggered conformations are possible with larger molecules such as butane (Fig. 4). The rst H* H 1 H H H Low energy Fig. 3. H Bond H H rotation H H HH* Bond rotation H 1 H H H etc H* High energy H Low energy Bond rotation of ethane. 60o H H 3C 2 C H C 3 CH3 CH3 H CH3 H 3C H H I H H 3 2 CH H C H H CH3 H 180o H CH3 II H = H = CH3 H Fig. 4. Gauche conformation (I) and anti conformation (II) of butane. 58 Section D Stereochemistry a) b) c) d) Fig. 5. Zigzag conformations of (a) butane; (b) hexane; (c) octane; (d) decane. and the third CC bonds in isomer I are at an angle of 60 with respect to each other when viewed along the middle CC bond. In isomer II, these bonds are at an angle of 180 . This angle is known as the torsional angle or dihedral angle. Isomer II is more stable than isomer I. This is because the methyl groups and the CC bonds in this conformer are as far apart from each other as possible. The methyl groups are bulky and in conformation I they are close enough to interact with each other and lead to some strain. There is also an interaction between the CC bonds in isomer I since a torsional angle of 60 is small enough for some electronic repulsion to exist between the CC bonds. When CC bonds have a torsional angle of 60 , the steric and electronic repulsions which arise are referred to as a gauche interaction. As a result, the most stable conformation for butane is where the CC bonds are at torsional angles of 180 which results in a zigzag shape. In this conformation, the carbon atoms and CC bonds are as far apart from each other as possible. The most stable conformations for longer chain hydrocarbons will also be zigzag (Fig. 5). However, since bond rotation is occurring all the time for all the CC bonds, it is unlikely that many molecules will be in a perfect zigzag shape at any one time. Cycloalkanes Cyclopropane (Fig. 6) is a at molecule as far as the carbon atoms are concerned, with the hydrogen atoms situated above and below the plane of the ring. There are no conformational isomers. Cyclobutane (Fig. 7) on the other hand can form three distinct shapes a planar shape and two buttery shapes. Cyclopentane (Fig. 8) can also form a variety of shapes or conformations. The planar structures for cyclobutane and cyclopentane are too strained to exist in practice due to eclipsed CH bonds. The two main conformational shapes for cyclohexane are known as the chair and the boat (Fig. 9). The chair is more stable than the boat since the latter has eclipsed CC and CH bonds. This can be seen better in the Newman projections (Fig. 10) which have been drawn such that we are looking along two bonds at the same time bonds 23 and 65. In the chair conformation, there are no eclipsed H H H H Fig. 6. H H H H H H H H H Cyclopropane. H H H H H H H 60o H H H H H H H H H H Fig. 7. Cyclobutane. D4 Conformational isomers 59 H H H H H H H H H H H H H H H H H H H H H H H H H H H H H H Planar Fig. 8. Cyclopentane. H H H H H Envelope Half-chair H H H H Chair H H H H H H H H H H H H H H Boat H Fig. 9. Cyclohexane. H H 2 H 1 6 H H H H 4 H H 5 32 H Boat H H 1 6 H H H H H H H H H H 2 1 4 6 H H H 4 H H H H H 2H 3H 1 H H Chair H 5H 6 H H H 4 H Fig. 10. H H H 4 H H Newman projections of the chair and boat conformations of cyclohexane. H 5 H 6 H H H 1 H H H 3 H Boat H 4 H H 5 2 6 H H H H 1 H H H 4 H H 3 Chair H H 2 H 5 H H 6 H H 1 H H 2 3H Chair Fig. 11. Ring ipping of cyclohexane. CC bonds. However, in the boat conformation, bond 12 is eclipsed with bond 34, and bond 16 is eclipsed with bond 54. This means that the boat conformation is less stable than the chair conformation and the vast majority of cyclohexane molecules exist in the chair conformation. However, the energy barrier is small enough for the cyclohexane molecules to pass through the boat conformation in a process called ring ipping (Fig. 11). The ability of a cyclohexane molecule to ring-ip is important when substituents are present. Each carbon atom in the chair structure has two CH bonds, but these are not identical (Fig. 12). One of these bonds is termed equatorial since it is roughly in the plane of the ring. The other CH bond is vertical to the plane of the ring and is called the axial bond. When ring ipping takes place from one chair to another, all the axial bonds become equatorial bonds and all the equatorial bonds become axial bonds. This does not matter for cyclohexane itself, but it becomes important when there is a 60 Section D Stereochemistry H 4 a) H H 3 2 H 5 6 H H H1 b) 3 H Fig. 12. (a) Equatorial CH bonds; (b) axial CH bonds. 4 5 H H H 6 1 H 2 substituent present in the ring. For example, methylcyclohexane can have two chair structures where the methyl group is either on an equatorial bond or on an axial bond (Fig. 13). These are different shapes of the same molecule which are interconvertable due to rotation of CC single bonds (the ring ipping process). The two chair structures are conformational isomers but they are not of equal stability. The more stable conformation is the one where the methyl group is in the equatorial position. In this position, the CC bond connecting the methyl group to the ring has a torsional angle of 180 with respect to bonds 56 and 32 in the ring. In the axial position, however, the CC bond has a torsional angle of 60 with respect to H H eq. H3C 4 H H Chair 5 H H 6 H H H 1 H H Boat H H3C 4 H H 5 3H 2 H 6 H H ax. H3C Chair H 1 H H H H4 H 3 H 5 H 6 H H H H 1 H H 2 2 3H Fig. 13. Ring ipping of methylcyclohexane. Equatorial methyl H 4 H3C H 3H H H 5 H 2 H 6 H H H H 1 H3C H Torsion angle = 180o Axial methyl H 5 H H 4 H CH3 3 H H 2 H6 H H 1 H H H 2 CH3 Torsion angle = 60o H 3 1 H H H 5 H H H 4 H CH3 6 H 2 H H 3 H H H 5 H H 3 1 4 H 3C 3 H Torsion angle = 180o H 2 H H 2 H H H H 6 H H Torsion angle = 60o Fig. 14. Newman projections of the chair conformations of methylcyclohexane. D4 Conformational isomers 61 these same two bonds. This can be illustrated by comparing Newman diagrams of the two methylcyclohexane conformations (Fig. 14). A torsion angle of 60 between CC bonds represents a gauche interaction and so an axial methyl substituent experiences two gauche interactions with the cyclohexane ring whereas the equatorial methyl substituent experiences none. As a result, the latter chair conformation is preferred and about 95% of methylcyclohexane molecules are in this conformation at any one time, compared to 5% in the other conformation. Section E Nucleophiles and electrophiles E1 DEFINITION Key Notes Nucleophiles Nucleophilic center Nucleophiles are electron-rich molecules and react with electrophiles. The nucleophilic center of a nucleophile is the specic atom or region of the molecule which is electron rich. Electrophiles are electron-decient molecules and can react with nucleophiles. The electrophilic center of an electrophile is the specic atom or region of the molecule which is electron decient. Charged species (E2) Neutral inorganic species (E3) Organic structures (E4) Electrophiles Electrophilic center Related topics Nucleophiles Most organic reactions involve the reaction between a molecule which is rich in electrons and a molecule which is decient in electrons. The reaction involves the formation of a new bond where the electrons are provided by the electron-rich molecule. Electron-rich molecules are called nucleophiles (meaning nucleusloving). The easiest nucleophiles to identify are negatively charged ions with lone pairs of electrons (e.g. the hydroxide ion), but neutral molecules can also act as nucleophiles if they contain electron-rich functional groups (e.g. an amine). Nucleophiles have a specic atom or region of the molecule which is electron rich. This is called the nucleophilic center. The nucleophilic center of an ion is the atom bearing a lone pair of electrons and the negative charge. The nucleophilic center of a neutral molecule is usually an atom with a lone pair of electrons (e.g. nitrogen or oxygen), or a multiple bond (e.g. alkene, alkyne, aromatic ring). Electron-decient molecules are called electrophiles (electron-loving) and react with nucleophiles. Positively charged ions can easily be identied as electrophiles (e.g. a carbocation), but neutral molecules can also act as electrophiles if they contain certain types of functional groups (e.g. carbonyl groups or alkyl halides). Electrophiles have a specic atom or region of the molecule which is electron decient. This region is called the electrophilic center. In a positively charged ion, the electrophilic center is the atom bearing the positive charge (e.g. the carbon atom of a carbocation). In a neutral molecule, the electrophilic center is an electrondecient atom within a functional group (e.g. a carbon or hydrogen atom linked to an electronegative atom such as oxygen or nitrogen). Nucleophilic center Electrophiles Electrophilic center Section E Nucleophiles and electrophiles E2 CHARGED SPECIES Key Notes Anions Negatively charged ions with lone pairs of electrons are nucleophiles. The atom bearing the negative charge is the nucleophilic center. Positively charged ions are electrophiles. The atom bearing the positive charge is the electrophilic center. In a series of anions, the relative nucleophilic strength matches their relative basicity if the nucleophilic center is the same atom. The same holds true for anions where the nucleophilic center is an atom from the same row of the periodic table. In protic solvents, anions having large nucleophilic centers (atoms lower down the periodic table) are less solvated and are stronger nucleophiles. In aprotic solvents nucleophilic strengths more closely match relative basicity. Acid strength (G2) Base strength (G3) Cations Relative nucleophilicity Related topics Anions A negatively charged molecule such as the hydroxide ion (Fig. 1) is electron rich and acts as a nucleophile. The atom which bears the negative charge and a lone pair of electrons is the nucleophilic center, which in the case of the hydroxide ion is the oxygen atom. Some ions (e.g. the carboxylate ion) are able to share the negative charge between two or more atoms through a process known as delocalization. In this case, the negative charge is shared between both oxygen atoms and so both of these atoms are nucleophilic centers (Fig. 1). A positively charged ion is electron decient and acts as an electrophile. The atom which bears the positive charge is the electrophilic center. In the case of a carbocation (Fig. 2), this is the carbon atom. Some molecules (e.g. the allylic cation) are able to delocalize their positive charge between two or more atoms in which case all the atoms capable of sharing the charge are electrophilic centers (Fig. 2). Cations a) Nucleophilic center b) Nucleophilic center O O C O R O Nucleophilic center H O R C Fig. 1. Examples of nucleophiles; (a) hydroxide ion; (b) carboxylate ion. E2 Charged species 65 a) H C H H Electrophilic center Electrophilic b) center H C H C H C H H H C C H C H Electrophilic center Fig. 2. Examples of electrophiles: (a) carbocation; (b) allylic cation. a) O C Me2N Fig. 3. H Me b) O S Me (a) Dimethylformamide (DMF); (b) dimethylsulfoxide (DMSO). Relative nucleophilicity In a series of anions, nucleophilic strength parallels basicity if the nucleophilic center is the same atom. For example the nucleophilic strengths of the following HO RCO2 ) matches their order of basicity. oxygen compounds (RO The same holds true for anions where the nucleophilic center is an element in the same row of the periodic table (e.g. C,N,O,F). Thus, the order of nucleophilicR2N > RO > F ) is the same as their order of ity of the following anions (R3C basicity. This trend is related to the electronegativities of these atoms. The more electronegative the atom (e.g. F), the more tightly it holds on to its electrons and the less available these electrons are for forming new bonds (less nucleophilic). The story becomes more complex if we compare anions having nucleophilic centers from different parts of the periodic table. Here, relative nucleophilicity does not necessarily match relative basicity. This is because the solvent used in a reaction has an important effect. In protic solvents such as water or alcohol, the stronger nucleophiles are those which have a large nucleophilic center, that is, an atom lower down the periodic table (e.g. S is more nucleophilic than O but is less basic). This is because protic solvents can form hydrogen bonds to the anion. The smaller the anion, the stronger the solvation and the more difcult it is for the anion to react as a nucleophile. The order of nucleophilicity of some common anions in protic solvents is as CN I OH N3 Br CH3CO2 Cl F. follows: SH When an organic solvent is used which is incapable of forming hydrogen bonds to the anion (e.g. DMF or DMSO; Fig. 3), the order of nucleophilicity changes to more closely match that of basicity. For example, the order of nucleophilicity of the Cl Br I. halides in DMSO is F Section E Nucleophiles and electrophiles E3 NEUTRAL INORGANIC SPECIES Key Notes Polar bonds Polar bonds are polarized such that the more electronegative atom has the greater share of the bonding electrons. As a result, it will be electron rich and will be a nucleophilic center. The less electronegative atom will be electron decient and will be an electrophilic center. Electronegative atoms are to the right of the periodic table and have lone pairs of electrons. The relative strengths of neutral nucleophilic centers are determined by how well they can accommodate a positive charge. The more electronegative the atom, the less nucleophilic it will be. Therefore, nitrogen is more nucleophilic than oxygen, and oxygen is more nucleophilic than uorine. The relative electrophilic strengths of hydrogen atoms in different molecules is determined by the stability of the ions formed. Hydrogen atoms attached to nitrogen are only weakly electrophilic, whereas hydrogens attached to halogen atoms are strongly electrophilic. Therefore, the electrophilic strength of hydrogen atoms depends on the electronegativity of the neighboring atom. It is possible to predict whether a molecule is likely to react as an electrophile or as a nucleophile, based on the strength of the nucleophilic or electrophilic centers present. Acid strength (G2) Base strength (G3) Nucleophilic strength Electrophilic strength Properties Related topics Polar bonds If two atoms of quite different electronegativities are linked together, then the bond connecting them will be polar covalent such that the bonding electrons are biased towards the more electronegative atom. This will give the latter a slightly negative charge and make it a nucleophilic center. Conversely, the less electronegative atom will gain a slightly positive charge and be an electrophilic center (Fig. 1). The further to the right an element is in the periodic table, the more electronegative it is. Thus, uorine is more electronegative than oxygen, which in turn is more electronegative than nitrogen. Note also that all the nucleophilic O + H H + + N H + H H + Cl Cl Al + Cl + H F Fig. 1. Nucleophilic ( ) and electrophilic ( ) centers in neutral inorganic molecules. E3 Neutral inorganic species 67 atoms identied above have lone pairs of electrons. This is another way of identifying nucleophilic atoms. Nucleophilic strength The molecules above have both nucleophilic and electrophilic centers and could react as nucleophiles or as electrophiles. However, it is usually found that there is a preference to react as one rather than the other. This is explained by considering the relative strengths of nucleophilic and electrophilic centers. First of all, let us consider the relative strengths of nucleophilic centers by comparing N, O, and F. If we compare the relative positions of these atoms in the periodic table, we nd that uorine is more electronegative than oxygen, which in turn is more electronegative than nitrogen. However, when we compare the nucleophilic strengths of these atoms, we nd that the nitrogen is more nucleophilic than oxygen, which in turn is more nucleophilic than uorine. The relative nucleophilic strengths of these atoms is explained by looking at the products which would be formed if these atoms were to act as nucleophiles. Let us compare the three molecules HF, H2O, and NH3 and see what happens if they were to form a bond to a proton (Fig. 2). Since the proton has no electrons, both electrons for the new bond must come from the nucleophilic centers (i.e. the F, O, and N). As a result, these atoms will gain a positive charge. If hydrogen uoride acts as a nucleophile, then the uorine atom gains a positive charge. Since the uorine atom is strongly electronegative, it does not tolerate a positive charge. Therefore, this reaction does not take place. Oxygen is less electronegative and is able to tolerate the positive charge slightly better, such that an equilibrium is possible between the charged and uncharged species. Nitrogen is the least electronegative of the three atoms and tolerates the positive charge so well that the reaction is irreversible and a salt is formed. Thus, nitrogen is strongly nucleophilic and will usually react as such, whereas halogens are weakly nucleophilic and will rarely react as such. Lastly, it is worth noting that all these molecules are weaker nucleophiles than their corresponding anions, i.e. HF, H2O, and NH3 are weaker nucleophiles than F , OH and NH2 respectively. The same argument can be used in reverse when looking at the relative electrophilic strengths of atoms in different molecules. Let us compare the electrophilic strengths of the hydrogens in HF, H2O, and NH3. In this case, reaction with a strong nucleophile or base would generate anions (Fig. 3). Fluorine being the most electronegative atom is best able to stabilize a negative charge and so the uoride ion is the most stable ion of the three. Oxygen is also able to stabilize a Electrophilic strength H H H F H F H H O H H O H H H H N H H H N H H H Fig. 2. Cations formed if HF, H2O, and NH3 act as nucleophiles. F H Fig. 3. O H N H Anions generated when HF, H2O, and NH3 act as electrophiles. 68 Section E Nucleophiles and electrophiles a) H O H H Nucleophile + b) H Electrophile H O H O + NH2 H H Electrophile Nucleophile O H + H NH2 Fig. 4. Water acting as (a) a nucleophile and (b) an electrophile. negative charge, though not as well as uorine. Nitrogen is the least electronegative of the three atoms and has the least stabilizing inuence on a negative charge and so the NH2 ion is unstable. The more stable the anion, the more easily it is formed and hence the hydrogen which is lost will be strongly electrophilic. This is the case for HF. In contrast, the hydrogen in ammonia is a very weak electrophilic center since the anion formed is unstable. As a result, nitrogen anions are only formed with very strong bases. Properties It is possible to predict whether molecules are more likely to react as nucleophiles or electrophiles depending on the strength of the nucleophilic and electrophilic centers present. For example, ammonia has both electrophilic and nucleophilic centers. However, it usually reacts as a nucleophile since the nitrogen atom is a strong nucleophilic center and the hydrogen atom is a weak electrophilic center. By contrast, molecules such as hydrogen uoride or aluminum chloride prefer to react as electrophiles. This is because the nucleophilic centers in both these molecules (halogen atoms) are weak, whereas the electrophilic centers (H or Al) are strong. Water is a molecule which can react equally well as a nucleophile or as an electrophile. For example, water reacts as a nucleophile with a proton and as an electrophile with an anion (Fig. 4). Section E Nucleophiles and electrophiles E4 ORGANIC STRUCTURES Key Notes Alkanes Polar functional groups Alkanes have no nucleophilic or electrophilic centers and are unreactive. The nucleophilic and electrophilic centers of functional groups can be identied by identifying polar bonds. Bonds such as CH and CC are considered to be nonpolar. Carbon bonded to oxygen or halogen is an electrophilic center. Some electrophilic and nucleophilic centers are weak and are not usually important. Alkenes, alkynes, and aromatic rings are nucleophiles. The multiple bonds in these functional groups represent an area of high electron density and are therefore nucleophilic centers. Recognition of functional groups (C1) Neutral inorganic species (E3) Acid strength (G2) Base strength (G3) Unsaturated hydrocarbons Related topics Alkanes Alkanes are made up of carboncarbon and carbonhydrogen single bonds and are unreactive compounds. This is because CC and CH bonds are covalent in nature and so there are no electrophilic or nucleophilic centers present. Since most reagents react with nucleophilic or electrophilic centers, alkanes are unreactive molecules. It is possible to identify the nucleophilic and electrophilic centers in common functional groups, based on the relative electronegativities of the atoms present. The following guidelines are worth remembering: Polar functional groups CH and CC bonds are covalent. Therefore, neither carbon nor hydrogen is a nucleophilic or electrophilic center; nitrogen is immediately to the right of carbon in the periodic table. The nitrogen is more electronegative but the difference in electronegativity between these two atoms is small and so the NC bond is not particularly polar. Therefore, the carbon atom can usually be ignored as an electrophilic center; NH and OH bonds are polar covalent. Nitrogen and oxygen are strong nucleophilic centers. Hydrogen is a weak electrophilic center; C O, C N and C N bonds are polar covalent. The O and N are nucleophilic centers and the carbon is an electrophilic center; CO and CX bonds (X halogen) are polar covalent. The oxygen atom is moderately nucleophilic whereas the halogen atom is weakly nucleophilic. The carbon atom is an electrophilic center. 70 Section E Nucleophiles and electrophiles Amine N H3C CH3 Alcohol + HO (+) CH3 O C H3C + O Ether (+) H3C O (+) CH3 Alkyl halide () + I CH3 Aldehyde O C H3C + H H (+) + CH3 Ketones O C Carboxylic acid Amide H + + H3C O C N CH3 CH3 Ester O C + O (+) CH3 H3C H3C Carboxylic acid anhydride O C + O O C + CH3 Carboxylic acid chloride H3C O C + () Cl H3C Nucleophilic center + Electrophilic center ( ) Weak nucleophilic center (+) Weak electrophilic center Fig. 1. Nucleophilic and electrophilic centers of common functional groups. Using the above guidelines, the nucleophilic and electrophilic centers of the common functional groups can be identied, where atoms having a slightly negative charge are nucleophilic centers and atoms having a slightly positive charge are electrophilic centers (Fig. 1). Not all the nucleophilic and electrophilic centers are of equal importance. For example, a nitrogen atom is more nucleophilic than an oxygen atom. Also halogen atoms are very weakly nucleophilic and will not usually react with electrophiles if there is a stronger nucleophilic center present. Hydrogen atoms attached to halogens are more electrophilic than hydrogen atoms attached to oxygen. Hydrogen atoms attached to nitrogen are very weakly electrophilic. Taking this into account, some functional groups are more likely to react as nucleophiles while some functional groups are more likely to react as electrophiles. For example, amines, alcohols and ethers are more likely to react as nucleophiles, since they have strong nucleophilic centers and weak electrophilic centers. Alkyl halides are more likely to react as electrophiles since they have strong electrophilic centers and weak nucleophilic centers. Aldehydes and ketones can react as nucleophiles or electrophiles since both electrophilic and nucleophilic centers are strong. Some functional groups contain several nucleophilic and electrophilic centers. For example, carboxylic acids and their derivatives fall into this class and so there are several possible centers where a nucleophile or an electrophile could react. a) CH3CH2 C C CH3 b) H C H3C C CH2CH3 H Nucleophilic center c) CH3 Nucleophilic center CH3 Nucleophilic center Fig. 2. Nucleophilic centers in (a) an alkyne; (b) an alkene; (c) an aromatic compound. E4 Organic structures 71 Unsaturated hydrocarbons Not all functional groups have polar bonds. Alkenes, alkynes, and aromatic compounds are examples of functional groups which have covalent multiple bonds. The space between the multiple bonded carbons is rich in electrons and is therefore nucleophilic. Thus, the nucleophilic center in these molecules is not a specic atom, but the multiple bond (Fig. 2)! Section F Reactions and mechanisms F1 REACTIONS Key Notes Bond formation Most organic reactions take place between nucleophiles and electrophiles, where the nucleophilic center of the nucleophile forms a bond to the electrophilic center of the electrophile. Reactions can be classied as acid/base reactions, functional group transformations or as carboncarbon bond formations. Reactions can also be classied according to the process or mechanism taking place and these are specic for particular functional groups. Denition (E1) Organic structures (E4) Nucleophilic substitution (L2) Classication of reactions Related topics Bond formation Synthetic organic chemistry is about creating complex molecules from simple starting materials a process which may involve many different reactions. Designing a synthesis is a bit like chess. A grand master has to know the pieces and the moves that can be made before planning a game strategy. As far as an organic chemist is concerned, he/she has to know the molecules and the sort of reactions which can be carried out before planning a synthetic game strategy. Inevitably, there is a lot of memory work involved in knowing reactions, but there is a logic involved as well. Basically, most reactions involve electronrich molecules forming bonds to electron decient molecules (i.e. nucleophiles forming bonds to electrophiles). The bond will be formed specically between the nucleophilic center of the nucleophile and the electrophilic center of the electrophile. There are a large number of reactions in organic chemistry, but we can simplify the picture by grouping these reactions into various categories. To begin with, we can classify reactions as being: Classication of reactions acid/base reactions; functional group transformations; carboncarbon bond formations. The rst category of reaction is relatively simple and involves the reaction of an acid with a base to give a salt. These reactions are covered in Section G. The second category of reaction is where one functional group can be converted into another. Normally these reactions are relatively straightforward and proceed in high yield. The third category of reactions is extremely important to organic chemistry since these are the reactions which allow the chemist to construct complex molecules from simple starting materials. In general, these reactions are the most difcult and temperamental to carry out. Some of these 74 Section F Reactions and mechanisms Table 1. Different categories of reaction undergone by functional groups. Functional group Alkenes and alkynes Aromatic Aldehydes and ketones Carboxylic acid derivatives Alkyl halides Alcohols and alkyl halides Alkenes, alkynes, aromatic, aldehydes, ketones, nitriles, carboxylic acids, and carboxylic acid derivatives, Alkenes, alcohols, aldehydes Carboxylic acids, phenols, amines Section H I J K L M,L HN Reaction category Electrophilic addition Electrophilic substitution Nucleophilic addition Nucleophilic substitution Elimination Reduction Oxidation Acid/base reactions HN G reactions are so important that they are named after the scientists who developed them (e.g. Grignard and Aldol reactions). Another way of categorizing reactions is to group similar types of reactions together, depending on the process or mechanism involved. This is particularly useful since specic functional groups will undergo certain types of reaction category. Table 1 serves as a summary of the types of reactions which functional groups normally undergo. Section F Reactions and mechanisms F2 MECHANISMS Key Notes Denition A mechanism describes how a reaction takes place by showing what is happening to valence electrons during the formation and breaking of bonds. Curly arrows are used to show what happens to valence electrons during the making and breaking of bonds. They always start from the source of two electrons (i.e. a lone pair of electrons on an atom or the middle of a bond about to be broken). They always point to where the valence electrons will end up. If the electrons end up as a lone pair of electrons on an atom, the arrow points to that specic atom. If the electrons are being used to form a new bond, the arrow points to where the center of the new bond will be formed. Half curly arrows are used to show the movement of single electrons during radical reactions. Bond breaking during a radical reaction involves homolytic cleavage where the bonding electrons move to different atoms. However, most reactions in organic chemistry involve heterolytic cleavage where the bonding electrons move as a pair onto one atom and not the other. Acid strength (G2) Curly arrows Half curly arrows Related topic Denition An understanding of electrophilic and nucleophilic centers allows a prediction of where reactions might occur but not what sort of reaction will occur. In order to understand and predict the outcome of reactions, it is necessary to understand what goes on at the electronic level. This process is known as a mechanism. A mechanism is the story of how a reaction takes place. It explains how molecules react together to give the nal product. The mechanism tells us how bonds are formed and how bonds are broken and in what order. It explains what is happening to the valence electrons in the molecule since it is the movement of these electrons which result in a reaction. Take as a simple example the reaction between a hydroxide ion and a proton to form water (Fig. 1). The hydroxide ion is a nucleophile and the proton is an electrophile. A reaction takes place between the nucleophilic center (the oxygen) and the electrophilic center (the hydrogen) and water is formed. A new bond has been formed between the oxygen of the hydroxide ion and the proton. The mechanism looks at what happens to the electrons. In + O H Fig. 1. H H O H Reaction of a hydroxide ion and a proton to form water. 76 Section F Reactions and mechanisms this example, a lone pair of electrons from oxygen is used to form a bond to the proton. By doing so, the oxygen effectively loses one electron and the proton effectively gains one electron. As a result, the oxygen loses its negative charge and the proton loses its positive charge. Curly arrows Explaining what happens to all the valence electrons during a reaction mechanism can be rather long-winded if you are trying to explain it all in words. Fortunately, there is a diagrammatic way of showing the same thing using curly arrows. For example, the mechanism described above can be explained by using a curly arrow to show what happens to the lone pair of electrons (Fig. 2). In this case, the arrow starts from a lone pair of electrons on the oxygen (the source of the two electrons) and points to where the center of the new bond will be formed. In some textbooks, you may see the arrow written directly to the proton (Fig. 3). Formally, this is incorrect. Arrows should only be drawn directly to an atom if the electrons are going to end up on that atom as a lone pair of electrons. The following rules are worth remembering when drawing arrows: curly arrows show the movement of electrons, not atoms; curly arrows start from the source of two electrons (i.e. a lone pair of electrons on an atom or the middle of a bond which is about to be broken); curly arrows point to an atom if the electrons are going to end up as a lone pair on that atom; curly arrows point to where a new bond will be formed if the electrons are being used to form a new bond. The mechanism (Fig. 4) explains what happens when a hydroxide ion reacts with a carboxylic acid and is a demonstration of how arrows should be drawn. One of the lone pairs of electrons on the hydroxide ion is used to form a bond to the acidic proton of the carboxylic acid. The curly arrow representing this starts from a lone pair of electrons and points to the space between the two atoms to show that a bond is being formed. H O H H O H Fig. 2. Mechanism for the reaction of a hydroxide ion with a proton. H O H H O H Fig. 3. Incorrect way of drawing a curly arrow. O C H3C O H O H O C H3C O + H O H Fig. 4. Mechanism for the reaction of a hydroxide ion with ethanoic acid. F2 Mechanisms 77 Light Cl Cl Cl Cl Fig. 5. Use of half curly arrows in a mechanism (homolytic cleavage). H Cl H Heterolytic cleavage of a bond. Cl Fig. 6. At the same time as this new bond is being formed, the OH bond of the carboxylic acid has to break. This is because the hydrogen atom is only allowed one bond. The electrons in this bond end up on the carboxylate oxygen as a third lone pair of electrons. The arrow representing this starts from the center of the bond being broken and points directly to the atom where the electrons will end up as a lone pair. Notice also what happens to the charges. The negatively charged oxygen of the hydroxide ion ends up as a neutral oxygen in water. This is because one of the oxygens lone pairs is used to form the new bond. Both electrons are now shared between two atoms and so the oxygen effectively loses one electron and its negative charge. The oxygen in the carboxylate ion (which was originally neutral in the carboxylic acid) becomes negatively charged since it now has three lone pairs of electrons and has effectively gained an extra electron. Half curly arrows Occasionally reactions occur which involve the movement of single electrons rather than pairs of electrons. Such reactions are known as radical reactions. For example, a chlorine molecule can be split into two chlorine radicals on treatment with light. One of the original bonding electrons ends up on one chlorine radical and the second bonding electron ends up on the other chlorine radical. The movement of these single electrons can be illustrated by using half curly arrows rather than full curly arrows (Fig. 5). This form of bond breaking is known as a homolytic cleavage. The radical atoms obtained are neutral but highly reactive species since they have an unpaired valence electron. There are some important radical reactions in organic chemistry, but the majority of organic reactions involve the heterolytic cleavage of covalent bonds where electrons move together as a pair (Fig. 6). Section G Acidbase reactions G1 BRNSTEDLOWRY ACIDS AND BASES Key Notes Denition The BrnstedLowry denition of an acid is a molecule which can provide a proton. The BrnstedLowry denition of a base is a molecule which can accept that proton. A hydrogen atom attached to an electronegative atom such as a halogen, oxygen, or nitrogen is potentially acidic. Therefore, compounds containing the following functional groups (carboxylic acid, phenol, alcohol, 1 and 2 amines, and 1 and 2 amides) can act as BrnstedLowry acids. Examples of BrnstedLowry bases include negatively charged ions and neutral molecules containing oxygen or nitrogen (e.g. water, ethers, alcohols, and amines). Neutral inorganic species (E3) Organic structures (E4) Acid strength (G2) Base strength (G3) Enolates (G5) BrnstedLowry acids BrnstedLowry bases Related topics Denition Put at its simplest, the BrnstedLowry denition of an acid is a molecule which can provide a proton. The BrnstedLowry denition of a base is a molecule which can accept that proton. An example of a simple acid/base reaction is the reaction of ammonia with water (Fig. 1). Here, water loses a proton and is an acid. Ammonia accepts that proton and is the base. + + NH4 H2O Fig. 1. NH3 OH Reaction of ammonia with water. As far as the mechanism of the reaction is concerned, the ammonia uses its lone pair of electrons to form a new bond to the proton and is therefore acting as a nucleophile. This means that the water is acting as an electrophile. As the nitrogen uses its lone pair of electrons to form the new bond, the bond between hydrogen and oxygen must break since hydrogen is only allowed one bond. The electrons making up the OH bond will move onto oxygen to produce a third lone pair of electrons, thus giving the oxygen a negative charge (Fig. 2). Since the nitrogen atom on ammonia has used its lone pair of electrons to form a new bond, it now has to share the electrons with hydrogen and so nitrogen gains a positive charge. 80 Section G Acidbase reactions H O H Fig. 2. H N H H O H H N H H H Mechanism for the reaction of ammonia with water. BrnstedLowry acids A BrnstedLowry acid is a molecule which contains an acidic hydrogen. In order to be acidic, the hydrogen must be slightly positive or electrophilic. This is possible if hydrogen is attached to an electronegative atom such as a halogen, oxygen, or nitrogen. The following mineral acids and functional groups contain hydrogens which are potentially acidic (Fig. 3). H F H Cl H Br H I Acidic O H3C C O Carboxylic acid Acidic H3C O Alcohol Fig. 3. H H Acidic O Acidic H3C C N H Amide Acidic H H3C H Acidic N H Amine Acidic Acidic Acidic O H Phenol Acidic protons in mineral acids and common functional groups. Hydrogens attached to carbon are not normally acidic. However, in topic G5, we shall look at special cases where hydrogens attached to carbon are acidic. BrnstedLowry bases A BrnstedLowry base is a molecule which can form a bond to a proton. Examples include negatively charged ions with a lone pair of electrons (Fig. 4). O H3C C O Carboxylate ion Amide ion H H3C C C O H3C N H H3C O O Alkoxide ion H H3C C H Phenoxide ion Acetylide ion Fig. 4. Hydroxide ion Carbanion Examples of BrnstedLowry bases. G1 BrnstedLowry acids and bases 81 Neutral molecules can also act as bases if they contain an oxygen or nitrogen atom. The most common examples are amines. However, water, ethers and alcohols are also capable of acting as bases (Fig. 5). Basic center H H3C N H Fig. 5. H3C O Basic center CH3 H3C O H Basic center H O H Basic center Examples of neutral BrnstedLowry bases. Section G Acidbase reactions G2 ACID STRENGTH Key Notes Electronegativity The acidity of protons depends on the electronegativity of the atoms to which they are attached. The more electronegative the atom, the more acidic the proton will be. Therefore, a hydrogen atom attached to a halogen atom will be more acidic than a hydrogen atom attached to oxygen. A hydrogen atom attached to oxygen will be more acidic than a hydrogen atom attached to nitrogen. Hydrogen atoms attached to carbon are not usually acidic at all. pKa is a measure of the strength of an acid. The lower the value of pKa the stronger the acid. pKa is the negative logarithm of Ka which is a measure of the dissociation or ionization of the acid. The larger the value of Ka, the stronger the acid. Inductive effects can affect the stability of the conjugate base by stabilizing or destabilizing the negative charge. Electron-withdrawing groups such as halogens diminish the charge and stabilize the conjugate base, resulting in a stronger acid. Electron-donating groups (e.g. alkyl groups) will increase the charge and destabilize the conjugate base, resulting in a weaker acid. A negative charge can be stabilized by resonance, resulting in delocalization of the charge over two or more atoms. Carboxylic acids are acidic because the resulting carboxylate ion can be stabilized by delocalization of the charge between two oxygen atoms. Phenols are acidic because the resulting phenolate ion can be stabilized by delocalization of the charge between the oxygen and three carbon atoms. Alcohols are only weakly acidic because the charge on the resulting alkoxide ion is localized on the oxygen and destabilized by the inductive effect of the alkyl group. Amines and amides are very weak acids. However, amides are more acidic than amines due to resonance and inductive effects. Neutral inorganic species (E3) Organic structures (E4) BrnstedLowry acids and bases (G1) Base strength (G3) Properties of alcohols and phenols (M3) Properties of amines (O2) pKa Inductive effects Resonance Amines and amides Related topics Electronegativity The acidic protons of various molecules are not equally acidic and their relative acidity depends on a number of factors, one of which is the electronegativity of the atom to which they are attached. For example, consider hydrouoric acid, ethanoic acid, and methylamine (Fig. 1). Hydrouoric acid has the most acidic proton since the hydrogen is attached to a strongly electronegative uorine. The G2 Acid strength 83 uorine strongly polarizes the HF bond such that the hydrogen becomes highly electron decient and is easily lost. Once the proton is lost, the uoride ion can stabilize the resulting negative charge. H a) H F b) H C H Fig. 1. C O H O c) H H C H N H H (a) Hydrouoric acid; (b) ethanoic acid; (c) methylamine. The acidic protons on methylamine are attached to nitrogen which is less electronegative than uorine. Therefore, the NH bonds are less polarized, and the protons are less electron decient. If one of the protons is lost, the nitrogen is left with a negative charge which it cannot stabilize as efciently as a halide ion. All of this means that methylamine is a much weaker acid than hydrogen uoride. Ethanoic acid is more acidic than methylamine but less acidic than hydrouoric acid. This is because the electronegativity of oxygen lies between that of a halogen and that of a nitrogen atom. These differences in acid strength can be demonstrated if the three molecules above are placed in water. Mineral acids such as HF, HCl, HBr, and HI are strong acids and dissociate or ionize completely (Fig. 2). H H Cl + H O H Fig. 2. Ionization of hydrochloric acid. Cl + H O H Ethanoic acid (acetic acid) partially dissociates in water and an equilibrium is set up between the carboxylic acid (termed the free acid) and the carboxylate ion (Fig. 3). An acid which only partially ionizes in this manner is termed a weak acid. O C H3C Fig. 3. O Partial ionization of ethanoic acid. H + H2O H3C O C O + H3O: If methylamine is dissolved in water, none of the acidic protons are lost at all and the amine behaves as a weak base instead of an acid, and is in equilibrium with its protonated form (Fig. 4). H H3C N H Fig. 4. + H2O H3C N H H H + HO Equilibrium acidbase reaction of methylamine with water. Methylamine can act as an acid but it has to be treated with a strong base such as butyl lithium (Fig. 5). Lastly, hydrogen atoms attached to carbon are not usually acidic since carbon atoms are not electronegative. There are exceptions to this rule as described in Topic G5. 84 Section G Acidbase reactions H H3C N H Fig. 5. + H2 C CH3 Li H 3C N H + H3C CH3 Methylamine acting as an acid with a strong base (butyl lithium). pKa Acids can be described as being weak or strong and the pKa is a measure of this. Dissolving acetic acid in water, results in an equilibrium between the carboxylic acid and the carboxylate ion (Fig. 6). O C H3C Fig. 6. O H + H2O H3C O C O + H3O Equilibrium acidbase reaction of ethanoic acid with water. Ethanoic acid on the left hand of the equation is termed the free acid, while the carboxylate ion formed on the right hand side is termed its conjugate base. The extent of ionization or dissociation is dened by the equilibrium constant (Keq ); Keq [PRODUCTS] [REACTANTS] [CH3CO2 ] [H3O ] [CH3CO2H] [H2O] . Keq is normally measured in a dilute aqueous solution of the acid and so the concentration of water is high and assumed to be constant. Therefore, we can rewrite the equilibrium equation in a simpler form where Ka is the acidity constant and includes the concentration of pure water (55.5 M). Ka Keq [H2O] [CH3CO2 ] [H3O ] [CH3CO2H] . The acidity constant is also a measure of dissociation and of how acidic a particular acid is. The stronger the acid, the more it is ionized and the greater the concentration of products in the above equation. This means that a strong acid has a high Ka value. The Ka values for the following ethanoic acids are in brackets and demonstrate that the strongest acid in the series is trichloroacetic acid. Cl3CCO2H (23 200 10 ) Cl2CHCO2H (5530 10 ) 5 5 (136 10 ) CH3CO2H (1.75 10 ). 5 5 ClCH2CO2H Ka values are awkward to work with and so it is more usual to measure the acidic strength as a pKa value rather than Ka. The pKa is the negative logarithm log10 Ka) and results in more manageable numbers. The pKa of Ka (pKa values for each of the above ethanoic acids is shown in brackets below. The strongest acid (trichloroacetic acid) has the lowest pKa value. Cl3CCO2H (0.63) Cl2CHCO2H (1.26) ClCH2CO2H (2.87) CH3CO2H (4.76). Therefore the stronger the acid, the higher the value of Ka, and the lower the value of pKa. An amine such as ethylamine (CH3CH2NH2) is an extremely weak acid (pKa = 40) compared to ethanol (pKa = 16). This is due to the relative electronegativities of oxygen and nitrogen as described above. However, the electronegativity of neighboring atoms is not the only inuence on acidic strength. For example, the pKa values of ethanoic acid (4.76), ethanol (16), and phenol (10) show that G2 Acid strength 85 ethanoic acid is more acidic than phenol, and that phenol is more acidic than ethanol. The difference in acidity is quite marked, yet hydrogen is attached to oxygen in all three structures. Similarly, the ethanoic acids Cl3CCO2H (0.63), Cl2CHCO2H (1.26), ClCH2CO2H (2.87), and CH3CO2H (4.76) have signicantly different pKa values and yet the acidic hydrogen is attached to an oxygen in each of these structures. Therefore, factors other than electronegativity have a role to play in determining acidic strength. Inductive effects Stabilizing the negative charge of the conjugate base is important in determining the strength of the acid and so any effect which stabilizes the charge will result in a stronger acid. Substituents can help to stabilize a negative charge and do so by an inductive effect. This is illustrated by comparing the pKa values of the alcohols CF3CH2OH and CH3CH2OH (12.4 and 16, respectively) where CF3CH2OH is more acidic than CH3CH2OH. This implies that the anion CF3CH2O is more stable than CH3CH2O (Fig. 7). a) F3C Fig. 7. CH2 O b) H3C CH2 O (a) 2,2,2-Triuoroethoxy ion; (b) ethoxy ion. Fluorine atoms are strongly electronegative and this means that each CF bond is strongly polarized such that the carbon bearing the uorine atoms becomes strongly electropositive. Since this carbon atom is now electron decient, it will demand a greater share of the electrons in the neighboring CC bond. This results in electrons being withdrawn from the neighboring carbon, making it electron decient too. This inductive effect will continue to be felt through the various bonds of the structure. It will decrease through the bonds but it is still signicant enough to be felt at the negatively charged oxygen. Since the inductive effect is electron withdrawing it will decrease the negative charge on the oxygen and help to stabilize it. This means that the original uorinated alcohol will lose its proton more readily and will be a stronger acid. This inductive effect explains the relative acidities of the chlorinated ethanoic acids Cl3CCO2H (0.63), Cl2CHCO2H (1.26), ClCH2CO2H (2.87), and CH3CO2H (4.76). Trichloroethanoic acid is the strongest acid since its conjugate base (the carboxylate ion) is stabilized by the inductive effect created by three electronegative chlorine atoms. As the number of chlorine atoms decrease, so does the inductive effect . Inductive effects also explain the difference between the acid strengths of ethylamine (pKa 40) and ammonia (pKa 33). The pKa values demonstrate that ammonia is a stronger acid than ethylamine. In this case, the inductive effect is electron donating. The alkyl group of ethylamine enhances the negative charge of the conjugate base and so destabilizes it, making ethylamine a weaker acid than ammonia (Fig. 8). a) H N H b) CH3CH2 N H Fig. 8. Conjugate bases of (a) ammonia and (b) ethylamine. 86 Section G Acidbase reactions Resonance The negative charge on some conjugate bases can be stabilized by resonance. Resonance involves the movement of valence electrons around a structure, resulting in the sharing of charge between different atoms a process called delocalization. The effects of resonance can be illustrated by comparing the acidities of ethanoic acid (pKa 4.76), phenol (pKa 10.0) and ethanol (pKa 12.4). The pKa values illustrate that ethanoic acid is a stronger acid than phenol, and that phenol is a stronger acid than ethanol. The differing acidic strengths of ethanoic acid, phenol and ethanol can be explained by considering the relative stabilities of their conjugate bases (Fig. 9). a) H3C Fig. 9. O C O b) O c) CH3CH2 O Conjugate bases of (a) ethanoic acid; (b) phenol; (c) ethanol. The charge of the carboxylate ion is on an oxygen atom, and since oxygen is electronegative, the charge is stabilized. However, the charge can be shared with the other oxygen leading to delocalization of the charge. This arises by a resonance interaction between a lone pair of electrons on the negatively charged oxygen and the electrons of the carbonyl group (Fig. 10). A lone pair of electrons on the bottom oxygen forms a new bond to the neighboring carbon. At the same time as this takes place, the weak bond of the carbonyl group breaks. This is essential or else the carbonyl carbon would end up with ve bonds and that is not permitted. Both electrons in the original bond now end up on the top oxygen which means that this oxygen ends up with three lone pairs and gains a negative charge. Note that the bond and the charge have effectively swapped places. Both the structures involved are called resonance structures and are easily interconvertible. The negative charge is now shared or delocalized equally between both oxygens and is stabilized. Therefore, ethanoic acid is a stronger acid than one would expect based on the electronegativity of oxygen alone. O H3C C O Fig. 10. Resonance interaction for the carboxylate ion. H3C C O O Phenol is less acidic than ethanoic acid but is more acidic than ethanol. Once again, resonance can explain these differences. The conjugate base of phenol is called the phenolate ion. In this case, the resonance process can be carried out several times to place the negative charge on four separate atoms the oxygen atom and three of the aromatic carbon atoms (Fig. 11). The fact that the negative charge can be spread over four atoms might suggest that the phenolate anion should be more stable than the carboxylate anion, since the charge is spread over more atoms. However, with the phenolate ion, three of the resonance structures place the charge on a carbon atom which is much less electronegative than an oxygen atom. These resonance structures will be far less important than the resonance structure having the charge on oxygen. As a result, delocalization is weaker for the G2 Acid strength 87 phenolate ion than it is for the ethanoate ion. Nevertheless, a certain amount of delocalization still takes place which is why a phenolate ion is more stable than an ethoxide ion. O O O O Fig. 11. Resonance interactions for the phenolate ion. Lastly, we turn to ethanol. The conjugate base is the ethoxide ion which cannot be stabilized by delocalizing the charge, since resonance is not possible. There is no bond available to participate in resonance. Therefore, the negative charge is localized on the oxygen. Furthermore, the inductive donating effect of the neighboring alkyl group (ethyl) enhances the charge and destabilizes it (Fig. 12). This makes the ethoxide ion the least stable (or most reactive) of the three anions we have studied. As a result, ethanol is the weakest acid. CH3CH2 Fig. 12. O Destabilizing inductive effect of the ethoxide ion. Amines and amides Amines and amides are very weak acids and only react with very strong bases. The pKa values for ethanamide and ethylamine are 15 and 40, respectively, which means that ethanamide has the more acidic proton (Fig. 13). This can be explained by resonance and inductive effects (Fig. 14). O a) H3C Fig. 13. C NH2 b) H3C NH2 (a) Ethanamide; (b) ethylamine. O C H3C NH H3C O CH2 C NH H3C NH Fig. 14. (a) Resonance stabilization for the conjugate base of ethanamide; (b) inductive destabilization for the conjugate base of ethylamine. Section G Acidbase reactions G3 BASE STRENGTH Key Notes Electronegativity The basicity of negatively charged compounds depends on the electronegativity of the atoms bearing the negative charge. The more electronegative the atom, the less basic the compound will be, due to stabilization of the charge by the electronegative atom. Therefore, carbanions are more basic than nitrogen anions. Nitrogen anions are more basic than oxygen anions. Oxygen anions are more basic than halides. The basicity of neutral molecules can be explained by comparing the stability of their positively charged conjugate acids. Amines are more basic than alcohols since nitrogen is less electronegative than oxygen and more capable of stabilizing a positive charge. Alkyl halides are extremely weak bases because the resulting cations are poorly stabilized by a strongly electronegative halogen atom. pKb is a measure of basic strength. The lower the value of pKb the stronger the base. pKa and pKb are related by the equation pKa pKb 14. Therefore, a knowledge of the pKa value for an acid allows the pKb of its conjugate base to be calculated and vice versa. Inductive effects affect the stability of the negative charge on charged bases. Electron-withdrawing groups diminish the charge and stabilize the base, making it less reactive and a weaker base. Electron-donating groups will increase the charge and destabilize the base, making it a stronger base. Inductive effects also affect the strength of neutral bases by stabilizing or destabilizing the positive charge on the conjugate acid. Electron-donating groups stabilize the positive charge and stabilize the conjugate acid which means that it will be formed more easily and the original base will be a strong base. Electron-withdrawing groups will have the opposite effect. Solvation affects basic strength. Water solvates alkyl ammonium ions by forming hydrogen bonds to NH protons. The greater the number of NH protons, the greater the solvation and the greater the stabilizing effect on the alkyl ammonium ion. The solvation effect is greater for alkyl ammonium ions formed from primary amines than it is for alkyl ammonium ions formed from secondary and tertiary amines. Therefore, primary amines should be stronger bases than secondary or tertiary amines. However, the inductive effect of alkyl groups is greater for tertiary amines than it is for primary and secondary amines. Therefore, it is not possible to predict the relative order of basicity for primary, secondary and tertiary amines. Resonance can stabilize a negative charge by delocalizing it over two or more atoms. Stabilization of the charge means that the ion is less reactive pK b Inductive effects Solvation effects Resonance G3 Base strength 89 and is a weaker base. Carboxylate ions are weaker bases than phenolate ions, and phenolate ions are weaker bases than alkoxide ions. Aromatic amines are weaker bases than alkylamines since the lone pair of electrons on an aromatic amine interacts with the aromatic ring through resonance and is less available for bonding to a proton. Amines and amides Amines are weak bases. They have a lone pair of electrons which can bind to a proton and are in equilibrium with their conjugate acid in aqueous solution. Amides are not basic because the lone pair of electrons on the nitrogen is involved in a resonance mechanism which involves the neighboring carbonyl group. Neutral inorganic species (E3) Organic structures (E4) BrnstedLowry acids and bases (G1) Acid strength (G2) Properties of amines (O2) Related topics Electronegativity Electronegativity has an important inuence to play on basic strength. If we compare the uoride ion, hydroxide ion, amide ion and the methyl carbanion, then the order of basicity is as shown (Fig. 1). Weakest base H H H N H Amide ion Hydroxide Fluoride Strongest base H C H > > O > F Carbanion Fig. 1. Comparison of basic strength. The strongest base is the carbanion since this has the negative charge situated on the least electronegative atom the carbon atom. The weakest base is the uoride ion which has the negative charge situated on the most electronegative atom the uorine atom. Strongly electronegative atoms such as uorine are able to stabilize a negative charge making the ion less reactive and less basic. The order of basicity of the anions formed from alkanes, amines, and alcohols follows a similar order for the same reason (Fig. 2). a) R Strongest base C H H b) c) R N H Weakest base R O > > Fig. 2. Comparison of basic strengths: (a) a carbanion; (b) an amide ion; (c) an alkoxide ion. Electronegativity also explains the order of basicity for neutral molecules such as amines, alcohols, and alkyl halides (Fig. 3). These neutral molecules are much weaker bases than their corresponding anions, but the order of basicity is still the same and can be explained by 90 Section G Acidbase reactions a) R Strongest base N H b) R O H c) R F Weakest base > H > Fig. 3. Comparison of basic strengths: (a) an amine; (b) an alcohol; (c) an alkyl uoride. considering the relative stability of the cations which are formed when these molecules bind a proton (Fig. 4). A nitrogen atom can stabilize a positive charge better than a uorine atom since the former is less electronegative. Electronegative atoms prefer to have a negative charge rather than a positive charge. Fluorine is so electronegative that its basicity is negligible. Therefore, amines act as weak bases in aqueous solution and are partially ionized. Alcohols only act as weak bases in acidic solution. Alkyl halides are essentially nonbasic even in acidic solutions. a) R N H Most stable H H b) c) O H Least stable H R R F H > > Fig. 4. Relative stability of the cations formed from (a) an amine; (b) an alcohol; (c) an alkyl uoride pKb pKb is a measure of basic strength. If methylamine is dissolved in water, an equilibrium is set up (Fig. 5). H N H3C Fig. 5. H + H2O H3C H N H H + HO Acidbase equilibrium of methylamine and water. Methylamine on the left hand side of the equation is termed the free base, while the methyl ammonium ion formed on the right hand side is termed the conjugate acid. The extent of ionization or dissociation in the equilibrium reaction is dened by the equilibrium constant (Keq); Keq [Products] [Reactants] [CH3NH3 ][HO ] [CH3NH2][H2O] Kb Keq[H2O] [CH3NH3 ][HO ] [CH3NH2] Keq is normally measured in a dilute aqueous solution of the base and so the concentration of water is high and assumed to be constant. Therefore, we can rewrite the equilibrium equation in a simpler form where Kb is the basicity constant and includes the concentration of pure water (55.5 M). pKb is the negative Log10Kb). logarithm of Kb and is used as a measure of basic strength (pKb A large pKb indicates a weak base. For example, the pKb values of ammonia and methylamine are 4.74 and 3.36, respectively, which indicates that ammonia is a weaker base than methylamine. pKb and pKa are related by the equation pKa pKb 14. Therefore, if one knows the pKa of an acid, the pKb of the conjugate base can be calculated and vice versa. G3 Base strength 91 Inductive effects Inductive effects affect the strength of a charged base by inuencing the negative charge. For example, an electron-withdrawing group helps to stabilize a negative charge, resulting in a weaker base. An electron-donating group will destabilize a negative charge resulting in a stronger base. We discussed this in Topic G2 when we compared the relative acidities of the chlorinated ethanoic acids Cl3CCO2H, Cl2CHCO2H, ClCH2CO2H, and CH3CO2H. Trichloroacetic acid is a strong acid because its conjugate base (the carboxylate ion) is stabilized by the three electronegative chlorine groups (Fig. 6). O Cl3C C OH Strong acid Fig. 6. pKa = 0.63 Cl3C C O O Weak conjugate base (stabilized) Inductive effect on the conjugate base of trichloroacetic acid. The chlorine atoms have an electron-withdrawing effect on the negative charge which helps to stabilize it. If the negative charge is stabilized, it makes the conjugate base less reactive and a weaker base. Note that the conjugate base of a strong acid is weak, while the conjugate base of a weak acid is strong. Therefore, the order of basicity for the ethanoate ions Cl3CCO2 , Cl2CHCO2 , ClCH2CO2 , and CH3CO2 is the opposite to the order of acidity for the corresponding carboxylic acids, that is, the ethanoate ion is the strongest base, while the trichlorinated ethanoate ion is the weakest base. Inductive effects also inuence the basic strength of neutral molecules (e.g. amines). The pKb for ammonia is 4.74, which compares with pKb values for methylamine, ethylamine, and propylamine of 3.36, 3.25 and 3.33 respectively. The alkylamines are stronger bases than ammonia because of the inductive effect of an alkyl group on the alkyl ammonium ion (RNH3 ; Fig. 7). Alkyl groups donate electrons towards a neighboring positive center and this helps to stabilize the ion since some of the positive charge is partially dispersed over the alkyl group. If the ion is stabilized, the equilibrium of the acidbase reaction will shift to the ion, which means that the amine is more basic. The larger the alkyl group, the more signicant this effect. If one alkyl group can inuence the basicity of an amine, then further alkyl groups should have an even greater inductive effect. Therefore, one might expect secondary and tertiary amines to be stronger bases than primary amines. In fact, this is not necessarily the case. There is no easy relationship between basicity and the number of alkyl groups attached to nitrogen. Although the inductive effect of more alkyl groups is certainly greater, this effect is counterbalanced by a solvation effect. R NH2 + H2O R NH3 + HO Inductive effect Fig. 7. Inductive effects of an alkyl group on the alkyl ammonium ion. 92 Section G Acidbase reactions Solvation effects Once the alkyl ammonium ion is formed, it is solvated by water molecules a process which involves hydrogen bonding between the oxygen atom of water and any NH group present in the alkyl ammonium ion (Fig. 8). Water solvation is a stabilizing factor which is as important as the inductive effect of alkyl substituents and the more hydrogen bonds which are possible, the greater the stabilization. Solvation is stronger for the alkyl ammonium ion formed from a primary amine than for the alkyl ammonium ion formed from a tertiary amine. This is because the former ion has three NH hydrogens available for H-bonding, compared with only one such NH hydrogen for the latter. As a result, there is more solvent stabilization experienced for the alkyl ammonium ion of a primary amine compared to that experienced by the alkyl ammonium ion of a tertiary amine. This means that tertiary amines are generally weaker bases than primary or secondary amines. H2O HR N H OH2 H OH2 RR N H OH2 H OH2 RR N R H-Bond Least solvent stabilization H OH2 Greatest solvent stabilization Fig. 8. Solvent effect on alkyl ammonium ions from primary, secondary, and tertiary amines. Resonance We have already discussed how resonance can stabilize a negative charge by delocalizing it over two or more atoms (Topic G2). This explains why a carboxylate ion is more stable than an alkoxide ion. The negative charge in the former can be delocalized between two oxygens whereas the negative charge on the former is localized on the oxygen. We used this argument to explain why a carboxylic acid is a stronger acid than an alcohol. We can use the same argument in reverse to explain the difference in basicities between a carboxylate ion and an alkoxide ion (Fig. 9). Since the latter is less stable, it is more reactive and is therefore a stronger base. Resonance effects also explain why aromatic amines (arylamines) are weaker bases than alkylamines. The lone pair of electrons on nitrogen can interact with the system of the aromatic ring, resulting in the possibility of three zwitterionic resonance structures (Fig. 10). (A zwitterion is a neutral molecule containing a positive and a negative charge.) Since nitrogens lone pair of electrons is involved in this interaction, it is less available to form a bond to a proton and so the amine is less basic. a) H3C C O b) H3C CH2 O Fig. 9. (a) Carboxylate ion; (b) alkoxide ion. O G3 Base strength 93 NH2 NH2 NH2 NH2 Fig. 10. Resonance structures for aniline. Amines and amides Amines are weak bases. They form water soluble salts in acidic solutions (Fig. 11a), and in aqueous solution they are in equilibrium with their conjugate acid (Fig. 11b). Amines are basic because they have a lone pair of electrons which can form a bond to a proton. Amides also have a nitrogen with a lone pair of electrons, but unlike amines they are not basic. This is because a resonance takes place within the amide structure which involves the nitrogen lone pair (Fig. 12). The driving force behind this resonance is the electronegative oxygen of the neighboring carbonyl group which is hungry for electrons. The lone pair of electrons on nitrogen forms a bond to the neighboring carbon atom. As this takes place, the bond of the carbonyl group breaks and both electrons move onto the oxygen to give it a total of three lone pairs and a negative charge. Since the nitrogens lone pair is involved in this resonance, it is unavailable to bind to a proton and therefore amides are not basic. a) R N H Free base b) R N H Free base H H H H + HCl R N H H + Cl Soluble salt H R N H Conjugate acid H + H O + H O Fig. 11. (a) Salt formation; (b) acidbase equilibrium. O C H3C Fig. 12. N H H O C H3C N H H Resonance interaction of an amide. Section G Acidbase reactions G4 LEWIS ACIDS AND BASES Key Notes Lewis acids Lewis acids are electron decient molecules which are termed acidic because they will accept a pair of electrons (in the form of a bond) from an electron-rich species in order to ll up their valence shell. BF3, AlCl3, TiCl4, and SnCl4 are examples of Lewis acids. Lewis bases are ions or neutral molecules containing an atom with a lone pair of electrons. Lewis bases use a lone pair of electrons to form a bond to a Lewis acid. BrnstedLowry acids and bases (G1) Electrophilic substitutions of benzene (I3) Lewis bases Related topics Lewis acids Lewis acids are ions or electron decient molecules with an unlled valence shell. They are classed as acids because they can accept a lone pair of electrons from another molecule to fill their valence shell. Lewis acids include all the 2 BrnstedLowry acids we have already discussed, as well as ions (e.g. H , Mg ), and neutral species such as BF3 and AlCl3. Both Al and B are in Group 3A of the periodic table and have three valence electrons in their outer shell. This means that these elements can form three bonds. However, there is still room for a fourth bond. For example in BF3, boron is surrounded by six electrons (three bonds containing two electrons each). However, borons valence shell can accommodate eight electrons and so a fourth bond is possible if the fourth group can provide both electrons for the new bond. Since both boron and aluminum are in Group 3A of the periodic table, they are electropositive and will react with electron-rich molecules in order to obtain this fourth bond. Many transition metal compounds can also act as Lewis acids (e.g.TiCl4 and SnCl4). A Lewis base is a molecule which can provide a lone pair of electrons to ll the valence shell of a Lewis acid (Fig. 1). The base can be a negatively charged group such as a halide, or a neutral molecule such as water, an amine, or an ether, as long as there is an atom present with a lone pair of electrons (i.e. O, N, or a halogen). All the BrnstedLowry bases discussed earlier can also be dened as Lewis bases. The crucial feature is the presence of a lone pair of electrons which is available for bonding. Therefore, all negatively charged ions and all functional groups containing a nitrogen, oxygen, or halogen atom can act as Lewis bases. (b) R R O Lewis base BF3 Lewis acid R R O BF3 Lewis bases (a) F Lewis base Fig. 1. BF3 Lewis acid F BF3 Reactions between Lewis acids and Lewis bases. Section G Acidbase reactions G5 ENOLATES Key Notes Acidic CH protons Hydrogen atoms attached to a carbon are not usually acidic, but if the carbon is next to a carbonyl group, any attached protons are potentially acidic. The negative charge resulting from loss of an proton can be stabilized by a resonance process which places it onto an electronegative oxygen atom. The ion formed is called an enolate ion. The mechanism is a concerted process whereby the acidic proton is lost at the same time as the C C double bond is formed and the C O bond is broken. The electronegative carbonyl oxygen is the reason why the proton is acidic. The enolate ion is a hybrid of two resonance structures where the negative 2 charge is delocalized over three sp hybridized atoms. Orbital diagrams can be used to predict whether an acidic proton is in the correct orientation to be lost. Reactions of enolate ions (J8) -Halogenation (J9) Enolate reactions (K7) Stabilization Mechanism Enolate ion Related topics Acidic CH protons Most acidic protons are attached to heteroatoms such as halogen, oxygen, and nitrogen. Protons attached to carbon are not normally acidic but there are exceptions. One such exception occurs with aldehydes or ketones when there is a CHR2, CH 2R or CH3 group next to the carbonyl group (Fig. 1). The protons indicated are acidic and are attached to what is known as the (alpha) carbon. They are therefore termed as protons. O H alpha protons C H H Fig. 1. Acidic protons. C Carbonyl group H alpha carbon Treatment with a base results in loss of one of the acidic protons (Fig. 2). 96 Section G Acidbase reactions O H C H H O H C H H C H O C H H O H Fig. 2. Loss of an proton and formation of a carbanion. A lone pair on the hydroxide oxygen forms a new bond to an proton. At the same time as this happens, the CH bond breaks. Both electrons of that bond end up on the carbon atom and give it a lone pair of electrons and a negative charge (a carbanion). However, carbanions are usually very reactive, unstable species which are not easily formed. Therefore, some form of stabilization is involved here. Stabilization Since carbon is not electronegative, it cannot stabilize the charge. However, stabilization is possible through resonance (Fig. 3). The lone pair of electrons on the carbanion form a new bond to the carbonyl carbon. As this bond is formed, the weak bond of the carbonyl group breaks and both these electrons move onto the oxygen. This results in the negative charge ending up on the electronegative oxygen where it is more stable. This mechanism is exactly the same as the one described for the carboxylate ion (Topic G2). However, whereas both resonance structures are equally stable in the carboxylate ion, this is not the case here. The resonance structure having the charge on the oxygen atom (an enolate ion) is more stable than the original carbanion resonance structure. Therefore, the enolate ion will predominate over the carbanion. O H C Carbanion H Fig. 3. C+ H H C H O C H Enolate ion Resonance interaction between carbanion and enolate ion. Mechanism Since the enolate ion is the preferred resonance structure, a better mechanism for the acid base reaction shows the enolate ion being formed at the same time as the acidic proton is lost (Fig. 4). As the hydroxide ion forms its bond to the acidic proton, the CH bond breaks, and the electrons in that bond form a bond to the carbonyl carbon atom. At the same time, the carbonyl bond breaks such that both electrons move onto the oxygen. Note that it is the electronegative oxygen which is responsible for making the proton acidic. Resonance structures represent the extreme possibilities for a particular molecule and the true structure is really a hybrid of both (Fig. 5). The hybrid structure 2 shows that the negative charge is smeared or delocalized between three sp 2 hybridized atoms. Since these atoms are sp hybridized, they are planar and have Enolate ion G5 Enolates 97 O H C H H H C H O H O C H H O H C + H Fig. 4. Mechanism for the formation of the enolate ion. O O R R C R C R R C R C R 'Hybrid' structure O R C R C Fig. 5. Resonance structures and hybrid structure for the enolate ion. R R R R C C O Fig. 6. Interaction of 2p orbitals to form a molecular orbital. a 2p orbital which can interact with its neighbors to form one molecular orbital, thus spreading the charge between the three atoms (Fig. 6). Bearing this in mind, it is possible to state which of the methyl hydrogens is most likely to be lost in the formation of an enolate ion. The hydrogen circled (Fig. 7a) is the one which will be lost since the CH bond is correctly orientated to interact with the orbital of the carbonyl bond. The orbital diagram (Fig. 7b) illustrates this interaction. A Newman diagram can also be drawn by looking along the CC bond to indicate the relative orientation of the hydrogen which will be lost (Fig. 7c). In this particular example, there is no difculty in the proton being in the correct orientation since there is free rotation around the CC single bond. However, in cyclic systems, the hydrogen atoms are locked in space and the relative stereochemistry is important if the proton is to be acidic. Enolate ions formed from ketones or aldehydes are extremely important in the synthesis of more complex organic molecules (Topics J8 and J9). The ease with which an enolate ion is formed is related to the acidity of the proton. The pKa of propanone (acetone) is 19.3 which means that it is a stronger acid compared to ethane (pKa 60) and a much weaker acid than acetic acid (pKa 4.7). This means that strong bases such as sodium hydride, sodium amide, and lithium diisopropylamide (LiN(i-C3H7)2) are required to form an enolate ion. 98 Section G Acidbase reactions HO a) H R C H H C H H b) C C H H H O c) H Fig. 7. (a) proton; (b) orbital diagram illustrating orbital interactions; (c) Newman projection. However, the acidity of the proton is increased if it is anked by two carbonyl groups rather than one, for example, 1,3-diketones (-diketones) or 1,3diesters (-keto esters). This is because the negative charge of the enolate ion can be stabilized by both carbonyl groups resulting in three resonance structures (Fig. 8). For example, the pKa of 2,4-pentanedione is 9. O C H3C H O C H3C C H Fig. 8. C O Base C CH3 H O C CH3 H3C H3C O C C H O C C H O C CH3 O C CH3 Resonance structures for the conjugate base of a 1,3-diketone. Section H Alkenes and alkynes H1 PREPARATION OF ALKENES AND ALKYNES Key Notes Alkenes Alkenes can be synthesized by the reduction of alkynes or by the elimination of alkyl halides or alcohols. Vicinal dibromides can be debrominated by treatment with zinc dust in acetic acid or with sodium iodide in acetone. Alkenes can be treated with bromine to give a vicinal dibromide. Treatment of the dibromide with a strong base such as sodium amide results in the loss of two molecules of hydrogen bromide (dehydrohalogenation) and the formation of an alkyne. Reduction of alkynes (H9) Elimination (L4) Reactions of alcohols (M4) Alkynes Related topics Alkenes Alkenes can be obtained by the transformation of various functional groups such as the reduction of alkynes (Topic H9), the elimination of alkyl halides (Topic L6), or the elimination of alcohols (Topic M4). Alkenes can also be synthesized from vicinal dibromides, that is, molecules which have bromine atoms on neighboring carbon atoms. This reaction is called a debromination reaction and is carried out by treating the dibromide with sodium iodide in acetone or with zinc dust in acetic acid (Fig. 1). The dibromide itself is usually prepared from the same alkene (Topic H3) and so the reaction is not particularly useful for the synthesis of alkenes. It is useful, however, in protection strategy. During a lengthy synthesis, it may be necessary to protect a double bond so that it does not undergo any undesired reactions. Bromine can be added to form the dibromide and removed later by debromination in order to restore the functional group. R R Br Fig. 1. Br2 CCl4 R H Br C C R Br R R Zn / HOAc or NaI, acetone R C C R R Synthesis of an alkene from a vicinal dibromide. NaNH2 heat R H R C C R H C R C R H C C Br + 2HBr Fig. 2. Synthesis of an alkyne from an alkene. 100 Section H Alkenes and alkynes Alkynes Alkynes can be synthesized from alkenes through a two-step process which involves the electrophilic addition of bromine to form a vicinal dibromide (Topic H3) then dehydrohalogenation with strong base (Fig. 2). The second stage involves the loss of two molecules of hydrogen bromide and so two equivalents of base are required. Section H Alkenes and alkynes H2 PROPERTIES OF ALKENES AND ALKYNES Key Notes Structure Alkenes are planar with bond angles of 120 . The carbon atoms of the C C 2 bond are sp hybridized and the double bond is made up of one bond and one bond. Alkynes are linear with the triple bond carbons being sp hybridized. The triple bond is made up of one bond and two bonds. The C C bond is stronger and shorter than a CC single bond. However, the two bonds making up the C C bond are not of equal strength. The bond is weaker than the bond. Bond rotation round a C C bond is not possible and isomers are possible depending on the substituents present. The more substituents which are present on an alkene, the more stable the alkene is. An alkyne triple bond is stronger than a CC single bond or a C C double bond. The two bonds present in the triple bond are weaker and more reactive than the bond. Alkenes and alkynes are nonpolar compounds which dissolve in nonpolar solvents and are very poorly soluble in water. They have low boiling points since only weak van der Waals interactions are possible between the molecules. Alkenes and alkynes act as nucleophiles and react with electrophiles by a reaction known as electrophilic addition. The nucleophilic centers are the multiple bonds which are areas of high electron density. Alkenes show characteristic C=C stretching absorptions in their IR spectra. Absorptions due to C-H stretching and bending may also be identiable. The latter can give an indication of the substitution pattern. The nmr signals for alkene protons and carbons occur in characteristic regions of the relevant nmr spectra. Chemical shifts, coupling patterns and coupling constants can be used to identify the stereochemistry of the alkene. Unsymmetrical alkynes show a characteristic triple bond stretching absorption in their IR spectra. This signal is absent for symmetrical alkynes. Terminal alkynes show a characteristic CH stretching absorption in their 1 IR spectra as well as a signal at low chemical shift in the H nmr. Alkyne 13 carbons appear in a characteristic region of the C nmr spectrum. sp Hybridization (A4) sp Hybridization (A5) Bonds and hybridized centers (A6) Congurational isomers alkanes and cycloalkanes (D2) Organic structures (E4) 2 C C Bond C C Bond Properties Nucleophilicity Spectroscopic analysis of alkenes Spectroscopic analysis of alkynes Related topics Visible and ultra violet spectroscopy (P2) Infra-red spectroscopy (P3) Proton nuclear magnetic resonance spectroscopy (P4) 13 C nuclear magnetic resonance spectroscopy (P5) 102 Section H Alkenes and alkynes Structure The alkene functional group (R2C CR2) is planar in shape with bond angles of 2 120 . The two carbon atoms involved in the double bond are both sp hybridized. 2 Each carbon has three sp hybridized orbitals which are used for bonds while the p orbital is used for a bond. Thus, the double bond is made up of one bond and one bond (Fig. 1). The alkyne functional group consists of a carbon carbon triple bond and is linear in shape with bond angles of 180 (Fig. 2). The two carbon atoms involved in the triple bond are both sp hybridized, such that each carbon atom has two sp hybridized orbitals and two p orbitals. The sp hybridized orbitals are used for two bonds while the p orbitals are used for two bonds. Thus, the triple bond is made up of one bond and two bonds. -bond sp2 center R C R -bond R C R R R 120o C C R R 120o R R C C R R R C R C R R 120o Planar Fig. 1. Structure of an alkene functional group. bond 180o R C C R R C C R R C C R R C C R sp centers Linear bond bond Fig. 2. Structure of an alkyne functional group. C C Bond The C C bond is stronger (152 kcal mol ) and shorter (1.33 ) than a CC single 1 bond (88 kcal mol and 1.54 respectively). A C C bond contains one bond and one bond, with the bond being weaker than the bond. This is important with respect to the reactivity of alkenes. Bond rotation is not possible for a C C double bond since this would require the bond to be broken. Therefore, isomers of alkenes are possible depending on the relative position of the substituents. These can be dened as cis or trans, but are more properly dened as (Z) or (E) (see Topic D2). Alkenes are dened as mono-, di-, tri-, or tetrasubstituted depending on the number of substituents which are present. The more substituents which are present, the more stable the alkene. The bond length of a carbon carbon triple bond is 1.20 and the bond strength is 1 200 kcal mol . The bonds are weaker than the bond. The presence of the bonds explains why alkynes are more reactive than alkanes. Alkenes and alkynes have physical properties similar to alkanes. They are relatively nonpolar, dissolve in nonpolar solvents and are not very soluble in water. Only weak van der Waals interactions are possible between unsaturated 1 C C Bond Properties H2 Properties of alkenes and alkynes 103 molecules such as alkene and alkynes, and so these structures have low boiling points compared to other functional groups. Nucleophilic center R C R Fig. 3. C R Nucleophilic centers of an alkene and an alkyne. R R C C R Nucleophilic center Nucleophilicity Alkenes and alkynes are nucleophilic and commonly react with electrophiles in a reaction known as electrophilic addition. The nucleophilic center of the alkene or alkyne is the double bond or triple bond (Fig. 3). These are areas of high electron density due to the bonding electrons. The specic electrons which are used to form bonds to attacking electrophiles are those involved in bonding. The IR spectrum of an alkene shows a characteristic stretching absorption for the 1 C=C bond at 16801620 cm . This is slightly higher than the corresponding absorptions for aromatic rings (see Topic I2). However, conjugation with aromatic rings, carbonyl groups or other double bonds can lower the absorption frequency 1 as far as 1590 cm . Some carbonyl absorptions can occur in the same region but are generally stronger if they are present. The CH stretching absorption of an alkene proton occurs in the region 1 30953010 cm but is generally weak and could be difcult to spot. It can also be confused with the CH stretching absorptions for an aromatic ring. Alkene CH out of plane bending absorptions may sometimes be visible in the ngerprint region and can indicate the substitution pattern. For example, an absorption in the 1 region 730675 cm is indicative of cis alkenes, while an absorption in the region 1 990960 cm is indicative of trans alkenes. Monosubstituted alkenes have two 1 absorptions at 910 and 990 cm . The nmr signals for the protons and carbons of an alkene group appear at char1 acteristic positions in their respective spectra (typically 4.56.5 ppm for H spectra 13 and 80145 ppm for C spectra). The chemical shifts of each signal can indicate the stereochemistry of the alkene, and nmr tables are available to work out the theoretical shifts based on the substituents present and their relative positions. If coupling is observed between the alkene protons in the proton spectrum, the coupling pattern and the coupling constants can indicate the stereochemistry. For example, the coupling constants for protons which are trans or cis with respect to each other are typically 1416 Hz and 68 Hz respectively. The coupling constants for geminal protons (i.e. protons on the same alkene carbon) are small (typically 12 Hz). In the uv spectrum of ethene, the max for the * transition is 171 nm. For conjugated systems the wavelength of this transition increases and can indicate the amount of conjugation as well as the substitution pattern. The IR spectrum of an alkyne shows a characteristic triple bond absorption in the 1 region 22602100 cm . This can often be weak and if the alkyne is symmetrical no absorption will be seen at all. Although the absorption may be weak, it can usually be identied since the relevant region is normally devoid of peaks. Spectroscopic analysis of alkenes Spectroscopic analysis of alkynes 104 Section H Alkenes and alkynes Terminal alkynes show an absorption at 3300 cm due to CH stretching. This is sharper than absorptions due to OH or NH stretching. The proton of a terminal alkyne typically gives a signal at 1.83.1 ppm in the 1 H nmr, while the carbons of any alkyne appear in the region 7095 ppm in the 13 C nmr. 1 Section H Alkenes and alkynes H3 ELECTROPHILIC ADDITION TO SYMMETRICAL ALKENES Key Notes Reactions Alkenes readily undergo electrophilic addition reactions. The bond is involved in the reaction and new substituents are added to either end of the original alkene. Symmetrical alkenes have the same substituents at each end of the double bond. Unsymmetrical alkenes do not. Treating an alkene with a hydrogen halide results in the formation of an alkyl halide. The proton from the hydrogen halide adds to one end of the double bond and the halogen atom to the other. The mechanism of electrophilic addition is a two stage process which goes through a carbocation intermediate. In the rst stage, the alkene acts as a nucleophile and the hydrogen halide acts as an electrophile. In the second stage of the mechanism, the halide ion acts as a nucleophile and the carbocation intermediate is an electrophile. Alkenes react with bromine or chlorine to produce vicinal dihalides with the halogen atoms adding to each end of the double bond. The reaction is useful in the protection or purication of alkenes or as a means of synthesizing alkynes. The halogen molecule is polarized as it approaches the alkene double bond thus generating the required electrophilic center. The intermediate formed is called a bromonium ion intermediate in the case of bromine and is stabilized since it is possible to share or delocalize the positive charge between three atoms. If the reaction is carried out in water, water can act as a nucleophile and intercept the reaction intermediate to form a halohydrin where a halogen atom is added to one end of the double bond and a hydroxyl group is added to the other. Alkenes can be converted to alcohols by treatment with aqueous acid (e.g. sulfuric acid). Milder conditions can be used if mercuric acetate is used to produce an organomercury intermediate which is reduced with sodium borohydride. A similar reaction to the mercuric acetate/sodium borohydride synthesis of alcohols allows the conversion of alkenes to ethers. In this case, mercuric triuoracetate is used. Symmetrical and unsymmetrical alkenes Hydrogen halide addition Halogen addition Alkenes to alcohols Alkenes to ethers 106 Section H Alkenes and alkynes Alkenes to arylalkanes Alkenes can be reacted with aromatic rings to give arylalkanes. The reaction is known as a FriedelCrafts alkylation of the aromatic ring but can also be viewed as another example of an electrophilic addition to an alkene. Organic structures (E4) Electrophilic addition to unsymmetrical alkenes (H4) Carbocation stabilization (H5) Hydroboration of alkenes (H7) Electrophilic substitutions of benzene (I3) Related topics Reactions Many of the reactions which alkenes undergo take place by a mechanism known as electrophilic addition (Fig. 1). In these reactions, the bond of the double bond has been used to form a bond to an incoming electrophile and is no longer present in the product. Furthermore, a new substituent has been added to each of the carbon atoms. In this section we shall look at the electrophilic addition of symmetrical alkenes. A symmetrical alkene is an alkene which has the same substituents at each end of the double bond (Fig. 2a). Unsymmetrical alkenes have different substituents at each end of the double bond (Fig. 2b). Electrophilic addition to unsymmetrical alkenes will be covered in Topic H4. Alkenes react with hydrogen halides (HCl, HBr, and HI) to give an alkyl halide. The hydrogen halide molecule is split and the hydrogen atom adds to one end of the double bond while the halogen atom adds to the other. The reaction of HBr with 2,3-dimethyl-2-butene is an example of this reaction (Fig. 3). In this reaction, the alkene acts as a nucleophile. It has an electron-rich double bond containing four R X C R C R R X R R C C R R HX H R R C C R R X Symmetrical and unsymmetrical alkenes Hydrogen halide addition R C R C R X2 R Fig. 1. Electrophilic additions. a) H3C C H3C C CH3 H C C CH3 b) H3C C C H H3C C C H CH3 H3C H H3C H H3C CH3 Fig. 2. (a) Symmetrical alkenes; (b) unsymmetrical alkenes. + Br H C H3C H3C C CH3 CH3 Br H3C C H3C C CH3 + CH3 H Nucleophilic center Fig. 3. Electrophilic center Reaction of HBr with 2,3-dimethyl-2-butene. H3 Electrophilic addition to symmetrical alkenes 107 electrons, two of which make up a strong bond and two of which make up a weaker bond. The double bond can be viewed as a nucleophilic center. Hydrogen bromide has a polar HBr bond and so the hydrogen is an electrophilic center and the bromine is a nucleophilic center. However, halogen atoms are extremely weak nucleophilic centers (see Topic E4) and so this molecule is more likely to react as an electrophile through its electrophilic hydrogen. In the rst step of electrophilic addition (Fig. 4), the alkene acts as a nucleophile and uses its two electrons to form a new bond to the hydrogen of HBr. As this new bond is formed, the HBr bond breaks since hydrogen is only allowed one bond. Both electrons in that bond end up on the bromine atom to produce a bromide ion. Since the electrons from the bond have been used for the formation of a new bond, the bond is no longer present. As a result, the left hand carbon has been left with only three bonds and becomes positively charged. This is known as a carbocation since the positive charge is on a carbon atom. This structure is known as a reaction intermediate. It is a reactive species and will not survive very long with the bromide ion in the vicinity. The carbocation is an electrophile since it is positively charged. The bromide ion is a nucleophile since it is negatively charged. Therefore, the bromide ion uses one of its lone pairs of electrons to form a new bond to the carbocation and the nal product is formed. The mechanism involves the addition of HBr to the alkene. It is an electrophilic addition since the rst step of the mechanism involves the addition of the electrophilic hydrogen to the alkene. Note that the second step involves a nucleophilic addition of the bromide ion to the carbocation intermediate, but it is the rst step which denes this reaction. In the mechanism shown (Fig. 4), the electrons of the alkene provide the electrons for a new bond between the right hand carbon and hydrogen. They could equally well have been used to form a bond between the left hand carbon and hydrogen (Fig. 5). Carbocation intermediate H3C C H3C C CH3 H+ Br Fig. 4. H3C CH3 H3C C C H CH3 CH3 H3C H3C Br C C H CH3 CH3 Br Mechanism of electrophilic addition of HBr to 2,3-dimethyl-2-butene. H3C H3C CH3 H + Br H C C CH3 H3C H3C H C C CH3 CH3 Br H3C C H3C C CH3 CH3 Br Fig. 5. Alternative mechanism for electrophilic addition of HBr to 2,3-dimethyl-2-butene. 108 Section H Alkenes and alkynes With a symmetrical alkene, the product is the same and so it does not matter which end of the double bond is used for the new bond to hydrogen. The chances are equal of the hydrogen adding to one side or the other. The electrophilic additions of HCl and HI follow the same mechanism to produce alkyl chlorides and alkyl iodides respectively. Halogen addition The reaction of an alkene with a halogen such as bromine or chlorine results in the formation of a vicinal dihalide. The halogen molecule is split and the halogens are added to each end of the double bond (Fig. 6). Vicinal dibromides are useful in the purication or protection of alkenes since the bromine atoms can be removed under different reaction conditions to restore the alkene. Vicinal dibromides can also be converted to alkynes (Topic H1). H3C C H3C Fig. 6. C CH3 CH3 Br Br2 H3C H3 C C C Br CH3 CH3 Electrophilic addition of bromine to 2,3-dimethyl-2-butene. The same mechanism described above is followed in this reaction. However, the rst stage of the mechanism should involve the nucleophilic alkene reacting with an electrophilic centre, and yet there is no obvious electrophilic center in bromine. The bond between the two bromine atoms is a covalent bond with both electrons equally shared between the bromine atoms. If there is no electrophilic center, how can a molecule like bromine react with a nucleophilic alkene? The answer lies in the fact that the bromine molecule approaches end-on to the alkene double bond and an electrophilic center is induced (Fig. 7). Since the alkene double bond is electron rich it repels the electrons in the bromine molecule and this results in a polarization of the BrBr bond such that the nearer bromine becomes electron decient (electrophilic). Now that an electrophilic center has been generated, the mechanism is the same as before. There is more to this mechanism than meets the eye. The carbocation intermediate can be stabilized by neighboring alkyl groups through inductive and hyperconjugation effects (see Topic H5). However, it can also be stabilized by sharing the positive charge with the bromine atom and a second carbon atom (Fig. 8). The positively charged carbon is an electrophilic center. The bromine is a weak nucleophilic center. A neutral halogen does not normally act as a nucleophile (see Topic E4), but in this case the halogen is held close to the carbocation Br + Br H3 C C H3C C CH 3 H3C Br Fig. 7. Mechanism for the electrophilic addition of Br2 with 2,3-dimethyl-2-butene. CH 3 H 3C C C Br CH 3 CH 3 H3C H3C Br C C Br CH 3 CH 3 H3 Electrophilic addition to symmetrical alkenes 109 H3C C H3C C Br CH3 CH3 H3C H3C C Br C CH3 CH3 Br H3C H3C C C CH3 CH3 Bromonium ion Fig. 8. Formation of the bromonium ion. making reaction more likely. Once the lone pair of electrons on bromine is used to form a bond to the carbocation, a bromonium ion is formed where the bromine gains a positive charge. The mechanism can go in reverse to regenerate the original carbocation. Alternatively, the other carbonbromine bond can break with both electrons moving onto the bromine. This gives a second carbocation where the other carbon bears the positive charge. Thus, the positive charge is shared between three different atoms and is further stabilized. Evidence for the existence of the bromonium ion is provided from the observation that bromine adds to cyclic alkenes (e.g. cyclopentene) in an anti-stereochemistry (Fig. 9). In other words, each bromine adds to opposite faces of the alkene to produce only the trans isomer. None of the cis isomer is formed. If the intermediate was a carbocation, a mixture of cis and trans isomers would be expected since the second bromine could add from either side. With a bromonium ion, the second bromine must approach from the opposite side. The reaction of an alkene with a halogen such as bromine and chlorine normally gives a vicinal dihalide. However, if the reaction is carried out in water as solvent, the product obtained is a halohydrin where the halogen adds to one end of the double bond and a hydroxyl group from water adds to the other (Fig. 10). In this reaction, the rst stage of the mechanism proceeds as normal, but then water acts as a nucleophile and intercepts the carbocation intermediate (Fig. 11). Since water is the solvent, there are far more molecules of it present compared to the number of bromide ions generated from the rst stage of the mechanism. Br H H H C Br Br C H + C Br C Br H C C H Br trans-Isomer Fig. 9. Anti-stereochemistry of bromine addition to a cyclic alkene. H3C C H3C C CH3 CH3 Br Br2 / H2O H3C H3C C C OH CH3 CH3 Bromohydrin Fig. 10. Formation of a bromohydrin from 2,3-dimethyl-2-butene. 110 Section H Alkenes and alkynes Br Br + H3C C H3C C CH3 H3C CH3 H3C C C Br CH3 CH3 H3C H3C H O H H C C Br CH3 CH3 -H H H3C H3C O C C Br CH3 CH3 O H Fig. 11. Mechanism of bromohydrin formation. Water uses a lone pair of electrons on oxygen to form a bond to the carbocation. As a result, the oxygen effectively loses an electron and gains a positive charge. This charge is lost and the oxygen regains its second lone pair when one of the OH bonds breaks and both electrons move onto the oxygen. Alkenes to alcohols Alkenes can be converted to alcohols by treatment with aqueous acid (sulfuric or phosphoric acid; Fig. 12). This electrophilic addition reaction involves the addition of water across the double bond. The hydrogen adds to one carbon while a hydroxyl group adds to the other carbon. Sometimes the reaction conditions used in this reaction are too harsh since heating is involved and rearrangement reactions can take place. A milder method which gives better results is to treat the alkene with mercuric acetate [Hg(OAc)2] then sodium borohydride (Fig. 13). The reaction involves electrophilic addition of the mercury reagent to form an intermediate mercuronium ion. This reacts with water to give an organomercury intermediate. Reduction with sodium borohydride replaces the mercury substituent with hydrogen and gives the nal product (Fig. 13) Alkenes can also be converted to alcohols by hydroboration (see Topic H7). R C R Fig. 12. C R H2SO4 R H2O H R R C C R R OH Synthesis of an alcohol from an alkene. H 3C C H C H Hg(OAc)2 H3C C H H2O/THF Hg(OAc) C H CH3 H2O H3C HO H C C Hg(OAc) H CH3 NaBH4 H 3C HO H C C H H CH3 CH3 Fig. 13. Synthesis of an alcohol from an alkene using mercuric acetate. Alkenes to ethers A similar reaction to the mercuric acetate/sodium borohydride synthesis of alcohols allows the conversion of alkenes to ethers. In this case, mercuric triuoracetate is used (Fig. 14). The reaction of an aromatic ring such as benzene with an alkene under acid conditions results in the formation of an arylalkane (Fig. 15). As far as the alkene Alkenes to arylalkanes H3 Electrophilic addition to symmetrical alkenes 111 H3C C H3C Fig. 14. C CH3 Hg(O2CCF3)2 ROH/THF H3C RO C C HgO2CCF3 CH3 CH3 NaBH4 HO H3C RO H3C C C CH3 CH3 CH3 CH3 H3C Synthesis of an ether from an alkene using mercuric triuoroacetate. Benzene H+ H R R R C R Fig. 15. C R R C C R Ph R Synthesis of arylalkanes from alkenes. is concerned this is another example of electrophilic addition involving the addition of a proton to one end of the double bond and the addition of the aromatic ring to the other. As far as the aromatic ring is concerned this is an example of an electrophilic substitution reaction called the FriedelCrafts alkylation (Topic I3). Section H Alkenes and alkynes H4 ELECTROPHILIC ADDITION TO UNSYMMETRICAL ALKENES Key Notes Addition of hydrogen halides The addition of a hydrogen halide to an unsymmetrical alkene can result in two different products. These products are not formed in equal amounts. Markovnikovs rule states that in the addition of HX to an alkene, the hydrogen atom adds to the carbon atom that already has the greater number of hydrogen atoms. This produces the more substituted alkyl halide. The favored product arising from addition of a hydrogen halide to an unsymmetrical alkene will be formed from the more stable of the two possible carbocations. The more stable carbocation will have more alkyl groups attached to the positive center. Different products are not possible from the reaction of a halogen with an unsymmetrical alkene unless water is used as a solvent, in which case a hydroxyl group ends up on the more substituted carbon. This demonstrates that the bromonium ion does not share the positive charge equally amongst the bromine and the two carbons. The more substituted alcohol is the preferred product from the acidic hydrolysis of an alkene as well as from the organomercuric synthesis of alcohols. Electrophilic addition to symmetrical alkenes (H3) Carbocation stabilization (H5) Carbocation stabilities Addition of halogens Addition of water Related topics Addition of hydrogen halides The reaction of a symmetrical alkene with hydrogen bromide produces the same product regardless of whether the hydrogen of HBr is added to one end of the double bond or the other. However, this is not the case with unsymmetrical alkenes (Fig. 1). In this case, two different products are possible. These are not H C II Hydrogen added to right hand end of double bond C H H H3C C H3C C H HBr H3C H3C C H I C H H Br H3C H3C Br H Hydrogen added to left hand end of double bond Fig. 1. Electrophilic addition of HBr to an unsymmetrical alkene. H4 Electrophilic addition to unsymmetrical alkenes 113 formed to an equal extent and the more substituted alkyl halide (II) is preferred. The reaction proceeds in a Markovnikov sense with hydrogen ending up on the least substituted position and the halogen ending up on the most substituted position. Markovnikovs rule states that in the addition of HX to an alkene, the hydrogen atom adds to the carbon atom that already has the greater number of hydrogen atoms. This produces the more substituted alkyl halide. Carbocation stabilities This reaction can be rationalized by proposing that the carbocation intermediate leading to product II is more stable than the carbocation intermediate leading to product I (Fig. 2). It is possible to predict the more stable carbocation by counting the number of alkyl groups attached to the positive center. The more stable carbocation on the right has three alkyl substituents attached to the positively charged carbon whereas the less stable carbocation on the left only has one such alkyl substituent. The reasons for this difference in stability is explained in Topic H5, but the result is summarized by Markovnikovs rule. However, Markovnikovs rule does not always hold true. For example, the reaction of CF3CH CH2 with HBr gives CF3CH2CH2Br rather than CF3CHBrCH3. Here, the presence of electron-withdrawing uorine substituents has a destabilizing inuence on the two possible intermediate carbocations (Fig. 3). The destabilizing effect will be greater for the more substituted carbocation since the carbocation is closer to the uorine substituents and so the favoured carbocation is the least substituted one in this case. a) H3C H3C H One alkyl group attached to positive centre C C H b) H3C C C H3C H H H More stable carbocation H Three alkyl groups attached to positive centre Fig. 2. (a) Carbocation leading to product I; (b) carbocation leading to product II. F F F C C CH3 F H F C C F CH2 H H Destabilized by inductive effect Fig. 3. Comparison of carbocations. Favored carbocation Addition of halogens There is no possibility of different products when a halogen such as bromine or chlorine is added to an unsymmetrical alkene. However, this is not the case if water is used as a solvent. In such cases, the halogen is attached to the least substituted carbon and the hydroxyl group is attached to the more substituted carbon (Fig. 4). This result can be explained by proposing that the bromonium ion is not symmetrical and that although the positive charge is shared between the bromine 114 Section H Alkenes and alkynes CH3CH2 C H3C Fig. 4. C CH3 Br2, H2O CH3CH2 HO C C CH3 Br H preferred halohydrin H H3C Reaction of 3-methyl-2-pentene with bromine and water. H3C C H3C C H H2O H2SO4 H3C HO C C H H H H3C H H3C 1o alcohol C C H OH H H H3C 3o alcohol preferred product Fig. 5. Reaction of 2-methyl-1-propene with aqueous sulfuric acid. H3C C H3C C H Hg(OAc)2 H3C C H2O/THF H3C Hg(OAc) C H H H2O H3C HO H3C C C Hg(OAc) H H NaBH4 H3C HO H3C C C H H H H Fig. 6. Organomercuric synthesis of alcohols. and the two carbon atoms, the positive charge is greater on the more substituted carbon compared with the less substituted carbon. Addition of water With unsymmetrical alkenes, the more substituted alcohol is the preferred product (Fig. 5). The same holds true for the organomercuric synthesis of alcohols (Fig. 6). Section H Alkenes and alkynes H5 CARBOCATION STABILIZATION Key Notes Stabilization Carbocations are delocalization. stabilized by induction, hyperconjugation, or Inductive effects Alkyl groups have an electron-donating effect on any neighboring positive charge. The more alkyl groups attached, the greater the stabilizing effect. In hyperconjugation, the vacant 2p orbital of the carbocation can interact with the orbitals of neighboring CH bonds. As a result, the electrons of the CH bond can spend a small amount of time entering the space occupied by the 2p orbital such that the latter orbital is not completely empty. This interaction serves to spread or delocalize the positive charge to neighboring bonds and thus stabilize it. The more substituents present, the more chances there are for hyperconjugation. Electrophilic substitution to symmetrical alkenes (H3) Electrophilic substitution to unsymmetrical alkenes (H4) Hyperconjugation Related topics Stabilization Positively charged species such as carbocations are inherently reactive and unstable. The more unstable they are, the less easily they are formed and the less likely the overall reaction. Any factor which helps to stabilize the positive charge (and by inference the carbocation) will make the reaction more likely. There are three ways in which a positive charge can be stabilized: inductive effects, hyperconjugation, and delocalization. We have already seen the effects of delocalization in stabilizing the bromonium ion (Topic H3). We will now look at the effects of induction and hyperconjugation. Alkyl groups can donate electrons towards a neighboring positive center and this helps to stabilize the ion since some of the positive charge is partially dispersed over the alkyl group (Fig. 1). The more alkyl groups which are attached, the greater the electron donating power and the more stable the carbocation. H C H3C Fig. 1. C H H H3C H3C H C C H H Inductive effects More stable carbocation H3C Comparison of possible carbocations. 2 Hyperconjugation Both carbons of an alkene are sp hybridized. However, this is altered on formation of the carbocation (Fig. 2). When an alkene reacts with an electrophile such as a proton, both electrons in the bond are used to form a new bond to 116 Section H Alkenes and alkynes H3C sp2 sp2 H C C H 3C Fig. 2. H H H3C H C C H 2 3 H3C sp sp H Hybridization of alkene and carbocation. the electrophile. As a result, the carbon which gains the electrophile becomes an 3 2 sp center. The other carbon containing the positive charge remains as an sp 2 center. This means that it has three sp hybridized orbitals (used for the three bonds still present) and one vacant 2p orbital which is not involved in bonding. Hyperconjugation involves the overlap of the vacant 2p orbital with a neighboring CH -bond orbital (Fig. 3). Vacant 2p orbital H R C R R' Fig. 3. H H H C H Fig. 4. H Hyperconjugation. H H C C C H H H3C H3C H C C H H R' R R' R 2p R' (a) More substituted carbocation; (b) less substituted carbocation. This interaction means that the 2p orbital is not completely vacant since the electrons of the CH bond can spend a small amount of time entering the space occupied by the 2p orbital. This means that the CH bond becomes slightly electron decient. As a result, the positive charge is delocalized and hence stabilized. The more alkyl groups attached to the carbocation, the more possibilities there are for hyperconjugation and the more stable the carbocation. For example, the more substituted carbocation (Fig. 4a) can be stabilized by hyperconjugation to nine CH bonds, whereas the less substituted carbocation (Fig. 4b) can only be stabilized by hyperconjugation to one CH bond. Section H Alkenes and alkynes H6 REDUCTION AND OXIDATION OF ALKENES Key Notes Alkenes to alkanes Alkenes can be converted to alkanes by reduction with hydrogen gas. A metal catalyst is necessary in order to lower the free energy of activation. Treating an alkene with ozone then with zinc and water results in cleavage of the alkene across the double bond to give two carbonyl compounds (ketones and/or aldehydes). The reaction is known as an ozonolysis and is an example of an oxidation reaction. Alkenes can be cleaved by oxidation with hot alkaline potassium permanganate. The products obtained are carboxylic acids and/or ketones depending on the substituents present on the alkene. Alkenes can be converted to 1,2-diols (or glycols) by reaction with osmium tetroxide or by reaction with cold alkaline potassium permanganate. In both cases, the two hydroxyl groups are added to the same face of the alkene syn-hydroxylation. Osmium tetroxide gives better yields, but is more toxic. Treatment of alkenes with a peroxyacid (RCO3H) results in the formation of an epoxide. The reaction is a one-step process without intermediates. Epoxides can also be obtained in a two-step process via a halohydrin. Reduction of alkynes (H9) Alkenes to aldehydes and ketones Alkenes to carboxylic acids and ketones Alkenes to 1,2-diols Alkenes to epoxides Related topic Alkenes to alkanes Alkenes are converted to alkanes by treatment with hydrogen over a nely divided metal catalyst such as palladium, nickel, or platinum (Fig. 1). This is an addition reaction since it involves the addition of hydrogen atoms to each end of the double bond. It is also called a catalytic hydrogenation or a reduction reaction. The catalyst is crucial since the reaction will not take place at room temperature in its absence. This is because hydrogenation has a high free energy of activation (G1*) (Fig. 2). The role of the catalyst is to bind the alkene and the hydrogen to a CH3 H2 Pd or Pt or Ni H H CH3 CH3 cis-Stereochemistry CH3 Fig. 1. Hydrogenation of an alkene. 118 Section H Alkenes and alkynes Potential energy G1* G2* Ho Reaction coordinate Fig. 2. Graph of potential energy versus reaction coordinate for an uncatalyzed and a catalyzed hydrogenation reaction of an alkene. R R H R R H H R Catalyst R C C R H R Fig. 3. Binding of alkene and hydrogen to catalytic surface. common surface such that they can react more easily. This results in a much lower energy of activation (G2*) allowing the reaction to proceed under much milder conditions. The catalyst itself is unchanged after the reaction and can be used in small quantity. Both the hydrogen and the alkene are bound to the catalyst surface before the hydrogen atoms are transferred, which means that both hydrogens are added to the same side of the double bond (see Fig. 3) syn-addition. Note that the hydrogen molecule is split once it has been added to the catalyst. Alkenes to aldehydes and ketones Treating an alkene with ozone (Fig. 4) results in oxidation of the alkene and formation of an initial ozonide which then rearranges to an isomeric ozonide. This second ozonide is unstable and potentially explosive and so it is not usually isolated. Instead, it is reduced with zinc and water resulting in the formation of two separate molecules. The alkene is split across the double bond to give two carbonyl compounds. These will be ketones or aldehydes depending on the substituents present. For example, 3-methyl-2-pentene gives an aldehyde and a ketone (Fig. 5). R R R O C C O R R R O O O Initial ozonide R R R C O R R C R C R O3 R O R Zn / H2O + O C R Ozonide Fig. 4. Ozonolysis of an alkene. H6 Reduction and oxidation of alkenes 119 CH3CH2 C H3C C CH3 1. O 3 2. Zn / H 2O CH3CH2 C O CH3 + O C H H H3C Ketone Aldehyde Fig. 5. Ozonolysis of 3-methyl-2-pentene. Alkenes to carboxylic acids and ketones CH3CH2 C H3C C H CH3 Alkenes can be oxidatively cleaved with hot permanganate solution to give carboxylic acids and/or ketones (Fig. 6). The products obtained depend on the substituents present on the alkene. 1. KMnO 4 HO , heat 2. H + CH3CH2 C H3C O Ketone CH3 + O C OH Carboxylic acid Fig. 6. Oxidative cleavage of 3-methyl-2-pentene. Alkenes to 1,2-diols The reaction of alkenes with osmium tetroxide (OsO4) is another example of an oxidation reaction (Fig. 7). However, in this case the alkene is not split. Instead, a 1,2-diol is obtained also known as a glycol. The reaction involves the formation of a cyclic intermediate where the osmium reagent is attached to one face of the alkene. On treatment with sodium bisulte, the intermediate is cleaved such that the two oxygen atoms linking the osmium remain attached. This results in both alcohols being added to the same side of the double bond syn-hydroxylation. The same reaction can also be carried out using cold alkaline potassium permanganate (KMnO4) followed by treatment with aqueous base (Fig. 8). It is important to keep the reaction cold since potassium permanganate can cleave the diol by further oxidation (Fig. 6). The reaction works better with osmium tetroxide. However, this is a highly toxic and expensive reagent and has to be handled with care. Anti-hydroxylation of the double bond can be achieved by forming an epoxide, then carrying out an acid-catalyzed hydrolysis (Topic N3). H OsO4 O C Os C O H Fig. 7. syn-Hydroxylation of an alkene. H MnO4 O C Mn C O H Fig. 8. syn-Hydroxylation with KMnO4. O H C OH O HO H 2O H OH C O C OH H O NaHSO3 H OH C 120 Section H Alkenes and alkynes O R C R Fig. 9. C R C R O OH O R C R C R R R Epoxidation of an alkene. Alkenes to epoxides Treatment of an alkene with a peroxyacid (RCO3H) results in the formation of an epoxide (Fig. 9). m-Chloroperoxybenzoic acid is one of the most frequently used peroxyacids for this reaction. The reaction is unusual in that there is no carbocation intermediate, and involves a one-step process without intermediates. Section H Alkenes and alkynes H7 HYDROBORATION OF ALKENES Key Notes Reaction Alkenes can be converted to alcohols by treatment with diborane followed by hydrogen peroxide. With unsymmetrical alkenes, the least substituted alcohol is obtained in contrast to the electrophilic addition of water where the most substituted alcohol is obtained. The mechanism involves an initial complex between the alkene and BH3. A four-centered transition state is then formed where the bond of the alkene and one of the BH bonds is partially broken and the bonds linking H and B to the alkene are partially formed. There is an imbalance of charge in the transition state, resulting in one of the carbon atoms being slightly positive. The reaction proceeds such that the most substituted carbon bears the partial charge and this results in the boron adding to the least substituted carbon. Oxidation with hydrogen peroxide involves a hydroperoxide molecule bonding to boron, followed by migration of an alkyl group from boron to oxygen. This is repeated twice more to form a trialkyl borate which is hydrolyzed to give the nal alcohol. Electrophilic addition to symmetrical alkenes (H3) Electrophilic addition to unsymmetrical alkenes (H4) Mechanism Related topics Reaction Alcohols can be generated from alkenes by reaction with diborane (B2H6 or BH3), followed by treatment with hydrogen peroxide (Fig. 1). The rst part of the reaction involves the splitting of a BH bond in BH3 with the hydrogen joining one end of the alkene and the boron joining the other. Each of the BH bonds is split in this way such that each BH3 molecule reacts with three alkenes to give an organoborane intermediate where boron is linked to three alkyl groups. This can then be oxidized with alkaline hydrogen peroxide to produce the alcohol. With unsymmetrical alkenes, the least substituted alcohol is obtained (antiMarkovnikov; Fig. 2) and so the organoborane reaction is complementary to the electrophilic addition reaction with aqueous acid (Topic H3). Steric factors appear to play a role in controlling this preference with the boron atom preferring to approach the least sterically hindered site. Electronic factors also play a role as described in the mechanism below. R 3 R C C R BH3 H R C R C R B R 3 H2O2 / NaOH 3H R C R C R OH R R Fig. 1. Hydroboration of an alkene. 122 Section H Alkenes and alkynes H3C C H3C Fig. 2. C H 1) BH3 2) H2O2 / H2O H3C H C I C H OH H H3C HO H3C C II C H H H H H3C Hydroboration of 2-methylpropene to give a primary alcohol (I). The tertiary alcohol (II) is not obtained. Mechanism The mechanism (Fig. 3) involves the alkene bond interacting with the empty p orbital of boron to form a complex. One of BH3s hydrogen atoms is then transferred to one end of the alkene as boron itself forms a bond to the other end. This takes place through a four-centered transition state where the alkenes bond and the BH bond are partially broken, and the eventual CH and CB bonds are partially formed. There is an imbalance of electrons in the transition state which results in the boron being slightly negative and one of the alkene carbons being slightly positive. The carbon best able to handle this will be the most substituted carbon and so the boron will end up on the least substituted carbon. (Note that boron has six valence electrons and is electrophilic. Therefore, the addition of boron to the least substituted position actually follows Markovnikovs rule.) Since subsequent oxidation with hydrogen peroxide replaces the boron with a hydroxyl group, the eventual alcohol will be on the least substituted carbon. Furthermore, the addition of the boron and hydrogen atoms take place such that they are on the same side of the alkene. This is called syn-addition. The mechanism of oxidation (Fig. 4) involves addition of the hydroperoxide to the electron decient H3C C H3C BH3 C H H3C H3C + C H C H H H3C H3C H C C H H BH2 H3C H3C H C H C H 3 B H BH2 Four-center transition state -Complex Fig. 3. Mechanism of hydroboration. R R B R O OH R R B R O OH -HO R B R RO OR B OR H2O 3 ROH + BO33- OR Fig. 4. Mechanism of oxidation with hydroperoxide. H BH3 H BR2 CH3 CH3 H H H2O2 / NaOH CH3 CH3 CH3 H + H H BR2 + H OH Retention of configuration H OH Syn - Addition Fig. 5. Stereochemical aspects of hydroboration. H7 Hydroboration of alkenes 123 boron to form an unstable intermediate which then rearranges such that an alkyl group migrates from the boron atom to the neighboring oxygen and expels a hydroxide ion. This process is then repeated for the remaining two hydrogens on boron and the nal trialkyl borate B(OR)3 can then be hydrolyzed with water to give three molecules of alcohol plus a borate ion. The mechanism of oxidation takes place with retention of stereochemistry at the alcohols carbon atom and so the overall reaction is stereospecic (Fig. 5). Note that the reaction is stereospecic such that the alcohol group is trans to the methyl group in the product. However, it is not enantiospecic and both enantiomers are obtained in equal amounts (a racemate). Section H Alkenes and alkynes H8 ELECTROPHILIC ADDITIONS TO ALKYNES Key Notes Additions to symmetrical alkynes Symmetrical alkynes undergo electrophilic addition with halogens or hydrogen halides by the same mechanism described for alkenes. The reaction can go once or twice depending on the amount of reagent used. Alkynes are less reactive than alkenes since the intermediate formed (a vinylic carbocation) is more unstable than the corresponding carbocation formed from electrophilic addition to an alkene. Reaction of an alkyne with aqueous acid and mercuric acid produces an intermediate enol which rearranges by ketoenol tautomerism to give a ketone. Addition of hydrogen halide to a terminal alkyne results in the hydrogen(s) adding to the terminal carbon and the halogen(s) adding to the more substituted carbon. This is another example of Markovnikovs rule. Similarly, reaction of a terminal alkyne with aqueous acid and mercuric sulfate leads to a ketone rather than an aldehyde following addition of one molecule of water followed by a ketoenol tautomerism. Congurational isomers alkenes and cycloalkanes (D2) Electrophilic addition to symmetrical alkenes (H3) Electrophilic addition to unsymmetrical alkenes (H4) Carbocation stabilization (H5) Additions to terminal alkynes Related topics Additions to symmetrical alkynes Alkynes undergo electrophilic addition reactions with the same reagents as alkenes (e.g. halogens and hydrogen halides). Since there are two bonds in alkynes, it is possible for the reaction to go once or twice depending on the amount of reagent added. For example, reaction of 2-butyne with one equivalent of bromine gives an (E)-dibromoalkene (Fig. 1a). With two equivalents of bromine, the initially formed (E)-dibromoalkene reacts further to give a tetrabromoalkane (Fig. 1b). Treatment of an alkyne with one equivalent of HBr gives a bromoalkene (Fig. 2a). If two equivalents of hydrogen bromide are present the reaction can go twice to give a geminal dibromoalkane where both bromine atoms are added to the same carbon (Fig. 2b). b) Br C H3C C Br CH3 H3C C C CH3 a) H3C C C CH3 1 equiv Br2 2 equivs Br2 Br H3C Br Br C C CH3 Br E- Isomer Fig. 1. Reaction of 2-butyne with (a) 1 equivalent of bromine; (b) 2 equivalents of bromine. H8 Electrophilic additions to alkynes 125 a) H3C C C CH3 1 equiv. HBr H3C C H C Br CH3 b) H3C C C CH3 2 equiv. HBr H H3C C H Br C CH3 Br Fig. 2. Reaction of 2-butyne with (a) 1 equivalent of HBr; (b) 2 equivalents of HBr. The above addition reactions are similar to the addition reactions of alkenes (Topic H3). However, the reaction is much slower for an alkyne, since alkynes are less reactive. One might expect alkynes to be more nucleophilic, since they are more electron rich in the vicinity of the multiple bond, that is, six electrons in a triple bond as compared to four in a double bond. However, electrophilic addition to an alkyne involves the formation of a vinylic carbocation (Fig. 3). This carbocation is much less stable than the carbocation intermediate resulting from electrophilic addition to an alkene. Due to this low reactivity, alkynes react slowly with aqueous acid, and mercuric sulfate has to be added as a catalyst. The product which might be expected from this reaction would be a diol (Fig. 4). In fact, a diol is not formed. The intermediate (an enol) undergoes acidcatalyzed rearrangement to give a ketone instead (Fig. 5). This process is known as a ketoenol tautomerism (Topic J2). CH3 H3C C I C H Br H3C C C H CH3 HBr H3C C C CH3 HBr Fig. 3. Electrophilic addition to an alkyne via a vinylic carbocation (I). H3C C HO C CH3 H HO H3C HO Diol C C H H CH3 H3C C C CH3 H+ / H2O HgSO4 H+ / H2O HgSO4 Intermediate Fig. 4. Reaction of 2-butyne with aqueous acid and mercuric sulfate. H3C C O H Fig. 5. Enol C H CH3 H H3C C O Ketone C H H CH3 Ketoenol tautomerism. Tautomerism is the term used to describe the rapid interconversion of two different isomeric forms (tautomers) in this case the keto and enol tautomers of a ketone. The keto tautomer is by far the dominant species for a ketone and the enol tautomer is usually present in only very small amounts (typically 0.0001%). Therefore, as soon as the enol is formed in the above reaction, it rapidly tautomerizes to the keto form and further electrophilic addition does not take place. 126 Section H Alkenes and alkynes HBr H3C C C H H3C C Br C H H HBr Br H3C Br C C H H H Intermediate Fig. 6. Reaction of propyne with HBr. H+ / H2O HgSO4 H3C C HO C H H H+ / H2O HgSO4 H3C C O C H H H H3C C C H Intermediate Fig. 7. Reaction of propyne with aqueous acid and mercuric sulfate. Additions to terminal alkynes If a terminal alkyne is treated with an excess of hydrogen halide the halogens both end up on the more substituted carbon (Fig. 6). This is another example of Markovnikovs rule which states that the additional hydrogens end up on the carbon which already has the most hydrogens (see Topics H4 and H5). The same rule applies for the reaction with acid and mercuric sulfate, which means that a ketone is formed after ketoenol tautomerism instead of an aldehyde (Fig. 7). Section H Alkenes and alkynes H9 REDUCTION OF ALKYNES Key Notes Hydrogenation Alkynes are reduced to alkanes with hydrogen gas over a platinum catalyst. Two molecules of hydrogen are added and the reaction goes through an alkene intermediate. The reaction can be stopped at the alkene stage if a less active or poisoned catalyst is used. The stereochemistry of the alkene from such a reaction is Z since both hydrogen atoms are added to the same side of the alkyne. Alkynes can also be reduced to E-alkenes using sodium or lithium in liquid ammonia. Congurational isomers alkenes and cycloalkanes (D2) Mechanisms (F2) Reduction and oxidation of alkenes (H6) Dissolving metal reduction Related topics Hydrogenation Alkynes react with hydrogen gas in the presence of a metal catalyst in a process known as hydrogenation an example of a reduction reaction. With a fully active catalyst such as platinum metal, two molecules of hydrogen are added to produce an alkane (Fig. 1). The reaction involves the addition of one molecule of hydrogen to form an alkene intermediate which then reacts with a second molecule of hydrogen to form the alkane. With less active catalysts, it is possible to stop the reaction at the alkene stage. In particular, Z-alkenes can be synthesized from alkynes by reaction with hydrogen gas and Lindlars catalyst (Fig. 2). This catalyst consists of metallic palladium deposited on calcium carbonate which is then treated with lead acetate and quinoline. The latter treatment poisons the catalyst such that the alkyne reacts with hydrogen to give an alkene, but does not react further. Since the starting materials are absorbed onto the catalytic surface, both hydrogens are added to the same side of the molecule to produce the Z isomer. R H Pt Fig. 1. Reduction of an alkyne to an alkane. Lindlar's Catalyst or P-2 Catalyst R C C R H2 H Fig. 2. Reduction of an alkyne to a ( Z )-alkene. H C C H R H 2 H2 R C C R R C C R H 128 Section H Alkenes and alkynes An alternative catalyst which achieves the same result is nickel boride (Ni2B) the P-2 catalyst. Dissolving metal reduction Reduction of an alkyne to an E-alkene can be achieved if the alkyne is treated with lithium or sodium metal in ammonia at low temperatures (Fig. 3). This is known as a dissolving metal reduction. 1) Na or Li NH3 R C C R 2) NH4Cl Fig. 3. Reduction of an alkyne to an E-alkene. Li R +e R C C R C C R Radical anion H Vinylic radical H-NH2 R C C R H Vinylic anion R C C R H R C C R H R C H C H R Li H-NH2 Fig. 4. Mechanism for the dissolving metal reduction of an alkyne. In this reaction, the alkali metal donates its valence electron to the alkyne to produce a radical anion (Fig. 4). This in turn removes a proton from ammonia to produce a vinylic radical which receives an electron from a second alkali metal to produce a trans-vinylic anion. This anion then removes a proton from a second molecule of ammonia and produces the trans- or E-alkene. Note that half curly arrows are used in the mechanism since this is a radical reaction involving the movement of single electrons (Topic F2). Section H Alkenes and alkynes H10 ALKYLATION OF TERMINAL ALKYNES Key Notes Terminal alkynes A terminal alkyne is dened as an alkyne having a hydrogen substituent. The hydrogen of a terminal alkyne is weakly acidic and can be removed with a strong base such as sodium amide to produce an alkynide ion. The alkynide ion can be treated with a primary alkyl halide to produce a disubstituted alkyne. BrnstedLowry acids and bases (G1) Nucleophilic substitution (L2) Elimination (L4) Alkylation Related topics Terminal alkynes A terminal alkyne is dened as an alkyne having a hydrogen substituent (Fig. 1). This hydrogen substituent is acidic and can be removed with strong base (e.g. sodium amide NaNH2) to produce an alkynide (Fig. 2). This is an example of an acidbase reaction (Topic G1). Once the alkynide has been formed, it can be treated with an alkyl halide to produce more complex alkynes (Fig. 3). This reaction is known as an alkylation as far as the alkynide is concerned, and is an example of nucleophilic substitution as far as the alkyl halide is concerned (Topic L2). Alkylation R Fig. 1. C C H Terminal alkyne. R C Acid C H + NH2 Base R C C + NH3 Alkynide Fig. 2. Reaction of a terminal alkyne with a strong base. R C C Alkynide + R' X R C C R' Alkyl halide Fig. 3. Reaction of an alkynide ion with an alkyl halide. 130 Section H Alkenes and alkynes H R C C Br C C H CH3 R C C H H H C C CH3 + H H + H + Br Alkynide Fig. 4. Elimination of HBr. This reaction works best with primary alkyl halides. When secondary or tertiary alkyl halides are used, the alkynide reacts like a base and this results in elimination of hydrogen halide from the alkyl halide to produce an alkene (Topic L4; Fig. 4). Section H Alkenes and alkynes H11 CONJUGATED DIENES Key Notes Structure Bonding A conjugated diene consists of two alkene units separated by a single bond. The single bond connecting the two alkene units of a conjugated diene has partial double-bond character. There are two possible explanations. Firstly, 2 the use of sp hybridized orbitals to form the bond results in a shorter bond. Secondly, the systems of the two alkene units can overlap to give partial double-bond character. Electrophilic addition to a diene produces a mixture of two products arising from 1,2-addition and 1,4-addition. The reaction proceeds through an allylic carbocation which is stabilized by delocalization and which accounts for the two possible products obtained. Heating a conjugated diene with an electron-decient alkene results in the formation of a cyclohexene ring. The mechanism is concerted and involves no intermediates. sp Hybridization (A4) Acid strength (G2) Enolates (G5) 2 Electrophilic addition DielsAlder cycloaddition Related topics Electrophilic addition to symmetrical alkenes (H3) Electrophilic addition to unsymmetrical alkenes (H4) Structure A conjugated diene consists of two alkene units separated by a single bond (Fig. 1a). Dienes which are separated by more than one single bond are called nonconjugated dienes (Fig. 1b). A conjugated diene does not behave like two isolated alkenes. For example, the length of the single bond connecting the two alkene units is slightly shorter than one would expect for a typical single bond (1.48 vs. 1.54 ). This demonstrates that there is a certain amount of double-bond character present in this bond. Two explanations can be used to account for this. First of all, the bond in question links H a) H C H3C Fig. 1. C H H C C H H3C CH2 CH3 b) H C C H CH2 C H C CH3 Bonding (a) Conjugated diene; (b) nonconjugated diene. 132 Section H Alkenes and alkynes Fig. 2. 2 -Orbital overlap. 3 two sp hybridized carbons rather than two sp hybridized carbons. Therefore, an 2 sp hybridized orbital from each carbon is used for the single bond. Since this 3 hybridized orbital has more s-character than an sp hybridized orbital, the bond is expected to be shorter. An alternative explanation is that the orbitals of the two alkene systems can overlap to produce the partial double-bond character (Fig. 2). Electrophilic addition The reactions of a conjugated diene reect the fact that a conjugated diene should be viewed as a functional group in its own right, rather than as two separate alkenes. Electrophilic addition to a conjugated diene results in a mixture of two possible products arising from 1,2-addition and 1,4 addition (Fig. 3). In 1,2-addition, new atoms have been added to each end of one of the alkene units. This is the normal electrophilic addition of an alkene with which we are familiar (Topics H3 and H4). In 1,4-addition, new atoms have been added to each end of the entire diene system. Furthermore, the double bond remaining has shifted position (isomerized) to the 2,3 position. The mechanism of 1,4-addition starts off in the same way as a normal electrophilic addition. We shall consider the reaction of a conjugated diene with hydrogen bromide as an example (Fig. 4). One of the alkene units of the diene uses its electrons to form a bond to the electrophilic hydrogen of HBr. The HBr bond breaks at the same time to produce a bromide ion. The intermediate carbocation produced has a double bond next to the carbocation center and is called an allylic carbocation. This system is now set up for resonance (cf. Topics G2 and G5) involving the remaining alkene and the carbocation center, resulting in delocalization of the H CH3 C C H3C C H C H Br2 H3C Br H C C H Br H C C CH3 H CH3 C C Br H H a) a) H + H H3C H C C Br 1,4-Addition CH3 H 1,2-Addition b) b) H H C H3C C H C C CH3 HBr H H3C H H C H C C H Br C CH3 C C Br H H + H H3C H C H C 1,2-Addition 1,4-Addition Fig. 3. Electrophilic addition to a conjugated diene of (a) bromine and (b) HBr. H11 Conjugated dienes 133 H H C H3C C H C C CH3 H CH3 C C H H H3C H H C H C C H C CH3 H - H Br H3C H C C H H Br Fig. 4. Mechanism of 1,4-addition rst step. positive charge between positions 2 and 4. Due to this delocalization, the carbocation is stabilized and this in turn explains two features of this reaction. First of all, the formation of two different products is now possible since the second stage of the mechanism involves the bromide anion attacking either at position 2 or at position 4 (Fig. 5). Secondly, it explains why the alternative 1,2-addition product is not formed (Fig. 6). The intermediate carbocation required for this 1,2-addition cannot be stabilized by resonance. Therefore, the reaction proceeds through the allylic carbocation instead. H H H3C H H H H3C H C C H Br H 1,4-Addition C C H H3C CH3 Br H C C H C C H C C H H3C H CH3 H C C H Br H C C Br CH3 H H C C H CH3 1,2-Addition Fig. 5. Mechanism of 1,2- and 1,4-addition second step. H H C H3C C H C C CH3 HBr H H 3C H C H C C H H C CH3 H H H3C Br C H C C H H C CH3 H Fig. 6. Unfavored reaction mechanism. O C CH3 Heat O C CH3 + Fig. 7. DielsAlder cycloaddition. 134 Section H Alkenes and alkynes O C CH3 Heat O C CH3 Fig. 8. Mechanism of DielsAlder cycloaddition. DielsAlder cycloaddition The DielsAlder cycloaddition reaction is an important method by which sixmembered rings can be synthesized. The reaction involves a conjugated diene and an alkene (Fig. 7). The alkene is referred to as a dienophile (diene-lover) and usually has an electron-withdrawing group linked to it (e.g. a carbonyl group or a nitrile). The mechanism is concerted with new bonds being formed at the same time as old bonds are being broken (Fig. 8). No intermediates are involved. Section I Aromatic chemistry I1 AROMATICITY Key Notes Denition Aromatic compounds such as benzene are more stable than suggested from their structure. They undergo reactions which retain the aromatic ring system, and behave differently from alkenes or polyenes. Aromatic compounds are cyclic and planar with sp hybridized atoms. They also obey the Hckel rule and have 4n 2 electrons where n 1, 2, 3, ... Aromatic systems can be monocyclic or polycyclic, neutral, or charged. sp Hybridization (A4) 2 Hckel rule 2 Related topic Denition The term aromatic was originally applied to benzene-like structures because of the distinctive aroma of these compounds, but the term now means something different in modern chemistry. Aromatic compounds undergo distinctive reactions which set them apart from other functional groups. They are highly unsaturated compounds, but unlike alkenes and alkynes, they are relatively unreactive and will tend to undergo reactions which involve a retention of their unsaturation. We have already discussed the reasons for the stability of benzene in Topic A4. Benzene is a six-membered ring structure with three formal double bonds (Fig. 1a). However, the six electrons involved are not localized between any two carbon atoms. Instead, they are delocalized around the ring which results in an increased stability. This is why benzene is often written with a circle in the center of the ring to signify the delocalization of the six electrons (Fig. 1b). Reactions which disrupt this delocalization are not favored since it means a loss of stability, so benzene undergoes reactions where the aromatic ring system is 2 retained. All six carbon atoms in benzene are sp hybridized, and the molecule itself is cyclic and planar the planarity being necessary if the 2p atomic orbitals on each carbon atom are to overlap and result in delocalization. a) b) Fig. 1. Representations of benzene. 2 Hckel rule An aromatic molecule must be cyclic and planar with sp hybridized atoms (i.e. conjugated), but it must also obey what is known as the Hckel rule. This rule states that the ring system must have 4n 2 electrons where n 1, 2, 3, etc. Therefore, ring systems which have 6, 10, 14, ... electrons are aromatic. Benzene ts the Hckel rule since it has six electrons. Cyclooctatetraene has eight electrons and does not obey the Hckel rule. Although all the carbon atoms in the 2 ring are sp hybridized, cyclooctatetraene reacts like a conjugated alkene. It is not 136 Section I Aromatic chemistry planar, the electrons are not delocalized and the molecule consists of alternating single and double bonds (Fig. 2a). However, the 18-membered cyclic system (Fig. 2b) does t the Hckel rule (n 4) and is a planar molecule with aromatic properties and a delocalized system. H H H H H H H H b) a) Fig. 2. (a) Cyclooctatetraene; (b) 18-membered aromatic ring. It is also possible to get aromatic ions. The cyclopentadienyl anion and the cycloheptatrienyl cation are both aromatic (Fig. 3). Both are cyclic and planar, con2 taining six electrons, and all the atoms in the ring are sp hybridized. Bicyclic and polycyclic systems can also be aromatic (Fig. 4). a) b) Fig. 3. (a) Cyclopentadienyl anion; (b) cycloheptatrienyl cation. a) b) c) Fig. 4. (a) Naphthalene; (b) anthracene; (c) benzo[a]pyrene. Section I Aromatic chemistry I2 PREPARATION AND PROPERTIES Key Notes Preparation Simple aromatic structures such as benzene, toluene, or naphthalene are isolated from natural sources and converted to more complex aromatic structures. Many aromatic compounds have a characteristic aroma and burn with a smoky ame. They are nonpolar, hydrophobic molecules which dissolve in organic solvents rather than water. Aromatic molecules can interact by van der Waals interactions or with a cation through an induced dipole interaction. Aromatic compounds undergo reactions where the aromatic ring is retained. Electrophilic substitution is the most common type of reaction. However, reduction is also possible. Aromatic compounds show characteristic absorptions in the IR spectrum due to ring vibrations. Signals due to Ar-H stretching and bending may also be observed. Signals for aromatic protons and carbons appear at characteristic positions in nmr spectra. Fragmentation ions can be observed in mass spectra which are characteristic of aromatic compounds. Electrophilic substitutions of benzene (I3) Oxidation and reduction (I7) Visible and ultra violet spectroscopy (P2) Infra-red spectroscopy (P3) Proton nuclear magnetic resonance spectroscopy (P4) 13 C nuclear magnetic resonance spectroscopy (P5) Mass spectroscopy (P6) Properties Spectroscopic analysis Related topics Preparation It is not practical to synthesize aromatic structures in the laboratory from scratch and most aromatic compounds are prepared from benzene or other simple aromatic compounds (e.g. toluene and naphthalene). These in turn are isolated from natural sources such as coal or petroleum. Many aromatic compounds have a characteristic aroma and will burn with a smoky ame. They are hydrophobic, nonpolar molecules which will dissolve in organic solvents and are poorly soluble in water. Aromatic molecules can interact with each other through intermolecular bonding by van der Waals interactions (Fig. 1a). However, induced dipole interactions are also possible with alkyl ammonium ions or metal ions where the positive charge of the cation induces a dipole in the aromatic ring such that the face of the ring is slightly negative and the edges are slightly positive (Fig. 1b). This results in the cation being sandwiched between two aromatic rings. Aromatic compounds are unusually stable and do not react in the same way as alkenes. They prefer to undergo reactions where the stable aromatic ring is Properties 138 Section I Aromatic chemistry a) b) R van der Waals interactions Induced dipole interaction Fig. 1. Intermolecular bonding involving aromatic rings. NH3 + retained. The most common type of reaction for aromatic rings is electrophilic substitution, but reduction is also possible. Spectroscopic analysis The presence of an aromatic ring can be indicated by IR, nmr and mass spectroscopy. In the IR spectrum, the stretching absorption of an Ar-H bond occurs at 1 30403010 cm which is higher than the range for an aliphatic CH stretch 1 (30002800 cm ). However, the absorption is usually weak and may be hidden. Absorptions due to ring vibrations are more reliable and can account for up to 1 four absorptions (typically about 1600, 1580, 1500 and 1450 cm ). These occur at lower wavenumbers to the C=C stretching absorptions of alkenes (1680 1 1620 cm ). Ar-H out of plane bending can give absorptions in the region 1 860680 cm . The number and position of these absorptions can indicate the substitution pattern of the aromatic ring. For example, an ortho disubstituted ring typ1 ically has an absorption at 770735 cm whereas a para disubstituted ring has an 1 absorption in the region 860800 cm . A monosubstituted aromatic ring has two 1 absorptions in the regions 690710 and 730770 cm while a meta-disubstituted 1 aromatic ring has two absorptions in the regions 690710 and 810850 cm . These bending absorptions are not always reliable and may be difcult to distinguish from other absorptions in the region. The nmr signals for aromatic protons and carbons occur in characteristic 1 regions of the nmr spectra (typically 6.58.0 ppm for H nmr; 110160 ppm for 13 C nmr). Moreover, it is possible to identify the substitution pattern of the aromatic ring based on the chemical shifts of the signals. Tables exist which allow the calculation of the expected chemical shifts based on the types of substituents that 1 are present and their relative positions on the ring. In the H spectrum, coupling patterns can often be useful in determining substitution patterns for the aromatic ring. For example, para-disubstituted aromatic rings often show two signals, both of which are doublets. There are characteristic fragmentation patterns in the mass spectra of aromatic compounds. For example, compounds containing monosubstituted aromatic rings typically show fragmentation ions at m/e 39, 50, 51, 52, & 77. Benzylic compounds usually have a strong signal at m/e 91 due to cleavage of a benzylic fragmentation ion. Since aromatic rings contain a conjugated electron system, they can be detected by uv spectroscopy. They generally show an intense absorption near 205 nm and a less intense absorption in the range 255275 nm. Section I Aromatic chemistry I3 ELECTROPHILIC SUBSTITUTIONS OF BENZENE Key Notes Denition An electrophilic substitution involves the substitution of one electrophile (a proton) from the aromatic ring with another electrophile. The aromatic ring remains intact. The mechanism of electrophilic substitution involves two stages. In stage 1, the aromatic ring uses two of its electrons to form a bond to the electrophile which results in a positively charged intermediate. In stage 2, a proton is lost from the ring and the electrons of the broken CH bond are used to reform the bond and restore aromaticity. Electrophilic substitution is aided by the fact that the positively charged intermediate is stabilized by resonance, resulting in delocalization of the positive charge. Since the intermediate is stabilized, the reaction takes place more readily. Benzene can be halogenated with chlorine and bromine. A Lewis acid such as FeBr3 or FeCl3 is required in order to activate the halogen and make it more electrophilic. Alkyl chains are linked to benzene by the FriedelCrafts alkylation, using an alkyl chloride and a Lewis acid. The Lewis acid is important in generating a carbocation which acts as the electrophile for the reaction. Primary alkyl chlorides are not ideal for the FriedelCrafts reaction since the primary carbocations generated can rearrange to more stable secondary or tertiary carbocations. The FriedelCrafts alkylation can also be carried out using an alkene or an alcohol in the presence of a mineral acid. The FriedelCrafts acylation involves the reaction of benzene with an acid chloride and a Lewis acid. An acylium ion is generated as the electrophile and has the advantage over a carbocation in that it does not rearrange. The product is an aromatic ketone. The ketone group can be reduced to give alkyl chains which would be difcult to attach by the FriedelCrafts alkylation. Benzene is sulfonated with concentrated sulfuric acid. The reaction involves the generation of sulfur trioxide which acts as the electrophile. Nitration is carried out using concentrated nitric acid and sulfuric acid. The sulfuric acid is present as an acid catalyst in the generation of the electrophilic nitronium ion. Both electrophiles in these reactions are strong and a Lewis acid is not required. Mechanism Intermediate stabilization Halogenation FriedelCrafts alkylation and acylation Sulfonation and nitration 140 Section I Aromatic chemistry Related topics Acid strength (G2) Lewis acids and bases (G4) Enolates (G5) Electrophilic addition to symmetrical alkenes (H3) Carbocation stabilization (H5) Conjugated dienes (H11) Electrophilic substitution of mono-substituted aromatic rings (I5) Denition Aromatic rings undergo electrophilic substitution, for example the bromination of benzene (Fig. 1). The reaction involves an electrophile (Br ) replacing another electrophile (H ) with the aromatic ring remaining intact. Therefore, one electrophile replaces another and the reaction is known as an electrophilic substitution. (At this stage we shall ignore how the bromine cation is formed.) H Br + Br + H Fig. 1. Electrophilic substitution of benzene. Mechanism In the mechanism (Fig. 2) the aromatic ring acts as a nucleophile and provides two of its electrons to form a bond to Br . The aromatic ring has now lost one of its formal double bonds resulting in a positively charged carbon atom. This rst step in the mechanism is the same as the one described for the electrophilic addition to alkenes, and so the positively charged intermediate here is equivalent to the carbocation intermediate in electrophilic addition. However in step 2, the mechanisms of electrophilic addition and electrophilic substitution differ. Whereas the carbocation intermediate from an alkene reacts with a nucleophile to give an addition product, the intermediate from the aromatic ring loses a proton. The CH bond breaks and the two electrons move into the ring to reform the bond, thus regenerating the aromatic ring and neutralizing the positive charge on the carbon. This is the mechanism undergone in all electrophilic substitutions. The only difference is the nature of the electrophile (Fig. 3). H H Br H H Step 1 Br Step 2 Br + H Intermediate Fig. 2. Mechanism of electrophilic substitution. I3 Electrophilic substitutions of benzene 141 O Br O N O O S O R C R R R C O Fig. 3. Examples of electrophiles used in electrophilic substitution. Intermediate stabilization The rate-determining step in electrophilic substitution is the formation of the positively charged intermediate, and so the rate of the reaction is determined by the energy level of the transition state leading to that intermediate. The transition state resembles the intermediate in character and so any factor stabilizing the intermediate also stabilizes the transition state and lowers the activation energy required for the reaction. Therefore, electrophilic substitution is more likely to take place if the positively charged intermediate can be stabilized. Stabilization is possible if the positive charge can be spread amongst different atoms a process called delocalization. The process by which this can take place is known as resonance (Fig. 4) see also Topics H11, G2, and G5. H Br H Br H Br Fig. 4. Resonance stabilization of the charged intermediate. The resonance process involves two electrons shifting their position round the ring to provide the top carbon with a fourth bond and thus neutralize its positive charge. In the process, another carbon in the ring is left short of bonds and gains the positive charge. This process can be repeated such that the positive charge is spread to a third carbon. The structures drawn in Fig. 4 are known as resonance structures. Halogenation The stable aromatic ring means that aromatic compounds are less reactive than alkenes to electrophiles. For example, an alkene will react with Br2 whereas an aromatic ring will not. Therefore, we have to activate the aromatic ring (i.e. make it a better nucleophile) or activate the Br2 (i.e. make it a better electrophile) if we want a reaction to occur. In Topic I5, we will explain how electron-donating substituents on an aromatic ring increase the nucleophilicity of the aromatic ring. Here, we shall see how a Br2 molecule can be activated to make it a better electrophile. This can be done by adding a Lewis acid such as FeCl3, FeBr3, or AlCl3 (Topic G4) to the reaction medium. These compounds all contain a central atom (iron or aluminum) which is strongly electrophilic and does not have a full valence shell of electrons. As a result, the central atom can accept a lone pair of electrons, even from a weakly nucleophilic atom such as a halogen. In the example shown (Fig. 5) bromine uses a lone pair of electrons to form a bond to the Fe atom in FeBr3 and becomes positively charged. Bromine is now activated to behave as an electrophile and will react more easily with a nucleophile (the aromatic ring) by the normal mechanism for electrophilic substitution. An aromatic ring can be chlorinated in a similar fashion, using Cl2 in the presence of FeCl3. 142 Section I Aromatic chemistry FeBr 3 FeBr3 Br FeBr3 Br -H H Br Br Br Br Br Fig. 5. Mechanism by which a Lewis acid activates bromine towards electrophilic substitution. FriedelCrafts alkylation and acylation FriedelCrafts alkylation and acylation (Fig. 6) are two other examples of electrophilic substitution requiring the presence of a Lewis acid, and are particularly important because they allow the construction of larger organic molecules by adding alkyl (R) or acyl (RCO) side chains to an aromatic ring. O C R R a) R R-Cl AlCl3 O b) C Cl AlCl3 Fig. 6. (a) FriedelCrafts alkylation; (b) FreidelCrafts acylation. An example of FriedelCrafts alkylation is the reaction of benzene with 2chloropropane (Fig. 7). The Lewis acid (AlCl3) promotes the formation of the carbocation required for the reaction and does so by accepting a lone pair of electrons from chlorine to form an unstable intermediate which fragments to give a carbocation and AlCl4 (Fig. 8). Once the carbocation is formed it reacts as an electrophile with the aromatic ring by the electrophilic substitution mechanism already described (Fig. 9). CI + H 3C CH CH3 CH3 CH CH3 + H + AICI3 Fig. 7. FreidelCrafts reaction of benzene with 2-chloropropane. H3C CH H3C Fig. 8. Mechanism of carbocation formation. Cl AlCl3 H3C CH H3C Cl AlCl3 H3C CH H3C Cl AlCl3 I3 Electrophilic substitutions of benzene 143 H3C CH CH3 H CH CH3 Fig. 9. Mechanism for the FriedelCrafts alkylation. CH3 + Resonance structures -H CH3 CH CH3 There are limitations to the FriedelCrafts alkylation. For example, the reaction of 1-chlorobutane with benzene gives two products with only 34% of the desired product (Fig. 10). This is due to the fact that the primary carbocation which is generated can rearrange to a more stable secondary carbocation where a hydrogen (and the two sigma electrons making up the CH bond) shift across to the neighboring carbon atom (Fig. 11). This is known as a hydride shift and it takes place because the secondary carbocation is more stable than the primary carbocation (see Topic H5). Such rearrangements limit the type of alkylations which can be carried out by the FriedelCrafts reaction. CH2CH3 CH2CH2CH2CH3 CH CH3 AlCl3 + Cl CH2CH2CH2CH3 + 34% 66% Fig. 10. FriedelCrafts reaction of 1-chlorobutane with benzene. H2C CHCH2CH3 H H2C H CHCH2CH3 Fig. 11. Hydride shift. Bearing this in mind, how is it possible to make structures like 1-butylbenzene in good yield? The answer to this problem lies in the FriedelCrafts acylation (Fig. 12). By reacting benzene with butanoyl chloride instead of 1-chlorobutane, the necessary 4-C skeleton is linked to the aromatic ring and no rearrangement takes place. The carbonyl group can then be removed by reducing it with hydrogen over a palladium catalyst to give the desired product. O CH3CH2CH2COCl AlCl3 H2 / Pd CH2CH2CH2CH3 Fig. 12. Synthesis of 1-butylbenzene by FriedelCrafts acylation and reduction. 144 Section I Aromatic chemistry The mechanism of the FriedelCrafts acylation is the same as the FriedelCrafts alkylation involving an acylium ion instead of a carbocation. As with the FriedelCrafts alkylation, a Lewis acid is required to generate the acylium ion (RC O) , but unlike a carbocation the acylium ion does not rearrange since there is resonance stabilization from the oxygen (Fig. 13). O C CH3CH2 CI O C CH2CH3 AlCl3 O C CH2CH3 CH3CH2 O C Cl AlCl3 Cl Fig. 13. AlCl3 Generation of the acylium ion. FriedelCrafts alkylations can also be carried out using alkenes instead of alkyl halides. A Lewis acid is not required, but a mineral acid is. Treatment of the alkene with the acid leads to a carbocation which can then react with an aromatic ring by the same electrophilic substitution mechanism already described (Fig. 14). As far as the alkene is concerned, this is another example of electrophilic addition where a proton is attached to one end of the double bond and a phenyl group is added to the other (Topic H3). H H3C C H3C CH2 H3C H3C C H CH2 CH3 C CH3 CH3 Fig. 14. FriedelCrafts alkylation of benzene with an alkene. FriedelCrafts reactions can also be carried out with alcohols in the presence of mineral acid. The acid leads to the elimination of water from the alcohol resulting in the formation of an alkene which can then be converted to a carbocation as already described (Fig. 15). The conversion of alcohols to alkenes under acid conditions will be covered in Topic M4. CH3 H3C HC H3C Fig. 15. OH CH2 -H2O H3C H H3C C CH2 C CH3 CH3 FreidelCrafts alkylation of benzene with an alcohol. I3 Electrophilic substitutions of benzene 145 Sulfonation and nitration Sulfonation and nitration are electrophilic substitutions which involve strong electrophiles and do not need the presence of a Lewis acid (Fig. 16). a) c. H 2SO4 Sulfonation b) c. H 2SO4 c. HNO 3 Nitration Fig. 16. (a) Sulfonation of benzene; (b) nitration of benzene. NO2 SO3H In sulfonation, the electrophile is sulfur trioxide (SO3) which is generated under the acidic reaction conditions (Fig. 17). Protonation of an OH group generates a protonated intermediate (I). Since the oxygen gains a positive charge it becomes a good leaving group and water is lost from the intermediate to give sulfur trioxide. Although sulfur trioxide has no positive charge, it is a strong electrophile. This is because the sulfur atom is bonded to three electronegative oxygen atoms which are all pulling electrons from the sulfur, and making it electron decient (i.e. electrophilic). During electrophilic substitution (Fig. 18), the aromatic ring forms a bond to sulfur and one of the bonds between sulfur and oxygen is broken. Both electrons move to the more electronegative oxygen to form a third lone pair and produce a negative charge on that oxygen. This will nally be neutralized when the third lone pair of electrons is used to form a bond to a proton. O O H S O H H O H H I O O S O H O + H 2O O -H + O O S Fig. 17. Generation of sulfur trioxide. H O S O O H S O O O O S O O O S O O H H Fig. 18. Sulfonation of benzene. In nitration, sulfuric acid serves as an acid catalyst for the formation of a nitronium ion (NO2 ) which is generated from nitric acid by a very similar 146 Section I Aromatic chemistry mechanism to that used in the generation of sulfur trioxide from sulfuric acid (Fig. 19). The mechanism for the nitration of benzene is very similar to sulfonation (Fig. 20). As the aromatic ring forms a bond to the electrophilic nitrogen atom, a bond between N and O breaks and both electrons move onto the oxygen atom. Unlike sulfonation, this oxygen keeps its negative charge and does not pick up a proton. This is because it acts as a counterion to the neighboring positive charge on nitrogen. H O H N O H O N H O O N O O O Fig. 19. Generation of the nitronium ion. H H N O O N H O O N O O Fig. 20. Nitration of benzene. Section I Aromatic chemistry I4 SYNTHESIS OF MONO-SUBSTITUTED BENZENES Key Notes Functional group transformations Many functional groups cannot be added directly to an aromatic ring by electrophilic substitution but can be obtained by converting functional groups already added. An amino group can be obtained by reduction of a nitro group then converted to a large range of other functional groups. Alkyl groups can be oxidized to a carboxylic acid group which can in turn be converted to other functional groups. When planning the synthesis of an aromatic compound, it is best to work backwards from the product in simple stages (retrosynthesis). If the substituent present cannot be added directly to the aromatic ring, it is best to consider what functional group could be transformed to give the desired substituent. Electrophilic substitutions of benzene (I3) Electrophilic substitutions of mono-substituted benzenes (I5) Reactions of amines (O3) Synthetic planning Related topics Functional group transformations Some substituents cannot be introduced directly onto an aromatic ring by electrophilic substitution. These include the following groups: NH2, NHR, NR2, NHCOCH3, CO2H, CN, OH. Although these groups cannot be added directly onto the aromatic ring they can be obtained by transforming a functional group which can be applied directly by electrophilic substitution. Three of the most important transformations are shown (Fig. 1). NO2 Sn / HCl NH2 R KMnO4 R = alkyl O C R CH2R Pd / H2 CO2H Fig. 1. Functional group transformations of importance in aromatic chemistry. 148 Section I Aromatic chemistry Nitro, alkyl, and acyl groups can readily be added by electrophilic substitution and can then be converted to amino, carboxylic acid, and alkyl groups respectively. Once the amino and carboxylic acid groups have been obtained, they can be further converted to a large range of other functional groups such as secondary and tertiary amines, amides, diazonium salts, halides, nitriles, esters, phenols, alcohols, and ethers (Topic O3 and Section K). Synthetic planning A knowledge of the electrophilic substitutions and functional group transformations which are possible is essential in planning the synthesis of an aromatic compound. When designing such a synthesis, it is best to work backwards from the product and to ask what it could have been synthesized from a process called retrosynthesis. We can illustrate this by designing a synthesis of an aromatic ester (Fig. 2). An ester functional group cannot be attached directly by electrophilic substitution, so the synthesis must involve several steps. The usual way to make an ester is from an acid chloride which is synthesized in turn from a carboxylic acid. Alternatively, the ester can be made directly from the carboxylic acid by treating it with an alcohol and an acid catalyst (Topics K2 and K5). Either way, benzoic acid is required to synthesize the ester. Carboxylic acids cannot be added directly to aromatic rings either, so we have to look for a different functional group which can be added directly, then transformed to a carboxylic acid. A carboxylic acid group can be obtained from the oxidation of a methyl group (Topic I7). Methyl groups can be added directly by FriedelCrafts alkylation. Therefore a possible synthetic route would be as shown in Fig. 2. O CH3Cl AlCl3 CH3 KMnO4 CO2H EtOH H+ OCH2CH3 Fig. 2. Possible synthesis of an aromatic ester. One possible problem with this route is the possibility of poly-methylation in the rst step. This is likely since the product (toluene) will be more reactive than the starting material (benzene) see Topic I5. One way round this problem would be to use an excess of benzene. As a second example, let us consider the synthesis of an aromatic amine (Fig. 3). The alkylamine group cannot be applied to an aromatic ring directly and so must be obtained by modifying another functional group. Working backwards, the alkylamine group could be obtained by alkylation of an amino group (NH2). An amino group cannot be directly applied to an aromatic ring either. However, an amino group could be obtained by reduction of a nitro group. A nitro group can be applied directly to an aromatic ring. Thus, the overall synthesis would be nitration followed by reduction, followed by alkylation. Note that there are two methods of converting aniline (PhNH2) to the nal product. Alkylation is the direct method, but sometimes acylation followed by reduction gives better yields, despite the extra step. This is because it is sometimes difcult to control the alkylation to only one alkyl group (Topic O3). I4 Synthesis of mono-substituted benzenes 149 HNO3 c.H2SO4 Sn / HCl NH2 NO2 CH3CH2I NHCH2CH3 CH3COCl NH C O CH3 LiAlH4 Fig. 3. Possible synthetic routes to an aromatic amine. As our last example, we shall consider the synthesis of an aromatic ether (Fig. 4). Here an ethoxy group is attached to the aromatic ring. The ethoxy group cannot be applied directly to an aromatic ring, so we have to nd a way of obtaining it from another functional group. Alkylation of a phenol group would give the desired ether, but a phenol group cannot be applied directly to the ring either. However, we can obtain the phenol from an amino group, which in turn can be obtained from a nitro group. The nitro group can be applied directly to the ring and so the synthesis involves a nitration, reduction, conversion of the amino group to a diazonium salt (see Topic O3), hydrolysis, and nally an alkylation. HNO3 c.H2SO4 a) NaNO2 HCl b) H2O OH 1.NaOH 2.Et I Possible synthetic route to an aromatic ether. OCH2CH3 NO2 Sn / HCl NH2 Fig. 4. Section I Aromatic chemistry I5 ELECTROPHILIC SUBSTITUTIONS OF MONO-SUBSTITUTED AROMATIC RINGS Key Notes ortho, meta and para substitution Electrophilic substitution can occur at three different positions on a monosubstituted aromatic ring. These positions are dened as the ortho, meta, and para positions. Substituents on an aromatic ring can activate or deactivate the ring towards further electrophilic substitution. They can also direct substitution either to the meta position or to the ortho and para positions. Inductive and resonance effects determine the directing effect. Substituents can be divided into four groups depending on whether they are activating or deactivating, and on their directing effect. The rst step of electrophilic substitution is the rate-determining step. The ease with which electrophilic substitution takes place is determined by the activation energy of this step, which depends on the stability of the transition state. The transition state resembles the carbocation intermediate; and so factors stabilizing the carbocation also stabilize the transition state and lower the activation energy. Alkyl substituents activate aromatic rings towards electrophilic substitution because they have an inductive effect which pushes electron density into the ring. This increases the nucleophilicity of the ring towards electrophiles and also stabilizes the positively charged intermediate; ortho/para attack is favored over meta attack. Inductive deactivating groups are groups having an electron decient atom directly attached to the aromatic ring. They include substituents such as nitro, acyl, carboxylic acid, sulfonic acid, and nitrile groups. Such groups have an electron-withdrawing effect which makes the aromatic ring less nucleophilic and less reactive to electrophiles; meta attack is favored over ortho/para. Substituents such as phenols, ethers, amines, and amides activate the aromatic ring and direct substituents to the ortho and para positions. In all these substituents, a nitrogen or an oxygen with a lone pair of electrons is attached directly to the ring and interacts with the ring by resonance. This resonance effect outweighs any electron-withdrawing effect of the electronegative oxygen or nitrogen. Amides are less activating than amines. This can be useful since amines can be temporarily converted to amides in order to lower reactivity and direct electrophilic substitution to the para position. Substituent effect Reaction prole Activating groups inductive o/p directing Deactivating groups inductive m directing Activating groups resonance o/p directing I5 Electrophilic substitutions of mono-substituted aromatic rings 151 Deactivating groups resonance o/p directing Halogen substituents deactivate aromatic rings towards electrophilic substitution by an inductive effect. These atoms are strongly electronegative and have an electron-withdrawing effect on the ring making it less nucleophilic and less reactive. However, once electrophilic substitution does take place, halogens direct to the ortho and para positions due to a resonance effect which helps to delocalize the positive charge onto the halogen atoms. This resonance effect is more important than the inductive effect which would normally direct substitution to the meta position. Carbocation stabilization (H5) Electrophilic substitutions of benzene (I3) Synthesis of di- and trisubstituted benzenes (I6) Related topics ortho, meta and para substitution Aromatic compounds which already contain a substituent can undergo electrophilic substitution at three different positions relative to the substituent. Consider the bromination of toluene (Fig. 1). Three different products are possible depending on where the bromine enters the ring. These products have the same molecular formula and are therefore constitutional isomers. The aromatic ring is said to be disubstituted and the three possible isomers are described as being ortho, meta, and para. The mechanisms leading to these three isomers are shown in Fig. 2. CH3 Br 2 FeBr3 CH3 Br or Br or CH3 CH3 ortho Fig. 1. ortho, meta, and para isomers of bromotoluene. meta para Br Substituent effect Of the three possible isomers arising from the bromination of toluene, only two (the ortho and para) are formed in significant quantity. Furthermore, the bromination of toluene goes at a faster rate than the bromination of benzene. Why? The answer lies in the fact that the methyl substituent can affect the rate and the position of further substitution. A substituent can either activate or deactivate the aromatic ring towards electrophilic substitution and does so through inductive or resonance effects. A substituent can also direct the next substitution so that it goes mainly ortho/para or mainly meta. We can classify substituents into four groups depending on the effect they have on the rate and the position of substitution, that is: activating groups which direct ortho/para by inductive effects; deactivating groups which direct meta by inductive effects; activating groups which direct ortho/para by resonance effects; deactivating groups which direct ortho/para by resonance effects. There are no substituents which activate the ring and direct meta. 152 Section I Aromatic chemistry orthoSubstitution CH3 Br CH3 H Br CH3 Br + H Intermediate CH3 CH3 CH3 metaSubstitution Br H Intermediate CH3 CH3 Br H Br + H CH3 paraSubstitution + H Br Br H Intermediate Br H Fig. 2. Mechanisms of ortho, meta, and para electrophilic substitution. Reaction prole Before explaining the reasons behind the substituent effect, we have to consider the reaction prole of electrophilic substitution with respect to the relative energies of starting material, intermediate, and product. The energy diagram (Fig. 3) illustrates the reaction pathway for the bromination of benzene. The rst stage in the mechanism is the rate-determining step and is the formation of the carbocation. This is endothermic and proceeds through a transition state which # # requires an activation energy (G ). The magnitude of G determines the rate at which the reaction will occur and this in turn is determined by the stability of the transition state. The transition state resembles the carbocation intermediate and so any factor which stabilizes the intermediate also stabilizes the transition state and favors the reaction. Therefore, in the discussions to follow we can consider the stability of relative carbocations in order to determine which reaction is more favorable. A methyl substituent is an example of an inductive activating group and so we shall consider again the bromination of toluene. In order to explain the directing properties of the methyl group, we need to look more closely at the mechanisms involved in generating the ortho, meta, and para isomers (Fig. 2). The preferred reaction pathway will be the one which goes through the most stable intermediate. Since a methyl group directs ortho and para, the intermediates involved in these reaction pathways are more stable than the intermediate involved in meta substitution. The relevant intermediates and their resonance structures are shown in Fig. 4. If we compare all the resonance structures above, we can spot one ortho and one para resonance structure (boxed) where the positive charge is positioned Activating groups inductive o/p directing I5 Electrophilic substitutions of mono-substituted aromatic rings 153 Transition state Energy G # Br H Go Br Reaction Progress Fig. 3. Energy diagram for electrophilic substitution. ortho Intermediate CH3 H Br CH3 H Br CH3 H Br CH3 CH3 CH3 meta Intermediate Br H H CH3 H CH3 Br H H CH3 H Br para Intermediate H Br H Br H H Br H H Fig. 4. Intermediates for ortho, meta, and para substitution. immediately next to the methyl substituent. An alkyl group can stabilize a neighboring positive charge by an inductive, electron-donating effect which results in some of the positive charge being spread over the alkyl group. This is an additional stabilizing effect which is only possible for the intermediates arising from ortho and para substitution. There is no such equivalent resonance structure for the meta intermediate and so that means that the ortho and para intermediates experience an increased stability over the meta, which results in a preference for these two substitution pathways. 154 Section I Aromatic chemistry By the same token, toluene will be more reactive than benzene. The electrondonating effect of the methyl group into the aromatic ring makes the ring inherently more nucleophilic and more reactive to electrophiles, as well as providing extra stabilization of the reaction intermediate. To sum up, alkyl groups are activating groups and are ortho, para directing. The nitration of toluene also illustrates this effect (Fig. 5). The amount of meta substitution is very small as we would expect, and there is a preference for the ortho and para products. However, why is there more ortho substitution compared to para substitution? Quite simply, there are two ortho sites on the molecule to one para site and so there is double the chance of ortho attack to para attack. Based on pure statistics we would have expected the ratio of ortho to para attack to be 2:1. In fact, the ratio is closer to 1.5:1. In other words, there is less ortho substitution than expected. This is because the ortho sites are immediately next door to the methyl substituent and the size of the substituent tends to interfere with ortho attack a steric effect. The signicance of this steric effect will vary according to the size of the alkyl substituent. The larger the substituent, the more ortho attack will be hindered. CH3 c. H 2SO4 HNO3 CH3 NO2 CH3 CH3 + + NO2 NO2 ortho (58%) Fig. 5. Nitration of toluene. meta (4%) para (38%) Deactivating groups inductive m directing Alkyl groups are activating groups and direct substitution to the ortho, para positions. Electron withdrawing substituents (Fig. 6) have the opposite effect. They deactivate the ring, make the ring less nucleophilic and less likely to react with an electrophile. The electron-withdrawing effect also destabilizes the reaction intermediate and makes the reaction more difcult. This destabilization is more pronounced in the intermediates arising from ortho/para attack and so meta attack is favored. O N O Fig. 6. O S OH OH N R R R O C OH O C H C N Examples of electron-withdrawing groups. All of these groups have a positively charged atom or an electron decient atom (i.e. an electrophilic center) directly attached to the aromatic ring. Since this atom is electron decient, it has an electron-withdrawing effect on the ring. Deactivating groups make electrophilic substitution more difcult but the reaction will proceed under more forcing reaction conditions. However, substitution is now directed to the meta position. This can be explained by comparing all the possible resonance structures arising from ortho, meta and para attack. As an example, we shall consider the bromination of nitrotoluene (Fig. 7). Of all the possible I5 Electrophilic substitutions of mono-substituted aromatic rings 155 resonance structures arising from ortho, meta, and para attack, there are two specic resonance structures (arising from ortho and para attack) where the positive charge is placed directly next to the electron-withdrawing nitro group (Fig. 8). As a result, these resonance structures are greatly destabilized. This does not occur with any of the resonance structures arising from meta attack and so meta attack is favored. NO2 Br2 FeBr 3 Br NO2 Br NO2 NO2 + + meta para ortho Br Fig. 7. Bromination of nitrobenzene. ortho Substitution NO2 H Br NO2 para Substitution H Br H Fig. 8. Destabilizing resonance structures for the intermediate arising from ortho and para substitution. Activating groups resonance o/p directing Phenol is an example of a substituent which activates the aromatic ring by resonance effects and which directs substitution to the ortho and para positions. In phenol, an electronegative oxygen atom is next to the aromatic ring. Since oxygen is electronegative, it should have an electron-withdrawing inductive effect and so might be expected to deactivate the ring. The fact that the phenolic group is a powerful activating group is due to the fact that oxygen is electron rich and can also act as a nucleophile, feeding electrons into the ring through a resonance process. As an example, we shall look at the nitration of phenol (Fig. 9). OH c.H2SO4 HNO3 OH NO2 OH OH + ortho + NO2 meta NO2 para Fig. 9. Nitration of phenol. There are three resonance structures for the intermediate formed in each form of electrophilic substitution, but there are two crucial ones to consider (Fig. 10), arising from ortho and para substitution. These resonance structures have the positive 156 Section I Aromatic chemistry ortho Substitution OH H NO2 para Substitution OH O2N Fig. 10. H Resonance structures for the intermediates arising from ortho and para substitution. charge next to the OH substituent. If oxygen only had an inductive effect, these resonance structures would be highly unstable. However, oxygen can act as a nucleophile and can use one of its lone pairs of electrons to form a new bond to the neighboring electrophilic center (Fig. 11). This results in a fourth resonance structure where the positive charge is moved out of the ring and onto the oxygen atom. Delocalizing the charge like this further stabilizes it and makes the reaction proceed more easily. OH H NO2 OH H NO2 OH OH O2 N Fig. 11. H O2N H Resonance interactions between the aromatic ring and oxygen. Since none of the resonance structures arising from meta attack places the positive charge next to the phenol group, this fourth resonance structure is not available to the meta intermediate and so meta attack is not favored. Thus, the phenol group is an activating group which is ortho, para directing because of resonance effects. This resonance effect is more important than any inductive effect which the oxygen might have. The same holds true for the following substituents: alkoxy (OR), esters (OCOR), amines (NH2, NHR, NR2), and amides (NHCOR). In all these cases, there is either a nitrogen or an oxygen next to the ring. Both these atoms are nucleophilic and have lone pairs of electrons which can be used to form an extra bond to the ring. The ease with which the group can do this depends on the nucleophilicity of the attached atom and how well it can cope with a positive charge. Nitrogen is more nucleophilic than oxygen since it is better able to cope with the resulting positive charge. Therefore amine substituents are stronger activating groups than ethers. On the other hand, an amide group is a weaker activating group since the nitrogen atom is less nucleophilic. This is because the nitrogens lone pair of electrons is pulled towards the carbonyl group and is less likely to form a bond to the ring (Fig. 12). This property of amides can be quite I5 Electrophilic substitutions of mono-substituted aromatic rings 157 O C R N R O C R N R Fig. 12. Amide resonance. NH2 NO2 c. H 2SO4 HNO3 Sn HCl NH2 para-Bromoaniline Br2 FeBr3 Br NH2 Br Br Br Fig. 13. Bromination of aniline. useful. Suppose for example we wanted to make para-bromoaniline by brominating aniline (Fig. 13). In theory, this reaction scheme should give the desired product. In practice, the NH2 group is such a strong activating group that the nal bromination goes three times to give the tri-brominated product rather than the mono-brominated product. In order to lower the activation of the amino group, we can convert it to the less activating amide group (Topic K5; Fig. 14). The bromination then only goes once. We also nd that the bromination reaction is more selective for the para position than for the ortho position. This is because the amide group is bulkier than the NH2 group and tends to shield the ortho positions from attack. Once the bromination has been completed the amide can be converted back to the amino group by hydrolysis (Topic K6). NO2 c. H 2SO4 HNO3 Sn HCl NH2 CH3COCl NHCOCH3 Br2 FeBr 3 NHCOCH3 H H2O NH2 Br Br Fig. 14. Synthesis of para-bromoaniline. 158 Section I Aromatic chemistry Deactivating groups resonance o/p directing The fourth and last group of aromatic substituents are the halogen substituents which deactivate the aromatic ring and which direct substitution to the ortho and para positions. These are perhaps the trickiest to understand since they deactivate the ring by one effect, but direct substitution by a different effect. The halogen atom is strongly electronegative and therefore we would expect it to have a strong electron-withdrawing inductive effect on the aromatic ring. This would make the aromatic ring less nucleophilic and less reactive to electrophiles. It would also destabilize the required intermediate for electrophilic substitution. Halogens are also poorer nucleophiles and so any resonance effects they might have are less important than their inductive effects. However, if halogen atoms are deactivating the ring because of inductive effects, why do they not direct substitution to the meta position like other electronwithdrawing groups? Let us look at a specic reaction the nitration of bromobenzene (Fig. 15). There are three resonance structures for each of the three intermediates leading to these products, but the crucial ones to consider are those which position a positive charge next to the substituent. These occur with ortho and para substitution, but not meta substitution (Fig. 16). These are the crucial resonance structures as far as the directing properties of the substituent is concerned. If bromine acts inductively, it will destabilize these intermediates and direct substitution to the meta position. However, we know that bromine directs ortho/para and so it must be stabilizing the ortho/para intermediates rather than destabilizing them. The only way that bromine can stabilize the neighboring positive charge is by resonance in the same way as a nitrogen or oxygen atom (Fig. 17). Thus, the bromine acts as a nucleophile and donates one of its lone pairs to form a new bond to the electrophilic center beside it. A new bond is formed and the positive charge is moved onto the bromine atom. This resonance effect is weak since the halogen atom is a much weaker nucleophile than oxygen or nitrogen and is less capable of stabilizing a positive charge. However, it is signicant enough to direct substitution to the ortho and para positions. Br c. H 2SO4 HNO3 Br NO2 Br Br + meta + NO2 ortho Fig. 15. Nitration of bromobenzene. NO2 para ortho Substitution Br H NO2 para Substitution Br O2N Fig. 16. Crucial resonance structures for ortho and para substitution. H I5 Electrophilic substitutions of mono-substituted aromatic rings 159 Br H NO2 Br H NO2 Br Br O2N Fig. 17. Resonance interactions involving bromine. H O2N H For halogen substituents, the inductive effect is more important than the resonance effect in deactivating the ring. However, once electrophilic substitution does take place, resonance effects are more important than inductive effects in directing substitution. Section I Aromatic chemistry I6 SYNTHESIS OF DI- AND TRISUBSTITUTED BENZENES Key Notes Di substituted benzenes When planning the synthesis of a di substituted benzene, it is important to consider the directing properties of the two substituents. If an ortho/paradisubstituted benzene is required, then the rst group introduced should be ortho/para directing. If a meta-di substituted benzene is required, the rst group introduced should be meta directing. In some cases, a different group may have to be introduced in order to achieve the desired substitution pattern and then transformed to the desired substituent. Two common functional groups which can be removed from the ring are the amino and the sulfonic acid groups. These groups can be used to direct or to block substitution at particular locations in the ring. The sulfonic acid group is particularly useful in obtaining ortho-di substituted benzenes. Synthesis of mono-substituted benzenes (I4) Electrophilic substitutions of mono-substituted aromatic rings (I5) Removable substituents Related topics Di substituted benzenes A full understanding of how substituents direct further substitution is crucial in planning the synthesis of a di substituted aromatic compound. For example, there are two choices which can be made in attempting the synthesis of pbromonitrobenzene from benzene (Fig. 1). We could brominate rst then nitrate, or nitrate rst then brominate. A knowledge of how substituents affect electrophilic substitution allows us to choose the most suitable route. NO2 NO2 Br2 FeBr 3 Br Br Br c. H 2SO4 HNO3 NO2 Br c. H 2SO4 HNO3 Br2 FeBr3 + NO2 Fig. 1. Synthetic planning to di-substituted benzenes. I6 Synthesis of di- and tri-substituted benzenes 161 In the rst method, nitrating rst then brominating would give predominantly the meta isomer of the nal product due to the meta directing properties of the nitro group. The second method is better since the directing properties of bromine are in our favor. Admittedly, we would have to separate the para product from the ortho product, but we would still get a higher yield by this route. The synthesis of m-toluidine requires a little more thought (Fig. 2). Both the methyl and the amino substituents are activating groups and direct ortho/para. However, the two substituents are meta with respect to each other. In order to get meta substitution we need to introduce a substituent other than the methyl or nitro group which will direct the second substitution to the meta position. Moreover, once that has been achieved, the meta directing substituent has to be converted to one of the desired substituents. The nitro group is ideal for this since it directs meta and can then be converted to the required amino group. NO2 c. H 2SO4 HNO3 CH3Cl AlCl3 CH3 CH3 NO2 Sn / HCl NH2 m-Toluidine Fig. 2. Synthesis of m-toluidine. This same strategy can be used for a large range of meta-disubstituted aromatic rings where both substituents are ortho/para directing since the nitro group can be transformed to an amino group which can then be transformed to a large range of different functional groups (see Topics I4 and O3). Another tricky situation is where there are two meta-directing substituents at ortho or para positions with respect to each other, for example, p-nitrobenzoic acid (Fig. 3). In this case, a methyl substituent is added which is o/p directing. Nitration is then carried out and the para isomer is separated from any ortho isomer which might be formed. The methyl group can then be oxidized to the desired carboxylic acid. Larger alkyl groups could be used to increase the ratio of para to ortho substitution since they can all be oxidized down to the carboxylic acid (Topic I7). CH3 CH3Cl AlCl3 c. H 2SO4 HNO3 CH3 KMnO4 CO2H p-Nitrobenzoic acid NO2 NO2 Fig. 3. Synthesis of para-nitrobenzoic acid. Removable substituents It is sometimes useful to have a substituent present which can direct or block a particular substitution, and which can then be removed once the desired substituents have been added. The reactions in Fig. 4 are used to remove substituents from aromatic rings. 162 Section I Aromatic chemistry SO3H H2O / H NH2 a) NaNO2 H b) H3PO2 Fig. 4. Reactions which remove substituents from aromatic rings. An example of how removable substituents can be used is in the synthesis of 1,3,5-tribromobenzene (Fig. 5). This structure cannot be made directly from benzene by bromination. The bromine atoms are in the meta positions with respect to each other, but bromine atoms direct ortho/para. Moreover, bromine is a deactivating group and so it would be difcult to introduce three such groups directly to benzene. This problem can be overcome by using a strong activating group which will direct ortho/para and which can then be removed at the end of the synthesis. The amino group is ideal for this and the full synthesis is shown in Fig. 5. NO2 c. H 2SO4 HNO3 NH2 Br Br a) NaNO2 HCl b) H3PO2 Br Br Sn / HCl NH2 Br2 FeBr 3 Br Fig. 5. Synthesis of 1,3,5-tribromobenzene. Br The synthesis of ortho-bromotoluene illustrates how a sulfonic acid can be used in a synthesis. o-Bromotoluene could conceivably be synthesized by bromination of toluene or by FriedelCrafts alkylation of bromobenzene (Fig. 6). However, the reaction would also give the para-substitution product and this is more likely if the electrophile is hindered from approaching the ortho position by unfavorable steric interactions. An alternative strategy would be to deliberately substitute a group at the para position of toluene before carrying out the bromination. This group would then act as a blocking group at the para position and would force the bromination to take place ortho to the methyl group. If the blocking group could then be removed, the desired product would be obtained. The sulfonic acid group is particularly useful in this respect since it can be easily removed at the end of the synthesis (Fig. 7). Note that the sulfonation of toluene could in theory take place at the ortho position as well as the para position. However, the SO3 electrophile is bulky and so the latter position is preferred for steric reasons. Once the sulfonic acid group is present, both it and the methyl group direct bromination to the same position (ortho to the methyl group meta to the sulfonic acid group). I6 Synthesis of di- and tri-substituted benzenes 163 CH3 CH3Cl AlCl3 Br2 FeBr3 CH3 Br + para CH3 Br Br2 FeBr3 CH3Cl AlCl3 Br + para Fig. 6. Possible synthetic routes to ortho-bromotoluene. CH3 CH3Cl AlCl3 c. H 2SO4 CH3 Br2 FeBr3 CH3 Br H2O / H CH3 Br SO3H SO3H Fig. 7. Synthesis of ortho-bromotoluene. Section I Aromatic chemistry I7 OXIDATION AND REDUCTION Key Notes Oxidation Aromatic rings are resistant to oxidation but alkyl chains attached to the ring are not. Alkyl substituents containing a benzylic hydrogen are oxidized to a carboxylic acid. The aromatic ring is difcult to reduce with hydrogen and requires vigorous reaction conditions using high pressure and heat, or strong catalysts such as rhodium. Cyclohexane products are obtained. The resistance of the aromatic ring to reduction allows the selective reduction of substituents such as ketones and nitro groups without affecting the aromatic ring itself. Electrophilic substitutions of benzene (I3) Synthesis of di- and trisubstituted benzenes (I6) Reduction Related topics Oxidation Aromatic rings are remarkably stable to oxidation and are resistant to oxidizing agents such as potassium permanganate or sodium dichromate. However, alkyl substituents on aromatic ring are surprisingly susceptible to oxidation. This can be put to good use in the synthesis of aromatic compounds since it is possible to oxidize an alkyl chain to a carboxylic acid without oxidizing the aromatic ring (see Topic I6; Fig. 1). The mechanism of this reaction is not fully understood, but it is known that a benzylic hydrogen has to be present (i.e. the carbon directly attached to the ring must have a hydrogen). Alkyl groups lacking a benzylic hydrogen are not oxidized. CH3 KMnO4 H2O, heat Benzylic position CO2H CH2CH2CH3 KMnO4 H2O, heat CO2H Fig. 1. Oxidation of alkyl side chains to aromatic carboxylic acids. Reduction Aromatic rings can be hydrogenated to cycloalkanes, but the reduction has to be carried out under strong conditions using a nickel catalyst, high temperature and high pressure (Fig. 2) much stronger conditions than would be required for the reduction of alkenes (Topic H6). This is because of the inherent stability of I7 Oxidation and reduction 165 aromatic rings (Topic I1). The reduction can also be carried out using hydrogen and a platinum catalyst under high pressure, or with hydrogen and a rhodium/carbon catalyst. The latter is a more powerful catalyst and the reaction can be done at room temperature and at atmospheric pressure. The resistance of the aromatic ring to reduction is useful since it is possible to reduce functional groups which might be attached to the ring without reducing the aromatic ring itself. For example, the carbonyl group of an aromatic ketone can be reduced with hydrogen over a palladium catalyst without affecting the aromatic ring (Fig. 3). This allows the synthesis of primary alkylbenzenes which cannot be synthesized directly by the FriedelCrafts alkylation (see Topic I3). It is worth noting that the aromatic ring makes the ketone group more reactive to reduction than would normally be the case. Aliphatic ketones would not be reduced under these conditions. Nitro groups can also be reduced to amino groups under these conditions without affecting the aromatic ring. H2 / Ni High temp High pressure Fig. 2. Reduction of benzene to cyclohexane. O C CH3 Pd / H2 CH3 Fig. 3. Reduction of an aromatic ketone. Section J Aldehydes and ketones J1 PREPARATION Key Notes Functional group transformations Functional group transformations allow the conversion of a functional group to an aldehyde or a ketone without affecting the carbon skeleton of the molecule. Aldehydes can be synthesized by the oxidation of primary alcohols, or by the reduction of esters, acid chlorides, or nitriles. Ketones can be synthesized by the oxidation of secondary alcohols. Methyl ketones can be synthesized from terminal alkynes. Reactions which result in the formation of aldehydes and ketones by carboncarbon bond formation are useful in the construction of more complex carbon skeletons from simple starting materials. Ketones can be synthesized from the reaction of acid chlorides with organocuprate reagents, or from the reaction of nitriles with a Grignard or organolithium reagent. Aromatic ketones can be synthesized by the FriedelCrafts acylation of an aromatic ring. Aldehydes and ketones can be obtained from the ozonolysis of suitably substituted alkenes. Reduction and oxidation of alkenes (H6) Electrophilic additions to alkynes (H8) Electrophilic substitutions of benzene (I3) Reactions (K6) Reactions of alkyl halides (L6) Reactions of alcohols (M4) Chemistry of nitriles (O4) CC Bond formation CC Bond cleavage Related topics Functional group transformations Functional group transformations allow the conversion of a functional group to an aldehyde or a ketone without affecting the carbon skeleton of the molecule. Aldehydes can be synthesized by the oxidation of primary alcohols (Topic M4), or by the reduction of esters (Topic K6), acid chlorides (Topic K6), or nitriles (Topic O4). Since nitriles can be obtained from alkyl halides (Topic L6), this is a way of adding an aldehyde unit (CHO) to an alkyl halide (Fig. 1). Ketones can be synthesized by the oxidation of secondary alcohols (Topic M4). Methyl ketones can be synthesized from terminal alkynes (Topic H8). Reactions which result in the formation of ketones by carboncarbon bond formation are extremely important because they can be used to construct complex carbon skeletons from simple starting materials. Ketones can be synthesized from the reaction of acid chlorides with organocuprate reagents (Topic K6), or from the reaction of nitriles with a Grignard or organolithium reagent (Topic O4). Aromatic ketones can be synthesized by the FriedelCrafts acylation of an aromatic ring (Topic I3). CC Bond formation 168 Section J Aldehydes and ketones KCN R X Alkyl halide 1. DIBAH, toluene R C N 2. H 3O R O C H Nitrile Fig. 1. Synthesis of an aldehyde from an alkyl halide with 1C chain extension. CC Bond cleavage Aldehydes and ketones can be obtained from the ozonolysis of suitably substituted alkenes (Topic H6). Section J Aldehydes and ketones J2 PROPERTIES Key Notes Carbonyl group The carbonyl group is a C=O group. The carbonyl group is planar with 2 bond angles of 120, and consists of two sp hybridized atoms (C and O) linked by a strong bond and a weaker bond. The carbonyl group is polarized such that oxygen is slightly negative and carbon is slightly positive. In aldehydes and ketones, the substituents must be one or more of the following an alkyl group, an aromatic ring, or a hydrogen. Aldehydes and ketones have higher boiling points than alkanes of comparable molecular weight due to the polarity of the carbonyl group. However, they have lower boiling points than comparable alcohols or carboxylic acids due to the absence of hydrogen bonding. Aldehydes and ketones of small molecular weight are soluble in aqueous solution since they can participate in intermolecular hydrogen bonding with water. Higher molecular weight aldehydes and ketones are not soluble in water since the hydrophobic character of the alkyl chains or aromatic rings outweighs the polar character of the carbonyl group. The oxygen of the carbonyl group is a nucleophilic center. The carbonyl carbon is an electrophilic center. Ketones are in rapid equilibrium with an isomeric structure called an enol. The keto and enol forms are called tautomers and the process by which they interconvert is called ketoenol tautomerism. The mechanism can be acid or base catalyzed. Aldehydes and ketones show strong carbonyl stretching absorptions in 13 their IR spectra as well as a quaternary carbonyl carbon signal in their C nmr spectra. Aldehydes also show characteristic CH stretching absorp1 tions in their IR spectra and a signal for the aldehyde proton in the H nmr which occurs at high chemical shift. The mass spectra of aldehydes and ketones usually show fragmentation ions resulting from cleavage next to the carbonyl group. The position of the uv absorption band is useful in the structure determination of conjugated aldehydes and ketones. sp Hybridization (A4) Recognition of functional groups (C1) Intermolecular bonding (C3) Organic structures (E4) Enolates (G5) Visible and ultra violet spectroscopy (P2) 2 Properties Nucleophilic and electrophilic centers Ketoenol tautomerism Spectroscopic analysis of aldehydes and ketones Related topics Infra-red spectroscopy (P3) Proton nuclear magnetic resonance spectroscopy (P4) 13 C nuclear magnetic resonance spectroscopy (P5) Mass spectroscopy (P6) 170 Section J Aldehydes and ketones Carbonyl group Both aldehydes and ketones contain a carbonyl group (C=O). The substituents attached to the carbonyl group determine whether it is an aldehyde or a ketone, and whether it is aliphatic or aromatic (Topics C1 and C2). The geometry of the carbonyl group is planar with bond angles of 120 (Topic 2 A4; Fig. 1). The carbon and oxygen atoms of the carbonyl group are sp hybridized and the double bond between the atoms is made up of a strong bond and a weaker bond. The carbonyl bond is shorter than a CO single bond (1.22 vs. 1.43 ) and is also stronger since two bonds are present as opposed to one (732 kJ 1 1 mol vs. 385 kJ mol ). The carbonyl group is more reactive than a CO single bond due to the relatively weak bond. The carbonyl group is polarized such that the oxygen is slightly negative and the carbon is slightly positive. Both the polarity of the carbonyl group and the presence of the weak bond explains much of the chemistry and the physical properties of aldehydes and ketones. The polarity of the bond also means that the carbonyl group has a dipole moment. O C R 120 Fig. 1. Geometry of the carbonyl group. 120 R' R Planar R + C O Properties Due to the polar nature of the carbonyl group, aldehydes and ketones have higher boiling points than alkanes of similar molecular weight. However, hydrogen bonding is not possible between carbonyl groups and so aldehydes and ketones have lower boiling points than alcohols or carboxylic acids. Low molecular weight aldehydes and ketones (e.g. formaldehyde and acetone) are soluble in water. This is because the oxygen of the carbonyl group can participate in intermolecular hydrogen bonding with water molecules (Topic C3; Fig. 2). As molecular weight increases, the hydrophobic character of the attached alkyl chains starts to outweigh the water solubility of the carbonyl group with the result that large molecular weight aldehydes and ketones are insoluble in water. Aromatic ketones and aldehydes are insoluble in water due to the hydrophobic aromatic ring. Due to the polarity of the carbonyl group, aldehydes and ketones have a nucleophilic oxygen center and an electrophilic carbon center as shown for propanal (Fig. 3; see also Topic E4). Therefore, nucleophiles react with aldehydes and ketones at the carbon center, and electrophiles react at the oxygen center. H O H-bond H O C H3C Fig. 2. CH3 Intermolecular hydrogen bonding of a ketone with water. Nucleophilic and electrophilic centers J2 Properties 171 Nucleophilic center CH3CH2 Fig. 3. O C + H Electrophilic center Nucleophilic and electrophilic centers of the carbonyl group. Ketoenol tautomerism Ketones which have hydrogen atoms on their -carbon (the carbon next to the carbonyl group) are in rapid equilibrium with an isomeric structure called an enol where the -hydrogen ends up on the oxygen instead of the carbon. The two isomeric forms are called tautomers and the process of equilibration is called tautomerism (Fig. 4). In general, the equilibrium greatly favors the keto tautomer and the enol tautomer may only be present in very small quantities. The tautomerism mechanism is catalyzed by acid or base. When catalyzed by acid (Fig. 5), the carbonyl group acts as a nucleophile with the oxygen using a lone pair of electrons to form a bond to a proton. This results in the carbonyl oxygen gaining a positive charge which activates the carbonyl group to attack by weak nucleophiles (Step 1). The weak nucleophile in question is a water molecule which removes the -proton from the ketone, resulting in the formation of a new C = C double bond and cleavage of the carbonyl bond. The enol tautomer is formed thus neutralizing the unfavorable positive charge on the oxygen (Step 2). Under basic conditions (Fig. 6), an enolate ion is formed (Topic G5), which then reacts with water to form the enol. The IR spectra of aldehydes and ketones are characterized by strong absorptions 1 due to C=O stretching. These occur in the region 17401720 cm for aliphatic 1 aldehydes and 17251705 cm for aliphatic ketones. However conjugation to aromatic rings or alkenes weakens the carbonyl bond resulting in absorptions at O C R C H Keto tautomer Fig. 4. Ketoenol tautomerism. R' R' R OH C C R' Enol tautomer R' Spectroscopic analysis of aldehydes and ketones H O C R C R' H R' R O Step 1 C H Step 2 R' C R' H H O H R OH C C R' R' Fig. 5. Acid-catalyzed mechanism for ketoenol tautomerism. 172 Section J Aldehydes and ketones H O H O C R C R' H H O Fig. 6. Base-catalyzed mechanism for ketoenol tautomerism. R' R O C C R' R' R OH C C R' R' lower wavenumbers. For example, the carbonyl absorptions for aromatic 1 1 aldehydes and ketones are in the regions 17151695 cm and 17001680 cm respectively. For cyclic ketones, the absorption shifts to higher wavenumber with increasing ring strain. For example, the absorptions for cyclohexanone and 1 cyclobutanone are 1715 and 1785 cm respectively. In the case of an aldehyde, two weak absorptions due to CH stretching of the 1 aldehyde proton may be spotted, one in the region 29002700 cm and the other 1 1 close to 2720 cm . The aldehyde proton gives a characteristic signal in the H nmr in the region 9.410.5 ppm. If the aldehyde group is linked to a carbon bearing a hydrogen, coupling will take place, typically with a small coupling constant of about 3 Hz. Indications of an aldehyde or ketone can be obtained indirectly from 1 the H nmr by the chemical shifts of neighboring groups. For example, the methyl signal of a methyl ketone appears at 2.2 ppm as a singlet. 13 The carbonyl carbon can be spotted as a quaternary signal in the C nmr spectrum in the region 200205 ppm for aliphatic aldehydes and 205218 ppm for aliphatic ketones. The corresponding regions for aromatic aldehydes and ketones are 190194 ppm and 196199 respectively. The mass spectra of aldehydes and ketones often show fragmentation ions resulting from bond cleavage on either side of the carbonyl group (-cleavage). Aromatic aldehydes and ketones generally fragment to give a strong peak at m/e + 105 due to the benzoyl fragmentation ion [PhC=O] . The carbonyl groups of saturated aldehydes and ketones give a weak absorption band in their uv spectra between 270 and 300 nm. This band is shifted to longer wavelengths (300350 nm) when the carbonyl group is conjugated with a double bond. The exact position of the uv absorption band can be useful in the structure determination of conjugated aldehydes and ketones. Section J Aldehydes and ketones J3 NUCLEOPHILIC ADDITION Key Notes Denition Nucleophilic addition involves the addition of a nucleophile to an aldehyde or a ketone. The nucleophile adds to the electrophilic carbonyl carbon. Charged nucleophiles undergo nucleophilic addition with an aldehyde or ketone to give a charged intermediate which has to be treated with acid to give the nal product. Neutral nucleophiles require acid catalysis and further reactions can take place after nucleophilic addition. Nucleophilic addition charged nucleophiles (J4) Nucleophilic addition nitrogen nucleophiles (J6) Nucleophilic addition oxygen and sulfur nucleophiles (J7) Overview Related topics Denition As the name of the reaction suggests, nucleophilic addition involves the addition of a nucleophile to a molecule. This is a distinctive reaction for ketones and O Nu C R (R'orH) R O C Nu (R'orH) H 3O R OH C Nu (R'orH) Fig. 1. Nucleophilic addition to a carbonyl group. Nu = NHR NR C Imine (R'orH) -H O C R (R'orH) H Nu H R OH Nu = NR2 C Nu (R'orH) R NR2 C Enamine (R'orH) R -H Nu = OR R OR C OR (R'orH) Acetal / ketal Fig. 2. Synthesis of imines, enamines, acetals, and ketals. 174 Section J Aldehydes and ketones aldehydes and the nucleophile will add to the electrophilic carbon atom of the carbonyl group. The nucleophile can be a negatively charged ion such as cyanide or hydride, or it can be a neutral molecule such as water or alcohol. Overview In general, addition of charged nucleophiles results in the formation of a charged intermediate (Fig. 1). The reaction stops at this stage and acid has to be added to complete the reaction (Topic J4). Neutral nucleophiles where nitrogen or oxygen is the nucleophilic center are relatively weak nucleophiles, and an acid catalyst is usually required. After nucleophilic addition has occurred, further reactions may take place leading to structures such as imines, enamines, acetals, and ketals (Topics J6 and J7; Fig. 2). Section J Aldehydes and ketones J4 NUCLEOPHILIC ADDITION CHARGED NUCLEOPHILES Key Notes Carbanion addition Grignard reagents (RMgX) and organolithium reagents (RLi) are used as the source of carbanions. The reaction mechanism involves nucleophilic addition of the carbanion to the aldehyde or ketone to form a negatively charged intermediate. Addition of acid completes the reaction. Both reactions are important because they involve CC bond formation allowing the synthesis of complex molecules from simple starting materials. Primary alcohols are obtained from formaldehyde, secondary alcohols from aldehydes and tertiary alcohols from ketones. Lithium aluminum hydride (LiAlH4) and sodium borohydride (NaBH4) are reducing agents and the overall reaction corresponds to the nucleophilic addition of a hydride ion (H: ). The reaction is a functional group transformation where primary alcohols are obtained from aldehydes and secondary alcohols are obtained from ketones. Reaction of aldehydes and ketones with HCN and KCN produce cyanohydrins. The cyanide ion is the nucleophile and adds to the electrophilic carbonyl carbon. The bisulte ion is a weakly nucleophilic anion which will only react with aldehydes and methyl ketones. The product is a water-soluble salt and so the reaction can be used to separate aldehydes and methyl ketones from larger ketones or from other water-insoluble compounds. The aldehyde and methyl ketone can be recovered by treating the salt with acid or base. The Aldol reaction involves the nucleophilic addition of enolate ions to aldehydes and ketones to form -hydroxycarbonyl compounds. Properties (J2) Nucleophilic addition (J3) Electronic and steric effects (J5) Nucleophilic addition nitrogen nucleophiles (J6) Nucleophilic addition oxygen and sulfur nucleophiles (J7) Reactions of enolate ions (J8) Organometallic reactions (L7) Hydride addition Cyanide addition Bisulte addition Aldol reaction Related topics Carbanion addition Carbanions are extremely reactive species and do not occur in isolation. However, there are two reagents which can supply the equivalent of a carbanion. These are Grignard reagents and organolithium reagents. We shall look rst of all at the reaction of a Grignard reagent with aldehydes and ketones (Fig. 1). The Grignard reagent in this reaction is called methyl magnesium iodide 176 Section J Aldehydes and ketones O C CH3CH2 H 1. H3C MgI CH3CH2 OH C CH3 H 2. H3O Fig. 1. Grignard reaction. (CH3MgI) and is the source of a methyl carbanion (Topic L7; Fig. 2). In reality, the methyl carbanion is never present as a separate ion, but the reaction proceeds as if it were. The methyl carbanion is the nucleophile in this reaction and the nucleophilic center is the negatively charged carbon atom. The aldehyde is the electrophile. Its electrophilic center is the carbonyl carbon atom since it is electron decient (Topic J2). The carbanion uses its lone pair of electrons to form a bond to the electrophilic carbonyl carbon (Fig. 3). At the same time, the relatively weak bond of the carbonyl group breaks and both electrons move to the oxygen to give it a third lone pair of electrons and a negative charge (Step 1). The reaction stops at this stage, since the negatively charged oxygen is complexed with magnesium which acts as a counterion (not shown). Aqueous acid is now added to provide an electrophile in the shape of a proton. The intermediate is negatively charged and can act as a nucleophile/base. A lone pair of electrons on the negatively charged oxygen is used to form a bond to the proton and the nal product is obtained (Step 2). H I Mg CH3 Grignard reagent. I Mg C H H Fig. 2. O CH3CH2 C + H H C H H Fig. 3. Step 1 CH3CH2 O C CH3 H H Step 2 CH3CH2 H O C CH3 H Mechanism for the nucleophilic addition of a Grignard reagent. The reaction of aldehydes and ketones with Grignard reagents is a useful method of synthesizing primary, secondary, and tertiary alcohols (Fig. 4). Primary alcohols can be obtained from formaldehyde, secondary alcohols can be obtained from aldehydes, and tertiary alcohols can be obtained from ketones. The reaction involves the formation of a carboncarbon bond and so this is an important way of building up complex organic structures from simple starting materials. The Grignard reagent itself is synthesized from an alkyl halide and a large variety of reagents are possible (Topic L7). Organolithium reagents (Topic L7) such as CH3Li can also be used to provide the nucleophilic carbanion and the reaction mechanism is exactly the same as that described for the Grignard reaction (Fig. 5). J4 Nucleophilic addition charged nucleophiles 177 O C H H 1. H3C MgI H OH C CH3 H H3C O C H 1. H3C MgI H3C OH C CH3 H 2. H3O 2. H3O Formaldehyde Aldehyde 1o Alcohol 2o Alcohol O C H3C Ketone CH3 1. CH3CH2 MgI H3C OH C CH3 2. H3O CH2CH3 3o Alcohol Fig. 4. Synthesis of primary, secondary, and tertiary alcohols by the Grignard reaction. O C CH3CH2 H H3C Li CH3CH2 O C CH3 H Li H3O CH3CH2 OH C CH3 H Fig. 5. Nucleophilic addition with an organolithium reagent. Hydride addition Reducing agents such as sodium borohydride (NaBH4) and lithium aluminum hydride (LiAlH4) react with aldehydes and ketones as if they are providing a hydride ion (:H ; Fig. 6). This species is not present as such and the reaction mechanism is more complex. However, we can explain the reaction by viewing these reagents as hydride equivalents (:H ). The overall reaction is an example of a functional group transformation since the carbon skeleton is unaffected. Aldehydes are converted to primary alcohols and ketones are converted to secondary alcohols. The mechanism of the reaction is the same as that described above for the Grignard reaction (Fig. 7). The hydride ion equivalent adds to the carbonyl group and a negatively charged intermediate is obtained which is complexed as a lithium salt (Step 1). Subsequent treatment with acid gives the nal product (Step 2). It should be emphasized again that the mechanism is actually more complex than this because the hydride ion is too reactive to exist in isolation. O C R R' Ketone a) LiAlH4 or NaBH4 R b) H3O OH C H R' 2o Alcohol Fig. 6. Reduction of a ketone to a secondary alcohol. 178 Section J Aldehydes and ketones H O R C + H Step 1 R O C H H Step 2 R OH C H H "" H Fig. 7. Mechanism for the reaction of a ketone with LiAIH4 or NaBH4. Cyanide addition Nucleophilic addition of a cyanide ion to an aldehyde or ketone gives a cyanohydrin (Fig. 8). In the reaction, there is a catalytic amount of potassium cyanide present and this supplies the attacking nucleophile in the form of the cyanide ion (CN ). The nucleophilic center of the nitrile group is the carbon atom since this is the atom with the negative charge. The carbon atom uses its lone pair of electrons to form a new bond to the electrophilic carbon of the carbonyl group (Fig. 9). As this new bond forms, the relatively weak bond of the carbonyl group breaks and the two electrons making up that bond move onto the oxygen to give it a third lone pair of electrons and a negative charge (Step 1). The intermediate formed can now act as a nucleophile/base since it is negatively charged and it reacts with the acidic hydrogen of HCN. A lone pair of electrons from oxygen is used to form a bond to the acidic proton and the HCN bond is broken at the same time such that these electrons move onto the neighboring carbon to give it a lone pair of electrons and a negative charge (Step 2). The products are the cyanohydrin and the cyanide ion. Note that a cyanide ion started the reaction and a cyanide ion is regenerated. Therefore, only a catalytic amount O C H3C CH3 2) H2O OH H3C C C N Fig. 8. Synthesis of a cyanohydrin. CH3 Cyanohydrin 1) HCN / KCN H O Step 1 H3C O C C N N CH3 C N H Step 2 H3C O C C N Cyanohydrin CH3 H3C C + CH3 C + C N Fig. 9. Mechanism for the formation of a cyanohydrin. J4 Nucleophilic addition charged nucleophiles 179 O C R R' HCN / KCN HO C R CN R' LiAlH4 HO C R CH2NH2 R' H3O HO C R CO2H R' Fig. 10. Further reactions of cyanohydrins. of cyanide ion is required to start the reaction and once the reaction has taken place, a cyanide ion is regenerated to continue the reaction with another molecule of ketone. Cyanohydrins are useful in synthesis because the cyanide group can be converted to an amine or to a carboxylic acid (Topic O4; Fig. 10). Bisulte addition The reaction of an aldehyde or a methyl ketone with sodium bisulte (NaHSO3) involves nucleophilic addition of a bisulte ion ( :SO3H) to the carbonyl group to give a water soluble salt (Fig. 11). The bisulte ion is a relatively weak nucleophile compared to other charged nucleophiles and so only the most reactive carbonyl compounds will react. Larger ketones do not react since larger alkyl groups hinder attack (Topic J5). The reaction is also reversible and so it is a useful method of separating aldehydes and methyl ketones from other ketones or from other organic molecules. This is usually done during an experimental work up where the products of the reaction are dissolved in a water immiscible organic solvent. Aqueous sodium bisulte is then added and the mixture is shaken thoroughly in a separating funnel. Once the layers have separated, any aldehydes and methyl ketones will have undergone nucleophilic addition with the bisulte solution and will be dissolved in the aqueous layer as the water soluble salt. The layers can now Na O C R H O Na H R OH C SO3 Water soluble H Na H H2 O R O C H + SO2 (g) + SO3H R C SO3H Fig. 11. Reaction of the bisulte ion with an aldehyde. O C CH O C R R' b) H3O Fig. 12. The Aldol reaction. R R' a) R" C R" O OH C CH R" R" 180 Section J Aldehydes and ketones be separated. If the aldehyde or methyl ketone is desired, it can be recovered by adding acid or base to the aqueous layer which reverses the reaction and regenerates the carbonyl compound. Aldol reaction Another nucleophilic addition involving a charged nucleophile is the Aldol reaction which is covered in Topic J8. This involves the nucleophilic addition of enolate ions to aldehydes and ketones to form -hydroxycarbonyl compounds (Fig. 12). Section J Aldehydes and ketones J5 ELECTRONIC AND STERIC EFFECTS Key Notes Reactivity Electronic factors Aldehydes are more reactive to nucleophiles than ketones. Alkyl groups have an inductive effect whereby they push electrons towards a neighboring electrophilic center and make it less electrophilic and less reactive. Ketones have two alkyl groups and are less electrophilic than aldehydes which have only one alkyl group. The transition state for nucleophilic addition resembles the tetrahedral product. Therefore, any factor affecting the stability of the product will affect the stability of the transition state. Since the tetrahedral product is more crowded than the planar carbonyl compound, the presence of bulky alkyl groups will increase crowding and decrease stability. Since ketones have two alkyl groups to aldehydes one, the transition state for ketones will be less stable than the transition state for aldehydes and the reaction will proceed more slowly. Bulky alkyl groups may also hinder the approach of the nucleophile to the reaction center the carbonyl group. Carbocation stabilization (H5) Nucleophilic addition charged nucleophiles (J4) Steric factors Related topics Reactivity Generally it is found that aldehydes are more reactive to nucleophiles than ketones. There are two factors (electronic and steric) which explain this difference in reactivity. The carbonyl carbon in aldehydes is more electrophilic than it is in ketones due to the substituents attached to the carbonyl carbon. A ketone has two alkyl groups attached whereas the aldehyde has only one. The carbonyl carbon is electron decient and electrophilic since the neighboring oxygen has a greater share of the electrons in the double bond. However, neighboring alkyl groups have an inductive effect whereby they push electron density towards the carbonyl carbon and make it less electrophilic and less reactive to nucleophiles (Fig. 1). Propanal has one alkyl group feeding electrons into the carbonyl carbon, whereas propanone has two. Therefore, the carbonyl carbon in propanal is more electrophilic than the carbonyl carbon in propanone. The more electrophilic the O C+ H3C CH3 Inductive effect of attached alkyl groups Electronic factors a) O C CH3CH2 + H b) Fig. 1. Inductive effect in (a) propanal; (b) propanone. 182 Section J Aldehydes and ketones a) Trifluoromethyl group is electron withdrawing and increases electrophilicity O F C F F C H b) O C H3C H Methyl group is electron donating and decreases electrophilicity Fig. 2. Inductive effect of (a) triuoroethanal; (b) ethanal. carbon, the more reactive it is to nucleophiles. Therefore, propanal is more reactive than propanone. Electron inductive effects can be used to explain differing reactivities between different aldehydes. For example the uorinated aldehyde (Fig. 2) is more reactive than ethanal. The uorine atoms are electronegative and have an electronwithdrawing effect on the neighboring carbon, making it electron decient. This in turn has an inductive effect on the neighboring carbonyl carbon. Since electrons are being withdrawn, the electrophilicity of the carbonyl carbon is increased, making it more reactive to nucleophiles. Steric factors Steric factors also have a role to play in the reactivity of aldehydes and ketones. There are two ways of looking at this. One way is to look at the relative ease with which the attacking nucleophile can approach the carbonyl carbon. The other is to consider how steric factors inuence the stability of the transition state leading to the nal product. Let us rst consider the relative ease with which a nucleophile can approach the carbonyl carbon of an aldehyde and a ketone. In order to do that, we must consider the bonding and the shape of these functional groups (Fig. 3). Both molecules have a planar carbonyl group. The atoms which are in the plane are circled in white. A nucleophile will approach the carbonyl group from above or below the plane. The diagram below shows a nucleophile attacking from above. Note that the hydrogen atoms on the neighboring methyl groups are not in the plane of the carbonyl group and so these atoms can hinder the approach of a nucleophile and thus hinder the reaction. This effect will be more signicant for a ketone where there are alkyl groups on either side of the carbonyl group. An aldehyde has only one alkyl group attached and so the carbonyl group is more accessible to nucleophilic attack. Nu: Nu: H H C H H Ethanal H H Fig. 3. Steric factors. C O C H H H C C Propanone O H J5 Electronic and steric effects 183 OH CH3 CH3 C O HCN CH3 NC C CH3 small large CH3 H C O HCN CH3 NC OH C H Propanone (planar molecule) Propanal (planar molecule) (Tetrahedral) (Tetrahedral) Fig. 4. Reactions of propanone and propanal with HCN. We shall now look at how steric factors affect the stability of the transition state leading to the nal product. For this we shall look at the reactions of propanone and propanal with HCN to give cyanohydrin products (Fig. 4). Both propanone and propanal are planar molecules. The cyanohydrin products are tetrahedral. Thus, the reaction leads to a marked difference in shape between the starting carbonyl compound and the cyanohydrin product. There is also a marked difference in the space available to the substituents attached to the reaction site the carbonyl carbon. The tetrahedral molecule is more crowded since there are four substituents crowded round a central carbon, whereas in the planar starting material, there are only three substituents attached to the carbonyl carbon. The crowding in the tetrahedral product arising from the ketone will be greater than that arising from the aldehyde since one of the substituents from the aldehyde is a small hydrogen atom. The ease with which nucleophilic addition takes place depends on the ease with which the transition state is formed. In nucleophilic addition, the transition state is thought to resemble the tetrahedral product more than it does the planar starting material. Therefore, any factor which affects the stability of the product will also affect the stability of the transition state. Since crowding is a destabilizing effect, the reaction of propanone should be more difcult than the reaction of propanal. Therefore, ketones in general will be less reactive than aldehydes. The bigger the alkyl groups, the bigger the steric effect. For example, 3-pentanone is less reactive than propanone and fails to react with the weak bisulte nucleophile whereas propanone does (Fig. 5). a) b) O C CH3CH2 CH2CH3 O C H3C CH3 Fig. 5. (a) 3-Pentanone; (b) propanone. Section J Aldehydes and ketones J6 NUCLEOPHILIC ADDITION NITROGEN NUCLEOPHILES Key Notes Imine formation Primary amines react with aldehydes and ketones to give an imine or Schiff base. The reaction involves nucleophilic addition of the amine followed by elimination of water. Acid catalysis aids the reaction, but too much acid hinders the reaction by protonating the amine. Secondary amines undergo the same type of mechanism as primary amines, but cannot give imines as the nal product. Instead, a proton is lost from a neighboring carbon and functional groups called enamines are formed. Aldehydes and ketones can be converted to crystalline derivatives called oximes, semicarbazones, and 2,4-dinitrophenylhydrazones. Such derivatives were useful in the identication of liquid aldehydes and ketones. Enamine formation Oximes, semicarbazones and 2,4-dinitrophenylhydrazones Related topics Nucleophilic addition (J3) Nucleophilic addition charged nucleophiles (J4) Nucleophilic addition oxygen and sulfur nucleophiles (J7) Imine formation The reaction of primary amines with aldehydes and ketones do not give the products expected from nucleophilic addition alone. This is because further reaction occurs once nucleophilic addition takes place. As an example, we shall consider the reaction of acetaldehyde (ethanal) with a primary amine methylamine (Fig. 1). The product contains the methylamine skeleton, but unlike the previous reactions there is no alcohol group and there is a double bond between the carbon and the nitrogen. This product is called an imine or a Schiff base. The rst stage of the mechanism (Fig. 2) is a normal nucleophilic addition. The amine acts as the nucleophile and the nitrogen atom is the nucleophilic center. The nitrogen uses its lone pair of electrons to form a bond to the electrophilic carbonyl carbon. As this bond is being formed, the carbonyl bond breaks with both electrons moving onto the oxygen to give it a third lone pair of electrons and a negative charge. The nitrogen also gains a positive charge, but both these charges can O C H3C Fig. 1. H CH3NH2 NHCH3 C Imine H R H Reaction of ethanal with methylamine. J6 Nucleophilic addition nitrogen nucleophiles 185 O Step 1 O C H3C N H NH2 CH3 H CH3 H Proton transfer Step 2 H3C OH C H N CH3 H H3C C + H Fig. 2. Mechanism of nucleophilic addition. be neutralized by the transfer of a proton from the nitrogen to the oxygen (Step 2). The oxygen uses up one of its lone pairs to form the new OH bond and the electrons in the NH bond end up on the nitrogen as a lone pair. An acid catalyst is present, but is not required for this part of the mechanism nitrogen is a good nucleophile and although the amine is neutral, it is sufciently nucleophilic to attack the carbonyl group without the need for acid catalysis. The intermediate obtained is the structure one would expect from nucleophilic addition alone, but the reaction does not stop there. The oxygen atom is now protonated by the acid catalyst and gains a positive charge (Fig. 3, Step 3). Since oxygen is electronegative, a positive charge is not favored and so there is a strong drive to neutralize the charge. This can be done if the bond to carbon breaks and the oxygen leaves as part of a water molecule. Therefore, protonation has turned the oxygen into a good leaving group. The nitrogen helps the departure of the water by using its lone pair of electrons to form a bond to the neighboring carbon atom and a positive charged intermediate is formed (Step 4). The water now acts as a nucleophile and removes a proton from the nitrogen such that the nitrogens lone pair is restored and the positive charge is neutralized (Step 5). H H OH C H3C N CH3 H H O H H H H3C N CH3 Step 3 OH Step 4 C H H Good leaving group H3C C N CH3 H Step 5 H3C C N CH3 H H + H O H Fig. 3. Mechanism for the elimination of water. Overall, a molecule of water has been lost in this second part of the mechanism. Acid catalysis is important in creating a good leaving group. If protonation did not occur, the leaving group would have to be the hydroxide ion which is a more reactive molecule and a poorer leaving group. Although acid catalysis is important to the reaction mechanism, too much acid can actually hinder the reaction. This is because a high acid concentration leads to protonation of the amine, and prevents it from acting as a nucleophile. Enamine formation The reaction of carbonyl compounds with secondary amines cannot give imines since there is no NH proton to be lost in the nal step of the mechanism. However, there is another way in which the positive charge on nitrogen the can be 186 Section J Aldehydes and ketones neutralized. This involves loss of a proton from a neighboring carbon atom (Fig. 4). Water acts as a base to remove the proton and the electrons which make up the CH bond are used to form a new bond to the neighboring carbon. This in turn forces the existing bond between carbon and nitrogen to break such that both the electrons end up on the nitrogen atom as a lone pair, thus neutralizing the charge. The nal structure is known as an enamine and can prove useful in organic synthesis. H O H3C C O H H H H2C H C N H3C CH3 CH3 H2C C N CH3 H3C H H O H H + H N H 3C + H Enamine Fig. 4. Mechanism for the formation of an enamine. Oximes, semicarbazones and 2,4dinitrophenylhydrazones The reaction of aldehydes and ketones with hydroxylamine (NH2OH), semicarbazide (NH2NHCONH2) and 2,4-dinitrophenylhydrazine takes place by the same mechanism described for primary amines to give oximes, semicarbazones, and 2,4-dinitrophenylhydrazones, respectively (Fig. 5). These compounds were frequently synthesized in order to identify a liquid aldehyde or ketone. The products are solid and crystalline, and by measuring their melting points, the original aldehyde or ketone could be identied by looking up melting point tables of these derivatives. Nowadays, it is easier to identify liquid aldehydes and ketones spectroscopically. O a) O C R R' NH2OH R NOH C R' Oxime b) O C R R' C H2NNH NH2 H N N C R R' Semicarbazone C O NH2 c) O C R R' H N NO2 NO2 H N N C NO2 R R' NO2 2,4-Dinitrophenylhydrazone + H2N Fig. 5. Synthesis of oximes, semicarbazones, and 2,4-dinitrophenylhydrazones. Section J Aldehydes and ketones J7 NUCLEOPHILIC ADDITION OXYGEN AND SULFUR NUCLEOPHILES Key Notes Acetal and ketal formation The reaction of aldehydes and ketones with two equivalents of an alcohol in the presence of anhydrous acid as a catalyst results in the formation of acetals and ketals respectively. The reaction involves nucleophilic addition of one molecule of alcohol, elimination of water, then addition of a second molecule of alcohol. The reaction is reversible and as a result acetals and ketals are good protecting groups for aldehydes and ketones. The synthesis of the acetal or ketal is carried out under anhydrous acid conditions while the reverse reaction is carried out using aqueous acid. Cyclic acetals and ketals are better protecting groups than acyclic ones. Dissolving aldehydes or ketones in alcohol results in an equilibrium between the carbonyl compound and the hemiacetal/hemiketal. The reaction is slow and the equilibrium favors the carbonyl compound. Most hemiacetals and hemiketals cannot be isolated since they break back down to the original carbonyl compounds when the solvent is removed. However, cyclic hemiacetals are important in sugar chemistry. Thioacetals and thioketals can be synthesized by treating aldehydes and ketones with a thiol or dithiol in the presence of an acid catalyst. These functional groups can also be used to protect aldehydes and ketones but are more difcult to hydrolyze. They can be useful in the reduction of aldehydes and ketones. Organic structures (E4) Nucleophilic addition (J3) Nucleophilic addition charged nucleophiles (J4) Nucleophilic addition nitrogen nucleophiles (J6) Reduction and oxidation (J10) Hemiacetals and hemiketals Thioacetal and thioketal formation Related topics Acetal and ketal formation When an aldehyde or ketone is treated with an excess of alcohol in the presence of an acid catalyst, two molecules of alcohol are added to the carbonyl compound to give an acetal or a ketal respectively (Fig. 1). The nal product is tetrahedral. a) R O C H 2 equiv. CH3CH2OH CH3CH2O C R OCH2CH3 b) R O C R' 2 equiv. CH3CH2OH H CH3CH2O C R Ketal OCH2CH3 H R' Aldehyde H Acetal Ketone Fig. 1. Formation of an acetal and a ketal. 188 Section J Aldehydes and ketones The reaction mechanism involves the nucleophilic addition of one molecule of alcohol to form a hemiacetal or hemiketal. Elimination of water takes place to form an oxonium ion and a second molecule of alcohol is then added (Fig. 2). The mechanism is quite complex and we shall look at it in detail by considering the reaction of methanol with acetaldehyde (ethanal; Fig. 3). The aldehyde is the electrophile and the electrophilic center is the carbonyl carbon. Methanol is the nucleophile and the nucleophilic center is oxygen. However, methanol is a relatively weak nucleophile (Topic E4). As a result, the carbonyl group has to be activated by adding an acid catalyst if a reaction is to take place. The rst step of the mechanism involves the oxygen of the carbonyl group using a lone pair of electrons to form a bond to a proton. This results in a charged intermediate where the positive charge is shared between the carbon and oxygen of the carbonyl group. Protonation increases the electrophilicity of the carbonyl group, making the carbonyl carbon even more electrophilic. As a result, it reacts better with the weakly nucleophilic alcohol. The alcoholic oxygen now uses one of its lone pairs of electrons to form a bond to the carbonyl carbon and the carbonyl bond breaks at the same time with the electrons moving onto the carbonyl oxygen and neutralizing the positive charge (Fig. 4). However, the alcoholic oxygen now has an unfavorable positive charge (which explains why methanol is a weak nucleophile in the rst place). This charge is easily lost if the attached proton is lost. Both electrons O C R H CH3CH2OH H CH3CH2O C R OH -H2O R OCH2CH3 C H CH3CH2OH CH3CH2O C OCH2CH3 H H R Acetal H Aldehyde Hemiacetal Oxonium ion Fig. 2. Acetal formation and intermediates involved. H O C H3C H H3C O C H O C CH3 H3C H Increased electrophilicity CH3 Fig. 3. Mechanism of acetal formation step 1. H O C H3C H H O H Fig. 4. Mechanism of acetal formation steps 2 and 3. CH3 H3C O C O CH3 H H3C H O C O CH3 Hemiacetal H H J7 Nucleophilic addition oxygen and sulfur nucleophiles 189 in the OH bond are captured by the oxygen to restore its second lone pair of electrons and neutralize the positive charge. The intermediate formed from this rst nucleophilic addition is called a hemiacetal. If a ketone had been the starting material, the structure obtained would have been a hemiketal. Once the hemiacetal is formed, it is protonated and water is eliminated by the same mechanism described in the formation of imines (Topic J6) the only difference being that oxygen donates a lone pair of electrons to force the removal of water rather than nitrogen (Fig. 5). The resulting oxonium ion is extremely electrophilic and a second nucleophilic addition of alcohol takes place to give the acetal. All the stages in this mechanism are reversible and so it is possible to convert the acetal or ketal back to the original carbonyl compound using water and an aqueous acid as catalyst. Since water is added to the molecule in the reverse mechanism, this is a process called hydrolysis. Acid acts as a catalyst both for the formation and the hydrolysis of acetals and ketals, so how can one synthesize ketals and acetals in good yield? The answer lies in the reaction conditions. When forming acetals or ketals, the reaction is carried out in the absence of water using a small amount of concentrated sulfuric acid or an organic acid such as para-toluenesulfonic acid. The yields are further boosted if the water formed during the reaction is removed from the reaction mixture. In order to convert the acetal or ketal back to the original carbonyl compound, an aqueous acid is used such that there is a large excess of water present and the equilibrium is shifted towards the carbonyl compounds. Both the synthesis and the hydrolysis of acetals and ketals can be carried out in high yield and so these functional groups are extremely good as protecting groups for aldehydes and ketones. Acetals and ketals are stable to nucleophiles and basic conditions and so the carbonyl group is disguised and will not react with these reagents. Cyclic acetals and ketals are best used for the protection of aldehydes and ketones. These can be synthesized by using diols rather than alcohols (Fig. 6). H O H H O R C O CH2CH3 H R CH2CH3 H O C O CH2CH3 H H -H2O R C O CH2CH3 Oxonium ion H R OCH2CH3 C O CH2CH3 H -H R C O CH2CH3 Acetal H OCH2CH3 H Fig. 5. Mechanism of acetal formation from a hemiacetal. a) R O C H HOCH2CH2OH O C H R H Cyclic acetal O b) R O HOCH2CH2OH C R' Ketone H O C R Cyclic ketal R' O Aldehyde Fig. 6. Synthesis of cyclic acetals and cyclic ketals. 190 Section J Aldehydes and ketones Hemiacetals and hemiketals When aldehydes and ketones are dissolved in alcohol without an acid catalyst being present, only the rst part of the above mechanism takes place with one alcohol molecule adding to the carbonyl group. An equilibrium is set up between the carbonyl group and the hemiacetal or hemiketal, with the equilibrium favoring the carbonyl compound (Fig. 7). O C H3C H OH CH3CH2OH H3 C C H Hemiacetal OCH2CH3 Fig. 7. Hemiacetal formation. a) O C HSCH2CH2SH S H C R H S b) R O C R' Ketone HSCH2CH2SH H S C R R' S R H Aldehyde Fig. 8. Formation of (a) cyclic thioacetals and (b) cyclic thioketals. The reaction is not synthetically useful, since it is not usually possible to isolate the products. If the solvent is removed, the equilibrium is driven back to starting materials. However, cyclic hemiacetals are important in the chemistry of sugars. Thioacetal and thioketal formation Thioacetals and thioketals are the sulfur equivalents of acetals and ketals and are also prepared under acid conditions (Fig. 8). These can also be used to protect aldehydes and ketones, but the hydrolysis of these groups is more difcult. More importantly, the thioacetals and thioketals can be removed by reduction and this provides a method of reducing aldehydes and ketones (Topic J10). Section J Aldehydes and ketones J8 REACTIONS OF ENOLATE IONS Key Notes Enolate ions Enolate ions are formed by treating aldehydes or ketones with a base. A proton has to be present on the -carbon. Enolate ions can be alkylated with an alkyl halide. O-Alkylation and C-alkylation are both possible, but the latter is more likely and more useful. The reaction allows the introduction of alkyl groups to the -carbon of aldehydes and ketones. If there are two -protons present, two different alkylations can be carried out in succession. -Ketoesters are useful starting materials since the -protons are more acidic and the alkylation is targeted to one position. The ester group is removed by decarboxylation. The Aldol reaction involves the dimerization of an aldehyde or a ketone. In the presence of sodium hydroxide, aldehyde or ketone is converted to an enolate ion, but not all the carbonyl molecules are converted and so the enolate ion can undergo a nucleophilic addition on free aldehyde or ketone. The product is a -hydroxyaldehyde or -hydroxyketone. Aldehydes react better than ketones in this reaction. If water is lost from the Aldol adduct, an ,-unsaturated carbonyl structure is obtained. The crossed Aldol reaction links two different aldehyde structures. The reaction works best if one of the aldehydes has no -proton present and the other aldehyde is added slowly to the reaction mixture to prevent selfcondensation. If a ketone is linked to an aldehyde, the reaction is known as the ClaisenSchmidt reaction. This works best if the aldehyde has no -proton. sp Hybridization (A4) Organic structures (E4) Enolates (G5) 2 Alkylation Aldol reaction Crossed Aldol reaction Related topics Nucleophilic substitution (L2) Elimination (L4) Enolate ions Enolate ions are formed by treating aldehydes or ketones with a base. An -proton has to be present. The mechanism of this acid base reaction was covered in Topic G5. Enolate ions can undergo a variety of important reactions including alkylation and the Aldol reaction. Treatment of an enolate ion with an alkyl halide results in a reaction known as alkylation (Fig. 1). The overall reaction involves the replacement of an -proton with an alkyl group. The nucleophilic and electrophilic centers of the enolate ion and methyl iodide are shown (Fig. 2). The enolate ion has its negative charge shared between the oxygen atom and the carbon atom due to resonance (Topic G5), and so both of these atoms are nucleophilic centers. Iodomethane has a polar Alkylation 192 Section J Aldehydes and ketones O H H C H Fig. 1. Alkylation of a ketone. Nucleophilic center H C H O Base CH3 H C H C CH3 Enolate ion H3C H3C I H C H O C CH3 C O C CH3 Nucleophilic center H C H O C CH3 Electrophilic center H3C I Weak nucleophilic center Fig. 2. Nucleophilic and electrophilic centers. a) O H C H C H3C I CH3 b) O H C CH3 H H3C C CH3 O CH3 O I H C H C - I H C H CH3 C CH3 I Fig. 3. (a) O-Alkylation; (b) C-alkylation. CI bond where the iodine is a weak nucleophilic center and the carbon is a good electrophilic center (Topics E3 and E4). One possible reaction between these molecules involves the nucleophilic oxygen using one of its lone pairs of electrons to form a new bond to the electrophilic carbon on iodomethane (Fig. 3a). At the same time, the CI bond and both electrons move onto iodine to give it a fourth lone pair of electrons and a negative charge. This reaction is possible, but in practice the product obtained is more likely to arise from the reaction of the alternative carbanion structure reacting with methyl iodide (Fig. 3b). This is a more useful reaction since it involves the formation of a carboncarbon bond and allows the construction of more complex carbon skeletons. An alternative mechanism to that shown in Fig. 3b, but which gives the same result, starts with the enolate ion. The enolate ion is more stable than the carbanion since the charge is on the electronegative oxygen and so it is more likely that the reaction mechanism will occur in this manner (Fig. 4). This is a very useful reaction in organic synthesis. However, there are limitations to the type of alkyl halide which can be used in the reaction. The reaction is SN2 with respect to the alkyl halide (see Topic L2) and so the reaction works best with primary alkyl, primary benzylic, and primary allylic halides. The enolate ion is a strong base and if it is reacted with secondary and tertiary halides, elimination of the alkyl halide takes place to give an alkene (Topic L4). J8 Reactions of enolate ions 193 O H C H H3C I C CH3 H C H CH3 O C CH3 I Fig. 4. O C CH3CH2O H C H O C CH3 Mechanism for C-alkylation of the enolate ion. O C CH3CH2O H3C C H O C CH3 H3C O H C H C CH3 a) NaOEt b) CH3I H3O Fig. 5. Alkylation of ethyl acetoacetate. H O C HO H 3C C H O C CH3 O H 3C O C C H O C CH3 CO2 H3C C H C CH3 H3C H O H C H O C CH3 Fig. 6. Decarboxylation mechanism. -Alkylation works well with ketones, but not so well for aldehydes since the latter tend to undergo Aldol condensations instead (see below). The -protons of a ketone such as propanone are only weakly acidic and so a powerful base (e.g. lithium diisopropylamide) is required to generate the enolate ion required for the alkylation. An alternative method of preparing the same product but using a milder base is to start with ethyl acetoacetate (a -keto ester) instead (Fig. 5). The -protons in this structure are more acidic since they are anked by two carbonyl groups (Topic G5). As a result, the enolate can be formed using a weaker base such as sodium ethoxide. Once the enolate has been alkylated, the ester group can be hydrolyzed and decarboxylated on heating with aqueous hydrochloric acid. The decarboxylation mechanism involves the -keto group and would not occur if this group was absent (Fig. 6). Carbon dioxide is lost and the enol tautomer is formed. This can then form the keto tautomer by the normal ketoenol tautomerism (Topic J2). It is possible for two different alkylations to be carried out on ethyl acetoacetate since there is more than one -proton present (Fig. 7). -keto esters such as ethylacetoacetate are also useful in solving a problem involved in the alkylation of unsymmetrical ketones. For example, alkylating butanone with methyl iodide leads to two different products since there are -protons on either side of the carbonyl group (Fig. 8). One of these products is obtained specically by using a -keto ester to make the target alkylation site more acidic (Fig. 9). 194 Section J Aldehydes and ketones O C EtO H C O a) NaOEt C CH3 H b) CH3I EtO O C C H3C O C CH3 H O a) NaOEt C b) CH3CH2I EtO H3C C O C CH3 CH2CH3 O H C H3C C CH3 CH2CH3 H3O Fig. 7. Double alkylation of ethylacetoacetate. O C H3C CH3 1) LDA 2) MeI H2C CH3 Fig. 8. Alkylation of butanone. O C CH3CH2O H C H O C CH2CH3 a) NaOEt C b) CH3I CH3CH2O H3C C H C CH2CH3 H3C O O O H C H C CH2CH3 O C CH3 O + C H3C CH3 CH3 H3O Fig. 9. Use of a b-keto ester to direct alkylation. O C H3C CHCH3 C EtO Fig. 10. O EtO a) NaOEt b) CH3I H3C O C C(CH3)2 C O O H3O H3C C CH CH3 CH3 Use of a b-keto ester to direct alkylation. The alternative alkylation product could be obtained by using a different -keto ester (Fig. 10). Aldol reaction Enolate ions can also react with aldehydes and ketones by nucleophilic addition. The enolate ion acts as the nucleophile while the aldehyde or ketone acts as an electrophile. Since the enolate ion is formed from a carbonyl compound itself, and can then react with a carbonyl compound, it is possible for an aldehyde or ketone to react with itself. We can illustrate this by looking at the reaction of acetaldehyde with sodium hydroxide (Fig. 11). Under these conditions, two molecules of acetaldehyde are linked together to form a -hydroxyaldehyde. In this reaction, two separate reactions are going on the formation of an J8 Reactions of enolate ions 195 O C H3C H O HO Base H H3C H C O C 3-Hydroxybutanal H + C H3C Fig. 11. Aldol reaction. enolate ion from one molecule of acetaldehyde, and the addition of that enolate to a second molecule of acetaldehyde. The mechanism begins with the formation of the enolate ion as described in Topic G5. It is important to realize that not all of the acetaldehyde is converted to the enolate ion and so we still have molecules of acetaldehyde present in the same solution as the enolate ions. Since acetaldehyde is susceptible to nucleophilic attack, the next stage in the mechanism is the nucleophilic attack of the enolate ion on acetaldehyde (Fig. 12). The enolate ion has two nucleophilic centers the carbon and the oxygen but the preferred reaction is at the carbon atom. The rst step is nucleophilic addition of the aldehyde to form a charged intermediate. The second step involves protonation of the charged oxygen. Since a dilute solution of sodium hydroxide is used in this reaction, water is available to supply the necessary proton. (Note that it would be wrong to show + a free proton (H ) since the solution is alkaline.) If the above reaction is carried out with heating, then a different product is obtained (Fig. 13). This arises from elimination of a molecule of water from the Aldol reaction product. There are two reasons why this can occur. First of all, the product still has an acidic proton (i.e. there is still a carbonyl group present and an -hydrogen next to it). This proton is prone to attack from base. Secondly, the dehydration process results in a conjugated product which results in increased stability (Topic A4). The mechanism of dehydration is shown in Fig. 14. First of all, the acidic proton is removed and a new enolate ion is formed. The electrons in the enolate ion can then move in such a fashion that the hydroxyl group is expelled to O H O C H3C H C H C H H O H H3C H O C C C H H O H3C H H O C CH2 H O C H O H Fig. 12. Mechanism of the Aldol reaction. O Base heat C H3C H H3C H Fig. 13. Formation of 2-butenal. H C O C H 196 Section J Aldehydes and ketones HO H H3C H H C O C H H H3C HO C O C H H HO H3C H C O C H H O H Fig. 14. Mechanism of dehydration. give the nal product an ,-unsaturated aldehyde. In this example, it is possible to vary the conditions such that one gets the Aldol reaction product or the ,-unsaturated aldehyde, but in some cases only the ,-unsaturated carbonyl product is obtained, especially when extended conjugation is possible. The Aldol reaction is best carried out with aldehydes. Some ketones will undergo an Aldol reaction, but an equilibrium is set up between the products and starting materials and it is necessary to remove the product as it is being formed in order to pull the reaction through to completion. Crossed Aldol reaction So far we have talked about the Aldol reaction being used to link two molecules of the same aldehyde or ketone, but it is also possible to link two different carbonyl compounds. This is known as a crossed Aldol reaction. For example, benzaldehyde and ethanal can be linked in the presence of sodium hydroxide (Fig. 15). In this example, ethanal reacts with sodium hydroxide to form the enolate ion which then reacts with benzaldehyde. Elimination of water occurs easily to give an extended conjugated system involving the aromatic ring, the double bond, and the carbonyl group. This reaction works well because the benzaldehyde has no -protons and cannot form an enolate ion. Therefore, there is no chance of benzaldehyde undergoing self-condensation. It can only act as the electrophile for another enolate ion. However, what is to stop the ethanal undergoing an aldol addition with itself as previously described (Fig. 11)? This reaction can be limited by only having benzaldehyde and sodium hydroxide initially present in the reaction ask. Since benzaldehyde has no -protons, no reaction can take place. A small quantity of ethanal can now be added. Reaction with excess sodium hydroxide turns most of the ethanal into its enolate ion. There will only be a very small amount of free ethanal left compared to benzaldehyde and so the enolate ion is more likely to react with benzaldehyde. Once the reaction O C H O NaOH H C C H H O C H + H3C C Fig. 15. Crossed Aldol reaction. J8 Reactions of enolate ions 197 O C H O NaOH CH3 H C C H O C CH3 + H3C C Fig. 16. ClaisenSchmidt reaction. is judged to have taken place, the next small addition of ethanal can take place and the process is repeated. Ketones and aldehydes can also be linked by the same method a reaction known as the ClaisenSchmidt reaction. The most successful reactions are those where the aldehyde does not have an -proton (Fig. 16). Section J Aldehydes and ketones J9 -HALOGENATION Key Notes Denition Aldehydes and ketones react with halogens under acid conditions, resulting in halogenation at the -carbon. The mechanism involves formation of the enol tautomer, which acts as a nucleophile. A halogen atom is bound to the -carbon and the nal step involves loss of a proton. Treatment of a methyl ketone with excess iodine and sodium hydroxide results in tri-iodination of the methyl group. The resulting CI3 group is a good leaving group and is displaced by the hydroxide ion to form a yellow precipitate (CHI3). Properties (J2) Mechanism Iodoform test Related topic Denition Aldehydes and ketones react with chlorine, bromine or iodine in acidic solution, resulting in halogenation at the -carbon (Fig. 1). Since acid conditions are employed, this process does not involve an enolate ion. Instead, the reaction takes place through the enol tautomer of the carbonyl compound (Topic J2). The enol tautomer acts as a nucleophile with a halogen by the mechanism shown (Fig. 2). In the nal step, the solvent acts as a base to remove the proton. O C R C H Fig. 1. R' R' H R X2 O C C X R' R' Mechanism a-Halogenation. Solvent O C R C H R' R' H H OH C R C R' R' R O C C X R' R' X R O C C R' R' X X Fig. 2. Mechanism of a-halogenation. J9 a-Halogenation 199 Iodoform reaction -Halogenation can also be carried out in the presence of base. The reaction proceeds through an enolate ion which is then halogenated (Fig. 3). However, it is difcult to stop the reaction at mono-halogenation since the resulting product is generally more acidic than the starting ketone due to the electron-withdrawing effect of the halogen. As a result, another enolate ion is quickly formed leading to further halogenation. O C R C R' H R' HO O C R C R' R' R O C C X R' R' X Fig. 3. -Halogenation in the presence of base. Fig. 3. a-Halogenation in the presence of base. X O C R CH3 I2 Fig. 4. The iodoform reaction. The reaction. NaOH R O C NaOH CI3 R O C O Na + CHI 3 yellow precipitate This tendency towards multiple halogenation is the basis for a classical test called the iodoform test which is used to identify methyl ketones. The ketone to be tested is treated with excess iodine and base and if a yellow precipitate is formed, a positive result is indicated. Under these conditions, methyl ketones undergo -halogenation three times (Fig. 4). The product obtained is then susceptible to nucleophilic substitution (Topic K2) whereby the hydroxide ion substitutes the tri-iodomethyl ( CI3) carbanion a good leaving group due to the three electron-withdrawing iodine atoms. Tri-iodomethane is then formed as the yellow precipitate. Section J Aldehydes and ketones J10 REDUCTION AND OXIDATION Key Notes Reduction to alcohols Reduction of an aldehyde with sodium borohydride or lithium aluminum hydride gives a primary alcohol. Similar reduction of a ketone gives a secondary alcohol. There are three methods of deoxygenating aldehydes and ketones. The method used depends on whether the compound is sensitive to acid or base. If sensitive to acid, reduction is carried out under basic conditions by the WolffKishner reduction. If sensitive to base, the reaction is carried out under acid conditions the Clemmenson reduction. If sensitive to both acid and base, the carbonyl group is converted to a dithioacetal or dithioketal then reduced with Raney nickel. Aldehydes can be oxidized to carboxylic acids, but ketones are resistant to oxidation. Nucleophilic addition charged nucleophiles (J4) Nucleophilic addition nitrogen nucleophiles (J6) Nucleophilic addition oxygen and sulfur nucleophiles (J7) Reduction to alkanes Oxidation Related topics Reduction to alcohols Aldehydes and ketones can be reduced to alcohols with a hydride ion provided by reducing reagents such as sodium borohydride or lithium borohydride (Topic J4). Primary alcohols are obtained from aldehydes, and secondary alcohols from ketones. Aldehydes and ketones can be reduced to alkanes by three different methods which are complementary to each other. The WolffKishner reduction is carried out under basic conditions and is suitable for compounds that might be sensitive to acid (Fig. 1). The reaction involves the nucleophilic addition of hydrazine followed by elimination of water to form a hydrazone. The mechanism is the same as that described for the synthesis of 2,4-dinitrophenylhydrazones (Topic J6). Reduction to alkanes O C R R' NH2 NH2NH2 NaOH R N C R' hydrazone -N2 (g) H C R R' R' = H or alkyl H Fig. 1. WolffKishner reduction. J10 Reduction and oxidation 201 However, the simple hydrazone formed under these reaction conditions spontaneously decomposes with the loss of nitrogen gas. The Clemmenson reduction (Fig. 2) gives a similar product but is carried out under acid conditions and so this is a suitable method for compounds which are unstable to basic conditions. Compounds which are sensitive to both acid and base can be reduced under neutral conditions by forming the thioacetal or thioketal (Topic J7), then reducing with Raney nickel (Fig. 3). Aromatic aldehydes and ketones can also be deoxygenated with hydrogen over a palladium charcoal catalyst. The reaction takes place because the aromatic ring activates the carbonyl group towards reduction. Aliphatic aldehydes and ketones are not reduced. O C R Fig. 2. R' Zn (Hg) HCl H C R H R' R' = H or alkyl Clemmenson reduction. O C R R' HSCH2CH2SH S C R S R' Raney nickel (H2) H C R H + CH3CH3 + NiS R' Fig. 3. Reduction via a cyclic thioketal. a) R O C H CrO3 H2SO4 R O C OH b) R O C H Ag2O NH3/H2O/EtOH R O C OH Fig. 4. (a) Oxidation of an aldehyde to form a carboxylic acid; (b) Oxidation of an aldehyde using silver oxide. O C R Fig. 5. H 1,1-Diol intermediate. O C H R OH H2O HO C R OH Oxidation Oxidation Ketones are resistant to oxidation whereas aldehydes are easily oxidized. Treatment of an aldehyde with an oxidizing agent results in the formation of a carboxylic acid (Fig. 4a). Some compounds may be sensitive to the acid conditions used in this reaction and an alternative way of carrying out the oxidation is to use a basic solution of silver oxide (Fig. 4b). Both reactions involve the nucleophilic addition of water to form a 1,1-diol or hydrate which is then oxidized in the same way as an alcohol (Fig. 5); see Topic M4. Section J Aldehydes and ketones J11 ,-UNSATURATED ALDEHYDES AND KETONES Key Notes Denition ,-Unsaturated aldehydes and ketones are aldehydes and ketones which are conjugated with a double bond. The carbonyl oxygen of an ,-unsaturated aldehyde or ketone is a nucleophilic center. The carbonyl carbon and the -carbon are electrophilic centers. Nucleophilic addition can take place at either the carbonyl carbon (1,2-addition), or the -carbon (1,4- or conjugate addition). 1,2-Addition to ,-unsaturated aldehydes and ketones takes place with Grignard reagents and organolithium reagents. 1,4-Addition to ,-unsaturated aldehydes and ketones takes place with organocuprate reagents, amines and the cyanide ion. ,-unsaturated ketones are reduced to allylic alcohols with lithium aluminum hydride. sp Hybridization (A4) Conjugated dienes (H11) Nucleophilic addition (J3) 2 Nucleophilic and electrophilic centers 1,2-Addition 1,4-Addition Reduction Related topics Nucleophilic addition charged nucleophiles (J4) Denition ,-Unsaturated aldehydes and ketones are aldehydes and ketones which are conjugated with a double bond. The -position is dened as the carbon atom next to the carbonyl group, while the -position is the carbon atom two bonds removed (Fig. 1). The carbonyl group of ,-unsaturated aldehydes and ketones consists of a nucleophilic oxygen and an electrophilic carbon. However, ,-unsaturated aldehydes and ketones also have another electrophilic carbon the -carbon. This is due to the inuence of the electronegative oxygen which can result in the resonance shown (Fig. 2). Since two electrophilic centers are present, there are two O b) C H H3C C CH3 Nucleophilic and electrophilic centers O a) H3C Fig. 1. (a) a, b-unsaturated aldehyde; (b) a, b-unsaturated ketone. J11 a,b-Unsaturated aldehydes and ketones 203 Electrophilic center O O O H3C C H H3C H H 3C Nucleophilic center H C C Electrophilic center Fig. 2. Nucleophilic and electrophilic centers. places where a nucleophile can react. In both situations, an addition reaction takes place. If the nucleophile reacts with the carbonyl carbon, this is a normal nucleophilic addition to an aldehyde or ketone and is called a 1,2-nucleophilic addition. If the nucleophile adds to the -carbon, this is known as a 1,4nucleophilic addition or a conjugate addition. 1,2-Addition The mechanism of 1,2-nucleophilic addition is the same mechanism already described in Topics J3 and J4. It is found that Grignard reagents and organolithium reagents will react with ,-unsaturated aldehydes and ketones in this way and do not attack the -position (Fig. 3). The mechanism for 1,4-addition involves two stages (Fig. 4). In the rst stage, the nucleophile uses a lone pair of electrons to form a bond to the -carbon. At the same time, the C=C bond breaks and both electrons are used to form a new bond to the carbonyl carbon. This in turn forces the carbonyl bond to break with both of the electrons involved moving onto the oxygen as a third lone pair of electrons. The resulting intermediate is an enolate ion. Aqueous acid is now added to the reaction mixture. The carbonyl bond is reformed, which forces open the C=C bond. These electrons are now used to form a bond to a proton at the carbon. 1,4-Addition O C H3C H RMgI OH C or RLi H3C R H Fig. 3. 1,2-Nucleophilic addition. Nu O C H3C H Enolate ion Nu H3C H O C H H3C H Nu O C H Fig. 4. Mechanism of 1,4-nucleophilic addition. 204 Section J Aldehydes and ketones O C H3C Fig. 5. O C H3C R a) LiAlH4 b) H 3O H3C H O C H3C R a) NaBH4 b) H 3O H3C H Fig. 6. Reduction of a, b-unsaturated ketones. OH C R H Alkylation with organocuprate reagents. OH C R Li+ (Me2Cu-) H3C H3C O C H OH + C H3C H R Conjugate addition reactions can be carried out with amines, or a cyanide ion. Alkyl groups can also be added to the -position by using organocuprate reagents (Topic L7; Fig. 5). A large variety of organocuprate reagents can be prepared allowing the addition of primary, secondary and tertiary alkyl groups, aryl groups, and alkenyl groups. Reduction The reduction of ,-unsaturated ketones to allylic alcohols is best carried out using lithium aluminum hydride under carefully controlled conditions (Fig. 6). With sodium borohydride, some reduction of the alkene also takes place. Section K Carboxylic acids and carboxylic acid derivatives K1 STRUCTURE AND PROPERTIES Key Notes Structure There are four common carboxylic acid derivaties derived from a parent carboxylic acid acid chlorides, acid anhydrides, esters, and amides. Car2 boxylic acids and their derivatives contain an sp hybridized carbonyl group linked to a group Y where the atom directly attached to the carbonyl group is a heteroatom (Cl, O or N). The functional groups are planar with bond angles of 120 . The carbonyl group is made up of a strong bond and a weaker bond. The carbonyl group is polarized such that the oxygen acts as a nucleophilic center and the carbon acts as an electrophilic center. Carboxylic acids are polar and can take part in hydrogen bonding. They are soluble in water and have high boiling points. Carboxylic acids are weak acids in aqueous solution and form water soluble salts when treated with a base. Primary and secondary amides participate in hydrogen bonding and have higher boiling points than comparable aldehydes or ketones. Acid chlorides, acid anhydrides, esters, and tertiary amides are polar but are not capable of hydrogen bonding. Their boiling points are similar to aldehydes and ketones of similar molecular weight. Carboxylic acids and acid derivatives undergo nucleophilic substitutions. The presence of a carboxylic acid or a carboxylic acid derivative can be demonstrated by spectroscopy. IR spectroscopy shows strong absorptions for carbonyl stretching. The position of the absorption is characteristic of different acid derivatives. Quaternary signals for the carbonyl carbon occur 13 in the C nmr spectrum and also occur in characteristic regions for each acid derivative. It is important to consider all other lines of evidence when interpreting spectra. This includes elemental analysis, molecular weight and molecular formula, as well as supporting evidence in various spectra. sp Hybridization (A4) Intermolecular bonding (C3) Organic structures (E4) Acid strength (G2) Nucleophilic addition (J3) Infra-red spectroscopy (P3) 2 Bonding Properties Reactions Spectroscopic analysis Related topics Proton nuclear magnetic resonance spectroscopy (P4) 13 C nuclear magnetic resonance spectroscopy (P5) Mass spectroscopy (P6) Structure Carboxylic acid derivatives are structures derived from a parent carboxylic acid structure. There are four common types of acid derivative acid chlorides, acid anhydrides, esters, and amides (Fig. 1). These functional groups contain a 2 carbonyl group (C O) where both atoms are sp hybridized (Fig. 2). The carbonyl group along with the two neighboring atoms is planar with bond angles of 120 . 206 Section K Carboxylic acids and carboxylic acid derivatives a) R O C Cl b) R O C O O C R c) R O C OR' O d) C R NR'2 e) R O C OH Fig. 1. (a) Acid chloride; (b) acid anhydride; (c) ester; (d) amide; (e) carboxylic acid. O 120o R C Y 120o 120o sp2 R O C Y R Acyl O C Y R O C OH Carboxyl R O C Y Carbonyl Fig. 2. Structure of the functional group. The carbonyl group along with the attached carbon chain is called an acyl group. Carboxylic acids and carboxylic acid derivatives differ in what is attached to the acyl group (i.e. Y = Cl, OCOR, OR, NR2, or OH). Note that in all these cases, the atom in Y which is directly attached to the carbonyl group is a heteroatom (Cl, O, or N). This distinguishes carboxylic acids and their derivatives from aldehydes and ketones where the corresponding atom is hydrogen or carbon. This is important with respect to the sort of reactions which carboxylic acids and their derivatives undergo. The carboxylic acid group (COOH) is often referred to as a carboxyl group. Bonding The bonds in the carbonyl C O group are made up of a strong bond and a weaker bond (Fig. 3). Since oxygen is more electronegative than carbon, the carbonyl group is polarized such that the oxygen is slightly negative and the carbon is slightly positive. This means that oxygen can act as a nucleophilic center and carbon can act as an electrophilic center. O R C+ Y Nucleophilic center R O C Y Electrophilic center Fig. 3. Bonding and properties. Properties Carboxylic acids and their derivatives are polar molecules due to the polar carbonyl group and the presence of a heteroatom in the group Y. Carboxylic acids can associate with each other as dimers (Fig. 4) through the formation of two intermolecular hydrogen bonds which means that carboxylic acids have higher boiling points than alcohols of comparable molecular weight. It also means that low molecular weight carboxylic acids are soluble in water. However, as the molecular weight of the carboxylic acid increases, the hydrophobic character of the alkyl portion eventually outweighs the polar character of the functional group such that higher molecular weight carboxylic acids are insoluble in water. Primary amides and secondary amides also have a hydrogen capable of hydrogen bonding (i.e. RCONHR , RCONH2), resulting in higher boiling points for K1 Structure and properties 207 H-bond O R C O Fig. 4. H H-bond Intermolecular H-bonding. O H O C R these compounds compared to aldehydes and ketones of similar molecular weight. Acid chlorides, acid anhydrides, esters, and tertiary amides are polar, but lack a hydrogen atom capable of participating in hydrogen bonding. As a result, they have lower boiling points than carboxylic acids or alcohols of similar molecular weight, and similar boiling points to comparable aldehydes and ketones. Carboxylic acids are weak acids in aqueous solution (Topic G2), forming an equilibrium between the free acid and the carboxylate ion. In the presence of a base such as sodium hydroxide or sodium hydrogen carbonate, they ionize to form water-soluble salts and this provides a method of separating carboxylic acids from other organic compounds. Reactions Carboxylic acids and carboxylic acid derivatives commonly react with nucleophiles in a reaction known as nucleophilic substitution (Fig. 5). The reaction involves replacement of one nucleophile with another. Nucleophilic substitution is possible because the displaced nucleophile contains an electronegative heteroatom (Cl, O, or N) which is capable of stabilizing a negative charge. O C R Y Nu R O C Nu + Y Y=Cl, OCOR, OR, NR2 Carboxylic acid derivatives Fig. 5. Nucleophilic substitution. Spectroscopic analysis The presence of a carboxylic acid can be demonstrated by spectroscopy. The IR spectrum of an aliphatic carboxylic acid shows a very broad OH stretching 1 absorption covering the range 32002500 cm , as well as a strong absorption for 1 carbonyl stretching in the range 17251700 cm . Less obvious absorptions may be observed in the fingerprint region for OH bending and CO stretching 1 (13201220 cm ). If the carboxylic acid is conjugated to a double bond or an aromatic ring, the carbonyl absorption occurs at relatively lower wavenumbers (in 1 1 the ranges 17151690 and 17001680 cm respectively). The H nmr spectrum of a carboxylic acid will contain a singlet for the acidic proton at a high chemical shift 13 (915 ppm) which is D2O exchangeable, while the C nmr spectrum shows a quaternary signal for the carbonyl carbon (166181 ppm). In the mass spectrum, fragmentation ions may be observed due to loss of OH (M-17) as well as loss of + CO2H (M-45). A fragmentation ion due to [CO2H] may be present at m/e 45. Distinguishing a carboxylic acid derivative from a carboxylic acid is easy since 1 the H nmr spectrum of the former will lack a signal for the acidic proton. More- 208 Section K Carboxylic acids and carboxylic acid derivatives over, the characteristic broad OH stretching absorption will be absent from the IR spectrum. Distinguishing between different carboxylic acid derivatives is less straightforward, but it is still feasible. All the acid derivatives show a carbonyl stretching absorption in the IR spectrum. The position of this absorption can 1 indicate the group present (e.g. acid chloride 18151790 cm ; acid anhydride 1 1 1 18501710 cm ; ester 17501735 cm ; amide 17001630 cm ). Unfortunately, there is an overlap between the regions, which can sometimes make the assignment difcult. This problem is compounded if the functional group is conjugated to an aromatic ring or double bond since this lowers the possible frequency range and increases possible overlap. For example, the carbonyl absorption for an 1 aliphatic ester is in the range 17501735 cm , whereas the absorption range for an ,-unsaturated ester and an aromatic ester are both within the range 1730 1 1715 cm . For that reason, it is important to look at supporting evidence before assuming the presence of a particular functional group. For example, there are other characteristic absorptions in the IR spectrum that can help to distinguish one acid derivative from another. Acid anhydrides are distinctive in having two carbonyl absorptions and may also have two visible CO stretching absorptions in 1 the range 13001050 cm . Esters may also have two visible CO stretching absorptions in the same region but will only have one carbonyl absorption. Primary 1 and secondary amides have NH stretching absorptions (35003400 cm and 1 34603400 cm respectively) as well as NH bending absorptions (1640 1 1 1600 cm and 15701510 cm respectively). Tertiary amides naturally lack these absorptions. 13 The C nmr spectra for acid derivatives will contain a quaternary signal for the carbonyl carbon. For an aliphatic ester this appears at 169176 ppm while conjugated esters have a signal at lower chemical shift (164169 ppm). The carbonyl signal for acid anhydrides occurs in the range 163175 ppm. For amides it occurs at 162179 ppm, and for acid chlorides it is present at 167172 ppm. If a mass spectrum and elemental analysis have been taken, the molecular weight and molecular formula will be known. This can establish whether a particular acid derivative is present or not. For example, the lack of chlorine or nitrogen in the formula clearly rules out the possibility of an acid chloride or amide; the presence of only one oxygen rules out the possibility of an ester or acid anhydride. This may seem obvious but it is surprising how often this information is ignored when students attempt to interpret IR spectra. The chemical shifts of certain groups can give indirect evidence of particular 1 13 acid derivatives, both in the H and C nmr spectra. For example, the methyl 1 group of a methyl alkanoate appears at 3.7 ppm in the H spectrum and at 5152 ppm in the carbon spectrum. In contrast, the N-methyl group of an amide 1 13 occurs at 2.9 ppm ( H nmr) and 3139 ppm ( C nmr). Section K Carboxylic acids and carboxylic acid derivatives K2 NUCLEOPHILIC SUBSTITUTION Key Notes Denition Nucleophilic substitutions are reactions which involve the substitution of one nucleophile for another nucleophile. Alkyl halides, carboxylic acids, and carboxylic acid derivatives undergo nucleophilic substitution, but the mechanisms for alkyl halides are quite different from those of carboxylic acids and carboxylic acid derivatives. There are two steps in the nucleophilic substitution of a carboxylic acid derivative with a charged nucleophile. The rst step is the same as the rst step of nucleophilic addition to aldehydes and ketones. The second step involves reformation of the carbonyl group and expulsion of the leaving group. The mechanism of nucleophilic substitution with neutral nucleophiles is the same as the mechanism for charged nucleophiles, except that an extra step is required in order to remove a proton. Aldehydes and ketones undergo nucleophilic addition rather than nucleophilic substitution since the latter mechanism would require the cleavage of a strong CH or CC bond with the generation of a highly reactive hydride ion or carbanion. Organic structures (E4) Base strength (G3) Nucleophilic addition (J3) Preparation of carboxylic acid derivatives (K5) Reactions (K6) Nucleophilic substitution (L2) Mechanism charged nucleophiles Mechanism neutral nucleophiles Addition vs substitution Related topics Denition Nucleophilic substitutions are reactions which involve the substitution of one nucleophile for another. Alkyl halides, carboxylic acids, and carboxylic acid derivatives undergo nucleophilic substitution. However, the mechanisms involved for alkyl halides (Topic L2) are quite different from those involved for carboxylic acids and their derivatives. The reaction of a methoxide ion with ethanoyl chloride is an example of nucleophilic substitution (Fig. 1), where one nucleophile (the methoxide ion) substitutes another nucleophile (Cl ). Nucleophilic center O CH3 + C Cl OCH3 C CH3 O CH3 Electrophilic center O + Cl Fig. 1. Nucleophilic substitution. 210 Section K Carboxylic acids and carboxylic acid derivatives Mechanism charged nucleophiles We shall use the reaction in Fig. 1 to illustrate the mechanism of nucleophilic substitution (Fig. 2). The methoxide ion uses one of its lone pairs of electrons to form a bond to the electrophilic carbonyl carbon of the acid chloride. At the same time, the relatively weak bond of the carbonyl group breaks and both of the electrons move onto the carbonyl oxygen to give it a third lone pair of electrons and a negative charge. This is exactly the same rst step involved in nucleophilic addition to aldehydes and ketones. However, with an aldehyde or a ketone, the tetrahedral structure is the nal product. With carboxylic acid derivatives, the lone pair of electrons on oxygen returns to reform the carbonyl bond (Step 2). As this happens, the CCl bond breaks with both electrons moving onto the chlorine to form a chloride ion which departs the molecule. This explains how the products are formed, but why should the CCl bond break in preference to the COMe bond or the CCH3 bond? The best explanation for this involves looking at the leaving groups which would be formed from these processes (Fig. 3). The leaving groups would be a chloride ion, a methoxide ion and a carbanion, respectively. The chloride ion is the best leaving group because it is the most stable. This is because chlorine is more electronegative than oxygen or carbon and can stabilize the negative charge. This same mechanism is involved in the nucleophilic substitutions of all the other carboxylic acid derivatives and a general mechanism can be drawn (Fig. 4). O Step 1 C CH3 Cl CH3 O C O CH3 Intermediate Susceptible bonds Cl O Step 2 C CH3 O CH3 + Cl OCH3 Fig. 2. Mechanism of the nucleophilic substitution. a) Fig. 3. Cl b) O Me c) H3C Leaving groups; (a) chloride; (b) methoxide; (c) carbanion. O C CH3 Y CH3 O C Nu Y CH3 O C Nu + Y Nu Fig. 4. General mechanism for nucleophilic substitution. K2 Nucleophilic substitution 211 Mechanism neutral nucleophiles Acid chlorides are sufciently reactive to react with uncharged nucleophiles. For example, ethanoyl chloride will react with methanol to give an ester (Fig. 5). Oxygen is the nucleophilic center in methanol and uses one of its lone pairs of electrons to form a new bond to the electrophilic carbon of the acid chloride (Fig. 6). As this new bond forms, the carbonyl bond breaks and both electrons move onto the carbonyl oxygen to give it a third lone pair of electrons and a negative charge (Step 1). Note that the methanol oxygen gains a positive charge since it has effectively lost an electron by sharing its lone pair with carbon in the new bond. A positive charge on oxygen is not very stable and so the second stage in the mechanism is the loss of a proton. Both electrons in the OH bond move onto the oxygen to restore a second lone pair of electrons and thus neutralize the charge. Methanol can aid the process by acting as a base. The nal stage in the mechanism is the same as before. The carbonyl bond is reformed and as this happens, the CCl bond breaks with both electrons ending up on the departing chloride ion as a fourth lone pair of electrons. Finally, the chloride anion can remove a proton from CH3OH2 to form HCl and methanol (not shown). O HOCH3 C CH3 Fig. 5. Cl CH3 C O CH3 O + HCl Ethanoyl chloride reacting with methanol to form methyl ethanoate. O C CH3 Cl Step 1 CH3 O C O H CH3 Cl Step 2 CH3 O C O CH3 H Cl Step 3 CH3 O C O CH3 + Cl OCH3 H H OCH3 H OCH3 Fig. 6. Mechanism for the reaction of an alcohol with an acid chloride. The above mechanism is essentially the same mechanism involved in the reaction of ethanoyl chloride with sodium methoxide, the only difference being that we have to remove a proton during the reaction mechanism. The same mechanism holds true for nucleophilic substitutions of other carboxylic acid derivatives with neutral nucleophiles and we can write a general mechanism (Fig. 7). In practice, acids or bases are often added to improve yields. Specic examples are described in Topic K5. Addition vs substitution Carboxylic acids and carboxylic acid derivatives undergo nucleophilic substitution whereas aldehydes and ketones undergo nucleophilic addition. This is because nucleophilic substitution of a ketone or an aldehyde would generate a carbanion or a hydride ion respectively (Fig. 8). These ions are unstable and highly reactive, so they are only formed with difculty. Furthermore, CC and CH bonds are not easily broken. Therefore, nucleophilic substitutions of aldehydes or ketones are not feasible. 212 Section K Carboxylic acids and carboxylic acid derivatives O C CH3 Y CH3 O C Nu H Nu H Y -H+ CH3 O C Nu Y CH3 O C Nu + Y= Cl, OCOR, OR, NR2 Y Fig. 7. General mechanism for the nucleophilic substitution of a neutral nucleophile with a carboxylic acid derivative. O C CH3 R(H) CH3 O C Nu R(H) CH3 O C Nu + R (H) Carbanion (Hydride ion) Nu Fig. 8. Unfavorable formation of an unstable carbanion or hydride ion. Section K Carboxylic acids and carboxylic acid derivatives K3 REACTIVITY Key Notes Reactivity order Acid chlorides are more reactive than acid anhydrides towards nucleophilic substitution. Acid anhydrides are more reactive than esters, and esters are more reactive than amides. It is possible to convert a reactive acid derivative to a less reactive acid derivative, but not the other way round. The relative reactivity of the four different acid derivatives is determined by the relative electrophilicities of the carbonyl carbon atom. Neighboring electronegative atoms increase the electrophilicity of the carbonyl group through an inductive effect. The greater the electronegativity of the neighboring atom, the greater the effect. Chlorine is more electronegative than oxygen, and oxygen is more electronegative than nitrogen. Thus, acid chlorides are more reactive than acid anhydrides and esters, while amides are the least reactive of the acid derivatives. Resonance effects play a role in diminishing the electrophilic character of the carbonyl carbon. Neighboring atoms containing a lone pair of electrons can feed these electrons into the carbonyl center to form a resonance structure where the carbonyl bond is broken. This resonance is signicant in amines where nitrogen is a good nucleophile, but is insignicant in acid chlorides where chlorine is a poor nucleophile. Resonance involving oxygen is weak but signicant enough to explain the difference in reactivity between acid anhydrides and esters. Since the resonance in acid anhydrides is split between two carbonyl groups, the decrease in reactivity is less signicant than in esters. Bulky groups attached to the carbonyl group can hinder the approach of nucleophiles and result in lowered reactivity. Bulky nucleophiles will also react more slowly. Carboxylic acids are more likely to undergo acidbase reactions with nucleophiles rather than nucleophilic substitution. Nucleophilic substitution requires prior activation of the carboxylic acid. Nucleophilic substitution (K2) Preparations of carboxylic acid derivatives (K5) Reactions (K6) Electronic factors Steric factors Carboxylic acids Related topics Reactivity order Acid chlorides can be converted to acid anhydrides, esters, or amides (Topic K5). These reactions are possible because acid chlorides are the most reactive of the four carboxylic acid derivatives. Nucleophilic substitutions of the other acid derivatives are more limited because they are less reactive. For example, acid anhydrides can be used to synthesize esters and amides, but cannot be used to synthesize acid chlorides. The possible nucleophilic reactions for each carboxylic 214 Section K Carboxylic acids and carboxylic acid derivatives acid derivative depends on its reactivity with respect to the other acid derivatives (Fig. 1). Reactive acid derivatives can be converted to less reactive (more stable) acid derivatives, but not the other way round. For example, an ester can be converted to an amide, but not to an acid anhydride. O C R Cl R .. O C O O C R R O C OR' Ester R O C N R' Acid chloride (most reactive) Acid anhydride R'' Amide (least reactive) Fig. 1. Relative reactivity of carboxylic acid derivatives. Electronic factors But why is there this difference in reactivity? The rst step in the nucleophilic substitution mechanism (involving the addition of a nucleophile to the electrophilic carbonyl carbon) is the rate-determining step. Therefore, the more electrophilic this carbon is, the more reactive it will be. The nature of Y has a signicant effect in this respect (Fig. 2). Y is linked to the acyl group by an electronegative heteroatom (Cl, O, or N) which makes the carbonyl carbon more electrophilic. The extent to which this happens depends on the electronegativity of Y. If Y is strongly electronegative (e.g. chlorine), it has a strong electron-withdrawing effect on the carbonyl carbon making it more electrophilic and more reactive to nucleophiles. Since chlorine is more electronegative than oxygen, and oxygen is more electronegative than nitrogen, acid chlorides are more reactive than acid anhydrides and esters, while acid anhydrides and esters are more reactive than amides. The electron-withdrawing effect of Y on the carbonyl carbon is an inductive effect. With amides, there is an important resonance contribution which decreases the electrophilicity of the carbonyl carbon (Fig. 3). The nitrogen has a lone pair of electrons which can form a bond to the neighboring carbonyl carbon. As this new bond is formed, the weak bond breaks and both electrons move onto oxygen to give it a third lone pair of electrons and a negative charge. Since the nitrogens lone pair of electrons is being fed into the carbonyl group, the carbonyl carbon becomes less electrophilic and is less prone to attack by an incoming nucleophile. In theory, this resonance could also occur in acid chlorides, acid anhydrides, and esters to give resonance structures (Fig. 4). However, the process is much less important since oxygen and chlorine are less nucleophilic than nitrogen. In these structures, the positive charge ends up on an oxygen or a chlorine atom. These atoms are more electronegative than nitrogen and less able to stabilize a positive charge. These resonance structures might occur to a small extent with esters and acid anhydrides, but are far less likely in acid chlorides. This trend also matches the trend in reactivity. Electrophilic center H3C Fig. 2. Y= Cl, OCOR, OR, NR2 O C + Y The electrophilic center of a carboxylic acid derivative. K3 Reactivity 215 O C R N R'' Fig. 3. Resonance contribution in an amide. R' R O C N R'' R' a) R Fig. 4. O C Cl b) R O C O O C R c) R O C O R' Resonance structures for (a) an acid chloride; (b) an acid anhydride; (c) an ester. Although the resonance effect is weak in esters and acid anhydrides, it can explain why acid anhydrides are more reactive than esters. Acid anhydrides have two carbonyl groups and so resonance can take place with either carbonyl group (Fig. 5). As a result, the lone pair of the central oxygen is split between both groups which means that the resonance effect is split between both carbonyl groups. This means that the effect of resonance at any one carbonyl group is diminished and it will remain strongly electrophilic. With an ester, there is only one carbonyl group and so it experiences the full impact of the resonance effect. Therefore, its electrophilic strength will be diminished relative to an acid anhydride. O C R O O C R R O C O O C R R O C O O C R Fig. 5. Resonance structures for an acid anhydride. Steric factors Steric factors can play a part in the reactivity of acid derivatives. For example, a bulky group attached to the carbonyl group can hinder the approach of nucleophiles and hence lower reactivity. The steric bulk of the nucleophile can also have an inuence in slowing down the reaction. For example, acid chlorides react faster with primary alcohols than they do with secondary or tertiary alcohols. This allows selective esterication if a molecule has more than one alcohol group present (Fig. 6). O C OH Cl Ph Pyridine O HO O C Ph HO Fig. 6. Selective esterication of a primary alcohol. 216 Section K Carboxylic acids and carboxylic acid derivatives Carboxylic acids Where do carboxylic acids t into the reactivity order described above? The nucleophilic substitution of carboxylic acids is complicated by the fact that an acidic proton is present. Since most nucleophiles can act as bases, the reaction of a carboxylic acid with a nucleophile results in an acidbase reaction rather than nucleophilic substitution. However, carboxylic acids can undergo nucleophilic substitution if they are activated in advance (Topic K5). Section K Carboxylic acids and carboxylic acid derivatives K4 PREPARATIONS OF CARBOXYLIC ACIDS Key Notes Functional group transformations Primary alcohols and aldehydes are converted to carboxylic acids by oxidation. Acid chlorides, acid anhydrides, esters, and amides can be hydrolyzed to their parent carboxylic acids, but only the hydrolysis of esters serves a useful synthetic role if the ester is being used as a protecting group. Aromatic carboxylic acids are obtained by the oxidation of alkyl benzenes. Alkyl halides can be converted to carboxylic acids where the carbon chain has been extended by one carbon unit. Two methods are possible. The alkyl halide can be converted to a cyanide which is then hydrolyzed. Alternatively, the alkyl halide can be converted to a Grignard reagent then treated with carbon dioxide. A range of carboxylic acids can be prepared by alkylating diethyl malonate, then hydrolyzing and decarboxylating the product. Alkenes can be cleaved across the double bond by potassium permanganate. Carboxylic acids are formed if a vinylic proton is present. Oxidation and reduction (I7) Nucleophilic addition charged nucleophiles (J4) Reduction and oxidation (J10) Reactions (K6) Enolate reactions (K7) Reactions of alkyl halides (L6) Organometallic reactions (L7) Chemistry of nitriles (O4) CC bond formation Bond cleavage Related topics Functional group transformations Carboxylic acids can be obtained by the oxidation of primary alcohols or aldehydes (Topic J10), the hydrolysis of nitriles (Topic O4), or the hydrolysis of esters (Topic K6) which can be used as protecting groups for carboxylic acids. Amides can also be hydrolyzed to carboxylic acids. However, ercer reaction conditions are required due to the lower reactivity of amides and so amides are less useful as carboxylic acid protecting groups. Although acid chlorides and anhydrides are easily hydrolyzed to carboxylic acids, the reaction serves no synthetic purpose since acid chlorides and acid anhydrides are synthesized from carboxylic acids in the rst place. They are also too reactive to be used as protecting groups. Aromatic carboxylic acids can be obtained by oxidation of alkyl benzenes (Topic I7). It does not matter how large the alkyl group is, since they are all oxidized to a benzoic acid structure. There are two methods by which alkyl halides can be converted to a carboxylic acid and in both cases, the carbon chain is extended by one carbon. One method involves substituting the halogen with a cyanide ion (Topic L6) , then hydrolyzing the cyanide group (Topic O4; Fig. 1a). This works best with primary alkyl halides. The other method involves the formation of a Grignard reagent (Topic L7) which is then treated with carbon dioxide (Fig. 1b). CC bond formation 218 Section K Carboxylic acids and carboxylic acid derivatives a) R X NaCN R CN H3O R CO2H Alkyl halide b) R X Alkyl halide Mg / ether R MgX b)H3O Fig. 1. Synthetic routes from an alkyl halide to a carboxylic acid. a) CO2 R CO2H The mechanism for the Grignard reaction is similar to the nucleophilic addition of a Grignard reagent to an aldehyde or ketone (Topic J4; Fig. 2). MgX O XMg R C O Fig. 2. R C O O H3O R C O OH Mechanism for the Grignard reaction with carbon dioxide. A range of carboxylic acids can be prepared by alkylating diethyl malonate, then hydrolyzing and decarboxylating the product (Topic K7; Fig. 3). O C EtO H C O C OEt H NaOEt EtOH R-I EtO O C C H O C OEt R NaOEt EtOH R'-I EtO O C C R' O C OEt R H3O heat R' H C O C OH R Fig. 3. Synthesis of carboxylic acids from diethyl malonate. Bond cleavage Alkenes can be cleaved with potassium permanganate to produce carboxylic acids (Fig. 4). A vinylic proton has to be present, that is a proton directly attached to the double bond. HO a) KMnO4 / OH H b) H3O R C O O C OH R H C R Fig. 4. C R Synthesis of carboxylic acids from alkenes. Section K Carboxylic acids and carboxylic acid derivatives K5 PREPARATIONS OF CARBOXYLIC ACID DERIVATIVES Key Notes Acid chlorides Acid chlorides are synthesized by treating carboxylic acids with thionyl chloride, phosphorus trichloride, or oxalyl chloride. The carboxylic acid reacts with the reagent to release a chloride ion which then acts as a nucleophile with the reaction intermediate to form the acid chloride. Acid anhydrides are best prepared by treating acid chlorides with a carboxylate salt. Cyclic anhydrides can be synthesized from acyclic di-acids by heating. Esters are prepared by the nucleophilic substitution of acid chlorides or acid anhydrides with alcohols, the nucleophilic substitution of carboxylic acids with alcohol in the presence of a catalytic amount of mineral acid, the SN2 nucleophilic substitution of an alkyl halide with a carboxylate ion, and nally the reaction of carboxylic acids with diazomethane to give methyl esters. Acid chlorides can be converted to primary, secondary, and tertiary amides by reaction with ammonia, primary amines, and secondary amines, respectively. Acetic anhydride can be treated with amines to synthesize ethanamides. Carboxylic acids and amines react together to form a salt. Some salts can be converted to amides by strong heating to remove water. Nucleophilic substitution (K2) Reactions (K6) Acid anhydrides Esters Amides Related topics Acid chlorides Acid chlorides can be prepared from carboxylic acids using thionyl chloride (SOCl2), phosphorus trichloride (PCl3), or oxalyl chloride (ClCOCOCl Fig. 1). The mechanism for these reactions is quite involved, but in general involves the OH group of the carboxylic acid acting as a nucleophile to form a bond to the reagent and displacing a chloride ion. This has three important consequences. First of all, the chloride ion can attack the carbonyl group to introduce the required chlorine atom. Secondly, the acidic proton is no longer present and so an O C R Fig. 1. OH SOCl2 or PCl3 or ClCOCOCl R O C Cl Preparation of acid chlorides. 220 Section K Carboxylic acids and carboxylic acid derivatives acidbase reaction is prevented. Thirdly, the original OH group is converted into a good leaving group and is easily displaced once the chloride ion makes its attack. The reaction of a carboxylic acid with thionyl chloride follows the general pathway shown in Fig. 2. Good leaving group O SOCl2 C R OH R O C O O S Cl O + Cl R C Cl + HCl + SO2 (g) Fig. 2. Intermediate involved in the thionyl chloride reaction to form an acid chloride. The leaving group (SO2Cl) spontaneously fragments to produce hydrochloric acid and sulfur dioxide. The latter is lost as a gas which helps to drive the reaction to completion. The detailed mechanism is shown in Fig. 3. O S O C R O H R Cl Cl O C O H CI CI O S Cl HCl R O C O O S Cl R O C Cl O O S Cl O C H3C Cl O O C Cl H3C Cl + O S + SO2 (g) + Cl Fig. 3. Mechanism for the thionyl chloride reaction with a carboxylic acid to form an acid chloride. Acid anhydrides Acid anhydrides are best prepared by treating acid chlorides with a carboxylate salt (Topic K6). Carboxylic acids are not easily converted to acid anhydrides directly. However ve-membered and six-membered cyclic anhydrides can be synthesized from diacids by heating the acyclic structures to eliminate water (Fig. 4). O OH OH Heat H2O C O C O Succinic anhydride O C Succinic acid C O Fig. 4. Synthesis of cyclic acid anhydrides from acyclic di-acids. K5 Preparations of carboxylic acid derivatives 221 Esters There are many different ways in which esters can be synthesized. A very effective method is to react an acid chloride with an alcohol in the presence of pyridine (Topic K6). Acid anhydrides also react with alcohols to give esters, but are less reactive (Topic K6). Furthermore, the reaction is wasteful since half of the acyl content in the acid anhydride is wasted as the leaving group (i.e. the carboxylate ion). This is not a problem if the acid anhydride is cheap and readily available. For example, acetic anhydride is useful for the synthesis of a range of acetate esters (Fig. 5). O C H3C O I O C CH3 ROH H3C NaOH II O C O R O + O C CH3 Fig. 5. Synthesis of alkyl ethanoates (II) from acetic anhydride (I). A very common method of synthesizing simple esters is to treat a carboxylic acid with a simple alcohol in the presence of a catalytic amount of mineral acid (Fig. 6). The acid catalyst is required since there are two difcult steps in the reaction mechanism. First of all, the alcohol molecule is not a good nucleophile and so the carbonyl group has to be activated. Secondly, the OH group of the carboxylic acid is not a good leaving group and this has to be converted into a better leaving group. The mechanism (Fig. 7) is another example of nucleophilic substitution. In the rst step, the carbonyl oxygen forms a bond to the acidic proton. This results in the carbonyl oxygen gaining a positive charge. This makes the carbonyl carbon more electrophilic and activates it to react with the weakly nucleophilic alcohol. In the second step, the alcohol uses a lone pair of electrons to form a bond to the carbonyl carbon. At the same time, the carbonyl bond breaks and both electrons move onto the carbonyl oxygen to form a lone pair of electrons and thus neutralize the positive charge. Activation of the carbonyl group is important since the incoming alcohol gains an unfavorable positive charge during this step. In the third stage, a proton is transferred from the original alcohol portion to the OH group which we want to remove. By doing so, the latter moiety becomes a much better leaving group. Instead of a hydroxide ion, we can now remove a neutral water molecule. This is achieved in the fourth step where the carbonyl bond is reformed and the water molecule is expelled. O C R' Fig. 6. OH Esterication of a carboxylic acid. ROH / H3O R' O C O R All the steps in the reaction mechanism are in equilibrium and so it is important to use the alcohol in large excess (i.e. as solvent) in order to drive the equilibrium to products. This is only practical with cheap and readily available alcohols such as methanol and ethanol. On the other hand, if the carboxylic acid is cheap and readily available it could be used in large excess instead. An excellent method of preparing methyl esters is to treat carboxylic acids with diazomethane (Fig. 8). Good yields are obtained because nitrogen is formed as one 222 Section K Carboxylic acids and carboxylic acid derivatives H Carbonyl group activated H O OH Step 1 R C OH Step 2 R O H O H R' R' O C OH H H O C R O R' O H Better leaving group Step 5 O C R OR' H 3O H H H 2O Step 4 R O C O R' O H H O C R Proton transfer Step 3 Fig. 7. Mechanism for the acid-catalyzed esterication of a carboxylic acid. O C R Fig. 8. OH R CH 3 N 2 O C OCH3 + N2 (g) Synthesis of methyl esters using diazomethane. of the products and since it is lost from the reaction mixture, the reaction is driven to completion. However, diazomethane is an extremely hazardous chemical which can explode, and strict precautions are necessary when using it. Lastly, the carboxylic acid can be converted to a carboxylate ion and then treated with an alkyl halide (Fig. 9). The reaction involves the SN2 nucleophilic substitution of an alkyl halide (Topics L2 & L6) and so the reaction works best with primary alkyl halides. O NaOH C R Fig. 9. OH R C O Na R O R'I O C O R' Synthesis of an ester by nucleophilic substitution of an alkyl halide. Amides Amides can be prepared from acid chlorides by nucleophilic substitution (Topic K6). Treatment with ammonia gives a primary amide, treatment with a primary amine gives a secondary amide, and treatment with a secondary amine gives a tertiary amide. Tertiary amines cannot be used in this reaction because they do not give a stable product. Two equivalents of amine are required for the above reactions since one equivalent of the amine is used up in forming a salt with the hydrochloric acid which is produced in the reaction. This is clearly wasteful on the amine, especially if the amine is valuable. To avoid this, one equivalent of sodium hydroxide can be added to the reaction in order to neutralize the HCl. Amides can also be synthesized from acid anhydrides and esters (Topic K6), but in general these reactions offer no advantage over acid chlorides since acid K5 Preparations of carboxylic acid derivatives 223 anhydrides and esters are less reactive. Furthermore, with acid anhydrides, half of the parent carboxylic acid is lost as the leaving group. This is wasteful and so acid anhydrides are only used for the synthesis of amides if the acid anhydride is cheap and freely available (e.g. acetic anhydride). The synthesis of amides directly from carboxylic acids is not easy since the reaction of an amine with a carboxylic acid is a typical acidbase reaction resulting in the formation of a salt (Fig. 10). Some salts can be converted to an amide by heating strongly to expel water, but there are better methods available as previously described. O C R Fig. 10. OH Salt formation. R O C O H3N R" R" -NH2 Section K Carboxylic acids and carboxylic acid derivatives K6 REACTIONS Key Notes Acidbase reactions Carboxylic acids form water soluble carboxylate salts when treated with a base. Reactive acid derivatives can be converted to less reactive acid derivatives. Acid chlorides can be converted to acid anhydrides, esters, or amides; acid anhydrides can be converted to esters or amides; and esters can be converted to amides. Transesterication is also possible by dissolving an ester into an excess of alcohol in the presence of an acid catalyst. Acid chlorides and acid anhydrides are sufciently reactive to be hydrolyzed by water to their constituent carboxylic acids. Heating under basic or acidic conditions is preferable for the hydrolysis of less reactive esters and amides. The reaction is another example of nucleophilic substitution. Under neutral or acidic conditions, the nucleophile is water. Under basic conditions, the nucleophile is the hydroxide ion and the reaction is driven by the irreversible formation of the carboxylate ion. Amides can also be effectively hydrolyzed under acid conditions due to the formation of an ammonium salt. In contrast, the acid-catalyzed hydrolysis of esters is an equilibrium reaction. Aromatic rings can be treated with acid chlorides in the presence of a Lewis acid to give an aromatic ketone. Acid chlorides and esters react twice with Grignard reagents to form tertiary alcohols, with the introduction of two alkyl substituents. Carboxylic acids and Grignard reagents react together in an acidbase reaction which serves no synthetic value. Esters react with organolithium reagents to produce tertiary alcohols in a similar process to that described for Grignard reagents. Carboxylic acids have to be protected to prevent destruction of the organolithium reagent in an acidbase reaction. Acid chlorides can be treated with an organocuprate reagent to give ketones. The reaction mechanism is radical based and is not a nucleophilic substitution. Lithium aluminum hydride (LiAlH4) is used to convert carboxylic acids, acid chlorides, acid anhydrides, and esters to primary alcohols. Amides are reduced to amines. Hindered hydride reagents are less reactive and can be used to convert acid chlorides or esters to aldehydes. Borane can be used to reduce carboxylic acids to primary alcohols when nitro groups are present. Interconversion of acid derivatives Hydrolysis FriedelCrafts acylation Grignard reaction Organolithium reactions Organocuprate reactions Reduction K6 Reactions 225 Sodium borohydride does not reduce carboxylic acids or their derivatives and can be used to reduce aldehydes and ketones without affecting carboxylic acids or acid derivatives. Dehydration of primary amides Primary amides are dehydrated to nitriles on treatment with a dehydrating agent such as thionyl chloride. Acid strength (G2) Electrophilic substitutions of benzene (I3) Nucleophilic addition charged nucleophiles (J4) Reduction and oxidation (J10) Nucleophilic substition (K2) Preparations of carboxylic acid derivatives (K5) Related topics Acidbase reactions Since carboxylic acids have an acidic proton (CO2H), they form water soluble carboxylate salts on treatment with a base (e.g. sodium hydroxide or sodium bicarbonate, Topic G2; Fig. 1). O NaOH or C R Fig. 1. OH Salt formation. NaHCO3 R O C O Na Interconversion of acid derivatives Reactive acid derivatives can be converted to less reactive acid derivatives by nucleophilic substitution. This means that acid chlorides can be converted to acid anhydrides, esters, and amides (Fig. 2). Hydrochloric acid is released in these reactions and this may lead to side reactions. As a result, pyridine or sodium hydroxide may be added in order to mop up the hydrochloric acid (Fig. 3). O CH3CO2 Na H3C O C H3C Cl ROH Pyridine H3C O C O C O O C CH3 + HCl R + HCl 2 R2NH Pyridine or NaOH Fig. 2. H3C O C N R R + HCl Nucleophilic substitutions of an acid chloride. 226 Section K Carboxylic acids and carboxylic acid derivatives H N Cl H N Cl Fig. 3. Role of pyridine in mopping up protons. Acid anhydrides can be converted to esters and amides but not to acid chlorides (Fig. 4). Esters can be converted to amides but not to acid chlorides or acid anhydrides (Fig. 5). O C O C H3C O O C CH3 2 R2NH H3C O C N R Fig. 4. Nucleophilic substitutions of acid anhydrides. R O NaOH H3C O R O ROH + H O C CH3 + H O C CH3 O C H3C OR R2NH H3C O C N R R Fig. 5. Nucleophilic substitutions of an ester. Esters can also be converted by nucleophilic substitution from one type of ester to another a process called transesterication. For example, a methyl ester could be dissolved in ethanol in the presence of an acid catalyst and converted to an ethyl ester (Fig. 6). The reaction is an equilibrium reaction, but if the alcohol to be introduced is used as solvent, it is in large excess and the equilibrium is shifted to the desired ester. Furthermore, if the alcohol to be replaced has a low boiling point, it can be distilled from the reaction as it is substituted, thus shifting the equilibrium to the desired product. Amides are the least reactive of the acid derivatives and cannot be converted to acid chlorides, acid anhydrides, or esters. O C H3C Fig. 6. OMe EtOH / H H3C O C OEt Transesterication. K6 Reactions 227 Hydrolysis Reactive acid derivatives (i.e. acid chlorides and acid anhydrides) are hydrolyzed by water to give the constituent carboxylic acids (Fig. 7). The reaction is another example of nucleophilic substitution where water acts as the nucleophile. Hydrochloric acid is a byproduct from the hydrolysis of an acid chloride, so pyridine is often added to the reaction mixture to mop it up (Fig. 3). a) O H2O C H3C b) O C R Fig. 7. O Cl O H2O C R 2 R Pyridine H3C O C O O C O H H + HCl Hydrolysis of (a) an acid chloride; (b) an acid anhydride. Esters and amides are less reactive and so the hydrolysis requires more forcing conditions using aqueous sodium hydroxide or aqueous acid with heating (Fig. 8). a) O NaOH or H C R b) O C R Fig. 8. NR2 NaOH or H C H2O R OH O R' H2O R O C OH O + H O R' + NHR2 Hydrolysis of (a) esters; (b) amides. Under basic conditions, the hydroxide ion acts as the nucleophile by the normal mechanism for nucleophilic substitution (Topic K2). For example, the mechanism of hydrolysis of ethyl acetate is as shown (Fig. 9). However, the mechanism does not stop here. The carboxylic acid which is formed reacts with sodium hydroxide to form a water soluble carboxylate ion (Fig. 10a). Furthermore, the ethoxide ion which is lost from the molecule is a stronger base than water and undergoes protonation (Fig. 10b). The basic hydrolysis of an ester is also known as saponication and produces a water soluble carboxylate ion. O OEt O O CH3 OEt O H C CH3 .. C CH3 .. C O H + OEt OH Fig. 9. Mechanism of hydrolysis of ethyl ethanoate. 228 Section K Carboxylic acids and carboxylic acid derivatives a) HOH O OH O H O CH3 .. C CH3 b) .. C O OEt H O Fig. 10. H H O HOEt (a) Ionization of a carboxylic acid; (b) neutralization of the ethoxide ion. The same mechanism is involved in the basic hydrolysis of an amide and also results in a water soluble carboxylate ion. The leaving group from an amide is initially charged (i.e. R2N: ). However, this is a strong base and reacts with water to form a free amine plus a hydroxide ion. In the basic hydrolysis of esters and amides, the formation of a carboxylate ion is irreversible and so serves to drive the reaction to completion. In order to isolate the carboxylic acid rather than the salt, it is necessary to add acid (e.g. dilute HCl) to the aqueous solution. The acid protonates the carboxylate salt to give the carboxylic acid which (in most cases) is no longer soluble in aqueous solution and precipitates out as a solid or as an oil. H H O C H3C O Step 1 CH3 H3C O C O Step 2 H O H H H O H H O H3C Step 4 H C O O H Step 5 H3C CH3 -CH3OH O C O H Step 6 H CH3 H3C O C O H CH3 O Step 3 H H -H + H O H3C C O H O CH3 O C H3C O H H + H O H Fig. 11. Mechanism for the acid-catalyzed hydrolysis of an ester. The mechanism for acidcatalyzed hydrolysis (Fig. 11) involves water acting as a nucleophile. However, water is a poor nucleophile since it gains an unfavorable positive charge when it forms a bond. Therefore, the carbonyl group has to be activated which occurs when the carbonyl oxygen is protonated by the acid catalyst (Step 1). Nucleophilic attack by water is now favored since it neutralizes the unfavorable positive charge on the carbonyl oxygen (Step 2). The intermediate has a positive charge on the oxygen derived from water, but this is neutralized by losing the attached proton such that the oxygen gains the electrons in the OH K6 Reactions 229 bond (Step 3). Another protonation now takes place (Step 4). This is necessary in order to convert a poor leaving group (the methoxide ion) into a good leaving group (methanol). The bond can now be reformed (Step 5) with loss of methanol. Finally, water can act as a base to remove the proton from the carbonyl oxygen (Step 6). The acid-catalyzed hydrolysis of an ester is not as effective as basic hydrolysis since all the steps in the mechanism are reversible and there is no salt formation to pull the reaction through to products. Therefore, it is important to use an excess of water in order to shift the equilibria to the products. In contrast to esters, the hydrolysis of an amide in acid does result in the formation of an ion (Fig. 12). The leaving group here is an amine and since amines are basic, they will react with the acid to form a water soluble aminum ion. This is an irreversible step which pulls the equilibrium through to the products. H H O C H3C NHCH3 H3C O C NHCH3 H O H H H O H H O H3C C O H H NHCH3 H3C O C O H H3C H O C O H H H3C O -H C O H H H NHCH3 H + H O H3C C O NHCH3 + H O H + CH3NH2 H CH3NH3 Fig. 12. Hydrolysis of an amide under acidic conditions. In the acid-catalyzed hydrolysis of an ester, only a catalytic amount of acid is required since the protons used during the reaction mechanism are regenerated. However with an amide, at least one equivalent of acid is required due to the ionization of the amine. FriedelCrafts acylation Acid chlorides can react with aromatic rings in the presence of a Lewis acid to give aromatic ketones (Fig. 13). The reaction involves formation of an acylium ion from the acid chloride, followed by electrophilic substitution of the aromatic ring (Topic I3). O O C AlCl3 C Cl Fig. 13. CH3 CH3 + FriedelCrafts acylation. 230 Section K Carboxylic acids and carboxylic acid derivatives Grignard reaction Acid chlorides and esters react with two equivalents of a Grignard reagent (Topic L7) to produce a tertiary alcohol where two extra alkyl groups are provided by the Grignard reagent (Fig. 14). OH a) 2 RMgI C H3C R R b) H 3C O a) 2 RMgI C OR' b) H3O H 3C R OH C R a) H3C O C Cl b) H3O Fig. 14. Grignard reaction with (a) an acid chloride; and (b) an ester to produce a tertiary alcohol. There are two reactions involved in this process (Fig. 15). The acid chloride reacts with the rst equivalent of Grignard reagent in a typical nucleophilic substitution to produce an intermediate ketone. However, this ketone is also reactive to Grignard reagents and immediately reacts with a second equivalent of Grignard reagent by the nucleophilic addition mechanism described for aldehydes and ketones (Topic J4). H O C H3C Cl H3C O -Cl C R R R Cl H3C C R H3C C R R O O H3O H3C OH C R R Fig. 15. Mechanism of the Grignard reaction with an acid chloride. Carboxylic acids react with Grignard reagents in an acidbase reaction resulting in formation of the carboxylate ion and formation of an alkane from the Grignard reagent (Fig. 16). This has no synthetic use and it is important to protect carboxylic acids when carrying out Grignard reactions on another part of the molecule so that the Grignard reagent is not wasted. O C R O H R MgBr R O C O MgBr + H R Fig. 16. Acidbase reaction of a Grignard reagent with a carboxylic acid. Organolithium reactions Esters react with two equivalents of an organolithium reagent to give a tertiary alcohol where two of the alkyl groups are derived from the organolithium reagent (Fig. 17). The mechanism of the reaction is the same as that described in the Grignard reaction, that is, nucleophilic substitution to form a ketone followed by nucleophilic addition. It is necessary to protect any carboxylic acids present when carrying out organolithium reactions since one equivalent of the organolithium reagent would be wasted in an acidbase reaction with the carboxylic acid. K6 Reactions 231 O a) 2 RLi C H3C Fig. 17. OR' b) H3O H3C OH C R R Reaction of an ester with an organolithium reagent to form a tertiary alcohol. Organocuprate reactions Acid chlorides react with diorganocuprate reagents (Topic L7) to form ketones (Fig. 18). Like the Grignard reaction, an alkyl group displaces the chloride ion to produce a ketone. However, unlike the Grignard reaction, the reaction stops at the ketone stage. The mechanism is thought to be radical based rather than a nucleophilic substitution. This reaction does not take place with carboxylic acids, acid anhydrides, esters, or amides. O R2Cu Li C Cl H3C R O C H3C Fig. 18. Reaction of an acid chloride with a diorganocuprate reagent to produce a ketone. Reduction Carboxylic acids, acid chlorides, acid anhydrides and esters are reduced to primary alcohols on treatment with lithium aluminum hydride (LiAlH4 ; Fig. 19). The reaction involves nucleophilic substitution by a hydride ion to give an intermediate aldehyde. This cannot be isolated since the aldehyde immediately undergoes a nucleophilic addition reaction with another hydride ion (Topic J4; Fig. 20). The detailed mechanism is as shown in Fig. 21. O C R Y b) H3O R a) LiAlH4 H C OH H Y = OH, Cl, OCOR', OR' Fig.19. O C H3C OEt LiAlH4 Reduction of acid chlorides, acid anhydrides, and esters with lithium aluminum hydride. O LiAlH4 C H3C H Nucleophilic addition H3C H 1o Alcohol OH C H Nucleophilic substitution Fig. 20. Intermediate involved in the LiAlH4 reduction of an ester. H O C H3C OEt H3C O -EtO C H H OEt H3C O C H H3C O H3O C H H H H3C OH C H H Fig. 21. Mechanism for the LiAlH4 reduction of an ester to a primary alcohol. 232 Section K Carboxylic acids and carboxylic acid derivatives Amides differ from carboxylic acids and other acid derivatives in their reaction with LiAlH4 . Instead of forming primary alcohols, amides are reduced to amines (Fig. 22). The mechanism (Fig. 23) involves addition of the hydride ion to form an intermediate which is converted to an organoaluminum intermediate. The difference in this mechanism is the intervention of the nitrogens lone pair of electrons. These are fed into the electrophilic center to eliminate the oxygen which is then followed by the second hydride addition. O a) LiAlH4 C H3C Fig. 22. NR2 b) H3O H C H3C NR2 H Reduction of an amide to an amine. AlH3 O C H3C NR2 H3C C H H NR2 H3C C H NR2 -OAlH3 O O AlH3 NR2 H 3C C H H H3C NR2 C H H Fig. 23. Mechanism for the LiAlH4 reduction of an amide to an amine. Although acid chlorides and acid anhydrides are converted to tertiary alcohols with LiAlH4, there is little synthetic advantage in this since the same reaction can be achieved on the more readily available esters and carboxylic acids. However, since acid chlorides are more reactive than carboxylic acids, they can be treated with a milder hydride-reducing agent and this allows the synthesis of aldehydes (Fig. 24). The hydride reagent used (lithium tri-tert-butoxyaluminum hydride) contains three bulky alkoxy groups which lowers the reactivity of the remaining hydride ion. This means that the reaction stops after nucleophilic substitution with one hydride ion. Another sterically hindered hydride reagent diisobutylaluminum hydride (DIBAH) is used to reduce esters to aldehydes (Fig. 24). Normally low temperatures are needed to avoid over-reduction. O C H3C Cl b) H3O H3C a) LiAlH[OC(CH3)3]3 O C H a) AlH[CH2CH(CH3)2]2(DIBAH) b) H 3O H3C O C OEt Fig. 24. Reduction of an acid chloride and an ester to an aldehyde. Borane (B2H6) can be used as a reducing agent to convert carboxylic acids to primary alcohols. One advantage of using borane rather than LiAlH4 is the fact that the former does not reduce any nitro groups which might be present. LiAlH4 reduces a nitro group (NO2) to an amino group (NH2). It is worth noting that carboxylic acids and acid derivatives are not reduced by the milder reducing agent sodium borohydride (NaBH4). This reagent can therefore be used to reduce aldehydes and ketones without affecting any carboxylic acids or acid derivatives which might be present. K6 Reactions 233 Dehydration Primary amides are dehydrated to nitriles using a dehydrating agent such as of primary amides thionyl chloride (SOCl2), phosphorus pentoxide (P2O5), phosphoryl trichloride (POCl3), or acetic anhydride (Fig. 25). O SOCl2 C H3C Fig. 25. NH2 - H2O H3C C N Conversion of a primary amide to a nitrile. O S Cl Cl O S O C NH2 CH3 N H Base Cl H CH3 O C N H Base O S Cl CH3 C N + SO2 (g) + Cl O C CH3 Fig. 26. Mechanism for the dehydration of a primary amide to a nitrile. The mechanism for the dehydration of an amide with thionyl chloride is shown in Fig. 26. Although the reaction is the equivalent of a dehydration, the mechanism shows that water itself is not eliminated. The reaction is driven by the loss of sulfur dioxide as a gas. Section K Carboxylic acids and carboxylic acid derivatives K7 ENOLATE REACTIONS Key Notes Enolates Esters contain acidic protons which can be removed with a strong base to form enolate ions. A bulky base is used to prevent the possibility of nucleophilic substitution taking place. Diethyl malonate can be converted to a stable enolate ion using sodium ethoxide as base. Enolate ions can be alkylated with alkyl halides. Diethyl malonate can be alkylated twice, hydrolyzed, and decarboxylated to give a disubstituted ethanoic acid. Two esters can be condensed together to form a -ketoester. The reaction involves the formation of an enolate ion from one molecule of ester, which then undergoes nucleophilic substitution with another ester molecule. Mixed Claisen condensations are possible with two different esters or between an ester and a ketone. Enolates (G5) Reactions of enolate ions (J8) Nucleophilic substitution (L2) Alkylations Claisen condensation Related topics Enolates Enolate ions can be formed from aldehydes and ketones (Topic J8) containing protons on an -carbon. Enolate ions can also be formed from esters if they have protons on an -carbon (Fig. 1). Such protons are slightly acidic (Topic G5) and can be removed on treatment with a powerful base such as lithium diisopropylamide (LDA). LDA acts as a base rather than as a nucleophile since it is a bulky molecule and this prevents it attacking the carbonyl group in a nucleophilic substitution reaction. O R R H N(Pri)2 R C C OR R C O C OR + HN(Pri)2 Fig. 1. Enolate ion formation. Formation of enolate ions is easier if there are two esters anking the carbon since the proton will be more acidic. The acidic proton in diethyl malonate can K7 Enolate reactions 235 be removed with a weaker base than LDA (e.g. sodium ethoxide; Fig. 2). The enolate ion is more stable since the charge can be delocalized over both carbonyl groups. O C EtO H C H O C C R OR EtO O C C R O C OR O C OEt NaOEt EtOH O C EtO C R Fig. 2. O C OR EtO O C Formation of an enolate ion from diethyl malonate. Alkylations Enolate ions can be alkylated with alkyl halides through the SN2 nucleophilic substitution of an alkyl halide (Topic L2; Fig. 3). O R C R H Fig. 3. -Alkylation of an ester. C OR a) LDA / THF b) CH3I R C R CH3 O C OR Although simple esters can be converted to their enolate ions and alkylated, the use of a molecule such as diethyl malonate is far more effective. This is because the protons of diethyl malonate (pKa 1012) are more acidic than the protons of a simple ester such as ethyl acetate (pKa 25) and can be removed by a milder base. It is possible to predict the base required to carry out the deprotonation reaction by considering the pKa value of the conjugate acid for that base. If this pKa is higher than the pKa value of the ester, then the deprotonation reaction is possible. For example, the conjugate acid of the ethoxide ion is ethanol (pKa 16) and so any ester having a pKa less than 16 will be deprotonated by the ethoxide ion. Therefore, diethyl malonate is deprotonated but not ethyl acetate. A further point worth noting is that the ethoxide ion is strong enough to deprotonate the diethyl malonate quantitatively such that all the diethyl malonate is converted to the enolate ion. This prevents the possibility of any competing Claisen reaction (see below) since that reaction requires the presence of unaltered ester. Diethyl malonate can be converted quantitatively to its enolate with ethoxide ion, alkylated with an alkyl halide, treated with another equivalent of base, then alkylated with a second different alkyl halide (Fig. 4). Subsequent hydrolysis and decarboxylation of the diethyl ester results in the formation of the carboxylic acid. The decarboxylation mechanism (Fig. 5) is dependent on the presence of the other carbonyl group at the position. 236 Section K Carboxylic acids and carboxylic acid derivatives O C EtO H C O C OEt H O O C C R' R OH NaOEt / EtOH R-I EtO O C C H O C OEt R O NaOEt / EtOH R'-I EtO O C C R' O C OEt R H3O Heat HO C CO2 (g) H C R' C OH R Fig. 4. Alkylations of diethyl malonate. O C R R' C O H O C OH CO 2 (g) R' R H C C OH OH R' R C C OH O Fig. 5. Decarboxylation mechanism. The nal product can be viewed as a disubstituted ethanoic acid. In theory, this product could also be synthesized from ethyl ethanoate. However, the use of diethyl malonate is superior since the presence of two carbonyl groups allows easier formation of the intermediate enolate ions. Claisen condensation The Claisen reaction involves the condensation or linking of two ester molecules to form a -ketoester (Fig. 6). This reaction can be viewed as the ester equivalent of the Aldol reaction (Topic J8). The reaction involves the formation of an enolate ion from one ester molecule, which then undergoes nucleophilic substitution with a second ester molecule (Fig. 7, Step 1). The ethoxide ion which is formed in step 2 removes an proton from the ketoester in step 3 to form a stable enolate ion and this drives the reaction to completion. The nal product is isolated by protonating the enolate ion with acid. Two different esters can be used in the Claisen condensation as long as one of the esters has no protons and cannot form an enolate ion (Fig. 8). Diketones can be synthesized from the mixed Claisen condensation of a ketone with an ester (Fig. 9). Again, it is advisable to use an ester which cannot form an enolate ion to prevent competing Claisen condensations. In both these last two examples, a very strong base is used in the form of LDA such that the enolate ion is formed quantitatively (from ethyl acetate and acetone respectively). This prevents the possibility of self-Claisen condensation and limits the reaction to the crossed Claisen condensation. K7 Enolate reactions 237 O C H3C OEt O O a) NaOEt / EtOH OEt b) H3O H3C H C C O C OEt H + H3C C Fig. 6. Claisen condensation. O C H3C OEt O C C H H OEt H3C Step 1 O OEt C C H O Step 2 C OEt H H3C O C C H O Step 3 C OEt H H3C O C C H O C OEt OEt H OEt Fig. 7. O C Ph Mechanism of the Claisen condensation. O O a) LDA/THF OEt b) H3O Ph H C C H O C OEt + OEt H3C C Fig. 8. Claisen condensation of two different esters. O C Ph OEt O O a) LDA/THF CH3 b) H3O Ph H C C O C CH3 H + H3C C Fig. 9. Claisen condensation of a ketone with an ester. Section L Alkyl halides L1 PREPARATION AND PHYSICAL PROPERTIES OF ALKYL HALIDES Key Notes Preparation Alkenes are converted to alkyl halides by reaction with hydrogen halides. Treatment with halogens results in dihaloalkanes. Tertiary alcohols can be converted to alkyl halides on treatment with hydrogen halides, whereas primary and secondary alcohols are best converted by using thionyl chloride or phosphorus tribromide. Alkyl halides consist of an alkyl group linked to a halogen. The carbon 3 linked to the halogen is sp hybridized and tetrahedral. The carbonhalogen bond length increases and the bond strength decreases as the halogen increases in size. The Chalogen bond (CX) is a polar bond where the halogen is slightly negative and the carbon is slightly positive. Intermolecular bonding is by weak van der Waals interactions. Alkyl halides have a dipole moment. They are poorly soluble in water, but dissolve in organic solvents. They react as electrophiles at the carbon center. Alkyl halides undergo nucleophilic substitution reactions and elimination reactions. The presence of a halogen atom can be shown by IR spectroscopy (CX stretching absorptions) as well as by mass spectroscopy. The latter shows a characteristic pattern of peaks for the molecular ion that matches the number and ratio of naturally occurring isotopes of the halogen. Elemental analysis also demonstrates the presence of halogens. sp Hybridization (A3) Intermolecular bonding (C3) Properties and reactions (C4) Electrophilic addition to symmetrical alkenes (H3) 3 Structure Bonding Properties Reactions Spectroscopic analysis Related topics Reactions of alcohols (M4) Infra-red spectroscopy (P3) Proton nuclear magnetic resonance spectroscopy (P4) Mass spectroscopy (P6) Preparation Alkenes can be treated with hydrogen halides (HCl, HBr, and HI) or halogens (Cl2 and Br2) to give alkyl halides and dihaloalkanes respectively (Topic H3). An extremely useful method of preparing alkyl halides is to treat an alcohol with a hydrogen halide (HX HCl, HBr, or HI). The reaction works best for tertiary alcohols (Topic M4). Primary and secondary alcohols can be converted to alkyl halides more effectively by treating them with thionyl chloride (SOCl2) or 240 Section L Alkyl halides phosphorus tribromide (PBr3). The conditions are less acidic and less likely to cause acid-catalyzed rearrangements. Structure Alkyl halides consist of an alkyl group linked to a halogen atom (F, Cl, Br, or I) by 3 a single () bond. The carbon atom linked to the halogen atom is sp hybridized and has a tetrahedral geometry with bond angles of approximately 109 . The carbonhalogen bond length increases with the size of the halogen atom and this is associated with a decrease in bond strength. For example, CF bonds are shorter and stronger than CCl bonds. The carbonhalogen bond (referred to as CX from here on) is a bond. The bond is polar since the halogen atom is more electronegative than carbon, resulting in the halogen being slightly negative and the carbon being slightly positive. Intermolecular hydrogen bonding or ionic bonding is not possible between alkyl halide molecules and the major intermolecular bonding force consists of weak van der Waals interactions. The polar CX bond means that alkyl halides have a substantial dipole moment. Alkyl halides are poorly soluble in water, but are soluble in organic solvents. They have boiling points which are similar to alkanes of comparable molecular weight. The polarity also means that the carbon is an electrophilic center and the halogen is a nucleophilic center. Halogens are extremely weak nucleophilic centers and therefore, alkyl halides are more likely to react as electrophiles at the carbon center. The major reactions undergone by alkyl halides are (a) nucleophilic substitution where an attacking nucleophile replaces the halogen (Fig. 1a), and (b) elimination where the alkyl halide loses HX and is converted to an alkene (Fig. 1b). Bonding Properties Reactions R a) R R C X Nu R R C R R C R C R R Nu + X Nucleophilic substitution R b) H R C R C R X Base + H X Elimination Fig. 1. Reactions of alkyl halides. Spectroscopic analysis The IR spectra of alkyl halides usually show strong CX stretching absorptions. The position of these absorptions depends on the halogen involved i.e. the absorptions for CF, CCl, CBr and CI occur in the regions 14001000, 800600, 1 750500 and 500 cm respectively. The presence of a halogen can sometimes be implicated by the chemical shifts of neighboring groups in the nmr spectra. For example the chemical shifts in the 1 H nmr spectrum for CH2I, CH2Br and CH2Cl are 3.2, 3.5 and 3.6 respectively. Good evidence for the presence of a halogen comes from elemental analysis and L1 Preparation and physical properties 241 mass spectroscopy. In the latter, there are characteristic peak patterns associated with particular halogens as a result of the natural abundance of various isotopes. For example, bromine has two naturally occurring isotopes of 79 and 81 that occur in a ratio of 1 : 1. This means that two peaks of equal intensity will be present for any organic compound containing bromine. For example, the mass spectrum for ethyl bromide has two peaks of equal intensity at m/e 108 and 110 for the molec1 79 1 81 12 12 ular ions C2 H5 Br and C2 H5 Br respectively. 35 37 In contrast, chlorine occurs naturally as two isotopes ( Cl and Cl ) in the ratio 3 : 1. This means that the mass spectrum of a compound containing a chlorine atom will have two peaks for the molecular ion. These peaks will be two mass units apart with an intensity ratio of 3 : 1. Section L Alkyl halides L2 NUCLEOPHILIC SUBSTITUTION Key Notes Denition Nucleophilic substitution of an alkyl halide involves the substitution of the halogen atom with a different nucleophile. The halogen is lost as a halide ion. There are two types of mechanism for alkyl halides SN1 and SN2. The SN2 mechanism is a concerted process where the incoming nucleophile forms a bond to the reaction center at the same time as the CX bond is broken. The transition state involves the incoming nucleophile approaching from one side of the molecule and the outgoing halide departing from the other side. As a result, the reaction center is inverted during the process. The reaction is second order since the rate is dependent both on the alkyl halide and the incoming nucleophile. Primary and secondary alkyl halides can undergo the SN2 mechanism, but tertiary alkyl halides react only very slowly. The SN1 mechanism is a two-stage mechanism where the rst stage is the rate determining step. In the rst stage, the CX bond is broken and the halogen is lost as a halide ion. The remaining alkyl portion becomes a planar carbocation. Since the rst stage is the rate-determining step, the rate is dependent on the concentration of the alkyl halide alone. In the second stage of the mechanism, the incoming nucleophile can bond to either side of 3 the carbocation to regenerate an sp hybridized, tetrahedral center. The reaction is not stereospecic. Asymmetric alkyl halides will be fully or partially racemized during the reaction. sp Hybridization (A4) Congurational isomers optical isomers (D3) Charged species (E2) 2 SN2 Mechanism SN1 Mechanism Related topics Organic structures (E4) Nucleophilic substitution (K2) Elimination versus substitution (L5) Reactions of alcohols (M4) Denition The presence of a strongly electrophilic carbon center makes alkyl halides susceptible to nucleophilic attack whereby a nucleophile displaces the halogen as a nucleophilic halide ion (Fig. 1). The reaction is known as nucleophilic substitution and there are two types of mechanism the SN1 and SN2 mechanisms. Carboxylic acids and carboxylic acid derivatives also undergo nucleophilic substitutions (Topic K2), but the mechanisms are entirely different. Nu R X R Nucleophilic substitution. Nu + X Halide Fig. 1. L2 Nucleophilic substitution 243 SN2 Mechanism The reaction between methyl iodide and a hydroxide ion is an example of the SN2 mechanism (Fig. 2). The hydroxide ion is a nucleophile and uses one of its lone pair of electrons to form a new bond to the electrophilic carbon of the alkyl halide. At the same time, the CI bond breaks. Both electrons in that bond move onto the iodine to give it a fourth lone pair of electrons and a negative charge. Since iodine is electronegative, it can stabilize this charge, so the overall process is favored. In the transition state for this process (Fig. 3), the new bond from the incoming nucleophile is partially formed and the CX bond is partially broken. The reaction center itself (CH3) is planar. This transition state helps to explain several other features of the SN2 mechanism. First of all, both the alkyl halide and the nucleophile are required to form the transition state which means that the reaction rate is dependent on both components. Secondly, it can be seen that the hydroxide ion approaches iodomethane from one side while the iodide leaves from the opposite side. The hydroxide and the iodide ions are negatively charged and will repel each other, so it makes sense that they are as far apart as possible in the transition state. In addition, the hydroxide ion has to gain access to the reaction center the electrophilic carbon. There is more room to attack from the rear since the large iodine atom blocks approach from the other side. Lastly from an orbital point of view, it is proposed that the orbital from the incoming nucleophile starts to overlap with the empty antibonding orbital of the CX bond (Fig. 4). As this interaction increases, the bonding interaction between the carbon and the halogen decreases until a transition state is reached where the incoming and outgoing nucleophiles H I C H H Fig. 2. SN2 Mechanism for nucleophilic substitution. O H I H + C H H O H H I C H H Fig. 3. Bonding orbital H I H H H OH I H O H Transition state for SN2 nucleophilic substitution. Antibonding orbital H OH I Antibonding orbital H Bonding orbital OH H H Fig. 4. Orbital interactions in the SN2 mechanism. 244 Section L Alkyl halides are both partially bonded. The orbital geometry requires the nucleophiles to be on opposite sides of the molecule. A third interesting feature about this mechanism concerns the three substituents on the carbon. Both the iodide and the alcohol product are tetrahedral compounds with the three hydrogens forming an umbrella shape with the carbon (Fig. 5). However, the umbrella is pointing in a different direction in the alcohol product compared to the alkyl halide. This means that the umbrella has been turned inside out during the mechanism. In other words, the carbon center has been inverted. The transition state is the halfway house in this inversion. There is no way of telling whether inversion has taken place in a molecule such as iodomethane, but proof of this inversion can be obtained by looking at the nucleophilic substitution of asymmetric alkyl halides with the hydroxide ion (Fig. 6). Measuring the optical activity of both the alkyl halide and the alcohol allows the conguration of each enantiomer to be identied. This in turn demonstrates that inversion of the asymmetric center takes place. This inversion is known as the Walden Inversion and the mechanism is known as the SN2 mechanism. The SN stands for substitution nucleophilic. The 2 signies that the rate of reaction is second order or bimolecular and depends on both the concentration of the nucleophile and the concentration of the alkyl halide. The SN2 mechanism is possible for the nucleophilic substitutions of primary and secondary alkyl halides, but is difcult for tertiary alkyl halides. We can draw a general mechanism (Fig. 7) to account for a range of alkyl halides and charged nucleophiles. The mechanism is much the same with nucleophiles such as ammonia or amines the only difference being that a salt is formed and an extra step is required in order to gain the free H I C H H Umbrella shape (open end to right) Fig. 5. Asymmetric center Asymmetric center H I C CH2CH3 CH3 Fig. 6. Walden inversion of an asymmetric center. H X C R R Fig. 7. Nu X H + O H I + H CH3CH2 H3C C O H Walden inversion. + O H I + H C H H Umbrella shape (open end to left) O H + C R R Nu General mechanism for the SN2 nucleophilic substitution of alkyl halides. L2 Nucleophilic substitution 245 I H I C H CH2CH3 N H H H H CH3CH2 H H C N H H H H CH3CH2 O H H H C N H O H Fig. 8. SN2 mechanism for the reaction of 1-iodopropane with ammonia. amine. As an example, we shall consider the reaction between ammonia and 1-iodopropane (Fig. 8). Ammonias nitrogen atom is the nucleophilic center for this reaction and uses its lone pair of electrons to form a bond to the alkyl halide. As a result, the nitrogen will effectively lose an electron and will gain a positive charge. The CI bond is broken as previously described and an iodide ion is formed as a leaving group, which then acts as a counterion to the alkylammonium salt. The free amine can be obtained by reaction with sodium hydroxide. This neutralizes the amine to the free base which becomes insoluble in water and precipitates as a solid or as an oil. The reaction of ammonia with an alkyl halide is a nucleophilic substitution as far as the alkyl halide is concerned. However, the same reaction can be viewed as an alkylation from the ammonias point of view. This is because the ammonia has gained an alkyl group from the reaction. Primary alkyl halides undergo the SN2 reaction faster than secondary alkyl halides. Tertiary alkyl halides react extremely slowly if at all. SN1 Mechanism When an alkyl halide is dissolved in a protic solvent such as ethanol or water, it is exposed to a nonbasic nucleophile (i.e. the solvent molecule). Under these conditions, the order of reactivity to nucleophilic substitution changes dramatically from that observed in the SN2 reaction, such that tertiary alkyl halides are more reactive then secondary alkyl halides, with primary alkyl halides not reacting at all. Clearly a different mechanism must be involved. As an example, we shall consider the reaction of 2-iodo-2-methylpropane with water (Fig. 9). Here, the rate of reaction depends on the concentration of the alkyl halide alone and the concentration of the attacking nucleophile has no effect. Clearly, the nucleophile has to be present if the reaction is to take place, but it does not matter whether there is one equivalent of the nucleophile or an excess. Since the reaction rate only depends on the alkyl halide, the mechanism is known as the SNl reaction, where SN stands for substitution nucleophilic and the 1 shows that the reaction is rst order or unimolecular, that is, only one of the reactants affects the reaction rate. CH3 I C CH3 Fig. 9. CH3 H2O H O CH3 C CH3 CH3 Reaction of 2-iodo-2-methylpropane with water. 246 Section L Alkyl halides CH3 I C CH3 CH3 - I HO H CH3 C H3C CH3 HO H C CH3 CH3 CH3 HO C CH3 CH3 CH3 Fig. 10. SN1 Mechanism. CH3 CH3 HO C* CH(CH3)2 CH2CH3 + H3C I C* CH(CH3)2 CH2CH3 * CH(CH3)2 CH2CH3 C OH *= Asymmetric center Fig. 11. Racemization of an asymmetric center during SN1 nucleophilic substitution. There are two steps in the SN1 mechanism (Fig. 10). The rst step is the ratedetermining step and involves loss of the halide ion. The CI bond breaks with both electrons in the bond moving onto the iodine atom to give it a fourth lone pair of electrons and a negative charge. The alkyl portion becomes a planar carbocation where all three alkyl groups are as far apart from each other as possible. 2 The central carbon atom is now sp hybridized with an empty 2py orbital. In the second step, water acts as a nucleophile and reacts with the carbocation to form an alcohol. In the mechanism shown, we have shown the water molecule coming in from the left hand side, but since the carbocation is planar, the water can attack equally well from the right hand side. Since the incoming nucleophile can attack from either side of the carbocation, there is no overall inversion of the carbon center. This is signicant when the reaction is carried out on chiral molecules. For example, if a chiral alkyl halide reacts with water by the SN1 mechanism, both enantiomeric alcohols would be formed resulting in a racemate (Topic D3; Fig. 11). However, it has to be stated that total racemization does not usually occur in SN1 reactions. This is because the halide ion (departing from one side of the molecule) is still in the vicinity when the attacking nucleophile makes its approach. As a result the departing halide ion can hinder the approach of the attacking nucleophile from that particular side. The term stereospecic indicates that the mechanism results in one specic stereochemical outcome (e.g. the SN2 mechanism). This is distinct from a reaction which is stereoselective where the mechanism can lead to more than one stereochemical outcome, but where there is a preference for one outcome over another. Many SN1 reactions will show a slight stereoselectivity. Section L Alkyl halides L3 FACTORS AFFECTING SN2 VERSUS SN1 REACTIONS Key Notes SN1 versus SN2 The nature of the nucleophile, the solvent, and the alkyl halide determine whether nucleophilic substitution takes place by the SN1 or the SN2 mechanism. With polar aprotic solvents, primary alkyl halides react faster than secondary halides by the SN2 mechanism, whereas tertiary alkyl halides hardly react at all. With polar protic solvents and nonbasic nucleophiles, tertiary alkyl halides react faster than secondary alkyl halides by the SN1 mechanism, and primary halides do not react. The reactivity of primary, secondary, and tertiary alkyl halides is controlled by electronic and steric factors. Polar, aprotic solvents are used for SN2 reactions since they solvate cations but not anions. As a result, nucleophiles are naked and more reactive. Protic solvent such as water or alcohol are used in SN1 reactions since they solvate and stabilize the intermediate carbocation. The nucleophile is also solvated, but this has no effect on the reaction rate since the rate is dependent on the concentration of the alkyl halide. The rate of the SN2 reaction increases with the nucleophilic strength of the incoming nucleophile. The rate of the SN1 reaction is unaffected by the nature of the nucleophile. The reaction rates of both the SN1 and the SN2 reaction is increased if the leaving group is a stable ion and a weak base. Iodide is a better leaving group than bromide and bromide is a better leaving group than chloride. Alkyl uorides do not undergo nucleophilic substitution. Tertiary alkyl groups are less likely to react by the SN2 mechanism than primary or secondary alkyl halides since the presence of three alkyl groups linked to the reaction center lowers the electrophilicity of the alkyl halide by inductive effects. Tertiary alkyl halides have three bulky alkyl groups attached to the reaction center which act as steric shields and hinder the approach of nucleophiles. Primary alkyl halides only have one alkyl group attached to this center and so access is easier. Formation of a planar carbocation in the rst stage of the SN1 mechanism is favored for tertiary alkyl halides since it relieves the steric strain in the crowded tetrahedral alkyl halide. The carbocation is also more accessible to an incoming nucleophile. The formation of the carbocation is helped by electronic factors involving the inductive and hyperconjugation effects of the three neighboring alkyl groups. Such inductive and hyperconjugation effects are greater in carbocations formed from tertiary alkyl halides than from those formed from primary or secondary alkyl halides. Solvent Nucleophilicity Leaving group Alkyl halides SN2 Alkyl halides SN1 248 Section L Alkyl halides Determining the mechanism Measuring how the reaction rate is affected by the concentration of the alkyl halide and the nucleophile determines whether a nucleophilic substitution is SN2 or SN1. Measuring the optical activity of products from the nucleophilic substitution of asymmetric alkyl halides indicates the type of mechanism involved. A pure enantiomeric product indicates an SN2 reaction. A partially or fully racemized product indicates an SN1 reaction. Base strength (G3) Carbocation stabilization (H5) Nucleophilic substitution (L2) Related topics SN1 versus SN2 There are two different mechanisms involved in the nucleophilic substitution of alkyl halides. When polar aprotic solvents are used, the SN2 mechanism is preferred. Primary alkyl halides react more quickly than secondary alkyl halides, with tertiary alkyl halides hardly reacting at all. Under protic solvent conditions with nonbasic nucleophiles (e.g. dissolving the alkyl halide in water or alcohol), the SN1 mechanism is preferred and the order of reactivity is reversed. Tertiary alkyl halides are more reactive than secondary alkyl halides, and primary alkyl halides do not react at all. There are several factors which determine whether substitution will be SN1 or SN2 and which also control the rate at which these reactions take place. These include the nature of the nucleophile and the type of solvent used. The reactivity of primary, secondary, and tertiary alkyl halides is controlled by electronic and steric factors. The SN2 reaction works best in polar aprotic solvents (i.e. solvents with a high dipole moment, but with no OH or NH groups). These include solvents such as acetonitrile (CH3CN) or dimethylformamide (DMF). These solvents are polar enough to dissolve the ionic reagents required for nucleophilic substitution, but they do so by solvating the metal cation rather than the anion. Anions are solvated by hydrogen bonding and since the solvent is incapable of hydrogen bonding, the anions remain unsolvated. Such naked anions retain their nucleophilicity and react more strongly with electrophiles. Polar, protic solvents such as water or alcohols can also dissolve ionic reagents but they solvate both the metal cation and the anion. As a result, the anion is caged in by solvent molecules. This stabilizes the anion, makes it less nucleophilic and makes it less likely to react by the SN2 mechanism. As a result, the SN1 mechanism becomes more important. The SN1 mechanism is particularly favored when the polar protic solvent is also a nonbasic nucleophile. Therefore, it is most likely to occur when an alkyl halide is dissolved in water or alcohol. Protic solvents are bad for the SN2 mechanism since they solvate the nucleophile, but they are good for the SN1 mechanism. This is because polar protic solvents can solvate and stabilize the carbocation intermediate. If the carbocation is stabilized, the transition state leading to it will also be stabilized and this determines whether the SN1 reaction is favored or not. Protic solvents will also solvate the nucleophile by hydrogen bonding, but unlike the SN2 reaction, this does not affect the reaction rate since the rate of reaction is independent of the nucleophile. Solvent L3 Factors affecting SN2 versus SN1 reactions 249 Nonpolar solvents are of no use in either the SN1 or the SN2 reaction since they cannot dissolve the ionic reagents required for nucleophilic substitution. Nucleophilicity The relative nucleophilic strengths of incoming nucleophiles will affect the rate of the SN2 reaction with stronger nucleophiles reacting faster. A charged nucleophile is stronger than the corresponding uncharged nucleophile (e.g. alkoxide ions are stronger nucleophiles than alcohols). Nucleophilicity is also related to base HO RCO2 strength when the nucleophilic atom is the same (e.g. RO ROH H2O) (Topic G3). In polar aprotic solvents, the order of nucleophilic strength for the halides is F > Cl > Br > I . Since the rate of the SN1 reaction is independent of the incoming nucleophile, the nucleophilicity of the incoming nucleophile is unimportant. The nature of the leaving group is important to both the SN1 and SN2 reactions the better the leaving group, the faster the reaction. In the transition states of both reactions, the leaving group has gained a partial negative charge and the better that can be stabilized, the more stable the transition state and the faster the reaction. Therefore, the best leaving groups are the ones which form the most stable anions. This is also related to basicity in the sense that the more stable the anion, the weaker the base. Iodide and bromide ions are stable ions and weak bases, and prove to be good leaving groups. The chloride ion is less stable, more basic and a poorer leaving group. The uoride ion is a very poor leaving group and as a result alkyl uorides do not undergo nucleophilic substitution. The need for a stable leaving group explains why alcohols, ethers, and amines do not undergo nucleophilic substitutions since they would involve the loss of a strong base (e.g. RO or R2N ). There are two factors which affect the rate at which alkyl halides undergo the SN2 reaction electronic and steric. In order to illustrate why different alkyl halides react at different rates in the SN2 reaction, we shall compare a primary, secondary, and tertiary alkyl halide (Fig. 1). Alkyl groups have an inductive, electron-donating effect which tends to lower the electrophilicity of the neighboring carbon center. Lowering the electrophilic strength means that the reaction center will be less reactive to nucleophiles. Therefore, tertiary alkyl halides will be less likely to react with nucleophiles than primary alkyl halides, since the inductive effect of three alkyl groups is greater than one alkyl group. Steric factors also play a role in making the SN2 mechanism difcult for tertiary halides. An alkyl group is a bulky group compared to a hydrogen atom, and can therefore act like a shield against any incoming nucleophile (Fig. 2). A tertiary alkyl halide has three alkyl shields compared to the one alkyl shield of a primary alkyl halide. Therefore, a nucleophile is more likely to be deected when it approaches a tertiary alkyl halide and fails to reach the electrophilic center. Leaving group Alkyl halides SN2 a) I CH3 C + H H b) I CH3 + C H CH3 c) I + C CH3 CH3 CH3 Inductive effect Fig. 1. (a) Iodoethane; (b) 2-iodopropane; (c) 2-iodo-2-methylpropane. 250 Section L Alkyl halides CH3 I C H Primary alkyl halide. Electrophilic carbon is easily accessible. H Nu I C H CH3 CH3 Nu I C CH3 CH3 CH3 Tertiary alkyl halide. Electrophilic carbon is inaccessible. Nu Secondary alkyl halide. Electrophilic carbon is a 'bit of a squeeze'. Fig. 2. Steric factors affecting nucleophilic substitution. Alkyl halides SN1 Steric and electronic factors also play a role in the rate of the SN1 reaction. Since the steric bulk of three alkyl substituents makes it very difcult for a nucleophile to reach the electrophilic carbon center of tertiary alkyl halides, these structures undergo nucleophilic substitution by the SN1 mechanism instead. In this mechanism, the steric problem is relieved because loss of the halide ion creates a planar carbocation where the alkyl groups are much further apart and where the carbon center is more accessible. Formation of the carbocation also relieves steric strain between the substituents. Electronic factors also help in the formation of the carbocation since the positive charge can be stabilized by the inductive and hyperconjugative effects of the three alkyl groups (cf. Topic H5; Fig. 3). CH3 I C H3C Inductive effect stabilizes carbocation CH3 I C CH3 Fig. 3. Inductive effects stabilizing a carbocation. CH3 CH3 Both the inductive and hyperconjugation effects are greater when there are three alkyl groups connected to the carbocation center than when there are only one or two. Therefore, tertiary alkyl halides are far more likely to produce a stable carbocation intermediate than primary or secondary alkyl halides. It is important to realize that the reaction rate is determined by how well the transition state of the rate determining step is stabilized. In a situation like this where a high energy intermediate is formed (i.e. the carbocation), the transition state leading to it will be closer in character to the intermediate than the starting material. Therefore, any factor which stabilizes the intermediate carbocation also stabilizes the transition state and consequently increases the reaction rate. Determining the mechanism It is generally fair to say that the nucleophilic substitution of primary alkyl halides will take place via the SN2 mechanism, whereas nucleophilic substitution of tertiary alkyl halides will take place by the SNl mechanism. In general, secondary alkyl halides are more likely to react by the SN2 mechanism, but it is not possible to predict this with certainty. The only way to nd out for certain is to try out the reaction and see whether the reaction rate depends on the concentration of L3 Factors affecting SN2 versus SN1 reactions 251 both reactants (SN2) or whether it depends on the concentration of the alkyl halide alone (SNl). If the alkyl halide is chiral the optical rotation of the product could be measured to see whether it is a pure enantiomer or not. If it is, the mechanism is SN2. If not, it is SN1. Section L Alkyl halides L4 ELIMINATION Key Notes Denition Alkyl halides undergo elimination reactions with nucleophiles or bases, where hydrogen halide is lost from the molecule to produce an alkene. There are two commonly occurring mechanisms. The E2 mechanism is the most effective for the synthesis of alkenes from alkyl halides and can be used on primary, secondary, and tertiary alkyl halides. The E1 reaction is not particularly useful from a synthetic point of view and occurs in competition with the SN1 reaction. Tertiary alkyl halides and some secondary alkyl halides can react by this mechanism, but not primary alkyl halides. Elimination is possible if the alkyl halide contains a susceptible -proton which can be lost during the elimination reaction. -Protons are situated on the carbon linked to the carbon of the CX group. The E2 mechanism is a concerted, one-stage process involving both alkyl halide and nucleophile. The reaction is second order and depends on the concentration of both reactants. The E1 mechanism is a two-stage process involving loss of the halide ion to form a carbocation, followed by loss of the susceptible proton to form the alkene. The rate determining step is the rst stage involving loss of the halide ion. As a result, the reaction is rst order, depending on the concentration of the alkyl halide alone. The carbocation intermediate is stabilized by substituent alkyl groups. The E2 reaction is more useful than the E1 reaction in synthesizing alkenes. The use of a strong base in a protic solvent favors the E2 elimination over the E1 elimination. The E1 reaction occurs when tertiary alkyl halides are dissolved in protic solvents. Electrophilic addition to symmetrical alkenes (H3) Reactions of alcohols (M4) Susceptible -protons E2 Mechanism E1 Mechanism E2 versus E1 Related topics Denition Alkyl halides which have a proton attached to a neighboring -carbon atom can undergo an elimination reaction to produce an alkene plus a hydrogen halide (Fig. 1). In essence, this reaction is the reverse of the electrophilic addition of a hydrogen halide to an alkene (Topic H3). There are two mechanisms by which this elimination can take place the E2 mechanism and the E1 mechanism. The E2 reaction is the most effective for the synthesis of alkenes from alkyl halides and can be used on primary, secondary, and tertiary alkyl halides. The E1 reaction is not particularly useful from a synthetic point of view and occurs in L4 Elimination 253 R R C H Fig. 1. X C R R Nu R C R C R R + H X Elimination of an alkyl halide. competition with the SN1 reaction of tertiary alkyl halides. Primary and secondary alkyl halides do not usually react by this mechanism. Susceptible -protons An alkyl halide can undergo an elimination reaction if it has a susceptible proton situated on a -carbon, that is, the carbon next to the CX group. This proton is lost during the elimination reaction along with the halide ion. In some respects, there is a similarity here between alkyl halides and carbonyl compounds (Fig. 2). Alkyl halides can have susceptible protons at the -position whilst carbonyl compounds can have acidic protons at their -position. If we compare both structures, we can see that the acidic/susceptible proton is attached to a carbon neighboring an electrophilic carbon. The E2 mechanism is a concerted mechanism involving both the alkyl halide and the nucleophile. As a result, the reaction rate depends on the concentration of both reagents and is dened as second order (E2 Elimination second order). To illustrate the mechanism, we shall look at the reaction of 2-bromopropane with a hydroxide ion (Fig. 3). The mechanism (Fig. 4) involves the hydroxide ion forming a bond to the susceptible proton. As the hydroxide ion forms its bond, the CH bond breaks. Both electrons in that bond could move onto the carbon, but there is a neighboring electrophilic carbon which attracts the electrons and so the electrons move in to form a bond between the two carbons. At the same time as this bond is formed, the CBr bond breaks and both electrons end up on the bromine atom which is lost as a bromide ion. The E2 elimination is stereospecific, with elimination occurring in an antiperiplanar geometry. The diagrams (Fig. 5) show that the four atoms involved in the reaction are in a plane with the H and Br on opposite sides of the molecule. Alkyl halides X R R C H C + R Susceptible proton R X= Cl, Br, I E2 Mechanism Carbonyl group R R C H O C + R Acidic proton Fig. 2. H H H C C Br H CH3 + Comparison of a carbonyl compound and an alkyl halide. H O H H C C CH3 H + H O H + Br Fig. 3. Reaction of 2-bromopropane with the hydroxide ion. 254 Section L Alkyl halides H H C H Br + H C CH3 H H C H H C CH3 Br H O O H Fig. 4. E2 Elimination mechanism. Br H H H C H Circled atoms are in one plane Fig. 5. C H CH3 H3C H Antiperiplanar arrangement H H Br Relative geometry of the atoms involved in the E2 elimination mechanism. Br Br bond H H bond H H CH3 bond breaking H H Transition state H H H CH3 bond forming H H H Br bond breaking CH3 bond Fig. 6. Orbital diagram of the E2 elimination process. The reason for this stereospecicity can be explained using orbital diagrams (Fig. 6). In the transition state of this reaction, the CH and CBr bonds are in 3 the process of breaking. As they do so, the sp hybridized orbitals which were used for these bonds are changing into p orbitals which start to interact with each other to form the eventual bond. For all this to happen in the one transition state, an antiperiplanar arrangement is essential. E1 Mechanism The E1 mechanism usually occurs when an alkyl halide is dissolved in a protic solvent where the solvent can act as a nonbasic nucleophile. These are the same conditions for the SN1 reaction and so both these reactions usually occur at the L4 Elimination 255 H3C H H Fig. 7. C C CH3 I CH3 Elimination reaction of 2-iodo-2-methyl-butane. + HO Me H3C C H C CH3 + CH3 HI H3C H H CH3 C C CH3 I I H3C H H C C CH3 H3C C C H CH3 + CH3 H2OMe CH3 OMe H Fig. 8. The E1 mechanism. same time resulting in a mixture of products. As an example of the E1 mechanism, we shall look at the reaction of 2-iodo-2-methylbutane with methanol (Fig. 7). There are two stages to this mechanism (Fig. 8). The rst stage is exactly the same process described for the SN1 mechanism and that is cleavage of the CX bond to form a planar carbocation intermediate where the positive charge is stabilized by the three alkyl groups surrounding it. In the second stage, the methanol forms a bond to the susceptible proton on the -carbon. The CH bond breaks and both electrons are used to form a bond to the neighboring carbocation. The rst step of the reaction mechanism is the rate-determining step and since this is only dependent on the concentration of the alkyl halide, the reaction is rst order (El elimination rst order). There is no stereospecicity involved in this reaction and a mixture of isomers may be obtained with the more stable (more substituted) alkene being favored. E2 versus E1 The E2 elimination occurs with a strong base (such as a hydroxide or ethoxide ion) in a protic solvent (such as ethanol or water). The E2 reaction is more common than the E1 elimination and more useful. All types of alkyl halide can undergo the E2 elimination and the method is useful for preparing alkenes. The conditions which suit E1 are the same which suit the SN1 reaction (i.e. a protic solvent and a nonbasic nucleophile). Therefore, the E1 reaction normally only occurs with tertiary alkyl halides and will be in competition with the SN1 reaction. Section L Alkyl halides L5 ELIMINATION VERSUS SUBSTITUTION Key Notes Introduction The ratio of substitution and elimination products formed from alkyl halides depends on the reaction conditions as well as the nature of the nucleophile and the alkyl halide. Primary alkyl halides will usually undergo SN2 substitution reactions in preference to E2 elimination reactions. However, the E2 elimination reaction is favored if a strong bulky base is used with heating. Substitution by the SN2 mechanism is favored over the E2 elimination if the nucleophile is a weak base and the solvent is polar and aprotic. E2 elimination is favored over the SN2 reaction if a strong base is used in a protic solvent. Elimination is further favored by heating. SN1 and E1 reactions may be possible when dissolving secondary alkyl halides in protic solvents. E2 elimination occurs virtually exclusively if a tertiary alkyl halide is treated with a strong base in a protic solvent. Heating a tertiary alkyl halide in a protic solvent is likely to produce a mixture of SN1 substitution and E1 elimination products, with the former being favored. Base strength (G3) Nucleophilic substitution (L2) Factors affecting SN2 and SN1 reactions (L3) Elimination (L4) Primary alkyl halides Secondary alkyl halides Tertiary alkyl halides Related topics Introduction Alkyl halides can undergo both elimination and substitution reactions and it is not unusual to nd both substitution and elimination products present. The ratio of the products will depend on the reaction conditions, the nature of the nucleophile and the nature of the alkyl halide. Primary alkyl halides Primary alkyl halides undergo the SN2 reaction with a large range of nucleophiles (e.g. RS , I , CN , NH3, or Br ) in polar aprotic solvents such as hexamethylphosphoramide (HMPA; [(CH3)2N]3PO). However, there is always the possibility of some E2 elimination occurring as well. Nevertheless, substitution is usually favored over elimination, even when using strong bases such as HO or EtO . If E2 elimination of a primary halide is desired, it is best to use a strong bulky base such as tert-butoxide [(CH3)3CO ]. With a bulky base, the elimination product is favored over the substitution product since the bulky base experiences more steric hindrance in its approach to the electrophilic carbon than it does to the acidic -proton. Thus, treatment of a primary halide (Fig. 1) with an ethoxide ion is likely to give a mixture of an ether arising from SN2 substitution along with an alkene arising L5 Elimination versus substitution 257 H3C CH H3C Fig. 1. CH2 I NaOEt HMPA H3C CH H3C CH2 OCH2CH3 + H3C C H3C C H H Reaction of 1-iodo-2-methylpropane with sodium ethoxide. from E2 elimination, with the ether being favored. By using sodium tert-butoxide instead, the preferences would be reversed. Increasing the temperature of the reaction shifts the balance from the SN2 reaction to the elimination reaction. This is because the elimination reaction has a higher activation energy due to more bonds being broken. The SN1 and E1 reactions do not occur for primary alkyl halides. Secondary alkyl halides Secondary alkyl halides can undergo both SN2 and E2 reactions to give a mixture of products. However, the substitution product predominates if a polar aprotic solvent is used and the nucleophile is a weak base. Elimination will predominate if a strong base is used as the nucleophile in a polar, protic solvent. In this case, bulky bases are not so crucial and the use of ethoxide in ethanol will give more elimination product than substitution product. Increasing the temperature of the reaction favors E2 elimination over SN2 substitution as explained above. If weakly basic or nonbasic nucleophiles are used in protic solvents, elimination and substitution may occur by the SN1 and E1 mechanisms to give mixtures. Tertiary alkyl halides are essentially unreactive to strong nucleophiles in polar, aprotic solvents the conditions for the SN2 reaction. Tertiary alkyl halides can undergo E2 reactions when treated with a strong base in a protic solvent and will do so in good yield since the SN2 reaction is so highly disfavored. Under nonbasic conditions in a protic solvent, E1 elimination and SN1 substitution both take place. H3C H C H Fig. 2. CH3 C CH3 I MeOH H3C H C H CH3 C CH3 OMe + H H3C C C CH3 CH3 Tertiary alkyl halides OMe Reaction of 1-iodo-2-methylbutane with methoxide ion. A tertiary alkyl halide treated with sodium methoxide could give an ether or an alkene (Fig. 2). A protic solvent is used here and this favors both the SN1 and E1 mechanisms. However, a strong base is also being used and this favors the E2 mechanism. Therefore, the alkene would be expected to be the major product with only a very small amount of substitution product arising from the SN2 reaction. Heating the same alkyl halide in methanol alone means that the reaction is being carried out in a protic solvent with a nonbasic nucleophile (MeOH). These conditions would result in a mixture of substitution and elimination products arising from the SN1 and E1 mechanisms. The substitution product would be favored over the elimination product. Section L Alkyl halides L6 REACTIONS OF ALKYL HALIDES Key Notes Nucleophilic substitution Primary and secondary alkyl halides can be converted to a large variety of different functional groups such as alcohols, ethers, thiols, thioethers, esters, amines, azides, alkyl iodides, and alkyl chlorides. Larger carbon skeletons can be created by the reaction of alkyl halides with nitrile, acetylide, and enolate ions. Substitution reactions of tertiary alkyl halides are more difcult and less likely to give good yields. Elimination reactions of alkyl halides allow the synthesis of alkenes and are best carried out using a strong base in a protic solvent with heating. Primary, secondary, and tertiary alkyl halides can all be used. However, the use of a bulky base is advisable for primary alkyl halides. The most substituted alkene is favored if there are several possible alkene products. Nucleophilic substitution (L2) Elimination (L4) Eliminations Related topics Nucleophilic substitution The nucleophilic substitution of alkyl halides is one of the most powerful methods of obtaining a wide variety of different functional groups. Therefore, it is possible to convert a variety of primary and secondary alkyl halides to alcohols, ethers, thiols, thioethers, esters, amines, and azides (Fig. 1). Alkyl iodides and alkyl chlorides can also be synthesized from other alkyl halides. It is also possible to construct larger carbon skeletons using alkyl halides. A simple example is the reaction of an alkyl halide with a cyanide ion (Fig. 2). This is an NaOH R X R OH R X Alcohol SH R X R SH Thiol N3 R X R N3 Azide R X NaOR" R OR" Ether I R X R I Iodide R"CO2Na R OCOR" Ester R X R X SR R SR" Thioether Cl R Cl Chloride a) R"NH2 R X b) HO R NHR" Amine Fig. 1. Nucleophilic substitutions of alkyl halides. NaCN R X Nitrile R CN H3O R CO2H Fig. 2. Constructing larger carbon skeletons from an alkyl halide. L6 Reactions of alkyl halides 259 O R" a) R X R" Na CC R' R C C R' b) R X R" R" R" R Fig. 3. (a) Synthesis of a disubstituted alkyne; (b) alkylation of an enolate ion. R" O important reaction since the nitrile product can be hydrolyzed to give a carboxylic acid (Topic O3). The reaction of an acetylide ion with a primary alkyl halide allows the synthesis of disubstituted alkynes (Fig. 3a). The enolate ions of esters or ketones can also be alkylated with alkyl halides to create larger carbon skeletons (Fig. 3b; Topics K7 and J9). The most successful nucleophilic substitutions are with primary alkyl halides. With secondary and tertiary alkyl halides, the elimination reaction may compete, especially when the nucleophile is a strong base. The substitution of tertiary alkyl halides is best done in a protic solvent with weakly basic nucleophiles. However, yields may be poor. Eliminations Elimination reactions of alkyl halides (dehydrohalogenations) are a useful method of synthesizing alkenes. For best results, a strong base (e.g. NaOEt) should be used in a protic solvent (EtOH) with a secondary or tertiary alkyl halide. The reaction proceeds by an E2 mechanism. Heating increases the chances of elimination over substitution. t For primary alkyl halides, a strong, bulky base (e.g. NaOBu ) should be used. The bulk hinders the possibility of the SN2 substitution and encourages elimination by the E2 mechanism. The advantage of the E2 mechanism is that it is higher yielding than the E1 mechanism and is also stereospecic. The geometry of the product obtained is determined by the antiperiplanar geometry of the transition state. For example, the elimination in Fig. 4 gives the E-isomer and none of the Z-isomer. Br H3C Ph Ph C H CH3 CH3O H3C Ph C C Ph CH3 Br Ph CH3 H3C H3C H Fig. 4. Stereochemistry of the E2 elimination reaction. Ph Ph CH3 Ph 260 Section L Alkyl halides CH3 NaOEt CH3CH2 C Br CH3 EtOH H3C C H 69% C CH3 + CH3 H3C C CH3CH2 31% C H H Fig. 5. Example of Zaitsevs rule. If the elimination occurs by the E1 mechanism, the reaction is more likely to compete with the SN1 reaction and a mixture of substitution and elimination products is likely. The E2 elimination requires the presence of a -proton. If there are several options available, a mixture of alkenes will be obtained, but the favored alkene will be the most substituted (and most stable) one (Zaitsevs rule; Fig. 5). The transition state for the reaction resembles the product more than the reactant and so the factors which stabilize the product also stabilize the transition state and make that particular route more likely (see Topic L4). However, the opposite preference is found when potassium tert-butoxide is used as base, and the less substituted alkene is favored. Section L Alkyl halides L7 ORGANOMETALLIC REACTIONS Key Notes Grignard reagents Alkyl halides are converted to Grignard reagents by treating them with magnesium metal in dry ether. The magnesium is bonded between the carbon and the halogen of the original CX bond and converts the carbon from an electrophilic center to a nucleophilic center. Grignard reagents react as if they were the equivalent of carbanions. Grignard reagents are particularly useful in the synthesis of larger carbon skeletons and are used in the synthesis of alcohols, ketones, and carboxylic acids. Alkyl halides are converted to organolithium reagents by treatment with lithium metal in an alkane solvent. They react similarly to Grignard reagents. Alkyl halides can be converted to organolithium reagents which can then be converted to organocuprate reagents. These reagents are useful in conjugate additions to ,-unsaturated carbonyls and for linking alkyl halides. Nucleophilic addition charged nucleophiles (J4) ,-Unsaturated aldehydes and ketones (J11) Reactions (K6) Reactions of ethers, epoxides and thioethers (N3) Chemistry of nitriles (O4) Organolithium reagents Organocuprate reagents Related topics Grignard reagents Alkyl halides of all types (1 , 2 and 3 ) react with magnesium in dry ether to form Grignard reagents, where the magnesium is inserted between the halogen and the alkyl chain (Fig. 1). These reagents are extremely useful in organic synthesis and can be used in a wide variety of reactions. Their reactivity reects the polarity of the atoms present. Since magnesium is a metal it is electropositive, which means that the electrons in the CMg bond spend more of their time closer to the carbon making it slightly negative and a nucleophilic center. This reverses the character of this carbon since it is an electrophilic center in the original alkyl halide (Topic E4). In essence, a Grignard reagent can be viewed as providing the equivalent of a carbanion. The carbanion is not a distinct species, but the reactions which take place can be explained as if it was. + Mg X + H3C X Mg Ether H3C H3C 'Carbanion' Electrophilic center Fig. 1. Formation of a Grignard reagent (X Cl, Br, I). Nucleophilic center 262 Section L Alkyl halides Mg R Fig. 2. X R MgX H2O or ROH or RCO2H or RNH2 R H Conversion of a Grignard reagent to an alkane. A Grignard reagent can react as a base with water to form an alkane. This is one way of converting an alkyl halide to an alkane. The same acidbase reaction can take place with a variety of proton donors (Brnsted acids) including functional groups such as alcohols, carboxylic acids, and amines (Fig. 2). This can prove a disadvantage if the Grignard reagent is intended to react at some other site on the target molecule. In such cases, functional groups containing an XH bond (where X a heteroatom) would have to be protected before the Grignard reaction is carried out. The reactions of Grignard reagents have been covered elsewhere and include reaction with aldehydes and ketones to give alcohols (Topic J4), reaction with acid chlorides and esters to give tertiary alcohols (Topic K6), reaction with carbon dioxide to give carboxylic acids (Topic K4), reaction with nitriles to give ketones (Topic O4), and reaction with epoxides to give alcohols (Topic N3). Organolithium reagents Alkyl halides can be converted to organolithium reagents using lithium metal in an alkane solvent (Fig. 3). Organolithium reagents react similarly to Grignard reagents. For example, reaction with aldehydes and ketones results in nucleophilic addition to give secondary and tertiary alcohols respectively (Topic K6). Li R Fig. 3. X Pentane R Li Formation of organolithium reagents. CuI 2 Li CH3 Li+ (Me2Cu) Fig. 4. Formation of organocuprate reagents. + R"2Cu Li R Fig. 5. X R R" X= Br, I Reaction of an organocuprate reagent with an alkyl halide. Organocuprate reagents Organocuprate reagents (another source of carbanion equivalents) are prepared by the reaction of one equivalent of cuprous iodide with two equivalents of an organolithium reagent (Fig. 4). These reagents are useful in the 1,4-addition of alkyl groups to ,-unsaturated carbonyl systems (Topic J11) and can also be reacted with alkyl halides to produce larger alkanes (Fig. 5). The mechanism is thought to be radical based. Section M Alcohols, phenols, and thiols M1 PREPARATION OF ALCOHOLS Key Notes Functional group transformation CC bond formation Functional groups such as alkyl halides, carboxylic acids, esters, alkenes, aldehydes, ketones, and ethers can be transformed into alcohols. Alcohols can be formed from epoxides, aldehydes, ketones, esters, and acid chlorides as a consequence of CC bond formation with Grignard or organolithium reagents. Electrophilic addition to symmetrical alkenes (H3) Hydroboration of alkenes (H7) Nucleophilic addition charged nucleophiles (J4) Reactions (K6) Reactions of alkyl halides (L6) Reactions of ethers, epoxides and thioethers (N3) Related topics Functional group transformation Alcohols can be synthesized by nucleophilic substitution of alkyl halides (Topic L6), hydrolysis of esters (Topic K6), reduction of carboxylic acids or esters (Topic K6), reduction of aldehydes or ketones (Topic J4), electrophilic addition of alkenes (Topic H3), hydroboration of alkenes (Topic H7), or substitution of ethers (Topic N3). Alcohols can also be formed from epoxides (Topic N3), aldehydes (Topics J4 and H10), ketones (Topics J4 and H10), esters (Topic K6), and acid chlorides (Topic K6) as a consequence of CC bond formation. These reactions involve the addition of carbanion equivalents through the use of Grignard or organolithium reagents and are described in detail elsewhere in the text. CC bond formation Section M Alcohols, phenols, and thiols M2 PREPARATION OF PHENOLS Key Notes Incorporation A phenol group can be incorporated into an aromatic ring by sulfonation, followed by conversion of the sulfonic acid group into the phenol by heating in strong base. The reaction is limited to alkyl substituted phenols. Alternatively, the aromatic ring can be nitrated and the nitro group reduced to an aniline, which is then converted to a diazonium salt and hydrolyzed. Although longer, the method is more general and a wider variety of substituents is tolerated. Phenyl esters can be hydrolyzed to their constituent carboxylic acid and phenol. Aryl ethers are cleaved by heating with HI or HBr to give an alkyl halide and a phenol. Synthesis of mono-substituted benzenes (I4) Reactions (K6) Reactions of ethers, epoxides, and thioethers (N3) Reactions of amines (O3) Functional group transformations Related topics Incorporation Phenol groups can be incorporated into an aromatic ring by sulfonation of the aromatic ring (Topic I4) followed by melting the product with sodium hydroxide to convert the sulfonic acid group to a phenol (Fig. 1). The reaction conditions are harsh and only alkyl-substituted phenols can be prepared by this method. A more general method of synthesizing phenols is to hydrolyze a diazonium salt (Topic O3), prepared from an aniline group (NH2) (Topic I4; Fig. 2). SO3H SO3 H2SO4 a) NaOH b) H3O CH3 Fig. 1. CH3 Synthesis of a phenol via sulfonation. CH3 OH NO2 H2NO3 H2SO4 Sn HCl NH2 HNO2 H2SO4 N2 HSO4 H3O OH Fig. 2. Synthesis of a phenol via a diazonium salt. M2 Preparation of phenols 265 a) O C O HO2C Fig. 3. R R H3O or NaOH OH b) Conc. HX heat O R X R Functional group transformations to a phenol. Functional group transformation Various functional groups can be converted to phenols. Sulfonic acids and amino groups have already been mentioned. Phenyl esters can be hydrolyzed as described in Topic K6 (Fig. 3a). Aryl ethers can be cleaved as described in Topic N3 (Fig. 3b). The bond between the alkyl group and oxygen is specically cleaved since the ArOH bond is too strong to be cleaved. Section M Alcohols, phenols and thiols M3 PROPERTIES OF ALCOHOLS AND PHENOLS Key Notes Alcohols The carbon and oxygen atoms of the alcohol group are sp hybridized such that the COH bond angle is approximately 109 . Hydrogen bonding means that alcohols have higher boiling points than comparable alkanes. Alcohols of low molecular weight are soluble in water and can act as weak acids and weak bases. Alcohols are polar. The oxygen atom is a nucleophilic center while the neighboring carbon and hydrogen are weak electrophilic centers. Alcohols will not react with nucleophiles, but will react with strong bases in an acidbase reaction to form an alkoxide ion. An alcohols CO bond can be split if the hydroxyl group is converted into a better leaving group. Phenols have an OH group directly linked to an aromatic ring. The oxygen 3 2 is sp hybridized and the aryl carbon is sp hybridized. Phenols are polar compounds which are capable of intermolecular hydrogen bonding such that phenols have higher boiling points than nonphenolic aromatic structures of comparable molecular weight. Hydrogen bonding also permits moderate water solubility and phenols act as weak acids in aqueous solution. Phenols are stronger acids than alcohols but weaker acids than carboxylic acids. They are soluble as their phenoxide salts in sodium hydroxide solution, but insoluble in sodium hydrogen carbonate solution. Alcohols and phenols can be identied by the presence of an OH stretching absorption in the IR spectrum as well as a D2O exchangeable OH signal 1 in the H nmr spectrum. Further evidence can be obtained from the IR spectrum if absorptions due to OH bending and CO stretching are identiable. In nmr spectra, the chemical shifts of neighboring groups give indirect evidence of an OH group. The molecular ion is often absent from the mass spectrum due to rapid dehydration. sp Hybridization (A3) 2 sp Hybridization (A4) Intermolecular bonding (C3) Properties and reactions (C4) Organic structures (E4) Acid strength (G2) Base strength (G3) 3 3 Phenols Spectroscopic analysis of alcohols and phenols Related topics Reactions of alcohols (M4) Infra-red spectroscopy (P3) Proton nuclear magnetic resonance spectroscopy (P4) 13 C nuclear magnetic resonance spectroscopy (P5) Mass spectroscopy (P6) Alcohols The alcohol functional group (R3COH) has the same geometry as water, with a 3 COH bond angle of approximately 109 . Both the carbon and the oxygen are sp M3 Properties of alcohols and phenols 267 hybridized. The presence of the OH group means that intermolecular hydrogen bonding is possible which accounts for the higher boiling points of alcohols compared with alkanes of similar molecular weight. Hydrogen bonding also means that alcohols are more soluble in protic solvents than alkanes of similar molecular weight. In fact, the smaller alcohols (methanol, ethanol, propanol, and tert-butanol) are completely miscible in water. With larger alcohols, the hydrophobic character of the bigger alkyl chain takes precedence over the polar alcohol group and so larger alcohols are insoluble in water. The OH and CO bonds are both polarized due to the electronegative oxygen, such that oxygen is slightly negative and the carbon and hydrogen atoms are slightly positive. This means that the oxygen serves as a nucleophilic center while the hydrogen and the carbon atoms serve as weak electrophilic centers (Topic E4; Fig. 1). O R R Fig. 1. C+ R + H R R C R O Nucleophilic center Electrophilic / acidic center H Weak electrophilic center Bond polarization and nucleophilic and electrophilic centers. Due to the presence of the nucleophilic oxygen and electrophilic proton, alcohols can act both as weak acids and as weak bases when dissolved in water (Fig. 2). However, the equilibria in both cases is virtually completely weighted to the unionized form. Alcohols will commonly react with stronger electrophiles than water. However, they are less likely to react with nucleophiles unless the latter are also strong bases, in which case the acidic proton is abstracted to form an alkoxide ion (RO ; Fig. 3). Alkoxide ions are extremely useful reagents in organic synthesis. However, O O H O CH3CH2 Weak base H CH3CH2 Strong acid O H CH3CH2 Weak acid H O H H H H O H CH3CH2 Strong base H O H O H Fig. 2. Acidbase properties of alcohols. O R R C R H Nu Strong base Acidbase reaction R O + H Nu Alkoxide ion Fig. 3. Formation of an alkoxide ion. 268 Section M Alcohols, phenols, and thiols they cannot be used if water is the solvent since the alkoxide ion would act as a base and abstract a proton from water to regenerate the alcohol. Therefore, an alcohol would have to be used as solvent instead of water. Nucleophiles which are also strong bases react with the electrophilic hydrogen of an alcohol rather than the electrophilic carbon. Nucleophilic attack at carbon would require the loss of a hydroxide ion in a nucleophilic substitution reaction (Topic L2). However, this is not favored since the hydroxide ion is a strong base and a poor leaving group (Fig. 4). Nevertheless, reactions which involve the cleavage of an alcohols CO bond are possible if the alcohol is rst activated such that the hydroxyl group is converted into a better leaving group (Topic M4; Fig. 5). One method is to react the alcohol under acidic conditions such that the hydroxyl group is protonated before the nucleophile makes its attack (Fig. 5a). Cleavage of the CO bond would then be more likely since the leaving group would be a neutral water molecule, which is a much better leaving group. Alternatively, the alcohol can be treated with an electrophilic reagent to convert the OH group into a different group (OY) which can then act as a better leaving group (Fig. 5b). In both cases, the alcohol must rst act as a nucleophile, with the oxygen atom acting as the nucleophilic center. The intermediate formed can then react more readily as an electrophile at the carbon center. O R R Fig. 4. C R H SN 2 reaction Nu R R C Nu + R OH Poor leaving group Nucleophilic substitution of alcohols is not favored. Good leaving group a) O R R C R H Strong acid R R H O C R H Good leaving group b) O R R C R H Y X R R C R O Y Fig. 5. Activation of an alcohol. Phenols Phenols are compounds which have an OH group directly attached to an aromatic 3 2 ring. Therefore, the oxygen is sp hybridized and the aryl carbon is sp hybridized. Although phenols share some characteristics with alcohols, they have distinct properties and reactions which set them apart from that functional group. Phenols can take part in intermolecular hydrogen bonding, which means that they have a moderate water solubility and have higher boiling points than aromatic compounds lacking the phenolic group. Phenols are weakly acidic, and in aqueous solution an equilibrium exists between the phenol and the phenoxide ion (Fig. 6a). On treatment with a base, the phenol is fully converted to the phenoxide ion (Fig. 6b). The phenoxide ion is stabilized by resonance and delocalization of the negative charge into the ring (Topic G2/G3), which means that phenoxide ions are weaker bases than alkoxide ions. This in turn means that phenols are more acidic than alcohols, but less acidic than carboxylic acids. The pKa values of most phenols is in M3 Properties of alcohols and phenols 269 a) OH H O + O H H H O H b) OH O Base + Phenoxide ion ion Phenoxide Phenol Phenol Fig. 6. Acidic reactions of phenol. Phenol Phenol Phenoxide ion Phenoxide ion the order of 11, compared to 18 for alcohols and 4.74 for acetic acid. This means that phenols can be ionized with weaker bases than those required to ionize alcohols, but require stronger bases than those required to ionize carboxylic acids. For example, phenols are ionized by sodium hydroxide but not by the weaker base sodium hydrogen carbonate. Alcohols being less acidic are not ionized by either base whereas carboxylic acids are ionized by both sodium hydroxide and sodium hydrogen carbonate solutions. These acidbase reactions permit a simple way of distinguishing between most carboxylic acids, phenols, and alcohols. Since the salts formed from the acidbase reaction are water soluble, compounds containing these functional groups can be distinguished by testing their solubilities in sodium hydrogen carbonate and sodium hydroxide solutions. This solubility test is not valid for low molecular weight structures such as methanol or ethanol since these are water soluble and dissolve in basic solution because of their water solubility rather than their ability to form salts. Spectroscopic analysis of alcohols and phenols The IR spectra of alcohols and phenols give characteristic broad OH stretching 1 absorptions in the region 36003200 cm . These absorptions are broader than NH absorptions but are not as broad as the OH absorption of a carboxylic acid. The exact position of the absorption depends on the extent of hydrogen bonding in the sample. The more H-bonding which is present, the broader the absorption and the lower the wavenumber. An absorption due to OH bending may be 1 visible in the region 14101260 cm , but this is in the ngerprint region and can easily be confused with other absorptions. Absorptions due to CO stretching also occur in the ngerprint region, but can sometimes be distinguished since they tend to be stronger than surrounding absorptions. They occur in the regions 1 1 10751000 cm for primary alcohols, 11251100 cm for secondary alcohols, 1 1 12101100 cm for tertiary alcohols, and 12601140 cm for phenols. 1 The OH proton is visible in the H nmr spectra of alcohols and phenols, normally as a broad signal in the region 0.54.5 ppm for alcohols and 4.510 ppm for phenols. The signal is lost if the sample is shaken with deuterated water. The presence of an alcohol can sometimes be indicated indirectly by the chemical shifts of neighboring groups. For example, a methylene unit next to OH 1 appears at 3.6 ppm in the H spectrum. Carbon atoms next to OH show signals in 13 the range 5080 ppm in the C spectrum. The mass spectra of alcohols often lack the molecular ion since dehydration can occur rapidly to give a fragmentation ion 18 mass units less than the parent ion. Fragmentation also occurs by -cleavage, i.e. cleavage, next to the carbon, which is bonded to the OH. Section M Alcohols, phenols, and thiols M4 REACTIONS OF ALCOHOLS Key Notes Acidbase reactions Elimination Alcohols are weak acids and react with strong bases to form an alkoxide ion. Alcohols are dehydrated to alkenes by heating with sulfuric acid. The reaction involves an E1 mechanism through an intermediate carbocation, and so tertiary alcohols react better than secondary alcohols, and secondary alcohols react better than primary alcohols. If a choice of alkenes is possible, the most substituted alkene is preferred. Dehydration of secondary and tertiary alcohols is also possible under milder basic conditions using POCl3. The reaction takes place by an E2 mechanism. Tertiary alcohols and some secondary alcohols are converted to alkyl chlorides and alkyl bromides on treatment with HCl and HBr respectively. The mechanism involves protonation of the hydroxyl group to turn it into a good leaving group, then a normal SN1 reaction. Primary and secondary alcohols are converted to alkyl chlorides and alkyl bromides by an SN2 reaction involving thionyl chloride and phosphorus tribromide respectively. The reagents serve to convert the hydroxyl group into a better leaving group and also act as a source of the halide ion. Alcohols can be treated with sulfonyl chlorides to give structures known as sulfonates. Two common examples are mesylates and tosylates. The mesylate and tosylate groups are excellent leaving groups and these compounds undergo the SN2 reaction in the same way as alkyl halides. Mesylates and tosylates serve to convert the hydroxyl group of an alcohol from a poor leaving group into a very good leaving group. Primary alcohols are oxidized to aldehydes with pyridinium chlorochromate (PCC) in dichloromethane, and oxidized to carboxylic acids with CrO3 in aqueous acid. The former reaction stops at the aldehyde since the PCC is a mild oxidizing agent and the reaction is carried out in dichloromethane. Under aqueous acidic conditions with CrO3 as the oxidizing agent, the primary alcohol is converted to an aldehyde which is then hydrated and oxidized again to the carboxylic acid. Secondary alcohols are oxidized to ketones while tertiary alcohols are resistant to oxidation. Alcohols can be converted to esters by reaction with carboxylic acids, acid chlorides or acid anhydrides. Acid strength (G2) Base strength (G3) Carbocation stabilization (H5) Preparations of carboxylic acid derivatives (K5) Nucleophilic substitution (L2) Elimination (L4) Synthesis of alkyl halides Synthesis of mesylates and tosylates Oxidation Esterication Related topics M4 Reactions of alcohols 271 Acidbase reactions Alcohols are slightly weaker acids than water which means that the conjugate base generated from an alcohol (the alkoxide ion) is a stronger base than the conjugate base of water (the hydroxide ion). As a result, it is not possible to generate an alkoxide ion using sodium hydroxide as base. Alcohols do not react with sodium bicarbonate or amines, and a stronger base such as sodium hydride or sodium amide is required to generate the alkoxide ion (Fig. 1). Alcohols can also be converted to alkoxide ions on treatment with potassium, sodium, or lithium metal. Some organic reagents can also act as strong bases, for example Grignard reagents and organolithium reagents. O R Fig. 1. H Base R O H Base Generation of an alkoxide ion. Alkoxide ions are neutralized in water and so reactions involving these reagents should be carried out in the alcohol from which they were derived, that is reactions involving sodium ethoxide are best carried out in ethanol. Alcohols have a typical pKa of 15.518.0 compared to pKa values of 25 for ethyne, 38 for ammonia and 50 for ethane. Elimination Alcohols, like alkyl halides, can undergo elimination reactions to form alkenes (see Topic L4; Fig. 2). Since water is eliminated, the reaction is also known as a dehydration. Like alkyl halides, the elimination reaction of an alcohol requires the presence of a susceptible proton at the -position (Fig. 3). Whereas the elimination of alkyl halides is carried out under basic conditions, the elimination of alcohols is carried out under acid conditions. Under basic conditions, an E2 elimination would require the loss of a hydroxide ion as a leaving group. Since the hydroxide ion is a strong base, it is not a good leaving group and so the elimination of alcohols under basic conditions is difcult to achieve. CH3 HO C CH3 Fig. 2. Elimination of an alcohol. Alcohols X + C R R O X= Cl, Br, I R R C H Susceptible proton Fig. 3. Susceptible -protons in an alkyl halide and an alcohol. C + R Susceptible proton H R CH3 H3C H3C C C H H + H2O 20% H2SO4 Alkyl halides R R C H 272 Section M Alcohols, phenols, and thiols Elimination under acidic conditions is more successful since the hydroxyl group is rst protonated and then departs the molecule as a neutral water molecule (dehydration) which is a much better leaving group. If different isomeric alkenes are possible, the most substituted alkene will be favored another example of Zaitsevs rule (Fig. 4). The reaction works best with tertiary alcohols since the elimination proceeds by the E1 mechanism (Topic L4). CH3 HO C CH3 Major product Fig. 4. Elimination of alcohols obeys Zaitsevs rule. H O H O H CH3 C CH3 C H H H Step 1 H O H CH3 C CH3 C H H H H -H2O H3C Step 2 C CH3 C H H H3C Step 3 C CH3 C H H H + H3O 20% H2SO4 CH2CH3 Heat H3C C H3C C H H CH2CH3 C C CH3 Minor product + CH3 H Fig. 5. E1 Elimination mechanism for alcohols. The mechanism (Fig. 5) involves the nucleophilic oxygen of the alcohol using one of its lone pairs of electrons to form a bond to a proton to produce a charged intermediate (Step 1). Now that the oxygen is protonated, the molecule has a much better leaving group since water can be ejected as a neutral molecule. The E1 mechanism can now proceed as normal. Water is lost and a carbocation is formed (Step 2). Water then acts as a base in the second step, using one of its lone pairs of electrons to form a bond to the -proton of the carbocation. The CH bond is broken and both the electrons in that bond are used to form a bond between the two carbons. Since this is an E1 reaction, tertiary alcohols react better than primary or secondary alcohols. The E1 reaction is not ideal for the dehydration of primary or secondary alcohols since vigorous heating is required to force the reaction and this can result in Cl Cl Cl Cl Cl O H P O CH 3 C CH 3 C H H H N N HN Step 1 H CH 3 Cl Cl P O O CH 3 C C H H H Cl Cl Step 2 P O O CH 3 C CH 3 C H H H Step 3 H3C H3 C C C H H P O O Fig. 6. Mechanism for the POCl3 dehydration of an alcohol. M4 Reactions of alcohols 273 rearrangement reactions. Therefore, alternative methods are useful. Reagents such as phosphorus oxychloride (POCl3) dehydrate secondary and tertiary alcohols under mild basic conditions using pyridine as solvent (Fig. 6). The phosphorus oxychloride serves to activate the alcohol, converting the hydroxyl function into a better leaving group. The mechanism involves the alcohol acting as a nucleophile in the rst step. Oxygen uses a lone pair of electrons to form a bond to the electrophilic phosphorus of POCl3 and a chloride ion is lost (Step 1). Pyridine then removes a proton from the structure to form a dichlorophosphate intermediate (Step 2). The dichlorophosphate group is a much better leaving group than the hydroxide ion and so a normal E2 reaction can take place. Pyridine acts as a base to remove a -proton and as this is happening, the electrons from the old CH bond are used to form a bond and eject the leaving group (Step 3). Synthesis of alkyl halides Tertiary alcohols can undergo the SN1 reaction to produce tertiary alkyl halides (cf. Topic L2; Fig. 7). Since the reaction requires the loss of the hydroxide ion (a poor leaving group), a little bit of trickery is required in order to convert the hydroxyl moiety into a better leaving group. This can be achieved under acidic conditions with the use of HCl or HBr. The acid serves to protonate the hydroxyl moiety as the rst step and then a normal SN1 mechanism takes place where water is lost from the molecule to form an intermediate carbocation. A halide ion then forms a bond to the carbocation center in the third step. The rst two steps of this mechanism are exactly the same as the elimination reaction described above. Both reactions are carried out under acidic conditions and one might ask why elimination does not occur. The difference here is that halide ions serve as good nucleophiles and are present in high concentration. The elimination reaction described earlier is carried out using concentrated sulfuric acid and only weak nucleophiles are present (i.e. water) in low concentration. Having said that, some elimination can occur and although the reaction of alcohols with HX produces mainly alkyl halide, some alkene by-product is usually present. Since primary alcohols and some secondary alcohols do not undergo the SN1 reaction, nucleophilic substitution of these compounds must involve an SN2 mechanism. Once again, protonation of the OH group is required as a rst step, then the reaction involves simultaneous attack of the halide ion and loss of water. The reaction proceeds with good nucleophiles such as the iodide or bromide ion, but fails with the weaker nucleophilic chloride ion. In this case, a Lewis acid (Topic G4) needs to be added to the reaction mixture. The Lewis acid forms a complex with the oxygen of the alcohol group, resulting in a much better leaving group for the subsequent SN2 reaction. Nevertheless, the reaction of primary and secondary alcohols with hydrogen halides can often be a problem since unwanted rearrangement reactions often take H O H CH3 C CH3 CH3 Step 1 H O H CH3 C CH3 CH3 -H2O Step 2 H3C C H 3C X CH3 Step 3 X CH3 C CH3 CH3 Fig. 7. Conversion of alcohols to alkyl halides. 274 Section M Alcohols, phenols, and thiols a) Cl S Cl O H Et3N b) Br P Br O H CH2CH3 H + HOPBr2 Br Br Br P O CH2CH3 Br CH2CH3 Br CH2CH3 H Cl O Cl S O CH2CH3 O Cl - Et3NH Alkyl chlorosulfite O S O CH2CH3 Cl CH2CH3 + SO2 (g) + Cl Fig. 8. Conversion of an alcohol to an alkyl halide using (a) thionyl chloride; (b) phosphorus tribromide. place. To avoid this, alternative procedures carried out under milder basic conditions have been used with reagents such as thionyl chloride or phosphorus tribromide (Fig. 8). These reagents act as electrophiles and react with the alcoholic oxygen to form an intermediate where the OH moiety has been converted into a better leaving group. A halide ion is released from the reagent in this process, and this can act as the nucleophile in the subsequent SN2 reaction. In the reaction with thionyl chloride, triethylamine is present to mop up the HCl formed during the reaction. The reaction is also helped by the fact that one of the products (SO2) is lost as a gas, thus driving the reaction to completion. Phosphorus tribromide has three bromine atoms present and each PBr3 molecule can react with three alcohol molecules to form three molecules of alkyl bromide. Synthesis of mesylates and tosylates It is sometimes convenient to synthesize an activated alcohol which can be used in nucleophilic substitution reactions like an alkyl halide. Mesylates and tosylates are examples of sulfonate compounds which serve this purpose. They are synthe- O a) RCH2 OH N CH3 O RCH2 O S O Tosylate CH3 + Cl S O p-Toluenesulfonyl chloride O b) RCH2 OH NEt3 CH3 CH2Cl2 O RCH2 O S O Mesylate CH3 + Cl S O Methanesulfonyl chloride Fig. 9. Synthesis of (a) tosylate and (b) mesylate. M4 Reactions of alcohols 275 sized by treating alcohols with sulfonyl chlorides in the presence of a base such as pyridine or triethylamine (Fig. 9). The base serves to mop up the HCl which is formed and prevents acid-catalyzed rearrangement reactions. The reaction mechanism (Fig. 10) involves the alcohol oxygen acting as a nucleophilic center and substituting the chloride ion from the sulfonate. The base then removes a proton from the intermediate to give the sulfonate product. Neither of these steps affects the stereochemistry of the alcohol carbon and so the stereochemistry of chiral alcohols is retained. The mesylate and tosylate groups are excellent leaving groups and can be viewed as the equivalent of a halide. Therefore mesylates and tosylates can undergo the SN2 reaction in the same way as alkyl halides (Fig. 11). NEt3 H RCH2 O Cl O S O CH3 RCH2 H O O S O CH3 O RCH2 O S O CH3 H NEt3 Fig. 10. Mechanism for the formation of a mesylate. O O RCH2 S O CH3 I RCH2 I O + O S O CH3 Stable tosylate ion Fig. 11. Nucleophilic substitution of a tosylate. Oxidation The oxidation of alcohols is an extremely important reaction in organic synthesis. Primary alcohols can be oxidized to aldehydes, but the reaction is tricky since there is the danger of over-oxidation to carboxylic acids. With volatile aldehydes, the aldehydes can be distilled from the reaction solution as they are formed. However, this is not possible for less volatile aldehydes. This problem can be overcome by using a mild oxidizing agent called pyridinium chlorochromate (PCC; Fig. 12a). If a stronger oxidizing agent is used in aqueous conditions (e.g. CrO3 in aqueous sulfuric acid), primary alcohols are oxidized to carboxylic acids (Fig. 12b), while secondary alcohols are oxidized to ketones (Fig. 12c). The success of the PCC oxidation in stopping at the aldehyde stage is solvent dependent. The reaction is carried out in methylene chloride, whereas oxidation CrO3Cl NH b) O R C H R CH2OH H2SO4 1o Alcohol 1 Alcohol CrO3 R C OH 2o c) O R CHOH H2SO4 R lcohol 2AAlcohol Ketone Ketone CrO3 R C R O a) PCC R CH2OH 1o 1Alcohol Alcohol Aldehyde Aldehyde Carboxylic acid Carboxylic acid Fig. 12. Oxidations of alcohols. 276 Section M Alcohols, phenols, and thiols with CrO3 is carried out in aqueous acid. Under aqueous conditions, the aldehyde which is formed by oxidation of the alcohol is hydrated and this structure is more sensitive to oxidation than the aldehyde itself (Fig. 13). In methylene chloride, hydration cannot occur and the aldehyde is more resistant to oxidation. O C R Fig. 13. H Hydration of an aldehyde. R H2O HO C H OH Sensitive to oxidation OH R R C H CrO3 R H2SO4 R C O CrO3 E2 R C O + R CrO3 2- H O H H Fig. 14. Mechanism of oxidation of a secondary alcohol with CrO3. The mechanism of oxidation for a secondary alcohol with CrO3 (Fig. 14) involves the nucleophilic oxygen reacting with the oxidizing agent to produce a charged chromium intermediate. Elimination then occurs where an -proton is lost along with the chromium moiety to produce the carbonyl group. The mechanism can be viewed as an E2 mechanism, the difference being that different bonds are being created and broken. Since the mechanism requires an -proton to be removed from the alcoholic carbon, tertiary alcohols cannot be oxidized since they do not contain such a proton. The mechanism also explains why an aldehyde product is resistant to further oxidation when methylene chloride is the solvent (i.e. no OH present to react with the chromium reagent). When aqueous conditions are used the aldehyde is hydrated and this generates two OH groups which are available to bond to the chromium reagent and result in further oxidation. Esterication Alcohols can be converted to esters by treatment with an acid chloride, acid anhydride or carboxylic acid (see Topic K5). Section M Alcohols, phenols, and thiols M5 REACTIONS OF PHENOLS Key Notes Acidbase reactions Phenols are stronger acids than alcohols and are converted to phenoxide ions with sodium hydroxide. However, they are weaker acids than carboxylic acids and do not react with sodium hydrogen carbonate. Electronwithdrawing substituents on the aromatic ring increase acidity whereas electron-donating groups decrease acidity. The position of substituents on the aromatic ring relative to the phenolic group is also important. Phenols can be treated with acid chlorides or acid anhydrides to give esters. Treatment with sodium hydroxide then an alkyl halide leads to the formation of aryl alkyl ethers. There are several reactions which are possible for alcohols but not for phenols. The synthesis of phenyl esters by reaction with a carboxylic acid under acid conditions is not possible. Reactions involving the cleavage of the aryl CO bond are also not possible. Phenols are powerful activating groups which direct electrophilic substitution to the ortho and para positions. Sulfonation and nitration result in ortho and para products. Bromination, however, results in the introduction of three bromine substituents at the para and both ortho positions. The activating power of the phenol group can be moderated by conversion to an ester such that bromination occurs only once and is directed para in preference to ortho. Phenols are susceptible to oxidation to quinones. Phenols can be converted to phenoxide ions then treated with an allyl bromide to form an allyl phenyl ether. On heating, these ethers undergo a concerted rearrangement reaction which results in the allyl group being transferred from the phenol group to the ortho carbon. The reaction is a useful method of obtaining ortho-alkyl phenols since the double bond can be subsequently hydrogenated. Acid strength (G2) Base strength (G3) Electrophilic substitutions of mono-substituted aromatic rings (I5) Reactions (K6) Reactions of alkyl halides (L6) Functional group transformations Electrophilic substitution Oxidation Claisen rearrangement Related topics Acidbase reactions Phenols are stronger acids than alcohols and react with bases such as sodium hydroxide to form phenoxide ions (Topic M3). However, they are weaker acids than carboxylic acids and do not react with sodium hydrogen carbonate. Phenols are acidic since the oxygens lone pair of electrons can participate in a resonance mechanism involving the adjacent aromatic ring (Fig. 1). Three 278 Section M Alcohols, phenols, and thiols H O O H O H O H + O H Fig. 1. Resonance structures for phenol. H O H O N O O O N O Fig. 2. Resonance effect of a para-nitro group on a phenol. resonance structures are possible where the oxygen gains a positive charge and the ring gains a negative charge. The net result is a slightly positive charge on the oxygen which accounts for the acidity of its proton. There are also three aromatic carbons with slightly negative charges. The type of substituents present on the aromatic ring can have a profound effect on the acidity of the phenol. This is because substituents can either stabilize or destabilize the partial negative charge on the ring. The better the partial charge is stabilized, the more effective the resonance will be and the more acidic the phenol will be. Electron-withdrawing groups such as a nitro substituent increase the acidity of the phenol since they stabilize the negative charge by an inductive effect. Nitro groups which are ortho or para to the phenolic group have an even greater effect. This is because a fourth resonance structure is possible which delocalizes the partial charge even further (Fig. 2). Electron-donating substituents (e.g. alkyl groups) have the opposite effect and decrease the acidity of phenols. Functional group transformations Phenols can be converted into esters by reaction with acid chlorides or acid anhydrides (Topic K6), and into ethers by reaction with alkyl halides in the presence of base (Topic L6; Fig. 3). These reactions can be carried out under milder conditions than those used for alcohols due to the greater acidity of phenols. Thus OH RCOCl or (RCO)2O O C Ester O R Base RX O R Ether Fig. 3. Functional group transformations for a phenol. M5 Reactions of phenols 279 phenols can be converted to phenoxide ions with sodium hydroxide rather than metallic sodium. Although the above reactions are common to alcohols and phenols, there are several reactions which can be carried out on alcohols but not phenols, and vice versa. For example, unlike alcohols, phenols cannot be converted to esters by reaction with a carboxylic acid under acid catalysis. Reactions involving the cleavage of the CO bond are also not possible for phenols. The aryl CO bond is stronger than the alkyl CO bond of an alcohol. Electrophilic substitution Electrophilic substitution is promoted by the phenol group which acts as an activating group and directs substitution to the ortho and para positions (Topic I5). Sulfonation and nitration of phenols are both possible to give ortho and para substitution products. On occasions, the phenolic groups may be too powerful an activating group and it is difcult to control the reaction to one substitution. For example, the bromination of phenol leads to 2,4,6-tribromophenol even in the absence of a Lewis acid (Fig. 4). The activating power of the phenolic group can be decreased by converting the phenol to an ester which can be removed by hydrolysis once the electrophilic substitution reaction has been carried out (Fig. 5). Since the ester is a weaker activating group, substitution occurs only once. Furthermore, since the ester is a bulkier group than the phenol, para substitution is favored over ortho substitution. Br OH Br2 H2O Br Fig. 4. OH CH3COCl OH Br Bromination of phenol. OAc OAc OH Br2 a) NaOH b) H3O Br Br Fig. 5. Synthesis of para-bromophenol. OH Na2Cr2O7 or (KSO3)2NO O Fig. 6. Oxidation of phenol. O Oxidation Claisen rearrangement Phenols are susceptible to oxidation to quinones (Fig. 6). A useful method of introducing an alkyl substituent to the ortho position of a phenol is by the Claisen rearrangement (Fig. 7). The phenol is converted to the phenoxide ion, then treated with 3-bromopropene (an allyl bromide) to form an ether. On heating, the allyl group (CH2CH CH2) is transferred from the phenolic group to the ortho position of the aromatic ring. The mechanism involves a 280 Section M Alcohols, phenols, and thiols OH NaH THF O Na Br O Heat Ether OH Fig. 7. Claisen rearrangement. O O OH H Fig. 8. Mechanism for the Claisen rearrangement. concerted process of bond formation and bond breaking called a pericyclic reaction (Fig. 8). This results in a ketone structure which immediately tautomerizes to the nal product. Different allylic reagents could be used in the reaction and the double bond in the nal product could be reduced to form an alkane substituent without affecting the aromatic ring. Section M Alcohols, phenols, and thiols M6 CHEMISTRY OF THIOLS Key Notes Preparation Thiols can be prepared by the reaction of an alkyl halide with KOH and an excess of hydrogen sulde. A hydrogen sulde anion is formed which undergoes an SN2 reaction with the alkyl halide. Hydrogen sulde has to be in excess in order to limit further reaction to a thioether. Alternatively, the alkyl halide can be treated with thiourea to form an S-alkylisothiouronium salt which is then hydrolyzed with aqueous base to give the thiol. Disuldes can be reduced to thiols with zinc and acid. Hydrogen bonding is weak, resulting in boiling points which are lower than comparable alcohols and similar to comparable thioethers. Thiols (RSH) contain a large polarizable sulfur atom. The SH bond is weak compared to alcohols, making thiols prone to oxidation. Thiolate ions are extremely good nucleophiles whilst being weak bases. Thiols are stronger acids than alcohols. Thiols are oxidized by bromine or iodine to give disuldes. Treatment of a thiol with a base results in the formation of a thiolate ion. Intermolecular bonding (C3) Nucleophilic substitution (L2) Reactions of alkyl halides (L6) Properties Reactivity Reactions Related topics Preparation Thiols can be prepared by the treatment of alkyl halides with an excess of KOH and hydrogen sulde (Fig. 1a). The preparation is an SN2 reaction involving the KOH/H 2S a) R X R SH Thiol X NH2 b) R X NH2 S NH2 R C NH2 H2O Thiol NaOH R SH NH2 + S C + O C NH2 S-Alkylisothiouronium salt c) R S S R Zn / H R SH Thiol Disulfide Fig. 1. Synthesis of thiols. 282 Section M Alcohols, phenols, and thiols generation of a hydrogen sulde anion (HS ) as nucleophile. A problem with this reaction is the possibility of the product being ionized and reacting with a second molecule of alkyl halide to produce a thioether (RSR) as a byproduct. An excess of hydrogen sulde is normally used to avoid this problem. The problem of thioether formation can also be avoided by using an alternative procedure involving thiourea (Fig. 1b). The thiourea acts as the nucleophile in an SN2 reaction to produce an S-alkylisothiouronium salt which is then hydrolyzed with aqueous base to give the thiol. Thiols can also be formed by reducing disuldes with zinc in the presence of acid (Fig. 1c). Properties Thiols form extremely weak hydrogen bonds much weaker than alcohols and so thiols have boiling points which are similar to comparable thioethers and which are lower than comparable alcohols. For example, ethanethiol boils at 37 C whereas ethanol boils at 78 C. Low molecular weight thiols are notorious for having disagreeable aromas. Thiols are the sulfur equivalent of alcohols (RSH). The sulfur atom is larger and more polarizable than oxygen which means that sulfur compounds as a whole are more powerful nucleophiles than the corresponding oxygen compounds. Thiolate ions (e.g. CH3CH2S ) are stronger nucleophiles and weaker bases than corresponding alkoxides (CH3CH2O ). Conversely, thiols are stronger acids than corresponding alcohols. The relative size difference between sulfur and oxygen also means that sulfurs bonding orbitals are more diffuse than oxygens bonding orbitals. This results in a poorer bonding interaction between sulfur and hydrogen, than between oxygen and hydrogen. As a result, the SH bond of thiols is weaker than the OH bond of 1 1 alcohols (80 kcal mol vs. 100 kcal mol ). This in turn means that the SH bond of thiols is more prone to oxidation than the OH bond of alcohols. Br2 or I2 R SH Thiol Fig. 2. Oxidation of thiols. R S S R Disulfide Reactivity Base R SH Thiol R S R'X R S R' Thiolate Fig. 3. Formation of thiolate ions. Reactions Thiols are easily oxidized by mild oxidizing agents such as bromine or iodine to give disuldes (Fig. 2). Thiols react with base to form thiolate ions which can act as powerful nucleophiles (Topic L6; Fig. 3). Section N Ethers, epoxides, and thioethers N1 PREPARATION OF ETHERS, EPOXIDES, AND THIOETHERS Key Notes Ethers Ethers can be prepared by the SN2 reaction of an alkyl halide with an alkoxide ion. The reaction works best for primary alkyl halides. Alcohols and alkyl halides can be reacted in the presence of silver oxide to give an ether. Alkenes can be treated with alcohols in the presence of mercuric triuoroacetate to form ethers by electrophilic addition. Epoxides can be synthesized from alkenes and meta-chloroperbenzoic acid, or by converting the alkene to a halohydrin and treating the product with base to induce an intramolecular SN2 reaction which displaces the halogen atom. Aldehydes and ketones can be converted to epoxides on treatment with a sulfur ylide. Thioethers are prepared by the SN2 reaction between an alkyl halide and a thiolate ion. Symmetrical thioethers can be prepared by treating the alkyl halide with KOH and hydrogen sulde where the latter is not in excess. Electrophilic addition to symmetrical alkenes (H3) Reduction and oxidation of alkenes (H6) Nucleophilic substitution (L2) Reactions of alkyl halides (L6) Reactions of alcohols (M4) Chemistry of thiols (M6) Reactions of ethers, epoxides, and thioethers (N3) Epoxides Thioethers Related topics Ethers The Williamson ether synthesis is the best method of preparing ethers (Fig. 1a). The procedure involves the SN2 reaction between a metal alkoxide and a primary alkyl halide or tosylate (Topic L2). The alkoxide required for the reaction is prepared by treating an alcohol with a strong base such as sodium hydride (Topic M4). An alternative procedure is to treat the alcohol directly with the alkyl halide in the presence of silver oxide, thus avoiding the need to prepare the alkoxide beforehand (Fig. 1b). NaOR'' a) R X R OR'' b) R X Ag2O Ether Fig. 1. Synthesis of ethers. Ether HOR'' R OR'' If an unsymmetrical ether is being synthesized, the most hindered alkoxide should be reacted with the simplest alkyl halide, rather than the other way round 284 Section N Ethers, epoxides, and thioethers (Fig. 2). Since this is an SN2 reaction, primary alkyl halides react better than secondary or tertiary alkyl halides. O H 3C I C CH3 CH3 CH3 H 3C O C CH3 CH3 CH3 H 3C O I C CH3 CH3 CH3 Fig. 2. Choice of synthetic routes to an unsymmetrical ether. Alkenes can be converted to ethers by the electrophilic addition of mercuric triuoroacetate, followed by addition of an alcohol. An organomercuric intermediate is obtained which can be reduced with sodium borohydride to give the ether (Topic H3; Fig. 3). H 3C C H 3C C H Hg(O2CCF3)2 ROH/THF H 3C RO C C HgO2CCF3 H H NaBH4 HO H 3C RO H 3C C C H H H H H 3C Fig. 3. Synthesis of an ether from an alkene and an alcohol. Epoxides Epoxides can be synthesized by treating aldehydes or ketones with sulfur ylides (Topic N3). They can also be prepared from alkenes by reaction with mchloroperoxybenzoic acid (Topic H6). Alternatively they can be obtained from alkenes in a two-step process (Fig. 4). The rst step involves electrophilic addition of a halogen in aqueous solution to form a halohydrin (Topic H3). Treatment of the halohydrin with base then ionizes the alcohol group, which can then act as a nucleophile (Fig. 5). The oxygen uses a lone pair of electrons to form a bond to the neighboring electrophilic carbon, thus displacing the halogen by an intramolecular SN2 reaction. R C R C R R X2/H2O X R C C R OH R R NaOH R R C C R R O Fig. 4. Synthesis of an epoxide via a halohydrin. R R X + C C O R R H O H R R C X C O R R SN2 R R C O C R R X Fig. 5. Mechanism of epoxide formation from a halohydrin. Thioethers Thioethers (or suldes) are prepared by the SN2 reaction of primary or secondary alkyl halides with a thiolate anion (RS ), (Topic L6; Fig. 6). The reaction is similar to the Williamson ether synthesis. N1 Preparation of ethers, epoxides, and thioethers 285 NaSR'' R X R SR'' Disulfide Fig. 6. Synthesis of a disulde from an alkyl halide. Symmetrical thioethers can be prepared by treating an alkyl halide with KOH and an equivalent of hydrogen sulde. The reaction produces a thiol which is ionized again by KOH and reacts with another molecule of alkyl halide (Topic M6). Section N Ethers, epoxides and thioethers N2 PROPERTIES OF ETHERS, EPOXIDES AND THIOETHERS Key Notes Ethers Ethers consist of an sp hybridized oxygen linked to two carbon atoms by a single bond. Alkyl ethers are ethers where two alkyl groups are linked to the oxygen. Aryl ethers are ethers where one or two aromatic rings are attached to the oxygen. Since ethers cannot form hydrogen bonds, they have lower boiling points than comparable alcohols, and similar boiling points to comparable alkanes. However, hydrogen bonding is possible with protic solvents which means that ethers have water solubilities similar to alcohols of equivalent molecular weight. Ethers are relatively unreactive since they have weak nucleophilic and electrophilic centers. Epoxides are three-membered cyclic ethers which are more reactive than other cyclic or acyclic ethers due to the ring strain inherent in threemembered rings. They will react with nucleophiles by an SN2 reaction at the electrophilic carbons. Thioethers are the sulfur equivalents of ethers. The polarizable sulfur can stabilize a negative charge on an adjacent carbon making protons attached to that carbon acidic. The presence of an ether or epoxide is indicated by CO stretching absorptions in the IR spectrum. Supporting evidence can be obtained from the 1 13 chemical shifts of neighboring groups in the H and C nmr spectra. It is important to consider other spectroscopic evidence as well as the molecular formula before deciding whether an ether or epoxide is present. sp Hybridization (A3) 2 sp Hybridization (A4) Intermolecular bonding (C3) Properties and reactions (C4) Organic structures (E4) Reactions of ethers, epoxides and thioethers (N3) 3 3 Epoxides Thioethers Spectroscopic analysis of ethers and epoxides Related topics Infra-red spectroscopy (P3) Proton nuclear magnetic resonance spectroscopy (P4) 13 C nuclear magnetic resonance spectroscopy (P5) Ethers Ethers consist of an oxygen linked to two carbon atoms by bonds. In aliphatic 3 ethers (ROR), the three atoms involved are sp hybridized and have a bond angle of 112 . Aryl ethers are ethers where the oxygen is linked to one or two aromatic 2 rings (ArOR or ArOAr) in which case the attached carbon(s) is sp hybridized. The CO bonds are polarized such that the oxygen is slightly negative and the carbons are slightly positive. Due to the slightly polar CO bonds, ethers have a small dipole moment. However, ethers have no XH groups (X heteroatom) and N2 Properties of ethers, epoxides and thioethers 287 cannot interact by hydrogen bonding. Therefore, they have lower boiling points than comparable alcohols and similar boiling points to comparable alkanes. However, hydrogen bonding is possible to protic solvents resulting in solubilities similar to alcohols of comparable molecular weight. The oxygen of an ether is a nucleophilic center and the neighboring carbons are electrophilic centers, but in both cases the nucleophilicity or electrophilicity is weak (Fig. 1). Therefore, ethers are relatively unreactive. Weak electrophilic centers R + C R R O + R C R R R R C R O C R R R Weak nucleophilic center Fig. 1. Properties of ethers. Epoxides Epoxides (or oxiranes) are three-membered cyclic ethers and differ from other cyclic and acyclic ethers in that they are reactive to various reagents. The reason for this reactivity is the strained three-membered ring. Reactions with nucleophiles can result in ring opening and relief of strain. Nucleophiles will attack either of the electrophilic carbons present in an epoxide by an SN2 reaction (Fig. 2). O + C + CR R R R C O C R R Nucleophilic center R R Electrophilic centers Fig. 2. Properties of an epoxide. Thioethers Thioethers (or suldes; RSR) are the sulfur equivalents of ethers (ROR). Since the sulfur atoms are polarizable, they can stabilize a negative charge on an adjacent carbon atom. This means that hydrogens on this carbon are more acidic than those on comparable ethers. The IR spectra of ethers are characterized by CO stretching absorptions. An 1 aliphatic ether tends to have an absorption in the region 11501070 cm which is often stronger than surrounding peaks. Alkyl aryl ethers tend to give two 1 relatively strong absorptions, one in the region 12751200 cm and the other in the 1 region 10751020 cm . The CO stretching absorption for epoxides occurs in the 1 region 12601200 cm . CO Stretching absorptions are also possible for carboxylic acids and esters (see Topic K1), as well as for alcohols and phenols (see Topic M3). Therefore it is important to consider other evidence before deciding whether an ether or epoxide is present. For example, if the molecular formula only has one oxygen, this rules out the possibility of an acid or an ester. If there are no Spectroscopic analysis of ethers and epoxides 288 Section N Ethers, epoxides, and thioethers D2O exchangeable protons in the H nmr spectrum, this rules out alcohols and phenols. 1 13 The H and C nmr spectra of an ether do not give direct evidence of the functional group but may indicate its presence indirectly by the chemical shifts of neighboring groups. For example, the methyl group of a methyl ether appears at 1 13 3.3 ppm in the H spectrum and at 59 ppm in the C spectrum. The protons of an epoxide show characteristic signals at 2.53.5 ppm in the 1 H nmr spectrum. 1 Section N Ethers, epoxides, and thioethers N3 REACTIONS OF ETHERS, EPOXIDES, AND THIOETHERS Key Notes Ethers Ethers are unreactive functional groups, but can be cleaved by strong acids such as HI or HBr. Primary and secondary ethers react by the SN2 mechanism to produce the least substituted alkyl halide and an alcohol. If the alcohol is primary, further reaction may occur to convert this to an alkyl halide as well. Tertiary ethers are cleaved by the SN1 reaction under milder conditions. However, an elimination reaction (E1) may occur in preference to the SN1 reaction resulting in formation of an alcohol and an alkene. Triuoroacetic acid can be used in such situations in place of HX. Most ethers react slowly with atmospheric oxygen to produce peroxides and hydroperoxides which can prove to be explosive. Epoxides are more reactive to nucleophiles than ethers since an SN2 reaction relieves ring strain by opening up the ring. Hydrolysis under acidic or basic conditions converts epoxides to 1,2-diols which are trans to each other in cyclic systems. Treatment with hydrogen halides produces 1,2-halohydrins and treatment with Grignard reagents allows the formation of CC bonds with simultaneous formation of an alcohol. Nucleophiles will attack unsymmetrical epoxides at the least substituted carbon when basic reaction conditions are employed. Under acidic reaction conditions, nucleophiles will prefer to attack the most substituted carbon atom. Thioethers are nucleophilic. The sulfur atom can act as a nucleophilic center and take part in an SN2 reaction with alkyl halides to form a trialkylsulfonium salt (R2SR ). This in turn can be treated with base to form a sulfur ylide (R2S - CR2 ) where the sulfur can stabilize the neighboring negative charge. Sulfur ylides can be used to synthesize epoxides from aldehydes or ketones. Thioethers can be oxidized to sulfoxides and sulfones, and can be reduced to alkanes. Nucleophilic substitution (L2) Elimination (L4) Reactions of alcohols (M4) Properties of ethers, epoxides, and thioethers (N2) Epoxides Thioethers Related topics Ethers Ethers are generally unreactive functional groups and the only useful reaction which they undergo is cleavage by strong acids such as HI and HBr to produce an alkyl halide and an alcohol (Fig. 1). The ether is rst protonated by the acid, then nucleophilic substitution takes place where the halide ion acts as the nucleophile. Primary and secondary ethers react by the SN2 mechanism (Topic L2) and the halide reacts at the least substituted carbon atom to produce an alkyl halide and 290 Section N Ethers, epoxides, and thioethers HI / H2O O CH3CH2 CH(CH3)2 Heat CH3CH2I + HO CH(CH3)2 Fig. 1. Cleavage of an ether to an alkyl halide and an alcohol. H H O CH3CH2 CH(CH3)2 CH3CH2 O CH(CH3)2 CH3CH2I + HO CH(CH3)2 I Fig. 2. Mechanism for the cleavage of an ether. an alcohol (Fig. 2). The initial protonation is essential since it converts a poor leaving group (an alkoxide ion) into a good leaving group (the alcohol). Primary alcohols formed from this reaction may be converted further to an alkyl halide (Topic M4). Tertiary ethers react by the SN1 mechanism to produce the alcohol. However, an alkene may also be formed due to E1 elimination (Topic L4) and this may be the major product (Fig. 3). HI O (CH3)3C CH(CH3)2 H2O H3C CH3 C CH2 E1 product Fig. 3. Cleavage of a tertiary ether. + HO CH(CH3)2 Triuoroacetic acid can be used instead of HX, resulting in an E1 reaction and production of the alcohol and the alkene. A problem with most ethers is their slow reaction with atmospheric oxygen by a radical process to form hydroperoxides (ROOH) and peroxides (ROOR). These products can prove to be explosive if old solvents are concentrated to dryness. Epoxides Epoxides are cyclic ethers, but they are more reactive than normal ethers because of the ring strain involved in a three-membered ring. Therefore, ring opening through an SN2 nucleophilic substitution is a common reaction of epoxides. For example, epoxides can be ring-opened under acidic or basic conditions to give a 1,2-diol (Fig. 4). In both cases, the reaction involves an SN2 mechanism (Topic L2) with the incoming nucleophile attacking the epoxide from the opposite direction of the epoxide ring. This results in a trans arrangement of the diol system when the reaction is carried out on cycloalkane epoxides. Under acidic conditions (Fig. 5), the epoxide oxygen is rst protonated, turning it into a better leaving group (Step 1). Water then acts as the nucleophile and attacks one of the electrophilic carbon atoms of the epoxide. Water uses a lone pair of electrons to form a new bond to carbon and as it does so, the CO bond of the epoxide cleaves with both electrons moving onto the epoxide oxygen to neutralize the positive charge (Step 2). N3 Reactions of ethers, epoxides, and thioethers 291 H H3O O or NaOH OH Fig. 4. OH trans-1,2-diol H Ring opening of an epoxide under acidic or basic conditions. H H Step 1 O O OH H O H Fig. 5. Mechanism for the ring opening of an epoxide under acidic conditions. H H H OH H H Step 2 H OH Step 3 OH Although water is a poor nucleophile, the reaction is favored due to the neutralization of the positive charge on oxygen and the relief of ring strain once the epoxide is opened up. Unlike other SN2 reactions of course, the leaving group is still tethered to the molecule. Ring opening under basic conditions is also possible with heating, but requires the loss of a negatively charged oxygen (Fig. 6). This is a poor leaving group and would not occur with normal ethers. It is only possible here because the reaction opens up the epoxide ring and relieves ring strain. H O O H H O O OH O H H OH H H OH H Fig. 6. Mechanism for the ring opening of an epoxide under basic conditions. Ring opening by the SN2 reaction is also possible using nucleophiles other than water. With unsymmetrical epoxides, the SN2 reaction will occur at the least substituted position if it is carried out under basic conditions (Fig. 7). However, under acidic conditions, the nucleophile will usually attack the most substituted position (Fig. 8). This is because the positive charge in the protonated intermediate is shared between the oxygen and the most substituted carbon. This makes the more substituted carbon more reactive to nucleophiles. 292 Section N Ethers, epoxides, and thioethers CH3 NaOEt O CH3 OH OEt Fig. 7. H Ring opening of an epoxide with the ethoxide ion. CH3 O CH3 + OH EtOH OEt CH3 H Fig. 8. Ring opening of an epoxide with ethanol under acidic conditions. H HX O X Fig. 9. Reaction of an epoxide with HX. H OH OH trans-1,2-Halohydrin The reaction of epoxides with hydrogen halides (Fig. 9) is analogous to the reaction of normal ethers with HX. Protonation of the epoxide with acid is followed by nucleophilic attack by a halide ion resulting in 1,2-halohydrins. The halogen and alcohol groups will also be in a trans arrangement if the reaction is done on an epoxide linked to a cyclic system. Unlike ethers, epoxides undergo the SN2 reaction with a Grignard reagent (Fig. 10). R MgX R H Fig. 10. Grignard reaction with an epoxide. H H OH O a) b) H3O H Thioethers Unlike ethers, thioethers make good nucleophiles due to the sulfur atom. This is because the sulfur atom has its valence electrons further away from the nucleus. As a result, these electrons experience less attraction from the nucleus, making them more polarizable and more nucleophilic. Since they are good nucleophiles, thioethers can react with alkyl halides to form trialkylsulfonium salts (R3S ; Fig. 11) a reaction which is impossible for normal ethers. Sulfur is also able to stabilize a negative charge on a neighboring carbon atom, especially when the sulfur itself is positively charged. This makes the protons on neighboring carbons acidic, allowing them to be removed with base to form sulfur ylides. Sulfur ylides are useful in the synthesis of epoxides from aldehydes or ketones (Fig. 12). They undergo a typical nucleophilic addition with the carbonyl group to form the expected tetrahedral intermediate (Topic J3). This intermediate now has a very good thioether leaving group which also creates an electrophilic carbon atom at the neighboring position. Therefore, the molecule is set up for further N3 Reactions of ethers, epoxides, and thioethers 293 I CH3 S H3C CH3 CH3I H3C S CH3 Base S H 3C CH2 Sulfur ylide H3C S CH2 CH3 CH3 Fig. 11. CH3 S H3C Formation of a sulphur ylide. O O H CH3CH2 C CH2 H + CH2 CH3CH2 -(CH3)2S CH3CH2 H C O CH2 C Electrophilic center H3C S CH3 Tetrahedral intermediate Fig. 12. Reaction of an aldehyde with a sulfur ylide to produce an epoxide. reaction which involves the nucleophilic oxygen anion displacing the thioether and forming an epoxide. Thioethers can also be oxidized with hydrogen peroxide to give a sulfoxide (R2SO) which, on oxidation with a peroxyacid, gives a sulfone (R2SO2; Fig. 13). Thioethers can be reduced using Raney nickel a catalyst which has hydrogen gas adsorbed onto the nickel surface (Fig. 14). This reaction is particularly useful for reducing thioacetals or thioketals since this provides a means of converting aldehydes or ketones to alkanes (Topic J7). The mechanism of the reduction reaction is radical based and is not fully understood. O S R Fig. 13. O C R H Aldehyde H R H2O2 H2O R S R CH3CO3H R O S R O Synthesis of sulfoxides and sulfones. HSCH2CH2SH S C R H S Raney Ni H C R H H + NiS Cyclic thioacetal O C R Ketone R' HSCH2CH2SH S C H R R' S Raney Ni H C R R' H + NiS Cyclic thioketal Fig. 14. Reduction of aldehydes and ketals via cyclic thioacetals and cyclic thioketals respectively. Section O Amines and nitriles O1 PREPARATION OF AMINES Key Notes Reduction Nitriles can be reduced to primary amines with lithium aluminum hydride (LiAlH4). Primary, secondary, and tertiary amides can be reduced with LiAlH4 to primary, secondary, and tertiary amines respectively. Nucleophilic substitution of an alkyl halide with an azide ion gives an alkyl azide which can then be reduced with LiAlH4 to give a primary amine. Alternatively, nucleophilic substitution of an alkyl halide with a phthalimide ion is carried out and the N-alkylated phthalimide is then hydrolyzed to the primary amine. Reductive amination of an aldehyde with ammonia is a third method of introducing an NH2 group. A fourth possible method is to react an alkyl halide with ammonia, but this is less satisfactory since overalkylation is possible. Primary and secondary alkylamines can be alkylated to secondary and tertiary alkylamines, respectively, by reaction with an alkyl halide. Primary alkylamines can also be synthesized if ammonia is used instead of an alkylamine. However, these reactions are difcult to control and over-alkylation is common. Reductive amination is a more controlled method of adding an extra alkyl group to an amine, where the amine (or ammonia) is treated with an aldehyde or a ketone in the presence of a reducing agent (sodium cyanoborohydride). Alternatively, primary and secondary amines can be acylated with an acid chloride or acid anhydride and then reduced with LiAlH4 to give a secondary and tertiary amine, respectively. The Hofmann and Curtius rearrangements are used to convert a carboxylic acid derivative to a primary amine with the loss of a carbon unit the original carbonyl group. In both cases the rearrangement reaction involves the alkyl group being transferred from the carbonyl group to the nitrogen atom to form an isocyanate intermediate. Hydrolysis then results in loss of the original carbonyl group. The Hofmann rearrangement involves the treatment of a primary amide with bromine under basic conditions. The Curtius rearrangement involves heating an acyl azide. Amino groups cannot be directly introduced to an aromatic ring. However, nitro groups can be added directly by electrophilic substitution, then reduced to the amine. Once the amine is present, reactions such as alkylation, acylation, or reductive amination can be carried out as described for alkylamines. Synthesis of mono-substituted benzenes (I4) Reactions (K6) Reactions of alkyl halides (L6) Chemistry of nitriles (O4) Substitution with NH2 Alkylation of alkylamines Rearrangements Arylamines Related topics 296 Section O Amines and nitriles Reduction Nitriles and amides can be reduced to alkylamines using lithium aluminum hydride (LiAlH4; Topics O4 and K6). In the case of a nitrile, a primary amine is the only possible product. Primary, secondary, and tertiary amines can be prepared from primary, secondary, and tertiary amides, respectively. Primary alkyl halides and some secondary alkyl halides can undergo SN2 nucleophilic substitution with an azide ion (N3 ) to give an alkyl azide (Topic L6). The azide can then be reduced with LiAlH4 to give a primary amine (Fig. 1). The overall reaction is equivalent to replacing the halogen atom of the alkyl halide with an NH2 unit. Another method of achieving the same result is the Gabriel synthesis of amines. This involves treating phthalimide with KOH to abstract the NH proton (Fig. 2). The NH proton of phthalimide is more acidic (pKa 9) than the NH proton of an amide since the anion formed can be stabilized by resonance with both neighboring carbonyl groups. The phthalimide ion can then be alkylated by treating it with an alkyl halide in a nucleophilic substitution (Topic L2). Subsequent hydrolysis (Topic K6) releases a primary amine (Fig. 3). A third possible method is to react an alkyl halide with ammonia, but this is less satisfactory since over-alkylation is possible (see below). The reaction of an aldehyde with ammonia by reductive amination is a fourth method of obtaining primary amines (see below). NaN3 Ethanol Alkyl azide a) LiAlH4 b) H2O Substitution with NH2 CH3CH2 Br CH3CH2 N N N CH3CH2 NH2 Fig. 1. Synthesis of a primary amine from an alkyl halide via an alkyl azide. O KOH N H Ethanol O O O N N N O Phthalimide O O O Fig. 2. Ionization of phthalimide. O R-X N N R O HO H2O CO2H O O CO2H H + H N R Fig. 3. Gabriel synthesis of primary amines. Alkylation of alkylamines It is possible to convert primary and secondary amines to secondary and tertiary amines respectively, by alkylation with alkyl halides by the SN2 reaction (Topic L6). However, over-alkylation can be a problem and better methods of amine synthesis are available. O1 Preparation of amines 297 Reductive amination is a more controlled method of adding an extra alkyl group to an alkylamine (Fig. 4). Primary and secondary alkylamines can be treated with a ketone or an aldehyde in the presence of a reducing agent called sodium cyanoborohydride. The alkylamine reacts with the carbonyl compound by nucleophilic addition followed by elimination to give an imine or an iminium ion (Topic J6) which is immediately reduced by sodium cyanoborohydride to give the nal amine. Overall, this is the equivalent of adding one extra alkyl group to the amine. Therefore, primary amines are converted to secondary amines and secondary amines are converted to tertiary amine. The reaction is also suitable for the synthesis of primary amines if ammonia is used instead of an alkylamine. The reaction goes through an imine intermediate if ammonia or a primary amine is used (Fig. 4a). When a secondary amine is used, an iminium ion intermediate is involved (Fig. 4b). An alternative way of alkylating an amine is to acylate the amine to give an amide (Topic K5), and then carry out a reduction with LiAlH4 (Topic K6; Fig. 5). Although two steps are involved, there is no risk of over-alkylation since acylation can only occur once. a) R O NH2R" C R' R NR" C R' NaBH3CN NHR" C R R' 2o amine b) R O C R' NHR"2 R NR"2 NaBH3CN C R' NR''2 C R R' o amine 3 Aldehyde Aldehyde or ketone ketone or Imine Imine 2 amine Aldehyde or Aldehyde ketone or ketone Iminium ionion Iminium 3 amine Fig. 4. Reductive amination of an aldehyde or ketone. CH3COCl R NH2 Pyridine O Fig. 5. Alkylation of an amide via an amine. R NH C CH3 a) LiAlH4 b) H2O R NH CH3 Rearrangements There are two rearrangement reactions which can be used to convert carboxylic acid derivatives into primary amines where the carbon chain in the product has been shortened by one carbon unit (Fig. 6). These are known as the Hofmann and the Curtius rearrangements. The Hofmann rearrangement involves the treatment of a primary amide with bromine under basic conditions, while the Curtius rearrangement involves heating an acyl azide. The end result is the same a primary amine with loss of the original carbonyl group. H2O heat R CO2 (g) N2 (g) O C N N N Acyl azide O C R NH2 Primary amide 4 NaOH, Br2, H2O R Na2CO3 2 NaBr 2 H2O NH2 Fig. 6. Hofmann rearrangement (left) and Curtius rearrangement (right). 298 Section O Amines and nitriles In both reactions, the alkyl group (R) is transferred from the carbonyl group to the nitrogen to form an intermediate isocyanate (O C NR). This is then hydrolyzed by water to form carbon dioxide and the primary amine. The Curtius rearrangement has the added advantage that nitrogen is lost as a gas which helps to drive the reaction to completion. Arylamines The direct introduction of an amino group to an aromatic ring is not possible. However, nitro groups can be added directly by electrophilic substitution and then reduced to the amine (Topic I4; Fig. 7). The reduction is carried out under acidic conditions resulting in an arylaminium ion as product. The free base can be isolated by basifying the solution with sodium hydroxide to precipitate the arylamine. NO2 HNO3 H2SO4 a) SnCl2 / H3O b) NaOH, H2O NH2 Fig. 7. Introduction of an amine to an aromatic ring. Once an amino group has been introduced to an aromatic ring, it can be alkylated with an alkyl halide, acylated with an acid chloride or converted to a higher amine by reductive animation as described for an alkylamine. Section O Amines and nitriles O2 PROPERTIES OF AMINES Key Notes Structure Amines consist of an sp hybridized nitrogen linked to three substituents by bonds. The functional group is pyramidal in shape with bond angles of approximately 109 . If the substituents are alkyl groups, the amine is aliphatic or an alkylamine. If one or more of the substituents is aromatic, the amine is aromatic or an arylamine. If the amine has only one alkyl or aryl substituent, it is dened as primary. If there are two such substituents, the amine is secondary, and if there are three such groups, the amine is tertiary. Amines can be chiral if they have three different substituents. However, it is not possible to separate enantiomers since they can easily interconvert by pyramidal inversion. The process involves a planar intermediate where the 3 2 nitrogen has changed from sp hybridization to sp hybridization and the lone pair of electrons are in a p orbital. Pyramidal inversion is not possible for chiral quaternary ammonium salts and enantiomers of these structures can be separated. Amines are polar compounds with higher boiling points than comparable alkanes. They have similar water solubilities to alcohols due to hydrogen bonding, and low molecular weight amines are completely miscible with water. Low molecular weight amines have an offensive shy smell. Amines are weak bases which are in equilibrium with their ammonium ion in aqueous solution. The basic strength of an amine is indicated by its pKb value. There are two main effects on basic strength. Alkyl groups have an inductive effect which stabilizes the ammonium ion and results in increased basicity. Solvation of the ammonium ion by water stabilizes the ion and increases basicity. The more hydrogen bonds which are possible between the ammonium ion and water, the greater the stability and the greater the basicity. The alkyl inductive effect is greatest for ammonium ions formed from tertiary amines, whereas the solvation effect is greatest for ammonium ions formed from primary amines. In general, primary and secondary amines are stronger bases than tertiary amines. Aromatic amines are weaker bases than aliphatic amines since nitrogens lone pair of electrons interacts with the system of the aromatic ring, and is less likely to form a bond to a proton. Aromatic substituents affect basicity. Activating substituents increase electron density in the aromatic ring which helps to stabilize the ammonium ion and increase basic strength. Deactivating groups have the opposite effect. Substituents capable of interacting with the aromatic ring by resonance have a greater effect on basicity if they are at the ortho or para positions. 3 Pyramidal inversion Physical properties Basicity 300 Section O Amines and nitriles Reactivity Amines react as nucleophiles or bases since they have a readily available lone pair of electrons which can participate in bonding. Primary and secondary amines can act as weak electrophiles or acids with a strong base, by losing an NH proton to form an amide anion (R2N ). Evidence for primary and secondary amines include NH stretching and bending absorptions in the IR spectrum as well as a D2O exchangeable 1 proton in the H nmr spectrum. sp Hybridization (A3) 2 sp Hybridization (A4) Intermolecular bonding (C3) Properties and reactions (C4) Organic structures (E4) Base strength (G3) Reactions of amines (O3) Infra-red spectroscopy (P3) 3 Spectroscopic analysis Related topics Proton nuclear magnetic resonance spectroscopy (P4) 13 C nuclear magnetic resonance spectroscopy (P5) Mass spectroscopy (P6) Structure Amines consist of an sp hybridized nitrogen linked to three substituents by three bonds. The substituents can be hydrogen, alkyl, or aryl groups, but at least one of the substituents has to be an alkyl or aryl group. If only one such group is present, the amine is dened as primary. If two groups are present, the amine is secondary. If three groups are present, the amine is tertiary (Topic C6). If the substituents are all alkyl groups, the amine is dened as being an alkylamine. If there is at least one aryl group directly attached to the nitrogen, then the amine is dened as an arylamine. 3 The nitrogen atom has four sp hybridized orbitals pointing to the corners of a 3 tetrahedron in the same way as an sp hybridized carbon atom. However, one of 3 the sp orbitals is occupied by the nitrogens lone pair of electrons. This means that the atoms in an amine functional group are pyramidal in shape. The CNC bond angles are approximately 109 which is consistent with a tetrahedral nitrogen. However, the bond angle is slightly less than 109 since the lone pair of electrons demands a slightly greater amount of space than a bond. Since amines are tetrahedral, they are chiral if they have three different substituents. However, it is not possible to separate the enantiomers of a chiral amine since amines can easily undergo pyramidal inversion a process which interconverts the enantiomers (Fig. 1). The inversion involves a change of 2 hybridization where the nitrogen becomes sp hybridized (Topic A4) rather than 3 Pyramidal inversion R" R' N R" R' R R" R' Planar R N R Fig. 1. Pyramidal inversion. O2 Properties of amines 301 sp hybridized. As a result, the molecule becomes planar and the lone pair of elec3 trons occupy a p orbital. Once the hybridization reverts back to sp , the molecule can either revert back to its original shape or invert. Although the enantiomers of chiral amines cannot be separated, such amines can be alkylated to form quaternary ammonium salts where the enantiomers can be separated. Once the lone pair of electrons is locked up in a bond, pyramidal inversion becomes impossible and the enantiomers can no longer interconvert. Physical properties Amines are polar compounds and intermolecular hydrogen bonding is possible for primary and secondary amines. Therefore, primary and secondary amines have higher boiling points than alkanes of similar molecular weight. Tertiary amines also have higher boiling points than comparable alkanes, but have slightly lower boiling points than comparable primary or secondary amines since they cannot take part in intermolecular hydrogen bonding. However, all amines can participate in hydrogen bonding with protic solvents, which means that amines have similar water solubilities to comparable alcohols. Low molecular weight amines are freely miscible with water. Low molecular weight amines have an offensive sh-like odor. Amines are weak bases but they are more basic than alcohols, ethers, or water. As a result, amines act as bases when they are dissolved in water and an equilibrium is set up between the ionized form (the ammonium ion) and the unionized form (the free base; Fig. 2). RR N R Fig. 2. Acidbase reaction between an amine and water. + H2O R 3 Basicity RR N H + HO The basic strength of an amine can be measured by its pKb value (typically 34; Topic G3). The lower the value of pKb, the stronger the base. The pKb for ammonia is 4.74, which compares with pKb values for methylamine, ethylamine, and propylamine of 3.36, 3.25 and 3.33, respectively. This demonstrates that larger alkyl groups increase base strength. This is an inductive effect whereby the ion is stabilized by dispersing some of the positive charge over the alkyl group (Fig. 3). This shifts the equilibrium of the acid base reaction towards the ion, which means that the amine is more basic. The larger the alkyl group, the more signicant this effect. R NH2 + H2O R NH3 + HO Fig. 3. Inductive effect of an alkyl group on an alkylammonium ion. Further alkyl substituents should have an even greater inductive effect and one might expect secondary and tertiary amines to be stronger bases than primary amines. This is not necessarily the case and there is no direct relationship between basicity and the number of alkyl groups attached to nitrogen. The inductive effect of more alkyl groups is counterbalanced by a solvation effect. 302 Section O Amines and nitriles Once the ammonium ion is formed, it is solvated by water molecules a stabilizing factor which involves hydrogen bonding between the oxygen atom of water and any NH group present in the ammonium ion (Fig. 4). The more hydrogen bonds which are possible, the greater the stabilization. As a result, solvation and solvent stabilization is stronger for alkylaminium ions formed from primary amines than for those formed from tertiary amines. The solvent effect tends to be more important than the inductive effect as far as tertiary amines are concerned and so tertiary amines are generally weaker bases than primary or secondary amines. HR N Greatest solvent stabilization H OH2 H OH2 H OH2 RR N H OH2 R Least solvent stabilization H-Bond RR N H OH2 H2O Fig. 4. Solvent effect on the stabilization of alkylammonium ions. Aromatic amines (arylamines) are weaker bases than alkylamines since the orbital containing nitrogens lone pair of electrons overlaps with the system of the aromatic ring. In terms of resonance, the lone pair of electrons can be used to form a double bond to the aromatic ring, resulting in the possibility of three zwitterionic resonance structures (Fig. 5). (A zwitterion is a molecule containing a positive and a negative charge.) Since nitrogens lone pair of electrons is involved in this interaction, it is less available to form a bond to a proton and so the amine is less basic. NH2 NH2 NH2 NH2 Fig. 5. Resonance interaction between nitrogens lone pair and the aromatic ring. The nature of aromatic substituent also affects the basicity of aromatic amines. Substituents which deactivate aromatic rings (e.g. NO2, Cl, or CN) lower electron density in the ring, which means that the ring will have an electron-withdrawing effect on the neighboring ammonium ion. This means that the charge will be destabilized and the amine will be a weaker base. Substituents which activate the aromatic ring enhance electron density in the ring which means that the ring will have an electron-donating effect on the neighboring charge. This has a stabilizing effect and so the amine will be a stronger base. The relative position of aromatic substituents can be important if resonance is possible between the aromatic ring and the substituent. In such cases, the substituent will have a greater effect if it is O2 Properties of amines 303 at the ortho or para position. For example, para-nitroaniline is a weaker base than meta-nitroaniline. This is because one of the possible resonance structures for the para isomer is highly disfavored since it places a positive charge immediately next to the ammonium ion (Fig. 6). Therefore, the number of feasible resonance structures for the para isomer is limited to three, compared to four for the meta isomer. This means that the para isomer experiences less stabilization and so the amine will be less basic. If an activating substituent is present, capable of interacting with the ring by resonance, the opposite holds true and the para isomer will be a stronger base than the meta isomer. This is because the crucial resonance structure mentioned above would have a negative charge immediately next to the ammonium ion and this would have a stabilizing effect. para Isomer NH3 NH3 NH3 NH3 N O O O N O O N O O Highly disfavored N O meta Isomer NH3 NH3 NH3 NH3 O N O N O O N O O N O O Fig. 6. Resonance structures for para-nitroaniline and meta-nitroaniline. Reactivity Amines react as nucleophiles or bases, since the nitrogen atom has a readily available lone pair of electrons which can participate in bonding (Fig. 7). As a result, amines react with acids to form water soluble salts. This allows the easy separation of amines from other compounds. A crude reaction mixture can be extracted with dilute hydrochloric acid such that any amines present are protonated and dissolve into the aqueous phase as water-soluble salts. The free amine can be recovered by adding sodium hydroxide to the aqueous solution such that the free amine precipitates out as a solid or as an oil. Amines will also react as nucleophiles with a wide range of electrophiles including alkyl halides, aldehydes, ketones, and acid chlorides. The NH protons of primary and secondary amines are weakly electrophilic or acidic and will react with a strong base to form amide anions. For example, diisoWeak electrophilic centers H Nucleophilic center R Weak electrophilic center H c) Nucleophilic center R a) Nucleophilic center R H N b) R N R N R Fig. 7. Nucleophilic and electrophilic centers in (a) primary, (b) secondary, and (c) tertiary amines. 304 Section O Amines and nitriles propylamine (pKa ~40) reacts with butyllithium to give lithium diisopropylamide (LDA) and butane. Spectroscopic analysis Primary and secondary amines are likely to show characteristic absorptions due to NH stretching and NH bending. The former occurs in the region 1 35003300 cm , and in the case of primary amines two absorptions are visible. The absorptions tend to be sharper but weaker than OH absorptions which can occur 1 in the same region. NH bending occurs in the region 16501560 cm for primary 1 amines and 15801490 cm for secondary amines although the latter tend to be weak and unreliable. These absorptions occur in the same region as alkene and aromatic C=C stretching absorptions, and care has to be taken in assigning them. Naturally, these absorptions are not present for tertiary amines. For aromatic amines, an absorption due to ArN stretching may be visible in the region 1 13601250 cm . 1 The H nmr spectrum of a primary or secondary amine will show a broad signal for the NH proton in the region 0.54.5 ppm which will disappear from the spectrum if the sample is shaken with deuterated water. For aromatic amines this signal is typically in the range 36 ppm. The chemical shifts of neighboring groups can also indicate the presence of an amine group indirectly. For example, an 1 N-methyl group gives a singlet near 2.3 ppm in the H spectrum and appears in 13 the region 3045 ppm in the C spectrum. If the molecular ion in the mass spectrum has an odd number, this indicates that an odd number of nitrogen atoms are present in the molecule. This supports the presence of an amine but does not prove it, since there are other functional groups containing nitrogen. Amines undergo -cleavage when they fragment (i.e. cleavage next to the carbon bearing the amine group. Section O Amines and nitriles O3 REACTIONS OF AMINES Key Notes Alkylation Ammonia, primary amines, and secondary amines can be alkylated with alkyl halides to give primary, secondary, and tertiary amines, respectively. However, over-alkylation usually occurs and mixtures are obtained. The method is best used for converting tertiary amines to quaternary ammonium salts. A better method of alkylating a primary or secondary amine is to treat the amine with an aldehyde or ketone in the presence of a reducing agent. Reaction of the amine with the carbonyl compound produces an intermediate imine which is reduced to the amine. No over-alkylation takes place. Primary and secondary amines can be acylated with an acid chloride or acid anhydride to give secondary and tertiary amides, respectively. Primary and secondary amines can be sulfonylated with a sulfonyl chloride to give a sulfonamide. Primary amines can be converted to alkenes if the amine is rst methylated to a quaternary ammonium salt, then treated with silver oxide. Elimination of triethylamine takes place to give the least substituted alkene. The reaction is known as the Hofmann elimination. The reaction can also be carried out on secondary and tertiary amines although a mixture of alkenes may be formed depending on the substituents present. Aromatic amines will also react if they contain a suitable N-alkyl substituent. Aromatic amines undergo electrophilic aromatic substitutions. The amino group is strongly activating and directs substitution to the ortho and para positions. Nitration, sulfonation, and bromination are all possible, but bromination may occur more than once. FriedelCrafts alkylation and acylation are not possible since the amino group complexes the Lewis acid involved in the reaction. The problems of excess bromination and Lewis acid complexation can be overcome by converting the amine to an amide before carrying out the substitution reaction. The amide can be hydrolyzed back to the amine once the substitution reaction has been carried out. Aromatic primary amines can be converted to diazonium salts on treatment with nitrous acid. These salts are extremely important in aromatic chemistry since they can be converted to a variety of other substituents. Diazonium salts also react with phenols or aromatic amines in a process called diazonium coupling to produce a highly conjugated system which is usually colored. Such products are often used as dyes. Acylation Sulfonylation Elimination Electrophilic aromatic substitution Diazonium salts 306 Section O Amines and nitriles Related topics Synthesis of di- and tri-substituted benzenes (I6) Preparations of carboxylic acid derivatives (K5) Reactions (K6) Reactions of alkyl halides (L6) Preparation of amines (O1) Alkylation Ammonia, primary amines, and secondary amines (both aromatic and aliphatic) can undergo the SN2 reaction with alkyl halides to produce a range of primary, secondary, and tertiary amines (Topic L6). Primary, secondary, and tertiary amines are produced as ammonium salts which are converted to the free amine by treatment with sodium hydroxide (Fig. 1a). In theory, it should be possible to synthesize primary amines from ammonia, secondary amines from primary amines, and tertiary amines from secondary amines. In practice, over-alkylation is common. For example, reaction of ammonia with methyl iodide leads to a mixture of primary, secondary, and tertiary amines along with a small quantity of the quaternary ammonium salt (Fig. 2). Alkylation of tertiary amines by this method is a good way of obtaining quaternary ammonium salts (Fig. 1b) since no other products are possible. However, alkylation of lower order amines is not so satisfactory. A better method of alkylating a primary or secondary amine is to treat the amine with a ketone or an aldehyde in the presence of a reducing agent sodium cyanoborohydride. This reaction is known as a reductive amination and is described in Topic O1. Over-alkylation cannot occur by this method. a) R R N H a) R" X R R N R" 1o , 2o or 3o Amines b) R R N R R=alkyl R" X R R N R R" X b) NaOH R=H or alkyl 4o Ammonium salt Fig. 1. Alkylation of amines. H H H N a) H3C b) NaOH I H3C H H 1o Amine N + H3C H3C H 2o Amine N + H3C H3C H3C 3o Amine N + H3C H3C H3C 4o Ammonium salt N CH3 I Fig. 2. Alkylation of ammonia with methyl iodide. Acylation Primary and secondary amines (both aromatic and aliphatic) can be acylated with an acid chloride or acid anhydride to form secondary and tertiary amides, respectively (Topic K5). This reaction can be viewed as the acylation of an amine or as the nucleophilic substitution of a carboxylic acid derivative. In a similar reaction to acylation, primary and secondary amines (both aromatic and aliphatic) can be treated with a sulfonyl chloride to give a sulfonamide (Fig. 3). Tertiary amines do not give a stable product and are recovered unchanged. Sulfonylation O3 Reactions of amines 307 O a) S O Cl + H2N CH3 Pyridine O S O Sulfonamides NHCH3 O b) S O Cl + HN CH3 CH3 Pyridine O S O N(CH3)2 Fig. 3. Reaction of benzenesulfonyl chloride with (a) primary amine; (b) secondary amine. Elimination Primary amines could be converted to alkenes if it was possible to eliminate ammonia from the molecule. However, the direct elimination of ammonia is not possible. A less direct method of achieving the same result is to exhaustively methylate the amine by the SN2 reaction (Topic L2) to give a quaternary ammonium salt. Once this is formed, it is possible to eliminate triethylamine in the presence of silver oxide and to form the desired alkene. The reaction is called the Hofmann elimination (Fig. 4). The silver oxide provides a hydroxyl ion which acts as the base for an E2 elimination (Topic L4; Fig. 5). However, unlike most E2 eliminations, the less substituted alkene is preferred if a choice is available (Fig. 6). The reason for this preference is not fully understood, but may have something to do with the large bulk of the triethylamine leaving group hindering the approach of the hydroxide ion such that it approaches the least hindered -carbon. Excess NH2 CH3I N(CH3)3 I Ag2O H2O heat + N(CH3)3 Fig. 4. Hofmann elimination. N(CH3)3 + H OH N(CH3)3 Fig. 5. Mechanism of the Hofmann elimination. NH2 Excess CH3I N(CH3)3 I Ag2O + Least hindered H2O heat Minor alkene Major alkene + N(CH3)3 Fig. 6. The less substituted alkene is preferred in the Hofmann elimination. 308 Section O Amines and nitriles NH Excess CH3I N(CH3)2 I Ag2O H2O heat + Fig. 7. Hofmann elimination of a secondary amine. Me H N Excess CH3I Me N Ag2O H2O heat Me N Me + Fig. 8. Hofmann elimination of an aromatic amine. Secondary and tertiary amines can also be exhaustively methylated then treated with silver oxide. However, mixtures of different alkenes may be obtained if the N-substituents are different alkyl groups (Fig. 7). The Hofmann elimination is not possible with primary arylamines, but secondary and tertiary arylamines will react if one of the substituents is a suitable alkyl group. Elimination of the aromatic amine can then occur such that the alkyl substituent is converted to the alkene (Fig. 8). Electrophilic aromatic substitution Aromatic amines such as aniline undergo electrophilic substitution reactions where the amino group acts as a strongly activating group, directing substitution to the ortho and para positions (Topic I6). Like phenols, the amino group is such a strong activating group that more than one substitution may take place. For example, reaction of aniline with bromine results in a tribrominated structure as the only product. This problem can be overcome by converting the amine to a less activating group. Typically, this involves acylating the group to produce an amide (Topic K5; Fig. 9). This group is a weaker activating group and so mono-substitution takes place. Furthermore, since the amide group is bulkier than the original amino group, there is more of a preference for para substitution over ortho substitution. Once the reaction has been carried out, the amide can be hydrolyzed back to the amino group (Topic K6). NHCOCH3 Ac2O Pyridine Br2 NHCOCH3 NaOH H2O NH2 NH2 Br Fig. 9. Synthesis of para-bromoaniline. Br O3 Reactions of amines 309 Anilines can be sulfonated and nitrated, but the FriedelCrafts alkylation and acylation are not possible since the amino group forms an acid base complex with the Lewis acid required for this reaction. One way round this is to convert the aniline to the amide as above before carrying out the reaction. Diazonium salts Primary arylamines or anilines can be converted to diazonium salts, which in turn can be converted to a large variety of substituents (Fig. 10). Reaction of an aniline with nitrous acid results in the formation of the stable diazonium salt in a process called diazotization (Fig. 11). In the strong acid conditions used, the nitrous acid dissociates to form an NO ion which can then act as an electrophile. The aromatic amine uses its lone pair of electrons to form a bond to this NO ion. Loss of a proton from the intermediate formed, followed by a proton shift leads to the formation of a diazohydroxide. The hydroxide group is now protonated turning it into a good leaving group, and a lone pair from the aryl nitrogen forms a second bond between the two nitrogen atoms and expels water. Once the diazonium salt has been formed, it can be treated with various nucleophiles such as Br , Cl , I , CN and OH (Fig. 12). The nucleophile displaces nitrogen from the aromatic ring and the nitrogen which is formed is lost from the N NH2 HNO2 H2SO4 Fig. 10. Synthesis and reactions of diazonium salts. N Nu + N2 (g) Nu H N Ar NH2 O Ar N H N O H Ar H N N O Proton shift Ar N N OH H Diazohydroxide Ar N N OH2 Ar N N Fig. 11. Mechanism of diazotization. H3O heat CuCl Ar CuBr Ar N N CuCN Ar CN Ar Br Ar N N a) HBF4 Cl KI Ar Ar Ar OH I F b) Heat H3PO2 Ar H Fig. 12. Reactions of diazonium salts. 310 Section O Amines and nitriles OH N N OH N N H N N OH Fig. 13. Diazonium coupling. reaction mixture as a gas, thus helping to drive the reaction to completion. Those reactions involving Cu(I) are also known as the Sandmeyer reaction. Diazonium salts are also used in a reaction called diazonium coupling where the diazonium salt is coupled to the para position of a phenol or an arylamine (Fig. 13). The azo products obtained have an extended conjugated system which includes both aromatic rings and the N N link. As a result, these compounds are often colored and are used as dyes. The above coupling is more efcient if the reaction is carried out under slightly alkaline conditions (NaOH) such that the phenol is ionized to a phenoxide ion (ArO ). Phenoxide ions are more reactive to electrophilic addition than phenols themselves. Strong alkaline conditions cannot be used since the hydroxide ion adds to the diazonium salt and prevents coupling. If the para position of the phenol is already occupied, diazo coupling can take place at the ortho position instead. Aliphatic amines, as well as secondary and tertiary aromatic amines, react with nitrous acid, but these reactions are less useful in organic synthesis. Section O Amines and nitriles O4 CHEMISTRY OF NITRILES Key Notes Preparation Primary alkyl halides can be treated with the cyanide ion and converted to nitriles of general formula RCH2CN. Primary amides can be dehydrated with thionyl chloride or phosphorus pentoxide to give a nitrile. The nitrile group is linear in shape with both the carbon and nitrogen being sp hybridized. The triple bond is made up of one bond and two bonds. The nitrile group is polarized such that the nitrogen is a nucleophilic center and the carbon is an electrophilic center. Nucleophiles react with nitriles at the electrophilic carbon center to form an imine intermediate which reacts further depending on the reaction conditions. Nitriles can be hydrolyzed to carboxylic acids on treatment with aqueous acid or base. The reaction involves the formation of an intermediate primary amide. Nitriles can be converted to primary amines by reduction with lithium aluminum hydride. The reaction involves addition of two hydride ions. With a milder reducing agent such as DIBAH, only one hydride ion is added and an aldehyde is obtained. Nitriles react with Grignard reagents to produce ketones. The Grignard reagent provides the equivalent of a carbanion which reacts with the electrophilic carbon center of the nitrile group. The presence of a nitrile group is indicated by a CN stretching absorption 13 in the IR spectrum and a quaternary carbon signal in the C nmr spectrum. sp Hybridization (A5) Organic structures (E4) Preparations of carboxylic acids (K4) Nucleophilic substitution (L2) Reactions of alkyl halides (L6) Preparation of amines (O1) Infra-red spectroscopy (P3) 13 C nuclear magnetic resonance spectroscopy (P5) Mass spectroscopy (P6) Properties Reactions Spectroscopic analysis Related topics Preparation Nitriles are commonly prepared by the SN2 reaction of a cyanide ion with a primary alkyl halide (Topic L6). However, this limits the nitriles which can be synthesized to those having the following general formula RCH2CN. A more general synthesis of nitriles involves the dehydration of primary amides with reagents such as thionyl chloride or phosphorus pentoxide (Fig. 1). The nitrile group (CN) is linear in shape with both the carbon and the nitrogen atoms being sp hybridized. The triple bond linking the two atoms consists of one bond and two bonds. Nitriles are strongly polarized. The nitrogen is a nucleophilic center and the carbon is an electrophilic center. Nucleophiles react with nitriles at the electrophilic carbon (Fig. 2). Typically, the nucleophile will form a bond to the electrophilic carbon resulting in simultaneous breaking of one of the Properties 312 Section O Amines and nitriles O N C H3C CH3 Fig. 1. NH2 SOCl2 H3C CH3 C + + SO2 (g) 2HCl Dehydration of primary amides with thionyl chloride. + RC N R C N Product Nu Nu Imine anion intermediate Fig. 2. Reaction between nucleophile and nitriles. bonds. The electrons end up on the nitrogen to form an sp hybridized imine anion which then reacts further to give different products depending on the reaction conditions used. Reactions Nitriles (RCN) are hydrolyzed to carboxylic acids (RCO2H) in acidic or basic aqueous solutions. The mechanism of the acid-catalyzed hydrolysis (Fig. 3) involves initial protonation of the nitriles nitrogen atom. This activates the nitrile group towards nucleophilic attack by water at the electrophilic carbon. One of the nitrile bonds breaks simultaneously and both the electrons move onto the nitrogen resulting in a hydroxy imine. This rapidly isomerizes to a primary amide which is hydrolyzed under the reaction conditions (Topic K6) to give the carboxylic acid and ammonia. Nitriles (RCN) can be reduced to primary amines (RCH2NH2) with lithium aluminum hydride which provides the equivalent of a nucleophilic hydride ion. The reaction can be explained by the nucleophilic attack of two hydride ions (Fig. 4). 2 H R C N R C NH R C NH -H R C NH R O H C NH2 O O H H H H O Primary amide Hydroxy imine Fig. 3. Acid-catalyzed hydrolysis of nitrile to carboxylic acid. N R C N R C H H Imine anion H R C NAlH3 NH2 H2O R C H H H Fig. 4. Reduction of nitriles to form primary amines. O4 Chemistry of nitriles 313 With a milder reducing agent such as DIBAH (diisobutylaluminum hydride), the reaction stops after the addition of one hydride ion, and an aldehyde is obtained instead (RCHO). Grignard reaction Nitriles can be treated with Grignard reagents or organolithium reagents (Topic L7) to give ketones (Fig. 5). Grignard reagents provide the equivalent of a nucleophilic carbanion which can attack the electrophilic carbon of a nitrile group (Fig. 6). One of the bonds is broken simultaneously resulting in an intermediate imine anion which is converted to a ketone when treated with aqueous acid. O C b) H3O R CH3 b) H3O a) CH3Li R C N a) CH3MgI R C N Fig. 5. Nitriles react with Grignard reagent or organolithium reagents to produce ketones. CH3MgI R C N R C N O H3O C R CH3 CH3 CH3 Fig. 6. Imine anion Mechanism of the Grignard reaction on a nitrile group. Spectroscopic analysis The IR spectrum of an aliphatic nitrile shows an absorption due to stretching of 1 the nitrile group in the region 22602240 cm . The corresponding absorption for 1 an aromatic nitrile is in the region 22402190 cm . These regions are normally devoid of absorptions and so any absorption here can usually be identied. 13 The carbon of the nitrile group gives a quaternary signal in the C nmr spectrum which is typically in the region 114124 ppm. If a single nitrile group is present, the molecular ion in the mass spectrum must be an odd number due to the presence of nitrogen (see Topic P6). Section P Organic spectroscopy and analysis P1 SPECTROSCOPY Key Notes Introduction The absorption or emission of energy from electromagnetic radiation is involved in IR, vis/uv and nmr spectroscopy. Mass spectroscopy involves measuring the deection of ions in a magnetic eld. Electromagnetic radiation has the properties of both a wave and a particle. The former can be dened by wavelength and frequency, which in turn dene the energy. Energy is proportional to frequency and inversely proportional to wavelength. Visible and ultra violet spectroscopy (P2) Infra-red spectroscopy (P3) Proton nuclear magnetic resonance spectroscopy (P4) Carbon-13 nuclear magnetic resonance spectroscopy (P5) Mass spectroscopy (P6) Electromagnetic radiation Related topics Introduction There are three important spectroscopic methods used in the analysis of organic compounds which involve the use of electromagnetic radiation. These are visible/ultra violet (vis/uv), infra-red (IR) and nuclear magnetic resonance (nmr) spectroscopy. These methods measure the absorption or emission of energy from electromagnetic radiation arising from different regions of the electromagnetic spectrum (Fig. 1). In contrast, mass spectroscopy measures the deection of ions in a magnetic eld. Increase frequency () and energy 10 Hz Cosmic and -rays X-rays Vacuum ultra violet (UV) Near ultra violet (UV) 19 10 Hz Visible Near infra-red (IR) Infra-red (IR) 15 10 Hz Microwave radio (NMR) 13 0.1 nm 200 nm 400 nm 800 nm 2 m 50 m Increasing wavelength () Fig. 1. The electromagnetic spectrum. Electromagnetic radiation Electromagnetic radiation has the properties of both a wave and a particle. The latter can be described in terms of quanta or photons. The former can be described by wavelength () the distance between the crests of different waves, and frequency () the number of waves that pass a given point each second. Frequency is measured in hertz (Hz), which is the same as cycles per second. The energy of electromagnetic radiation is related to frequency and wavelength by the following equation: 316 Section P Organic spectroscopy and analysis E = h = hc where h = Plancks constant (6.63 10 J s ), and c is the velocity of light 8 1 (2.99792458 10 m s ). Therefore, the higher the frequency of radiation, the higher the energy. Conversely, the higher the wavelength, the lower the energy. Thus in the visible spectrum, violet light ( = 400 nm) has a higher energy than red light ( = 750 nm). 34 1 Section P Organic spectroscopy and analysis P2 VISIBLE AND ULTRA VIOLET SPECTROSCOPY Key Notes Introduction Visible/ultra violet spectroscopy is useful in the analysis of extended conjugated systems. Absorption of vis/uv radiation results in the promotion of electrons from low electronic levels to higher ones. Vis-uv spectroscopy is useful in the analysis of unsaturated molecules such as conjugated alkenes and involves the measurement of electronic transitions from the highest occupied molecular orbital to the lowest unoccupied molecular orbital (*). If a heteroatom is present in the conjugated system n-* transitions are possible as well as * transitions. Absorbance is a measure of the amount of energy absorbed by a sample, having corrected for any energy absorbed by the solvent. A uv spectrum measures the absorbance (A) versus the wavelength of energy absorbed. The wavelength at which absorbance is a maximum for a peak is max. The strength of absorption at max is known as the molar absorptivity () and takes into account the concentration of the sample and length of the sample cell. Vis-uv spectra can be used to measure the concentrations of samples. The theoretical value for max can be calculated using tables which quantify the effects of extra conjugation and substituents for a particular parent system. This can be compared versus the observed max to help conrm a proposed structure or to choose between different possible structures. Covalent bonding and hybridization (A2) Conjugated dienes (H11) Spectroscopy (P1) Electronic transitions Measurements Structural analysis Related topics Introduction Visible/ultra violet spectroscopy is one of the oldest forms of spectroscopy, but its use in identifying the structure of organic compounds has waned with the advent of more recent spectroscopic techniques. Nevertheless, vis-uv spectroscopy can still be a worthwhile tool for the organic chemist, especially in the structural analysis of organic molecules which contain extended conjugated systems. This typically occurs when functional groups such as alkenes, ketones, aldehydes, carboxylic acids, esters and aromatic rings are in conjugation with other unsaturated systems. When electromagnetic radiation in the visible-uv region is absorbed by a molecule, the energy absorbed excites electrons from low electronic levels to higher ones. For that reason, visible and UV spectra are often called electronic spectra. The easiest transition involves the promotion of an electron from the highest occupied molecular orbital (HOMO) to the lowest unoccupied molecular orbital Electronic transitions 318 Section P Organic spectroscopy and analysis (LUMO). In Topic A2, we described the formation of two molecular orbitals for the hydrogen molecule a bonding () MO of lower energy and an antibonding () MO of higher energy. In a hydrogen molecule both electrons ll the MO resulting in stabilization. An electronic transition would involve promoting one of the electrons in the MO to the MO. The energy required for this transition is too great to be measured in the vis-uv spectrum. This is also true for the -bonds present in organic molecules which means that vis-uv spectroscopy cannot be used to analyze saturated organic molecules. However, vis-UV spectroscopy is useful in the analysis of unsaturated compounds compounds that contain -bonds. When two half lled p orbitals form a bond, two molecular orbitals are formed a more stable bonding MO and a less stable antibonding * MO (Fig. 1). Both electrons occupy the bonding MO and this becomes the HOMO (since it is less stable than any of the -MOs present in the molecule). The antibonding * MO remains unoccupied and becomes the LUMO. * molecular orbital LUMO p orbital electronic transition * p orbital * molecular orbital HOMO Fig. 1. and * molecular orbitals. The easiest and least energetic electronic transition is the promotion of one of the electrons from the MO to the * MO. The energy separation between the MO and the * MO is less than that between a MO and a * MO, but for a simple alkene this corresponds to a wavelength of less than 200 nm which is still too energetic for the vis-uv spectrum. When it comes to conjugated systems, the energy difference between the HUMO and LUMO is greatly reduced allowing electronic transitions to occur in the vis-uv region. In Topic H11 we saw that it was possible for the two -orbitals in conjugated dienes to interact with each other. This interaction can result in modied molecular orbitals as shown in Fig. 2. The two orbitals of the isolated alkenes interact to give two new orbitals 1 and 2 for the diene. A similar process takes place with the antibonding orbitals with the result that the energy difference between the HOMO and LUMO is reduced. For example, the max for ethene is 171 nm whereas it is 217 nm for 1,3-butadiene. (Remember that a higher wavelength means a lower energy.) As the amount of conjugation increases, the energy difference between the HOMO and the LUMO decreases until the difference is small enough for P2 Visible and ultra violent spectroscopy 319 4 (LUMO) (LUMO) 3 (LUMO) 2 (HOMO) (HOMO) isolated alkene 1 conjugated diene Fig. 2. Molecular orbitals for a conjugated diene. (HOMO) isolated alkene transitions to occur in the visible region resulting in a colored compound. For example, -carotene (Fig. 3) is the precursor for Vitamin A and is responsible for the orange color in carrots. It has an absorption maximum of 497 nm which corresponds to blue-green. Since this is the light that is absorbed, the color observed is what remains (i.e. red-orange). CH3 CH3 CH3 CH3 H3C CH3 CH3 Fig. 3. b-Carotene. CH3 CH3 CH3 With conjugated dienes, the electronic transitions are due to * transitions. If a heteroatom such as oxygen is present (e.g. an unsaturated aldehyde), * transitions are still possible, but it is also possible for one of the non-bonding electrons (i.e. from a lone pair of electrons) to be promoted to the LUMO. This transition is known as n*. This transition involves less energy than a * transition but the absorption bands observed in the spectrum are usually weaker in intensity than those due to * transitions. Measurements When measuring vis-uv spectra, the light beam is split such that one half goes through a solution of the sample (the sample beam) and the other half goes through the solvent alone (the reference beam). If energy is absorbed by the sample, the intensity of the sample beam (IS) after it has passed through the 320 Section P Organic spectroscopy and analysis sample will be less than the intensity of the reference beam (IR) after it has passed through the solvent. This is measured as the absorbance (A) where: A = log(IR/IS) The absorbance will change depending on the wavelength of light used and so a spectrum is produced measuring wavelength (in nm) versus absorbance. There may be one or several broad absorption peaks in the spectrum. The wavelength at which the absorption is a maximum for any of these peaks is called max and is reported for the compound. The strength of the absorption at this point is quantied by a term known as the molar absorptivity (), which is related to absorbance (A), the concentration of the sample (C) and the length (l) in centimeters of the cell 1 1 containing the sample. The units of are M cm . A=Cl Knowing max and for a particular compound means that it is possible to measure the concentration of a sample if the absorbance of a solution is measured at max. The ability to quantify concentrations using vis-uv spectroscopy is important in the analysis of mixtures using a technique known as high performance liquid chromatography (hplc). In this procedure, mixtures are passed down a column and exit the column at different rates. The compounds can be detected and quantied by passing them through a vis-uv spectrometer as they come off the column. Structural analysis The max for an absorption related to a particular electronic transition depends on the extent of conjugation in the molecule and also the types of substituent which might be present. The predicted value for max can be calculated using tables that quantify these effects for a particular parent system, e.g. the table for conjugated dienes is shown in Fig. 4. Parent Values Parent Value for Acyclic Diene of Heteroannular Diene Parent Value for Homoannular Diene Increments Double Bond Extension Exocyclic Double Bond Increments for Substituents Alkyl substituent or ring residue OAc OR SR Cl or Br NR2 Fig. 4. Table for conjugated dienes. 214 nm 253 nm 30 nm 5 nm 5 nm 0 nm 6 nm 30 nm 5 nm 60 nm The predicted max for the triene in Fig. 5 is calculated as follows. The parent system is the conjugated diene (214 nm). There is one extra double bond in conjugation with the diene which means adding an extra 30 nm for double bond extension. There are also substituents attached to the triene system three methyl groups worth 5 nm each, and one methoxy group worth 6 nm. This gives a predicted max of 265 nm. P2 Visible and ultra violent spectroscopy 321 Parent diene Extension 5 nm CH3O 6 nm CH3O 5 nm Fig. 5. Theoretical lmax for a triene. 5 nm A comparison of the predicted max versus the observed max can be used as supporting evidence for a proposed structure. It can also be useful in choosing between two or more likely structures for a test compound. Separate tables are available for ,-unsaturated aldehydes and ketones, ,-unsaturated acids and esters, and benzene derivatives. Section P Organic spectroscopy and analysis P3 INFRA-RED SPECTROSCOPY Key Notes Introduction Energy absorption in the IR region of the electromagnetic spectrum results in the stretching or bending of covalent bonds. More energy is required in a stretching vibration than a bending vibration. More energy is required to stretch multiple bonds compared to single bonds. Bonds to light atoms vibrate faster than bonds to heavy atoms. An IR spectrum is a measure of energy absorption versus the reciprocal wavelength (known as the wavenumber) of the radiation involved. The higher the wavenumber the greater the energy involved. IR energy is only absorbed if the vibration results in a change in dipole moment. The ngerprint region contains many peaks and it is not possible to identify the majority of peaks present in that region. Some peaks associated with particular functional groups can be identied if they are more intense than their neighbors. The ngerprint region is useful when comparing two compounds to see if they are identical. Functional groups display characteristic absorptions at particular regions of the IR spectrum allowing the identication of such groups in a molecule. Properties of alkenes and alkynes (H2) Preparation and properties (I2) Properties (J2) Structures and properties (K1) Preparation and physical properties of alkyl halides (L1) Properties of alcohols and phenols (M3) Properties of ethers, epoxide and thioethers (N2) Spectroscopy (P1) Properties of amines (O2) Chemistry of nitriles (O4) The IR spectrum Detectable absorptions The ngerprint region Identication of functional groups Related topics Introduction Molecules can absorb energy in the infra-red region of the electromagnetic spectrum resulting in the increased vibration of covalent bonds. There are two types of vibration resulting either in the stretching or the bending of bonds. These vibrations occur at specic frequencies (or energies) depending on the bond involved. It is useful to think of the bonds as springs and the atoms as weights in order to rationalize the energy required for such vibrations. There are two factors affecting the frequency of vibration the masses of the atoms and the stiffness of the bond. Multiple bonds such as double or triple bonds are stronger and stiffer than single bonds and so their stretching vibrations occur at higher frequency (or energy). The stretching vibration of bonds also depends on the mass of the atoms. The vibration is faster when the bond involves a light atom rather than a heavy atom. Stretching vibrations require more energy than bending vibrations. P3 Infra-red spectroscopy 323 The IR spectrum An IR spectrum is a graph of the absorbed energy versus the wavenumber (). The wavenumber is the reciprocal of the wavelength (i.e. 1/) and is measured in 1 units of cm . It is proportional to the frequency or energy of the radiation and so the higher the wavenumber, the higher the energy. For example, the absorption peak due to the stretching of an alkyne triple bond comes in the region 1 21002600 cm . This corresponds to a higher energy than the stretching 1 absorption of an alkene double bond that is in the range 16201680 cm . 1 The stretching vibration for a C-H bond occurs in the region 28532962 cm , compared to the stretching vibration of a CO bond which occurs in the nger1 print region below 1500 cm , illustrating the effect of mass on vibrational frequency. 1 Most stretching vibrations occur in the region 36001000 cm , whereas bending 1 vibrations are restricted to the region below 1600 cm . The normal range for IR 1 spectra is 4000600 cm . Not all vibrations can be detected by infra-red spectroscopy. IR energy is only absorbed if the vibration leads to a change in the molecules dipole moment. Thus, the symmetrical C=C stretching vibration of ethene does not result in the absorption of IR energy, and no absorption peak is observed. For most organic molecules, there are a large number of possible bond vibrations, and this number increases as the molecule becomes more complex. As a result, there are usually a large number of peaks observed such that the IR spectrum of one molecule is almost certain to be different from that of another. The region 1 where most peaks occur is generally below 1500 cm and is called the ngerprint region. This region is particularly useful when comparing the spectrum of a test compound against the spectrum of a known compound. If the spectra are identical this is good evidence that both compounds are identical. Since the ngerprint region is usually complex with many peaks present, it is not possible to assign the type of vibration associated with each peak unless a particular peak shows greater intensity over its neighbors or stands alone. Absorptions for some functional groups such as esters, nitro or sulfonate groups do occur in the ngerprint region and can be identied because of their position and intensity. IR spectra are particularly useful for identifying the presence of specic functional groups in a molecule, since the characteristic vibrations for these groups are known to occur in specic regions of the IR spectrum. For example, absorptions 1 due to the carbonyl stretching of an aldehyde occur in the region 16901740 cm whereas the corresponding absorptions for an ester occur in the region 1 17351750 cm . IR tables can be used to assign the various peaks and hence the functional groups present. Detectable absorptions The ngerprint region Identication of functional groups Section P Organic spectroscopy and analysis P4 PROTON NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY Key Notes Introduction Nmr spectroscopy involves the detection of nuclei. Nuclei are charged spinning bodies that have an associated magnetic moment. In proton nmr, an external magnetic eld is applied to force protons into two possible orientations which are not of equal energy. Those nuclei spinning with their magnetic moments aligned with the eld are more stable than those spinning with their magnetic moments aligned against the eld. There is a greater population of nuclei in the more stable orientation. Applying energy in the form of electromagnetic radiation causes the nuclei to ip or resonate between the two orientations resulting in an overall absorption of energy. When the radiation is stopped, the nuclei relax to the more stable population ratio resulting in an emission of energy. A spectrum can be obtained by measuring the energy absorbed or the energy emitted. The energy required for resonance is in the radiofrequency region of the electromagnetic spectrum and is equal to the frequency with which the magnetic moment precesses round the axis of the applied magnetic eld. The precessional frequency increases if the applied magnetic eld is increased. Nmr spectrometers and spectra are dened by the energy required for resonance. The presence of secondary magnetic elds in a molecule means that nonequivalent protons experience slightly different magnetic elds when the external magnetic eld is applied. This means that different protons require different energies for resonance and give different signals in a spectrum. Electrons are charged spinning bodies, which set up a secondary magnetic eld that opposes the applied eld and shields the proton. The greater the electron density around a proton, the greater the shielding and the less energy is required for resonance. The protons which give signals at the right hand side of an nmr spectrum are more shielded than those at the left-hand side and require less energy to resonate. The scale used in nmr is known as the chemical shift which is measured in parts per million relative to the signal for a reference compound called tetramethylsilane. The position of a signal in the nmr spectrum is affected by the inductive effects of various groups. Electron donating groups increase the electron density round a neighboring proton and lower the chemical shift. Electron withdrawing groups have the opposite effect. Secondary magnetic elds Secondary magnetic elds due to electrons The nmr spectrum Inductive effects on chemical shift P4 Proton nuclear magnetic resonance spectroscopy 325 Diamagnetic circulation Spin-spin coupling If an unsaturated group is present in a molecule, it is possible to get secondary magnetic elds due to diamagnetic circulation. This is a result of the external magnetic eld causing the electrons to circulate around the axis of the magnetic eld. The effect is large for aromatic rings since six electrons are involved, and smaller for groups such as alkenes and ketones. For most unsaturated systems, the secondary magnetic eld enhances the applied magnetic eld and increases chemical shift. The protons of aldehydes and carboxylic acids experience secondary magnetic elds due to diamagnetic circulation as well as electron withdrawing inductive effects, resulting in very large chemical shifts. Spin-spin coupling takes place between protons on neighboring carbon atoms if the protons concerned have different chemical shifts. When the protons on one carbon are in resonance, the protons on the neighboring carbon are not and each neighboring proton can adopt two possible orientations. These orientations affect the signal of the proton(s) that are in resonance, resulting in a splitting of the signal. The effect is transmitted through bonds rather than through space and decreases in magnitude with the number of bonds involved, such that coupling does not usually take place beyond three bonds. The number of peaks resulting from splitting is one more than the number of neighboring protons. The size of the splitting is called the coupling constant and this is identical for both signals involved in the coupling. Integration measures the relative intensity of each signal in the nmr spectrum and is proportional to the number of protons responsible for that signal. Integration Related topics Properties of alkenes and alkynes (H2) Preparation and properties (I2) Properties (J2) Structures and properties (K1) Preparation and physical properties of alkyl halides (L1) Properties of alcohols and phenols (M3) Properties of ethers, epoxide and thioethers (N2) Properties of amines (O2) Spectroscopy (P1) Introduction Of all the spectroscopic methods, nuclear magnetic resonance (nmr) spectroscopy is the most useful in determining the structure and stereochemistry of organic compounds. Nmr spectroscopy detects the nuclei of atoms in a molecule, and one of the most useful forms of nmr is the detection of hydrogen atoms. The nucleus of a hydrogen atom is a single proton and so the method is also known as proton nmr. A proton spins around its axis, and whenever a charged body spins, a magnetic eld is set up which can be represented by a magnetic dipole moment (Fig. 1a). Under normal conditions, the protons and their magnetic moments are randomly orientated and so there is no overall magnetic eld (Fig. 2a). However, the situation changes if an external magnetic eld is applied to the sample. In Fig. 1b and c an external magnetic eld has been applied in the direction of the z-axis. This eld interacts with the magnetic moment of the nucleus, forcing the nucleus to spin in only two possible orientations. In Fig. 1b, the nucleus is spinning such that the magnetic moment is pointing in roughly the same 326 Section P Organic spectroscopy and analysis (a) Z axis (b) Z axis (c) Z axis + Dipole moment + + Magnetic field Fig. 1. Orientation of a protons magnetic dipole moment; A) No magnetic eld B) Alignment with magnetic eld C) Alignment against magnetic eld. (a) Energy (b) + ++++ + + ++ ++ No applied magnetic field Against the field + +++ ++ Applied magnetic field With the field Fig. 2. Energy levels before and after applying an external magnetic eld. direction as the eld. The other orientation (Fig. 1c) has the nucleus spinning such the dipole moment is pointed roughly against the eld. Crucially, these two orientations are not of equal energy. The orientation against the eld is less stable than the orientation with the eld (Fig. 2b). This is crucial to understanding why we get an nmr spectrum. The energy difference between the two orientations is extremely small and so the energy levels involved are almost equally populated. However, there is a slight excess of nuclei in the more stable energy level, and so if we were to promote these nuclei to the higher energy level, energy would be absorbed and a P4 Proton nuclear magnetic resonance spectroscopy 327 spectrum could be measured. Before we look at what energy is required, we shall return to our picture of the spinning nucleus. Fig. 1b shows the nucleus spinning with the eld the more stable orientation. Notice that the dipole moment is not directly aligned with the magnetic eld, but is at an angle to it. This means that the dipole moment experiences a force or a torque, which causes it to rotate or precess around the z-axis (Fig. 3a) like a gyroscope. A gyroscope is a spinning body which, when set at an angle to the vertical axis of gravity, precesses round that vertical axis. The nucleus is undergoing exactly the same kind of motion. It too is a spinning body but it precesses round the axis of an applied magnetic eld. The rate at which the dipole moment precesses round the z-axis is called the Larmor frequency and is dependant on the strength of the applied magnetic eld. If the magnetic eld increases, the rate of precession increases. (a) Z axis (b) Z axis (c) Z axis (d) Z axis Larmor frequency Dipole moment Energy + Larmor frequency Magnetic field (Bo) Magnetic field (Bo) + = Larmor frequency Energy + + Energy Fig. 3. Larmor frequency and energy transitions. In order to get a spectrum we need to get transitions between the two energy levels. This can be achieved by ring in a burst of energy in the form of electromagnetic radiation (Fig. 3b). The effect of this energy is to excite the nucleus and to cause it to ip such that it is now against the magnetic eld (Fig. 3c). This orientation is less stable than the original orientation and so the nucleus has absorbed energy. It is found that the energy required to do this has the same frequency as the Larmor frequency. If the electromagnetic radiation is now stopped, the nucleus relaxes back to the more stable orientation (Fig. 3d). As a result, energy is emitted. Such energy can be detected and measured leading to a signal in an nmr spectrum. The energy difference between the two orientations is extremely small and is in the radiofrequency region of the electromagnetic spectrum. The energy difference is proportional to the Larmor frequency, which is proportional to the strength of the external applied magnetic eld. In a 6 magnetic eld of 14 100G, the energy difference is 60 10 Hz or 60 MHz. In a magnetic eld of 23 500G the energy difference is 100 MHz. NMR spectrometers work at a specic magnetic eld and thus a specic electromagnetic radiation is required for resonance. The convention is to identify the spectrometers and their spectra by the strength of the electromagnetic radiation used (i.e. 60 MHz or 100 MHz). 328 Section P Organic spectroscopy and analysis Secondary magnetic elds At this stage, we can see how a proton is detected by nmr spectroscopy, but if that was all there was to it we would only see one signal for every proton in a molecule. This would tell us nothing about the structure apart from the fact that protons are present. Fortunately, not all protons require the same energy for resonance. This is because there are secondary magnetic elds within the molecule, which inuence the magnetic eld experienced by each proton. Secondary magnetic elds are produced by the electrons in the molecule and are much smaller in magnitude than the applied magnetic eld in the order of 010 parts per million (ppm). However, they are sufciently large enough to result in different signals for different protons. This means that there should be one signal for every different (or non-equivalent) proton in the structure. Therefore, it is useful to identify the number of non-equivalent protons in a molecule in order to identify the number of signals that should be present in the spectrum. Note that the protons in a methyl group are equivalent and do not give separate signals because they are in identical molecular environments. This is also true for the protons in a CH2 group. (However, there are two situations where the two protons on a CH2 group become non equivalent, i.e. when they are constrained within a ring system and when they are next to an asymmetric center.) The size and direction of secondary magnetic elds depends on electron density, diamagnetic circulation and spin-spin coupling all of which are discussed below. Fig. 3a shows an isolated proton spinning and precessing in an applied magnetic eld. So far we have only considered the nucleus of the hydrogen atom, but we know that electrons must be present. Let us consider the effect of one electron orbiting the nucleus (Fig. 4). Since the electron is a spinning, charged body, it sets up a secondary magnetic eld of its own (Be, Fig. 4). The secondary magnetic eld (Be) opposes the external magnetic eld (Bo). Thus the nucleus is shielded from the external magnetic eld. This means the actual magnetic eld experienced by the nucleus is reduced (BoBe). Since the nucleus experiences a reduced magnetic eld, the precessional or Larmor frequency is reduced. This in turn means that less energy is required to make that nucleus resonate and give a signal. The greater the electron density round a proton, the greater the shielding and so the position of a signal in an nmr spectrum can be an indication of electron density in different parts of a molecule. Secondary magnetic elds due to electrons Z axis Electron + Be Bo External magnetic field Fig. 4. Secondary magnetic eld from an electron. P4 Proton nuclear magnetic resonance spectroscopy 329 The nmr spectrum The signals at the right hand side of an nmr spectrum (Fig. 5) are due to protons having a low precessional frequency while the signals at the left-hand side are due to protons having a high precessional frequency. Low precessional frequency is associated with high electron density (shielding) while high precessional frequency is associated with low electron density (deshielding). The energy required for resonance increases from right to left. Low precessional frequency High electron density High precessional frequency Low electron density TMS reference 10 9 8 7 6 5 4 Chemical shift (ppm) 360 300 240 3 2 1 0 600 1000 540 900 480 800 420 700 180 300 120 200 6 100 0A 0B 600 500 400 Chemical shift (Hz) Fig. 5. An nmr spectrum. A scale is needed in order to quantify the position of signals in an nmr spectrum. The scale used in nmr does not have absolute values, but is relative to the signal of a reference compound called tetramethylsilane (TMS) (Fig. 6). The methyl protons of TMS are equivalent and give one signal that is dened as the zero point on the scale. The scale is known as the chemical shift and is measured in parts per million (ppm). What does this mean and why do we not use an absolute scale, which uses frequency or energy units? Let us look at what happens if we measure the chemical shift in frequency units of hertz. The scale shown in Fig. 5A is for a 60 MHz nmr spectrometer. The 60 MHz refers to the frequency of the energy required to cause resonance. Thus, the signal at 3 ppm has a Larmor frequency which is 180 Hz faster than the signal due to TMS (180 Hz is 3 ppm of 60 MHz). However, we could also measure this spectrum using a more powerful nmr spectrometer which results in the protons having precessional frequencies in the CH3 H3C Si CH3 CH3 Fig. 6. Tetramethylsilane (TMS). 330 Section P Organic spectroscopy and analysis order of 100 MHz (Fig. 5b). In this situation, the signal at 3 ppm is due to a proton that is precessing 300 Hz faster than the protons for TMS. If we measure the chemical shift of this peak in ppm, this would still be 3 ppm, since 300 Hz is 3 ppm of 100 MHz. However, if we used a scale measured in Hertz, we would have to dene the power of the nmr spectrometer used. With chemical shift measured in parts per million, the chemical shift will be the same no matter which instrument is used. Inductive effects on chemical shift TMS is called an internal reference since it is dissolved in the deuterated solvent used to dissolve the sample. There is a good reason why TMS is used as an internal reference. Silicon has a tendency to repel the electrons in the siliconcarbon bonds such that they are pushed towards the methyl groups (Fig. 6) an inductive effect. This means that the protons in these methyl groups experience a high electron density that shields the nuclei and results in a low chemical shift, lower in fact than the vast majority of nmr signals observed in organic molecules. O + R CH3 R C R CH3 H3C CH3 Si CH3 0.0 Strongly shielded CH3 RO CH3 R3N CH3 RO CH3 R C 3.8 Strongly deshielded Fig. 7. 3.3 3.3 2.2 0.9 The inductive effect and chemical shift. Inductive effects have an important inuence on chemical shift. We can see this with a series of methyl groups (Fig. 7). Going from right to left we have TMS which sets the scale at 0 ppm. Next we have the methyl group of a saturated hydrocarbon. The alkyl groups of a hydrocarbon also push electrons away from them and hence increase electron density round a neighboring methyl group. However this inductive effect is not as powerful as the one caused by a silicon atom and so the methyl signals in hydrocarbons usually occur about 0.9 ppm. In the next case we have a methyl group next to a ketone group. A ketone group has an electron withdrawing effect, which reduces the electron density around the neighboring methyl group (deshielding), and so the chemical shift is higher at a O C O CH3 a b b HC 3 10 9 8 7 6 5 4 3 2 1 0 Fig. 8. Nmr spectrum of methyl ethanoate P4 Proton nuclear magnetic resonance spectroscopy 331 about 2.2 ppm. The electron withdrawing effect of an oxygen atom or a positively charged nitrogen is greater still and so a methyl ether group has a signal at about 3.3 ppm, similar to the methyl signal of a quaternary ammonium salt. Since the position of a signal in the nmr spectrum is related to inductive effects, it is possible to use this knowledge to assign different signals in an nmr spectrum. For example, the nmr spectrum for methyl ethanoate contains two signals at 2.0 a and 3.5 ppm (Fig. 8). The signal at 3.5 ppm can be assigned to CH3 since it is directly attached to oxygen. The oxygen has a stronger electron withdrawing effect than the carbonyl group. NMR tables are also available which show the typical chemical shifts for particular groups. Diamagnetic circulation A special type of secondary magnetic effect is called diamagnetic circulation. This occurs in functional groups which contain bonds. As an example, we shall consider the aromatic ring (Fig. 9). H Be Bo Fig. 9. Diamagnetic circulation of an aromatic ring. The applied external magnetic eld (Bo) used in nmr has an interesting effect on the -electrons of the aromatic ring, causing them to circulate round the ring in a process known as diamagnetic circulation. This movement in turn sets up a secondary magnetic eld (Be) represented by the force lines shown in Fig. 9. The direction of these lines opposes the applied magnetic eld at the center of the aromatic ring, but enhances it at the edges where the aromatic protons are situated. This means that the eld observed by the aromatic protons is increased (Bo+Be) causing their precessional frequency to increase. This means that a greater energy is required for resonance, resulting in a higher chemical shift. The effect of diamagnetic circulation on aromatic protons is greater than inductive effects and this can be seen in the nmr spectrum of benzyl methyl ether (Fig. 10). The methyl group at 3.6 ppm has a relatively high chemical shift due to the inductive effect of oxygen. The methylene group at 5.2 ppm has an even higher chemical shift since it is next to oxygen and the aromatic ring, both of which are electron withdrawing groups. However, the aromatic protons have the highest chemical shift at 7.3 ppm since they experience the secondary magnetic eld set up by diamagnetic circulation. 332 Section P Organic spectroscopy and analysis Ar-H CH2 CH3 H H CH2 O H H H CH3 10 Fig. 10. 9 8 7 6 5 4 3 2 1 0 Nmr spectrum of benzyl methyl ether. Diamagnetic circulation is also possible for other unsaturated systems such as alkenes. However, the diamagnetic circulation for an alkene is much smaller since only two electrons are circulating within a double bond, and so the effect is smaller. This can be seen in the nmr spectrum of 1,1-diphenylethene where the alkene protons have a smaller chemical shift at 5.2 ppm compared to the aromatic protons at 7.3 ppm (Fig. 11). An aldehyde proton also experiences a secondary magnetic eld due to diamagnetic circulation, but in addition there is an inductive effect resulting from the electron withdrawing effect of the carbonyl group. Thus, an aldehyde proton experiences two deshielding effects, which means that it has a higher chemical shift than even an aromatic ring. Typically, the signal appears about 9.6 ppm. The combined inuences of diamagnetic circulation and inductive effects also result in high chemical shifts for the OH of a carboxylic acid where the signal can have a chemical shift larger than 10 ppm. For most unsaturated systems, diamagnetic circulation sets up a secondary eld which enhances the applied magnetic eld. The exception is alkynes where the secondary eld opposes the applied eld and causes shielding. H H H H H H C C H H H H H H 10 Fig. 11. 9 8 7 6 5 4 3 2 1 0 NMR spectrum of 1,1-diphenylethene. P4 Proton nuclear magnetic resonance spectroscopy 333 Spin-spin coupling So far, we have looked at spectra where each signal is a single peak (singlet). However, in many spectra, the signal for a particular proton is made up of two or more peaks. This is due to an effect known as spin-spin coupling which is normally seen when non-equivalent protons are on neighboring carbon atoms. An example of this can be seen in the nmr spectrum of the alkene shown in Fig. 12. There are four non-equivalent protons present in this molecule and so we would expect four signals. The spectrum does indeed show four signals although there are six peaks present. The signals at 2.2 ppm and 4.7 ppm are due to the two methyl groups and are both singlets. However, the signals for the two alkene protons are both split into doublets. Thus, the two peaks between 5 and 6 ppm X constitute one signal due to H . The chemical shift of this signal is the midpoint between the two peaks, i.e. at 5.65 ppm. Similarly the two peaks between 7 and A 8 ppm constitute one signal due to H , with the chemical shift being the midpoint between the two peaks at 7.6 ppm. The alkene signals are present as doublets since the alkene protons A and X are coupling with each other and are mutually inuencing the magnetic eld that they experience. In Fig. 13, we have a simplied diagram where the two alkene protons are in white, separated from each other by three bonds and the two alkene carbon atoms in black. Y H3C O C HA C HX Y C O A X CH3 Z Z 10 Fig. 12. 9 8 7 6 5 4 3 2 1 0 NMR spectrum of a disubstituted alkene. (a) A (b) A (c) A (d) A X X X X Energy =Larmor Bo Fig. 13. AX Coupling. Bo Bo Bo 334 Section P Organic spectroscopy and analysis Let us concentrate on proton X in Fig.13a. An external magnetic eld Bo forces this proton to adopt two possible orientations with the more stable orientation shown in Fig. 13a. Energy having the same frequency as the Larmor frequency is now applied resulting in resonance and a signal in the nmr spectrum. So much for proton X, but what is happening to proton A while all this is happening? Applying a magnetic eld also forces this proton to adopt two possible orientations (Figs. 13c and d). However, the precessional frequency for proton A is different from that of proton X since proton A is in a different environment. Therefore, applying energy which has the correct frequency to make proton X resonate will have no such effect on proton A. This means that the two possible orientations for proton A are long lived, and resonance does not take place between them. The dipole moments associated with these orientations can thus generate a small magnetic eld that will inuence X. So essentially proton A can be viewed as a small magnet which has two different orientations. The two different magnetic elds generated by A are experienced by proton X but it is important to realize that the effect is not transmitted through space. The nuclei are too far apart from each other for that to happen. Instead the effect is transmitted through the three bonds between the two protons. A full explanation of how this happens is not possible here but the overall effect is that proton A generates two equal but opposing secondary magnetic elds at proton X. The same thing happens in reverse when energy is applied to resonate proton A. In that situation, proton X does not resonate but has two equal and opposite secondary magnetic effects on A. Let us look at what happens to the signal for proton A when this coupling takes place (Fig. 14). If coupling did not place, the signal would be a singlet. However with coupling, A experiences two different secondary magnetic elds from X and is split into two peaks. HA HX JAX JXA Neighbouring protons 8 Fig. 14. Spin spin coupling. 7 6 5 P4 Proton nuclear magnetic resonance spectroscopy 335 The peak at higher chemical shift occurs when the secondary eld generated by proton X is aligned with the applied eld. The peak at lower chemical shift occurs when the secondary eld is against the applied eld. Since both effects are equally likely and of the same magnitude the signal for A is split into a doublet where the peaks are of equal height and equally shifted from the original chemical shift. The separation between the peaks can be measured and is called the coupling constant. It is given the symbol J and is measured in hertz rather than ppm. The coupling is further specied by dening the coupled protons. Thus, JAX is the coupling constant between proton A and proton X. If we look now at the signal for X, the same thing happens except the secondary magnetic elds are now due to the different orientations of proton A. The coupling constant for this signal is JXA and must be equal in magnitude to JAX (Fig. 15). H3C O C HA C C O CH3 HX JAX JXA 10 9 8 Chem shift 7 6 Chem shift 5 4 3 2 1 0 Fig. 15. Coupling constants. Let us now look at a more complicated situation where we have a methyl group linked to a methine group (see 1,1-dichloroethane; Fig. 16). In this situation, we have three identical methyl protons (X) separated by three bonds from one CH proton (A). The spectrum shows two signals. The signal for the methyl protons is a doublet at 1.55 ppm, while the signal for the methine proton is a quartet at 5.05 ppm. We look rst of all at the effect the methine proton has on the three equivalent methyl protons. The methine proton can have two possible orientations either with the eld or against it. The secondary magnetic eld associated with these orientations is transmitted to the methyl protons through the connecting bonds, which means that the methyl protons are inuenced by two equal but opposing secondary magnetic elds. The signal for the methyl protons is split into a doublet. Let us now consider the inuence of the methyl protons on the methine proton. There are several possibilities here. The methyl protons could all be opposed to the applied eld or they could all be aligned with the eld. Another possibility is for two of the protons to be with the eld while one is against the eld. Note that this sort of arrangement is three times more likely than having all the protons 336 Section P Organic spectroscopy and analysis pointing the same way. Finally, two of the protons could be against the eld and one could be with the eld. Once again the possibility of this kind of arrangement is three times more likely than having all the nuclei pointing the same way. Since there are four different ways of orientating the three methyl protons, the signal for the methine proton is split into four different peaks (a quartet). These peaks will not be of equal intensity as there is more chance of certain orientations than others. The relative intensities match the statistical probability of the different orientations, i.e. 1 : 3 : 3 : 1. JAX a H C CI CI C HX HX HX JXA JAX JAX 10 Fig. 16. 9 8 7 6 5 4 3 2 1 0 NMR Spectrum of 1,1-dichloroethane. We can predict the number of peaks in the methine signal (A) and their relative intensity in the following manner (Fig. 17). If no coupling took place, the signal would be a singlet. However, there are three neighboring protons due to the methyl group. We shall see what happens when we split the methine signal with each of these methyl protons in turn. Coupling with one of the methyl protons splits the signal into a doublet of intensity 1 : 1. Splitting with a second methyl proton splits each of these peaks into a doublet. Since the splitting is identical, the two inner peaks of each doublet overlap to give a single peak such that we end up with a triplet having an intensity of 1 : 2 : 1. Each of these peaks is now split by the effect of the third methyl proton to give a quartet of ratio 1 : 3 : 3 : 1. The peak at highest chemical shift corresponds to the arrangement where the secondary magnetic eld of all three methyl protons is with the applied eld and enhancing it. The peak at the next highest chemical shift corresponds to the situation where two of the methyl protons are with the applied eld and the third is against it. The next peak has two protons against the applied eld and one proton with it. Finally we have the peak at the lowest chemical shift, which corresponds to the situation where the magnetic elds of all three methyl protons oppose the applied eld. Note that the chemical shift for the signal is the same as it would have been if no splitting had occurred (i.e. the middle of the signal). The coupling constants JAX and JXA are identical for both signals since they are coupled together. It is possible to rationalize the coupling patterns and peak intensities for other coupling systems in a similar manner, but a quicker method is to use a system known as Pascalls triangle (Fig. 18). To use the triangle, you rst identify the number of protons that are neighboring the group of interest. This denes which row of the triangle is relevant. The row indicates the number of peaks one would expect in the signal and their relative intensity. Consider for example 1,1dichloroethane (Fig. 16). The methine group has a neighboring methyl group and P4 Proton nuclear magnetic resonance spectroscopy 337 HA CH3X Split by HX Split by HX Split by HA Split by HX JAX JXA Neighbouring protons Fig. 17. Splitting pattern for CHCH3. so there are three neighboring protons. The relevant row in Pascalls triangle has four entries and so the signal for the methine proton is a quartet with a ratio of 1 : 3 : 3 : 1. When we consider the methyl group, it has one neighboring proton and so Pascalls triangle predicts a doublet of ratio 1 : 1. Note that the number of peaks in a signal is always one more than the number of neighboring protons. It is important to note that coupling can only take place between non-equivalent protons of different chemical shifts. Coupling between the protons making up a methyl group is not possible since they are equivalent to each other. Similarly, coupling is not possible between the methyl groups of ethane since these groups cannot be distinguished from each other. It is also important to remember that the coupling is transmitted through bonds and that the size of this coupling decreases with the number of bonds involved. In fact, coupling is rarely seen between protons which are separated from each other by more than three bonds. In effect, this Number of neighboring protons 0 1 1 1 1 1 1 2 2 1 1 3 3 3 1 4 4 1 4 6 1 5 10 10 5 1 5 1 6 15 20 15 6 1 6 Fig. 18. Pascalls Triangle. 338 Section P Organic spectroscopy and analysis means that most coupling takes place between non-equivalent protons on neighboring carbon atoms. Integration An nmr spectrum contains another piece of useful information which is called integration. Integration measures the intensity of each signal and is proportional to the number of protons responsible for that signal. Thus, a signal due to a methyl group will be three times more intense than one due to a methine (CH) group. The integration signal on the nmr spectrum is the sloping line above the signals (Fig. 19). There is no absolute scale to this line, but the relative heights of the integration over each signal are proportional to the number of protons responsible for each signal. Note that it is the height increase over the whole signal that should be measured (i.e. you measure the height increase over all the peaks in the coupling pattern). Another thing to watch out for is the possibility of OH or NH2 groups being present in a spectrum. These will also be integrated, but can be distinguished from CH, CH2 and CH3 groups since the protons in the former disappear from the spectrum if the sample is shaken with D2O. Integration (measures area under each signal) 6.0 Fig. 19. 5.0 Integration. 4.0 3.0 2.0 1.0 Section P Organic spectroscopy and analysis P5 13 C NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY Key Notes Introduction C nmr spectroscopy is a valuable tool in structural analysis. The C nucleus is only 1.1% naturally abundant and so signals are weaker than 1 those present in H nmr spectra. No coupling is seen between C nuclei since the chances of neighboring 13 carbons both being C are negligible. Coupling is possible between C and H nuclei. However, proton decoupling is usually carried out by continually resonating all the protons while 13 the C spectrum is run. This leads to one singlet for each non-equivalent carbon. Integration of signals is not possible since this process distorts signal intensities. 13 1 13 1 13 13 13 Coupling between 13 C nuclei Coupling between 13 1 C and H nuclei Advantages of 13 C NMR C nmr spectra contain singlets over a wider range of chemical shifts than H nmr meaning that there is less chance of signals overlapping. Direct information is obtained about the carbon skeleton of a molecule including quaternary carbons. The number of protons attached to each carbon atom can be determined by off resonance decoupling or by running DEPT spectra. The number of signals indicates the number of non-equivalent carbons. The number of protons attached to carbon is determined by methods such as DEPT. The chemical shifts are compared to theoretical chemical shifts determined from nmr tables or software packages. Properties of alkenes and alkynes (H2) Preparation and properties (I2) Properties (J2) Structures and properties (K1) Properties of alcohols and phenols (M3) Properties of ethers, epoxides, and thioethers (N2) Properties of amines (O2) Chemistry of nitriles (O4) Spectroscopy (P1) Proton nuclear magnetic resonance spectroscopy (P4) Interpreting 13 C spectra Related topics Introduction H NMR spectroscopy is not the only useful form of nmr spectroscopy. There are 32 19 2 a large variety of other isotopes which can be used (e.g. P, F, D). However, the 1 13 13 most frequently studied isotope apart from H is the C nucleus. Like protons, C nuclei have a spin quantum number of 1/2. Thus, the same principles which 13 1 apply to proton nmr also apply to C nmr. However, whereas the H nucleus is 13 the naturally abundant isotope of hydrogen, the C nucleus is only 1.1% naturally 1 340 Section P Organic spectroscopy and analysis abundant. This means that the signals for a C nmr spectrum are much weaker 1 than those for a H spectrum. In the past, this was a problem since early nmr spectrometers measured the absorption of energy as each nucleus in turn came 1 into resonance. This was a lengthy process and although it was acceptable for H 13 nuclei, it meant that it was an extremely lengthy process for C nuclei since several thousand scans were necessary in order to detect the signals above the background noise. Fortunately, that problem has now been overcome. Modern nmr spectrometers are much faster since all the nuclei are excited simultaneously with a pulse of energy. The nuclei are then allowed to relax back to their ground state, emitting energy as they do so. This energy can be measured and a spectrum 13 produced. Consequently, C nmr spectra are now run routinely. At this point, you 13 1 may ask whether a C nmr spectrum also contains signals for H nuclei? The answer is that totally different energies are required to resonate the nuclei of 1 different atoms. Therefore, there is no chance of seeing the resonance of an H 13 1 13 nucleus and a C nucleus within the limited range covered in a typical H or C spectrum. Coupling 13 between C nuclei Unlike H nmr where spin spin coupling is observed between different protons, 13 coupling between different carbon nuclei is not observed in C NMR. This is due 13 to the low natural abundance of C nuclei. There is only 1.1% chance of any 13 specic carbon in a molecule being present as the C isotope. For most mediumsized molecules encountered by organic chemists, this effectively means that there 13 13 will only be one C isotope present in a molecule. The chances of having two C 13 isotopes in the same molecule are extremely small, and the chances of two C isotopes being on neighboring carbons are even smaller, so much so that they are negligible. Although C C coupling is not seen, it is possible to see coupling between C 1 nuclei and H nuclei. This might appear strange since we have already stated that 1 13 H signals are not observed in the C spectrum. However, it is perfectly logical to 13 1 1 see coupling between C and H nuclei even if we dont see the H signals. This is 1 because the H nuclei will still take up two possible orientations in the applied magnetic eld, each of which produce their own secondary magnetic eld (see 13 Topic P4). In practice, such coupling makes the interpretation of C nmr spectra 13 13 1 difcult and so C spectra are usually run with C H coupling eliminated. This 13 is done by continuously resonating all the proton nuclei while the C spectrum is being run such that the signal for each non-equivalent carbon atom appears as a singlet. This results in a very simple spectrum that immediately allows you to identify the number of non-equivalent carbon atoms in the molecule from the number of signals present. This process is known as proton decoupling. One disadvantage of this technique is that it distorts the intensity of signals and so integration cannot be used to determine the number of carbon atoms responsible for each signal. This distortion is particularly marked for signals due to quaternary carbons, which are much weaker than signals for other types of carbons. C nmr gives a signal for each non equivalent carbon atom in a molecule and this 1 gives direct information about the carbon skeleton. In contrast, H nmr provides information about the carbon skeleton indirectly and gives no information about 13 quaternary carbon atoms such as carbonyl carbons. Another advantage of C 13 13 13 13 1 13 Coupling 13 between C 1 and H nuclei Advantages of 13 C NMR P5 13 C nuclear magnetic resonance spectroscopy 341 NMR is the wide range of chemical shifts. The signals are spread over 200 ppm compared to 10 ppm for protons. This means that signals are less likely to overlap. Moreover, each signal is a singlet. This can also be a disadvantage since information about neighboring groups is lost. However, there are techniques that can be used to address this problem. For example, information about the number of protons attached to each carbon atom can be obtained by off resonance 13 decoupling. In this technique, the C spectrum is run such that all the protons are decoupled except those directly attached to the carbon nuclei. Hence, the methyl carbons (CH3) appear as a quartet, the methylene carbons (CH2) appear as a triplet, the methine carbons (CH) appear as a doublet and the quaternary carbons (C) still appear as a singlet. In practice, off resonance decoupling is rarely used nowadays, since a technique known as DEPT is more convenient and easier to analyze. Unfortunately, it is not possible to cover the theory behind this technique here. However, a knowledge of the theory is not necessary in order to interpret DEPT spectra. Such spectra can be run so that only one type of carbon is detected. In other words, a DEPT spectrum can be run so that only the methyl signals are detected or the methylene signals, etc. This allows us to distinguish all four types of carbon, but it means that we have to run four different spectra. There is a quicker way of getting the same information by only running two spectra. A DEPT spectrum can be run such that it picks up the methyl and methine carbons as positive signals and the methylene carbons as negative signals (i.e. the signals go down from the baseline instead of up). The quaternary carbons are not seen. This one spectrum therefore allows you to identify the quaternary signals by their absence and the methylene signals, which are negative. We still have to distinguish between the methyl signals and the methine signals, but this can be done by running one more DEPT spectrum such that it only picks up the methine carbons. Interpreting 13 C spectra In general, C spectra of known structures can be interpreted in the following stages. First, the number of non-equivalent carbon atoms is counted by counting the number of signals present in the spectrum, excluding those signals due to the internal reference (TMS at 0 ppm) or the solvent. The signal for CDCl3 is a triplet (1 : 1 : 1) at 77 ppm (caused by coupling to the deuterium atom where I=1). Second, each signal is identied as CH3, CH2, CH or quaternary using off resonance decoupling or DEPT spectra. Third, the chemical shifts of the signals are measured, then compared with the theoretical chemical shifts for the carbons present in the molecule. There are a variety of tables and equations which can help in this analysis but it should be 1 noted that the use of such tables is not as straightforward as for H nmr analysis. However, software packages are now available which can calculate the theoretical chemical shifts for organic structures. These are often incorporated into chemical drawing packages such as ChemDraw. 13 Section P Organic spectroscopy and analysis P6 MASS SPECTROSCOPY Key Notes Introduction A mass spectrum is obtained by ionizing a molecule to give a molecular ion. This is then accelerated through a magnetic eld and the ion is deviated according to its mass and charge. Routinely, ionization is carried out by electron ionization, but chemical ionization and fast atom bombardment are milder methods. Detecting the molecular ion allows identication of the molecular weight. If this is an odd number it indicates that an odd number of nitrogen atoms are present. The pattern of peaks present for a molecular ion can reveal the presence of chlorine or bromine since there are two naturally occurring isotopes for 12 these elements. Carbon also has two naturally occurring isotopes ( C and 13 C) and so a small peak is often observed one mass unit higher than the molecular ion. The molecular ion is unstable and fragments, producing daughter ions. The fragmentation patterns that take place are indicative of functional groups in the molecule. Daughter ions vary in stability and the more stable ones give stronger peaks. The most intense peak in the spectrum is called the base peak. The molecular ion and base peak are identied rst. Daughter ions are then identied and fragmentation patterns determined. High-resolution mass spectroscopy is used to measure the mass of a molecular ion to four decimal places. This allows the determination of the molecular formula. Preparation and properties (I2) Properties (J2) Structure and properties (K1) Preparation and physical properties of alkyl halides (L1) Properties of alcohols and phenols (M3) Spectroscopy (P1) Isotopic ratios Fragmentation patterns and daughter ions Analysis of a mass spectrum High-resolution mass spectroscopy Related topics Introduction Mass spectroscopy is useful in the analysis of an organic compound since it can provide information about the molecular weight, the presence of specic elements (e.g. nitrogen, chlorine or bromine) and the presence of specic functional groups. Put at its simplest, a mass spectrum measures the mass of ions, but to be more precise, it is a measure of the mass/charge ratio (m/e). However, the vast majority of ions detected are singly charged (e=1). In order to obtain a mass spectrum, the molecules of the test compound have to be ionized under reduced pressure. There P6 Mass spectroscopy 343 are several ways in which this can be carried out, but the most common method is known as electron ionization (EI). Electron ionization involves bombarding the test molecule with high-energy electrons such that the molecule loses an electron and ionizes to give a radical cation called a molecular ion (also called the parent ion). This molecular ion is then accelerated through a magnetic eld towards a detector. The magnetic eld causes the ion to deviate from a straight path and the extent of deviation is related to mass and charge (i.e. the lighter the ion the greater the deviation). Assuming a charge of 1, the deviation will then be a measure of the mass. The mass can then be measured to give the molecular weight. The mass of a molecular ion must be even unless the molecule contains an odd number of nitrogen atoms. This is because nitrogen is the only organic element with an even mass number and an odd valency. Therefore, an odd numbered mass for a molecular ion is an indication of the presence of at least one nitrogen atom. Sometimes, the molecular ion is not observed in the spectrum. This is because electron ionization requires compounds to be vaporized at high temperature and the molecular ion may fragment before it can be detected. In cases like this, it is necessary to carry out the ionization under milder conditions such that the molecular ion is less likely to fragment (i.e. by chemical ionization or by fast atom bombardment). You may ask why these milder conditions are not used routinely. The reason is that fragmentation can give useful information about the structure of the molecule (see below). The molecular ion peak is usually strong for aromatic amines, nitriles, uorides and chlorides. Aromatic and heteroaromatic hydrocarbons will also give intense peaks if there are no alkyl side chains present greater than a methyl group. However, the peaks for molecular ions can be absent for long chain hydrocarbons, highly branched molecules, and alcohols. Isotopic ratios The pattern of peaks observed for a molecular ion often indicates the presence of particular halogens such as chlorine or bromine. This is because each of these elements has a signicant proportion of two naturally occurring isotopes. Since the position of the peaks in the mass spectrum depends on the mass of each individual molecular ion, molecules containing different isotopes will appear at different positions on the spectrum. Chlorine occurs naturally as two isotopes 35 37 ( Cl and Cl ) in the ratio 3 : 1. This means that the spectrum of a compound containing a chlorine atom will have two peaks for the molecular ion. The two peaks will be two mass units apart with a ratio of 3 : 1. For example ethyl chloride 35 37 will have two peaks for C2H5 Cl and C2H5 Cl at m/e 64 and 66 in a ratio of 3 : 1. 12 13 The naturally abundant isotope for carbon is C. However, the C isotope is also present at a level of 1.1%. This can result in a peak one mass unit above the 12 13 molecular ion. For methane, the relative ratios of the peaks due to CH4 and CH4 13 is 98.9 : 1.1, and so the peak for CH4 is very small. However, as the number of carbon atoms increase in a molecule, there is a greater chance of a molecule contain13 ing a C isotope. For example, the mass spectrum for morphine shows a peak at m/e 308 and a smaller peak at m/e 309 which is about a fth as intense. The peak at m/e 308 is due to morphine containing carbon atoms of isotope 12. The peak at 13 13 12 309 is due to morphine where one of the carbon atoms is C (i.e. C C16H18NO3). The intensity of the peak can be rationalized as follows. The natural abundance of 13 C is 1.1%. In morphine there are 17 carbon atoms and so this increases the 13 chances of a C isotope being present by a factor of 17. Hence, the peak at 309 is approximately 18% the intensity of the molecular ion at 308. 344 Section P Organic spectroscopy and analysis Fragmentation patterns and daughter ions The molecular ion is not the only ion detected in a mass spectrum. The molecular ion is a high-energy species, which fragments to give daughter ions that are also detected in the spectrum. At rst sight, fragmentation may seem to be a random process, but fragmentation patterns are often characteristic of certain functional groups and demonstrate the presence of those groups. Due to fragmentation, a mass spectrum contains a large number of peaks of varying intensities. The most intense of these peaks is known as the base peak and is usually due to a relatively stable fragmentation ion rather than the molecular + + ion. Examples of stable ions are the tertiary carbonium (R3C ), allylic (=C-CR2 ), + + + + benzylic (Ar-CR2 ), aromatic (Ar ), oxonium (R2O ) and immonium (R3N ) ions. It is not possible to explain every peak observed in a mass spectrum and only the more intense ones or those of high mass should be analyzed. These will be due to relatively stable daughter ions. Alternatively, a fragmentation may result in a stable radical. The radical being neutral is not observed, but the other half of the fragmentation will result in a cation which is observed. Many fragmentations give a series of daughter ions that are indicative of a particular functional group. In other words, the molecular ion fragments to a daughter ion, which in turn fragments to another daughter ion and so on. The intensity of a peak may sometimes indicate a favored fragmentation route. However, care has to be taken since intense peaks can arise due to different fragmentation routes leading to the same ion, or be due to different fragmentation ions of the same m/e value. To illustrate the analysis of a mass spectrum, we shall look at the simple alkane nonane (Fig. 1). Nonane has a molecular formula of C9H20 and a molecular weight of 128. The parent ion is the molecular ion at 128. There is a small peak at m/e 129, which is Analysis of a mass spectrum 100 43 80 57 Relative abundance 60 H3C CH3 41 40 29 27 20 71 85 128 99 0 10 20 30 40 50 60 70 80 m/e 90 100 110 120 130 140 150 Fig. 1. Mass spectrum for nonane. P6 Mass spectroscopy 345 due to a molecule of nonane containing one C isotope (i.e. C8 CH20). The nat13 13 ural abundance of C is 1.1%. Therefore the chances of a C isotope being present in nonane are 9 1.1% = 9.9%. + The base peak is at m/e 43. This is most likely a propyl ion [C3H7] . There are peaks at m/e 29, 43, 57, 71, 85 and 99. These peaks are all 14 mass units apart which corresponds to a CH2 group. The presence of a straight chain alkane is often indicated by peaks which are 14 mass units apart (Fig. 2). 13 12 13 43 71 99 H3C 85 57 CH3 29 Fig. 2. Fragmentations for nonane (Fragmentations are indicated by the dotted lines. The solid line at the end of each dotted line points to the part of the molecule which provides the ion observed in the spectrum.). The characteristic peaks for a straight chain alkane are 14 mass units apart, but this does not mean that the chain is being pruned one methylene unit at a time. Decomposition of carbocations occurs with the loss of neutral molecules such as methane, ethene and propene, and not by the loss of individual methylene units. For example, the daughter ion at m/e 99 can fragment with loss of propene to give the ion at m/e 57. The daughter ion at m/e 85 can fragment with loss of ethene or propene to give the ions at m/e 57 and m/e 43 respectively. The daughter ion at m/e 71 can fragment with loss of ethene to give the ion at m/e 43. There are signicant peaks at m/e 27 and m/e 41. These peaks result from dehydrogenation of the ions at m/e 29 and m/e 43 respectively. The peak at m/e 41 can also arise from the ion at m/e 57 by loss of methane. The most intense peaks in the mass spectrum are at m/e 43 and m/e 57. The + + ions responsible for these peaks [C3H7] and [C4H9] can arise from primary fragmentations of the molecular ion itself, as well as from secondary fragmentations of daughter ions (m/e 99 to m/e 57; m/e 85 to m/e 43; m/e 71 to m/e 43). In mass spectroscopy, the ions responsible for particular peaks are enclosed in square brackets. This is because it is not really possible to specify the exact structure of an ion or the exact location of the charge. The ionization conditions used in mass spectroscopy are such that fragmentation ions can easily rearrange to form structures more capable of stabilizing the positive charge. For example, the fragmentation ion at m/e 57 arising from primary fragmentation is a primary carbocation, but this can rearrange to the more stable tertiary carbocation (Fig. 3). High-resolution mass spectroscopy The molecular weight is measured by mass spectroscopy and is usually measured as a whole number with no decimal places. However, it is possible to measure the molecular weight more accurately (high resolution mass spectroscopy) to four + Rearrangement CH3 H3C CH3 + H3C 57 Fig. 3. CH3 CH3 Rearrangement of a primary carbocation to a tertiary carbocation. 346 Section P Organic spectroscopy and analysis decimal places and establish the molecular formula. Consider the molecules CO, N2, CH2N and C2H4. All of these molecules have the same molecular weight of 28 and in a normal mass spectrum would produce a molecular ion of that value. In a high-resolution mass spectrum, the molecular ion is measured to four decimal places and so we have to consider the accurate atomic masses of the component atoms. The accurate mass values for the ions are as follows: CO + N2 + CH2N + C2H4 + = CO + = 14N2 14 + 12 1 = C H2 N 1 + 12 = C2 H4 12 16 + Accurate mass = 12.0000 + 15.9949 = 27.9949 Accurate mass = 28.0061 Accurate mass = 12.0000 + 2.0156 + 14.0031 = 28.0187 Accurate mass = 24.0000 + 4.0313 = 28.0313 If the measured mass of the molecular ion is 28.0076, this would be in line with the theoretical accurate mass for nitrogen (i.e. 28.0062). Note that the peak being measured in the mass spectrum is for the molecular ion. This ion contains the most abundant isotope of all the elements present. For example, the molecular ion 12 16 for carbon monoxide is made up of C and O only. There are no molecules pre13 17 sent containing C or O since these would occur at a higher position in the mass spectrum. Therefore, the theoretical values for the molecular weight are calculated using the atomic weights for specic isotopes and not the accurate atomic weights of the elements as they occur in nature. The latter (relative atomic weights) take the relative abundances of the different isotopes into account and will be different 12 in value. For example, the accurate atomic weight of the carbon isotope C is 12.0000 and this is the value used for calculating the accurate mass of a molecular ion. The accurate relative atomic weight of carbon is higher at 12.011 due to the 13 presence of the isotope C. F URTHER R EADING General reading McMurray, J. (2000) Organic Chemistry, 5th edn. Brooks/Cole Publishing Co., Pacic Grove, CA. Morrison, R.T. and Boyd, R.N. (2000) Organic Chemistry, 7th edn. Prentice Hall International, Inc., New York (in press). Solomons, T.W.G. (2000) Organic Chemistry, 7th edn. John Wiley & Sons, Inc., New York. Self learning texts Patrick, G.L. (1997) Beginning Organic Chemistry 1. Oxford University Press, Oxford. Patrick, G.L. (1997) Beginning Organic Chemistry 2. Oxford University Press, Oxford. INDEX Acetals, 173174, 187189 Acetic anhydride, 221, 223, 233 Acetylide ion, 80, 259 Achiral, 51 Acid base reactions, 7374, 7998, 129130, 225, 230, 262, 267268, 271, 277278, 303304 Acid anhydrides bonding 205206 electrophilic and nucleophilic centers, 6970, 206 hydrolysis to form carboxylic acids, 227 nucleophilic substitution, 207, 209215 preparation, 220 properties, 206207 reaction with alcohols to form esters, 221, 226 reaction with amines to form amides, 222223, 226, 306 reaction with phenols to form esters, 278 reactivity, 213216 reduction to alcohols, 231232 shape, 205206 spectroscopic properties, 207208 Acid chlorides bonding 205206 electrophilic and nucleophilic centers, 6970, 206 Friedal Crafts acylation, 142144, 229 hydrolysis to form carboxylic acids, 227 nomenclature, 41 nucleophilic substitution, 207, 209214 preparation, 219220 properties, 206207 reaction with alkoxides or alcohols to form esters, 209211, 215, 221, 225 reaction with amines to form amides, 149, 222, 225, 297 reaction with carboxylate ions to form acid anhydrides, 220, 225 reaction with Grignard reagents to form alcohols, 230 reaction with organocuprates to form ketones, 231 reaction with phenols to form esters, 278 reactivity, 213216 reduction to alcohols, 231232 reduction to aldehydes, 232 shape, 205206 spectroscopic properties, 207208 Acids acid strength, 8287 Brnsted-Lowry, 7980 conjugate, 90 electronegativity effects,8384 inductive effects, 85 Lewis, 94, 141144, 273 pKa, 8485 Acyl azide, 297 Acyl group, 205206 Acylium ion, 144 Alanine, 52 Alcohols acidity, 80, 85, 87, 267269, 271 basicity, 81, 8990 bonding, 7, 266267 E1 elimination, 272 E2 elimination, 272273 electrophilic and nucleophilic centers, 6970, 267268 elimination to alkenes, 271273 esterication, 148, 221222 hydrogen bonding, 31, 267 nomenclature, 39, 44 nucleophilic substitution, 267268, 273274 oxidation, 275276 preparation, 263 properties, 266268 reaction with acid anhydrides to form esters, 221, 226 reaction with acid chlorides to form esters, 211, 215, 221, 225 reaction with alkyl halides to form ethers, 247 reaction with aromatics to form arylalkanes, 144 reaction with base to form alkoxide ions, 267268, 271 reaction with esters, 226 reaction with hydrogen halides to form alkyl halides, 273274 reaction with sulfonyl chlorides to form mesylates and tosylates, 274275 shape, 266 spectroscopic properties, 269 Aldehydes acidity of alpha protons, 9598, 171172, 191 Aldol reaction, 179180, 194197 -alkylation, 191194 bonding, 170 electrophilic and nucleophilic centers, 6970, 170171 -halogenation, 198199 nomenclature, 40 nucleophilic addition, 74, 173174, 175180 oxidation to carboxylic acids, 201 preparation, 167168 properties, 169172 protection, 189 reaction with alcohols to form acetals, 173174, 187189 reaction with alcohols to form hemiacetals, 190 reaction with amines to form imines and enamines, 173174, 184186 reaction with bisulte, 179180 reaction with cyanide to form cyanohydrins, 178179 reaction with Grignard reagents to form alcohols, 175176 reaction with organolithium reagents to form alcohols, 176177 reaction with thiols to form thioacetals, 190 reactivity, 181183 reduction to form alcohols, 177178, 200 reduction to form alkanes, 200201 shape, 170 spectroscopic properties, 171172, 319, 332 350 Index Aldehydes contd ,-unsaturated, 196, 202204 Aldol reaction, 179180, 194197, 236 Alkanals see Aldehydes Alkanes, 1925 bonding, 19 conformational isomers, 5658 constitutional isomers, 45 nomenclature, 2224, 4344 properties, 69 reactivity, 19 spectroscopic properties, 330, 344345 van der Waals interactions, 32 Alkanoic acids see Carboxylic acids Alkanols see Alcohols Alkanones see Ketones Alkenes bonding, 10, 18, 102 congurational isomers, 4648, 102 electrophilic addition, 105 114 hydroboration, 121123 nomenclature, 37 nucleophilic center, 7071, 103 preparation,99 properties, 102103 protection, 99 reaction with acid to form alcohols, 110, 114 reaction with aromatics to form arylalkanes, 111, 144 reaction with diborane and hydrogen peroxide to form alcohols, 121123 reaction with halogens to form vicinal dihalides, 108110, 113. reaction with halogen and water to form halohydrins, 109110, 113114 reaction with hydrogen to form alkanes, 117118 reaction with hydrogen halides to form alkyl halides, 106108, 112113 reaction with mercuric acetate and sodium borohydride to form alcohols, 110, 114 reaction with mercuric triuoroacetate to form ethers, 110 reaction with osmium tetroxide to form 1,2diols, 119 reaction with ozone to form aldehydes and ketones, 118119 reaction with permanganate to form carboxylic acids and ketones, 119, 218 reaction with permanganate to form 1,2diols, 119 reaction with a peroxy acid to form epoxides, 120 reactivity, 102 shape, 10, 102 spectroscopic properties, 103, 318319, 332, 333 symmetrical and unsymmetrical, 106 van der Waals interactions, 32, 102103 Alkoxide ion basicity, 80, 92, 271 formation, 267, 271 inductive effects, 85, 87 reaction with acid chlorides to form esters, 209 210 Alkyl groups, 19 Alkyl halides basicity, 8990 bonding, 7, 240 E1 elimination, 254255 E2 elimination, 253254 E1 vs, E2 eliminations, 255 electrophilic and nucleophilic centers, 6970, 240 elimination to form alkenes, 240, 252257, 259260 elimination vs. substitution, 256257 Friedal Crafts alkylation, 142144 nomenclature, 40, 44 nucleophilic substitution, 242251 preparation, 239240 properties, 240 reaction with alcohols to form ethers, 245, 258 reaction with alkynide ion to form alkenes, 130 reaction with alkynide ion to form alkynes, 129, 259 reaction with amines, 244245, 258 reaction with azide ion, 258 reaction with carboxylate ions to form esters, 222, 258 reaction with cyanide to form nitriles, 258 reaction with enolate ions, 191194, 235236, 259 reaction with halides, 258 reaction with hydroxide ion to form alcohols, 243244, 258 reaction with lithium metal, 262 reaction with Mg to form Grignard reagents, 261262 reaction with organocuprates, 262 reaction with thiolates to form thioethers, 258 reaction with water to form alcohols, 245248 SN1 substitution, 245248 SN2 substitution, 243245 SN1 vs. SN2 reactions, 247251 shape, 240 spectroscopic properties, 240241, 336 van der Waals interactions, 240 Alkylammonium ions, 301302, 306 Alkylation Friedal Crafts, 111, 142144, 309 of amines, 306 of terminal alkynes, 129130 of enolate ions, 191194, 235236 Alkynes bonding, 1516, 18, 102 electrophilic addition, 124126 nomenclature, 37 nucleophilic center, 7071, 103 preparation, 100 properties, 102103 reaction of terminal alkynes with base and alkyl halides, 129 reaction with acid and mercuric sulfate to form ketones, 125126 reaction with halogens, 124 reaction with hydrogen to form alkanes, 127 reaction with hydrogen to form (Z)- alkenes, 127128 reaction with hydrogen halides, 124126 reaction with lithium or sodium metal to form (E)alkenes, 128 reactivity, 102 shape, 16, 102 Index 351 spectroscopic properties, 103104, 323, 332 van der Waals interactions, 32 Alkynide, 129 Allenes, chiral, 54 Allylic cation, 6465 Amide ion, basicity, 80, 89 Amides acidity, 80, 87 aliphatic and aromatic, 29 basicity, 93 bonding 205206 dehydration to nitriles, 233, 311312 electrophilic and nucleophilic centers, 6970, 206 Hofmann rearrangement, 297298 hydrogen bonding, 31, 206207 hydrolysis, 227229, 308 nomenclature, 4142, 44 nucleophilic substitution, 207, 209215 preparation, 222223 properties, 206207 reactivity, 213216 reduction to amines, 149, 232, 297 shape, 205206 spectroscopic properties, 207208 Amines acidity, 80, 8385, 87, 303304 aromatic, 147148, 156157, 308309 basicity, 81, 8993, 301303 bonding, 7, 300 electrophilic and nucleophilic centers, 6970, 303 ionic bonding, 31 Hofmann elimination to alkenes, 307308 hydrogen bonding, 31, 301 Lewis base, 94 nomenclature, 42, 44, 300 nucleophiles, 301 preparation, 295298 properties, 299304 pyramidal inversion, 300301 reaction with acid anhydrides and esters to form amides, 222223, 226, 306, 308 reaction with acid chlorides to form amides, 149, 222, 225, 297, 306 reaction with acids, 303 reaction with aldehydes and ketones to form imines and enamines, 173174, 184186 reaction with alkyl halides, 244245, 258, 306 reaction with bases, 303304 reaction with carboxylic acids, 223 reaction with nitrous acid to form diazonium salts, 309 reaction with sulfonyl chlorides to form sulfonamides, 306307 reaction with ,-unsaturated aldehydes and ketones, 173174, 184186 reductive amination of an aldehyde or ketone, 297, 306 shape, 300 spectroscopic properties, 304 synthesis of aromatic amine, 148149 Amino acids, 31 Ammonium salts,quaternary, 301, 306, 307308 Aromatic aromaticity, 135136 bonding, 1213, 18, 135 diamagnetic circulation, 331332 electrophilic substitution, 138, 139146, 150159 Friedal Crafts acylation, 142144, 229 Friedal Crafts alkylation, 142144 Huckel rule, 135136 induced dipole interactions, 137138 nomenclature, 3739 nucleophilic center, 7071 oxidation, 147148, 164 preparation, 137 properties, 137138 reaction with halogens to form aromatic halides, 140142, 151154, 154155 reaction with hydrogen to form cyclohexanes, 164165 reaction with nitric acid to form aromatic nitro compounds, 145146, 154, 155 156 reaction with sulfuric acid to form aromatic sulfonic acids, 145146 reactivity, 13, 135, 137138 reduction, 138, 164165 removable substituents, 161163 shape, 12, 135 spectroscopic properties, 138, 331332 substituent effect, 151159 synthesis of di- and trisubstituted aromatic rings, 160163 van der Waals interactions, 32, 137 Asymmetric centers, 5152 molecules, 5051 Atomic orbitals, 12 degeneracy, 2 energy levels, 2 shape, 1 Aufbau principle, 2 Bases Brnsted-Lowry, 7981 conjugate, 84, 86, 271 electronegative effect, 8990 inductive effect, 91 Lewis, 94 pKb, 90 relative basicity, 65, 8893 resonance effect, 9293 solvation effect, 92 Benzenesulfonyl chloride, 307 Benzyl methyl ether, 331332 Bond formation, 73 Bonding, covalent, 34 dipole-dipole, 3032 hydrogen, 3031, 206207, 267, 268, 282, 287, 301 intermolecular, 3032 ionic, 3031 polar, 6667 van der Waals, 30, 32, 102103, 137, 240 Bonds pi, 1011, 1517 pi bond reactivity, 18 sigma, 4, 67, 10, 1517 Borane, 120122, 232 Bromohydrin, 109110 Bromonium ion, 108109 Cahn-Ingold-Prelog rules, 5254 Carbanion, 80, 89, 96, 175177, 210212, 261262 Carbocation, 6465, 142144 allylic, 6465, 132133 in mass spectroscopy, 344, 345 352 Index Carbocation contd intermediate in E1 mechanism, 255, 272 intermediate in electrophilic addition, 107, 110, 113, 115116 intermediate in electrophilic substitution, 140145, 152156, 158159 intermediate in SN1 mechanism, 246, 250, 273 vinylic, 125 Carbon atomic structure, 12 electronic conguration, 2 sp hybridization 1416 sp2 hybridization, 813 sp3 hybridization, 57 tetrahedral, 6 Carbon-carbon bond formation, 7374 Carbonyl group, acidity of alpha protons, 9598, 171172 bonding, 11, 18, 170, 206 dipole-dipole interactions, 3132 nucleophilic addition, 74, 173174, 175180 nucleophilic and electrophilic centers, 170171, 206 reactivity, 11 shape, 11, 170, 205206 spectroscopic properties, 171172, 207, 208 Carboxyl group, 206 Carboxylate ion, basicity, 80, 92 delocalization, 86 formation, 83, 207, 225, 227228 inductive effects, 85 nucleophilic substitution, 220, 222, 225 nucleophilicity, 6465 reaction with alkyl halides to form esters, 222, 258 Carboxylic acid acidity, 80, 8385, 207, 216, 225, 268269 aliphatic and aromatic, 29 basicity, 91 bonding 205206 electrophilic and nucleophilic centers, 6970, 206 hydrogen bonding, 31, 206207 ionic bonding, 31 nomenclature, 41 nucleophilic substitution, 207, 209216 preparation, 217218 properties, 206207 reaction with alcohols to form esters, 148, 221222 reaction with amines, 223 reaction with diazomethane to form esters, 221224 reaction with Grignard reagents, 230 reaction with SOCl2, PCl3 or ClCOCOCl to form acid chlorides, 219220 reactivity, 216 reduction to alcohols, 231232 shape, 205206 spectroscopic properties, 207 Carboxylic acid anhydride see Acid anhydrides Carboxylic acid chlorides see acid chlorides Carboxylic acid derivatives, 205206 spectroscopic properties, 207208 -Carotene, 319 ChemDraw, 341 Chirality, 51 Chlorine, sp3 hybridization, 7 meta-Chloroperoxybenzoic acid, 284 Claisen reaction, 235237 Claisen rearrangement, 279280 Claisen-Schmidt reaction, 197 Cleavage, heterolytic & homolytic, 77 Clemmenson reaction, 201 Conjugate addition to aldehydes and ketones, p203204 Conjugated systems dienes, 13, 131134 ,-unsaturated aldehydes, 195196, 202204 ,-unsaturated esters, 13 ,-unsaturated ketones, 13, 197, 202204 Crossed Aldol reaction, 196197 Curly arrows, 7677 Curtius rearrangement, 297298 Cyanohydrin, 178179 Cycloalkanes, 1925 bonding, 19 congurational isomers, 46, 48 conformational isomers, 5861 nomenclature, 2425 reactivity, 19 Cycloheptatrienyl cation, 136 Cyclohexane chair and boat conformations, 5860 equatorial and axial bonds, 5860 Cyclopentadienyl anion, 136 Debromination, 99 Decarboxylation, 193194, 218, 235236 Dehydration of alcohols, 269, 271273 of amides, 233 Dehydrogenation, 345 Dehydrohalogenation, 100, 259 Delocalization allylic cation, 6465, 132133 amide, 93, 156157 aniline, 9293 aromatic, 1213, 135136 carbocation, 141, 152153, 156 carboxylate ion, 64, 86 conjugated systems, 13 enolate ion, 9698, 235 hyperconjugation, 116 phenoxide ion, 87, 268 pthalimide ion, 296 Diastereomers, 55 Diazomethane, 221222 Diazonium coupling, 310 Diazonium salts, 149, 264, 309310 Diazotization, 309 Diborane, see Borane 1,1Dichloroethane, 326 Diels-Alder cycloaddition, 133134 Dienes (conjugated), 13, 131134, 318319 Dienophile, 134 Diethyl malonate, 218, 234236 Dihedral angle, 58 Diisobutylaluminium hydride, 168, 232, 313 -Diketones, 98, 236237 2,4Dinitrophenylhydrazones, 186 1,2Diols, 119 1,1Diphenylethene, 332 Dipole moment, 170, 240, 286, 323 Electromagnetic radiation, 315316 frequency, 315316 wavelength, 315316 Electromagnetic spectrum, 315 Index 353 Electronic spectra, 317 Electronic transitions, 318319 Electrophiles, 6371, 73 electrophilic centers, 6371, 73 relative electrophilicity, 6768 Electrophilic addition, 74 alkenes, 105114 alkynes, 124126 conjugated dienes, 132133 Electrophilic substitution, 74, 138, 139146, 150159, 279 Elimination, 74, 192, 240, 252257, 271273, 290 Enantiomers, 51 (R) and (S) nomenclature, 5254 Enol, 125 Enolates, 9598, 171, 191197, 199, 203, 234237, 259 Epoxides electrophilic and nucleophilic centers, 287 nucleophilic substitution, 287, 290292 preparation, 284, 292293 properties, 287 reaction with Grignard reagents to form alcohols, 292 reaction with hydrogen halides to form 1,2halohydrins, 292 reaction with water to form 1,2diols, 290291 spectroscopic properties, 287288 Esters aliphatic and aromatic, 29 alkylation, 235236 bonding 205206 Claisen reaction, 236237 electrophilic and nucleophilic centers, 6970, 206 hydrolysis, 227229, 265 nomenclature, 41 nucleophilic substitution, 207, 209215 preparation, 221222 properties, 206207 reaction with alcohols, 226 reaction with amines to form amides, 222224, 226 reaction with base to form enolate ions, 234 reaction with Grignard reagents, 230 reaction with ketones, 236 237 reaction with organolithium reagents, 230231 reactivity, 213216 reduction to alcohols, 231232 reduction to aldehydes, 232 shape, 205206 spectroscopic properties, 207208, 330 synthesis of aromatic ester, 148 ,-unsaturated, 13 Ethers basicity, 81 bonding, 7, 286287 cleavage, 265, 289290 electrophilic and nucleophilic centers, 6970, 287 elimination, 290 hydrogen bonding, 286287 Lewis base, 94 nomenclature, 40 nucleophilic substitution, 289290 preparation, 283284 properties, 286287 reaction with atmospheric oxygen, 290 spectroscopic properties, 287288, 330, 331332 Fischer diagrams, 52 Friedal-Crafts acylation, 142, 144, 229, 309 Friedal-Crafts alkylation, 111, 142143, 309 Functional groups aliphatic, 29 aromatic, 29 common functional groups, 2728 denition, 27 electrophilic and nucleophilic centers, 6971 identication by ir spectroscopy, 323 nomenclature, 3542 properties, 3334 reactions, 34 transformations, 73, 147148, 167, 217, 263, 265, 278279 Gabriel synthesis, 296 Gauche interactions, 5758, 61 Geminal dihaloalkane, 124 Grignard reagents electrophilic and nucleophilic centers, 261262 preparation, 261262 reaction with acid chlorides and esters, 230 reaction with alcohols, 271 reaction with aldehydes and ketones, 175176, 203 reaction with carbon dioxide, 217218 reaction with carboxylic acids, 230 reaction with epoxides, 292 reaction with nitriles, 313 reaction with water to form alkanes, 262 Half curly arrows, 77 Halogenation aldehydes and ketones, 198199 aromatic rings, 141142 Halogenoalkanes see Alkyl halides Halohydrins, 109110, 113114, 284, 292 Hemiacetals and hemiketals, 188190 High performance liquid chromatography (hplc), 320 Hofmann elimination, 307308 Hofmann rearrangement, 297298 Huckel rule, 135136 Hunds rule, 2, 56, 9, 15 Hybridization, 4 hybridized centers, 1718 sp hybridization, 4, 1416 sp2 hybridization, 4, 813 sp3 hybridization, 47 shape, 18 Hydrazine, 231 Hydrazone, 200 Hydride ion, 177178, 231232 Hydride shift, 143 Hydroboration, 121123 Hydrogen, molecular orbitals, 34 Hydrogenation of alkenes, 117118 of alkynes, 127128 of aromatics, 164165 Hydrolysis of alkenes, 110, 114 of carboxylic acid derivatives, 227229, 265, 308 of nitriles, 312 Hydroperoxides, 290 Hydrophilic, 33 Hydrophobic, 3234 Hyperconjugation, 115116, 250 354 Index Inductive effect carbocation stabilization, 115 effect on acidity, 85, 87, 278 effect on basicity, 301 nucleophilic addition, 181182 nucleophilic substitution, 214, 249250 on chemical shift (nmr), 330331, 332 Infrared spectroscopy, 315, 322323 dipole moment, 323 ngerprint region, 269, 323 wavenumber, 323 of acid anhydrides, 208 of acid chlorides, 208 of alcohols, 269 of aldehydes, 171172 of alkyl halides, 240 of alkynes, 323 of amides, 208 of amines, 304 of aromatic compounds, 138 of carboxylic acid derivatives, 208 of carboxylic acids, 207 of epoxides, 287 of esters, 208 of ethers, 287 of ketones, 171172 of nitriles, 313 of phenols, 269 Iodoform reaction, 199 Isomers cis and trans, 4748 congurational, 4648, 4955 conformational, 5661 constitutional, 45 optical isomers, 4955 ortho, meta and para, 151 (Z) and (E), 4748 (R) and (S), 5254 Ketals, 173174, 187189 Keto-enol tautomerism, 125, 171, 172, 198 -Keto esters, 98, 193194, 236237 Ketones acidity of alpha protons, 9598, 171, 191 Aldol reaction, 179180, 196197 aliphatic and aromatic, 29 -alkylation, 191194 bonding, 170 dipole-dipole interactions, 3132 electrophilic and nucleophilic centers, 6970, 170171 -halogenation, 198199 iodoform reaction, 199 nomenclature, 40 nucleophilic addition, 74, 173174, 175180 preparations, 167168 properties, 169172 protection, 189 reaction with alcohols to form ketals, 173174, 187189 reaction with alcohols to form hemiketals, 190 reaction with amines to form imines and enamines, 173174, 184186 reaction with bisulte, 179180 reaction with cyanide to form cyanohydrins, 178179 reaction with esters, 236237 reaction with Grignard reagents to form alcohols, 175176 reaction with hydroxylamine, semicarbazide and 2,4DNP, 186 reaction with organolithium reagents to form alcohols, 176177 reaction with thiols to form thioketals, 190 reactivity, 181183 reduction to alcohols, 143, 147, 165, 177178 shape, 170 spectroscopic properties, 171172, 330, 333 ,-unsaturated, 13, 197, 202204 Lactic acid, 5051, 5253 Larmor frequency, 327, 333334 Lewis acids see Acids Lindlars catalyst, 127 Lithium aluminium hydride, 149, 177178, 204, 231232, 296, 297, 312 Lithium diisopropylamide, 193194, 234, 303304 Lithium tri-tertbutoxyaluminium hydride, 232 Markovnikovs rule, 113, 121122, 126 Mass spectroscopy, 315, 342346 base peak, 344, 345 chemical ionisation, 343 daughter ions, 344, 345 electron ionisation, 343 fast atom bombardment, 343 fragmentation patterns, 172, 207, 269, 344345 high resolution, 345346 isotopic ratios, 241, 343, 345 molecular ion, 343, 344 mass spectrum of nonane, 344345 of alcohols, 269 of aldehydes, 172 of alkyl halides, 241 of amines, 304 of aromatics, 138 of carboxylic acids, 207 of ketones, 172 of nitriles, 313 parent ion, 343 Mechanisms, 7577 acetal formation, 188189 acid base reactions, 230, 267 Aldol reaction, 195196 -alkylation of ketones, 191194 Claisen condensation, 236237 decarboxylation, 193, 236 dehydration of primary amides, 233 diazonium salt formation, 309 Diels-Alder cycloaddition, 134 dissolving metal reduction of an alkyne, 128 E1 elimination, 254255, 272 E2 elimination, 253254, 272273 electrophilic addition, 107110, 132133 electrophilic substitution, 140143, 151152 enolate ion formation, 234 epoxide formation, 284, 289290 esterication, 221222 Friedal Crafts alkylation, 142143 Grignard reaction with acid chloride, 230 Grignard reaction with carbon dioxide, 218 Grignard reaction with a nitrile, 313 -halogenation of aldehydes and ketones, 198199 Hofmann elimination, 307 Index 355 hydroboration of alkenes, 122123 hydrolysis of amides, 229 hydrolysis of esters, 227229 hydrolysis of nitriles, 312 keto-enol tautomerism, 171 mesylate formation, 275 nucleophilic addition, 176 179 1,4nucleophilic addition to ,-unsaturated aldehydes and ketones, 203 nucleophilic addition of Nnucleophiles, 184186 nucleophilic substitution (SN1), 245246, 273 nucleophilic substitution (SN2), 243243, 273275 nucleophilic substitution of carboxylic acid derivatives, 210212 oxidation of alcohols, 276 reduction of an amide by LiAlH4, 232 reduction of an ester by LiAlH4, 231 reduction of nitriles with LiAlH4, 312 thionyl chloride reaction with a carboxylic acid, 220 Mercuric acetate, 110, 114 Mercuric sulfate, 125126 Mercuric triuoroacetate, 110, 284 Mercuronium ion, 110 Meso structures, 5455 Mesylates, 274275 Methanesulfonyl chloride, 274275 (E)-4Methoxybut-3en-2one, 333 Methyl ethanoate, 330 Molecular orbitals, 34, 12, 97, 317319 Newman projections, 5657 Nickel boride, 128 Nitration of aromatic compounds, 145146 Nitriles bonding, 1516, 311 electrophilic and nucleophilic centers, 311 hydrolysis to carboxylic acids, 312 preparation, 311 reaction with Grignard reagents, 313 reaction with organolithium reagents, 313 reduction to amines and aldehydes, 312313 shape, 311 spectroscopic properties, 313 Nitrogen, sp3 hybridization, 7 Nitronium ion, 145146 Nomenclature, cis and trans, 4748 (E) and (Z), 4748 functional groups, 3542 primary-quaternary, 4344 (R) and (S), 5254 Nonane, 344 Nuclear magnetic resonance spectroscopy (13C), 315, 339341 chemical shift, 341 DEPT nmr spectra, 341 of acid anhydrides, 208 of acid chlorides, 208 of alcohols, 269 of aldehydes, 172 of alkenes, 103 of alkynes, 104, of amides, 208 of amines, 304 of aromatics, 138 of carboxylic acid derivatives, 208 of carboxylic acids, 207 of esters, 208 of ethers, 288 of ketones, 172 of nitriles, 313 off resonance decoupling, 341 proton decoupling, 340 spin-spin coupling, 340 Nuclear magnetic resonance spectroscopy (1H), 315, 325338 chemical shift, 329331 coupling constant, 103, 172, 335, 336 diamagnetic circulation, 331332 integration, 338 larmor frequency, 327, 333334 magnetic dipole moment, 325328 of alcohols, 269 of aldehydes, 172, 332 of alkanes, 330 of alkenes, 103 of alkyl halides, 240 of alkynes, 104, 332 of amides, 208 of amines, 304 of aromatics, 138 of benzyl methyl ether, 331332 of carboxylic acid derivatives, 207208 of carboxylic acids, 207 of 1,1dichloroethane, 326 of 1,1diphenylethene, 332 of epoxides, 288 of esters, 208, 330 of ethers, 288, 333 of ketones, 172, 330 of (E)-4methoxybut-3en2one, 333 of methyl ethanoate, 330 of phenols, 269 Pascalls triangle, 336337 precessional frequency, 327, 329330, 331, 334 secondary magnetic elds, 328338 spin-spin coupling, 333338 Nucleophiles, 6371, 73 relative nucleophilicity, 65, 67, 249 Nucleophilic addition, 74, 173190, 194197, 203204, 211212 Nucleophilic centers, 6371, 73 Nucleophilic substitution, 74, 129 intramolecular, 284 of alcohols, 268, 273274 of alkyl halides, 222, 235236, 240, 242251, 284285 of carboxylic acids and acid derivatives, 207, 209216, 225232 of epoxides, 290292 of ethers, 289290 Optical purity, 54 Optical rotation, 54 Organocuprate reagents 1,4nucleophilic addition to ,-unsaturated aldehydes and ketones, 203204 preparation, 262 reaction with acid chlorides to form ketones, 231 Organolithium reagents preparation, 262 reaction with alcohols, 271 reaction with aldehydes and ketones, 176177, 203 reaction with esters, 230231 reaction with nitriles, 313 356 Index Osmium tetroxide, 119 Oxalyl chloride, 219 Oxidation, 74 oxidation of alcohols, 275276 oxidation of aldehydes and ketones, 201 of alkenes, 118120 of aromatics, 164, of phenols, 279 of thioethers, 293 Oximes, 186 Oxonium ion, 189 Oxygen sp2 hybridization, 11 sp3 hybridization, 7 Ozonide, 118 Ozonolysis, 118119 Pascalls triangle, 336337 Pauli exclusion principle, 2 Pericyclic reaction, 280 Peroxides, 289 Peroxyacid, 120 Phenols acidity, 80, 8687, 268269, 277278 bonding, 268 Claisen rearrangement, 279280 diazonium coupling, 310 electrophilic substitution, 155156, 279 hydrogen bonding, 31, 268 oxidation, 279 preparation, 264 properties, 268269 reaction with acid anhydrides, 278 reaction with acid chlorides, 278 reaction with alkyl halides, 149, 278 reaction with base, 268269 spectroscopic properties, 269 Phenoxide ion basicity, 80 delocalization, 8687, 268 formation, 268269, 277, 279, 310 Phosphorus oxychloride, 272273 Phosphorus pentoxide, 233, 311 Phosphorus tribromide, 240, 273274 Phosphorus trichloride, 219 Phosphoryl trichloride, 233 Plancks constant, 316 Pthalimide, 296 Pyridinium chlorochromate, 275276 Racemate, 51, 246 Radical reactions, 77, 128 Reduction, 74 of aldehydes and ketones, 200201 of alkenes, 117118, 121124 of alkynes, 127128 of aromatics, 138, 164165 of aromatic ketones, 143, 147148, 165 of azides, 296 of carboxylic acids and carboxylic acid derivatives, 231233 of nitriles to aldehydes, 167, 313 of nitriles to amines, 312 of nitro groups, 147149, 161, 162, 231, 263, 298 of thioethers, thioacetals and thioketals, 293 of ,-unsaturated aldehydes and ketones, 204 Resonance structures, acid anhydride, 215 allylic cations, 6465, 132 133 amide, 93, 157, 215 aniline, 302 aromatic amines, 9293 carboxylate ion, 8687, 92 conjugate base of ethanamide, 87 conjugate base of 1,3diketones, 98 electrophilic substitution intermediates, 141, 152, 153, 156, 159 enolate ion, 9697, 192, 235 nitroaniline, 303 phenol, 278 pthalimide anion, 296 Retrosynthesis, 148 Sandmeyer reaction, 310 Saponication, 227228 Schiff base, 185 Semicarbazones, 186 Sodium amide, 271 Sodium borohydride, 110, 114, 177178, 204, 232233 Sodium cyanoborohydride, 297, 306 Sodium hydride, 271, 283 Spiro compounds, 54 Stereoelectronic effects, 34 Stereogenic center, 51 Stereoisomers, 55 Steric factors, 182183, 215, 249250 Sulde see Thioethers Sulfonamides, 306307 Sulfonation, 145 Sulfonation of aromatics, 145146 Sulfur ylids, 284, 292293 Tautomerism, 125 Tetramethylsilane (TMS), 329330, 341 Thioacetals & thioketals, 190, 201, 293 Thioethers acidity, 287 nomenclature, 42 oxidation, 293 preparation, 258, 284285 properties, 287 reaction with alkyl halides, 292293 reduction, 293 Thiolate, 282, 284285 Thiols acidity, 282 hydrogen bonding, 282 nomenclature, 42 oxidation to disuldes, 282 preparation, 258, 281282 properties, 282 reaction with aldehydes and ketones, 190, 201 reaction with base to form thiolates, 282 Thionyl chloride, 219220, 233, 239, 273274, 311 Thiourea, 282 Threonine, 55 para-Toluenesulfonyl chloride, 274 Torsional angle, 58 Tosylate, 274275, 283 Transesterication, 226 Ultra violet spectroscopy (see visible/uv spectroscopy) Vicinal dibromides, 99100, 108109 Visible/uv spectroscopy, 315, 317321 absorbance, 320 measurement, 319320 Index 357 molar absorptivity, 320 of -Carotene, 319 of aldehydes, 172, 318319 of alkenes, 103, 318319 of aromatics, 138 of dienes, 318319 of ketones, 172 of Vitamin A, 319 structure analysis, 320321 Vitamin A, 319 Walden inversion, 244 Williamson ether synthesis, 283284 Wolff-Kishner reduction, 200 Zaitsevs rule, 260, 272 Zwitterion, 31, 9293 ... 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