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University of Illinois, Urbana Champaign - STAT - STAT530
Tutorial A Tutorial on R Programming ProgrammingPing MaIntroductionGNU S-Plus GNU A flexible programming language for statistical computing. flexible Multitude of packages exist for computational biology analyses. BioConductor Project. BioConductor Som
University of Illinois, Urbana Champaign - STAT - STAT530
STAT530 Homework 1 Due: September 20thDownload the integrin 47 data from course website (hw1.zip). This experiment was conducted by the Erle Lab in UC San Francisco. This experiment aims to study the cell adhesion molecule integrin alpha4/beta7 which ass
University of Illinois, Urbana Champaign - STAT - STAT530
STAT530 Homework 2 Due: October 3rd Download the schizophrenic data from course website (schizophrenia.xls: 7072 probe sets, 24 samples). This dataset is a matrix of the estimated expression values from the postmortem dorsolateral prefrontal cortex of 12
University of Illinois, Urbana Champaign - STAT - STAT530
STAT 530 STAT Introduction to Computational Biology ComputationalPing Ma PingOutlineCourse information Course Course structure Course Literature retrieval and Mining LiteraturePing Ma STAT5302Ping Ma STAT 5301STAT 530Lecture MW 10:00-10:50pm Lect
University of Illinois, Urbana Champaign - STAT - STAT530
STAT 530 Introduction to Computational BiologyPing MaOutlineCourse information Course structure Literature retrieval and MiningPing Ma STAT5302Ping Ma STAT 5301STAT 530Lecture MW 10:00-10:50pm Instructor: Ping Ma pingma@uiuc.edu office hour: Mond
University of Illinois, Urbana Champaign - STAT - STAT530
STAT 530 STAT Introduction to Microarray MicroarrayPing Ma PingMicroarrayHigh throughput gene expression platforms SAGE Microarrays: cDNA and oligonucleotide arrays Microarray analysis: Very low level: image analysis Low level: normalization Dye swap L
University of Illinois, Urbana Champaign - STAT - STAT530
University of Illinois, Urbana Champaign - STAT - STAT530
STAT 530 STAT Oligonucleotide Oligonucleotide MicroarrayPing Ma PingSource: Affymetrix, Inc.Ping Ma STAT530 2Ping Ma STAT 5301Ping Ma STAT5303Affymetrix Microarray Imagine AnalysisAffymetrix GeneChip Operating System (GCOS) cel file X Y MEAN STDV
University of Illinois, Urbana Champaign - STAT - STAT530
Detecting differentially expressed Detecting genes in comparative experiments genesPing MaPing MaSTAT530OutlineDifferential gene expression Fold change Parametric test: t and Welch-t test Non-parametric test: permutation t and Wilcoxon Multiple hypot
U. Houston - INDE - INDE2333
AGENDAContinuous Random VariablesNormal DistributionNormal Approximation to the BinomialUniform DistributionLognormal DistributionNORMAL DISTRIBUTIONMost important distributionFrequently encountered in bothNature Man made processesAKABell c
U. Houston - INDE - INDE2333
AGENDAProbabilityReviewGo over homeworkQuizREVIEWRandom VariablesBinomialHypergeometricPoisson and binomial approximationGeometricMultinomialRANDOM VARIABLESDiscrete or continuousProbability densityCumulative distribution functionBINOMIA
U. Houston - INDE - INDE2333
AGENDAProbabilityHypergeometric DistributionPoisson Distribution and approximation of Geometric DistributionMultinomial DistributionHYPERGEOMETRIC DISTRIBUTIONSituations involving sampling without replacementOnce you make an observation of an it
U. Houston - INDE - INDE2333
AGENDAProbability DistributionsRandom variable conceptsBernoulli trialsBinomial distributionRANDOM VARIABLES CONCEPTSRandom variablesA function that assigns a value to a possible outcomeDiscrete take on specific values in a rangeContinuous take on
U. Houston - INDE - INDE2333
AGENDAProbabilityReview for quizOptional homework problemsQuizDESCRIPTIVE MEASURESMeanMedianModeMinimumMaximumRangeVarianceStandard DeviationSAMPLE VARIANCEPERMUTATIONSn objects total r objects selected (less than n)Particular order of
U. Houston - INDE - INDE2333
AGENDAProbabilitySample spaces and eventsCountingProbabilityConditional ProbabilityBayes TheormMathematical Expectation SAMPLE SPACES AND EVENTSSample spaceSet of all possible experimental outcomesDiscreteFinite number of elementsOnly certa
U. Houston - INDE - INDE2333
AGENDASome statistics related quotesImportance of Probability and StatisticsBasic ConceptsTreatment of dataSOME STATISTICS RELATED QUOTESNot all that can be counted counts, not all that counts can be countedIn order to improve a process, you must f
U. Houston - INDE - 2333
AGENDAExam 3 ReviewEXAM 3 REVIEWChi-squared goodness of fit testU and H Rank Sum TestsLinear RegressionGOODNESS OF FIT TESTSBased on a comparison of observations betweenObserved dataTheoretical data The comparison utilizes a set of intervals
U. Houston - INDE - 2333
AGENDALinear RegressionLINEAR REGRESSIONStatistical method for determining a linear relationship between two variables assuming normality and independenceTwo types of variablesIndependentDependentMethod of least squaresDATAWHICH PREDICTION LIN
U. Houston - INDE - 2333
AGENDAComputer implementation of Chi-square goodness of fit testReviewReturn tests?Optional homework problemsQuizGOODNESS OF FIT TESTSBased on a comparison of observations betweenObserved dataTheoretical data The comparison utilizes a set of
U. Houston - INDE - 2333
AGENDANonparametric Test ConceptsU-TestH-TestNON-PARAMETRIC TEST CONCEPTSUsed when the sample data is eitherNon-normal (from goodness of fit test)Sample is too small to determine normalityRank sum testsBased on the rank order of sorted data sa
U. Houston - INDE - 2333
AGENDAChi-square goodness of fit testGOODNESS OF FIT TESTSUsed to determine if a sample could have come from a distribution with the specified parametersCommonly used to determine if data is normally distributedMany tests such as the ones that we
U. Houston - INDE - 2333
AGENDAHypotheses concerning two variancesExam 2 reviewExtra credit project proposalsHYPOTHESES CONCERNING TWO VARIANCESUsed to compare the differences in variance of two populationsWhich hypotheses test concerning two variances to useUsed in qua
U. Houston - INDE - 2333
AGENDAConfidence Intervals Concerning Two MeansInferences Concerning VariancesCONFIDENCE INTERVALS CONCERNING TWO MEANSConfidence intervals can also be generated for the difference between two meansConfidence intervals are based on corresponding t ca
U. Houston - INDE - 2333
AGENDAPaired-T testExtra creditReviewOptional HomeworkReturn QuizzesQuizPAIRED T-TEST UseCompare before and after paired results n1 and n2 must be equal Assuming normality of populations Data is not independent, pairs are correlatedExampl
U. Houston - INDE - 2333
AGENDAHypotheses concerning one meanHypotheses concerning two meansEXAMPLE 2Claimed tire lifetime of at least 28,000 miles is suspectSample40 tiresMean=27,463Std=1,348Conclusions at an alpha level = 0.05?APPROACHInterested in if the lifetime
U. Houston - INDE - 2333
AGENDAReturn examsReviewOptional homeworkReturn last quizQuizSTANDARDIZED SAMPLE MEAN t DISTRIBUTION t DISTRIBUTIONfor a particular number of degrees of freedomCHI-SQUARE DISTRIBUTIONCHI-SQUAREfor a particular number of degrees of freedomF D
U. Houston - INDE - 2333
AGENDAPoint EstimationInterval EstimationTests of HypothesesNull Hypothesis and Tests of HypothesesHypotheses concerning one meanPOINT ESTIMATIONHave an population of unknown meanTake a samplePoint EstimatorX bar of sampleEstimate of errorK
U. Houston - INDE - 2333
AGENDAPopulations and sampleSampling distribution of the mean (sigma known)Central Limit TheoremSampling distribution of the mean (sigma unknown)Sampling distribution of the variancePOPULATIONS AND SAMPLEPopulations can be eitherInfiniteFinite
U. Houston - INDE - 2333
AGENDAGamma distributionExponential distributionBeta distributionWeibull distributionExam reviewOptional HomeworkQuizGAMMA DISTRIBUTIONGAMMA DISTRIBUTIONGAMMA DISTRIBUTIONEXPONENTIAL DISTRIBUTIONGamma distribution with alpha parameter=1Rel
DeVry Denver - FINANCE - FI516
1. If a firm adheres strictly to the residual dividend policy, then if its optimal capital budget requires the use of allearnings for a given year (along with new debt according to the optimal debt/total assets ratio), then the firm should pay a. no divi
UC Irvine - SOCIAL SCI - 109824
Writing for Media Final Exam Story AssignmentYour final exam will be a 1,200 -word news feature on how Orange County residents feel about the economy. It is due Tuesday, July 27th at 1 p.m. Hard copies only should be delivered to me at our classroom. I w
UCSD - BIOLGY - BICD 110
UCSD Biology #1!A cell is an organism or a unit of a multi-cellular organism 2We are going to cover everything you see on this slide!Suggestions for studying Cell Biology 1.Read! You should read the textbook BEFORE and after (PodCast) 2. Come to lectur
UCSD - BIOLGY - BICD 110
Summary 1. Eukaryotic cells keep genetic information in DNA enclosed in cell nucleus and mitochondria and chloroplasts (plants); 1. The genomes of several model organisms are completely sequenced; 3. Long DNA molecules are efficiently packed in chromosome
UCSD - BIOLGY - BICD 110
Summary331. Cells follow rules of chemistry; 2. Water is the most abundant substance proteins constitutes most of a cells dry mass; 1. Four major classes of small organic molecules make macromolecules; 1. Living cells undergo metabolism; 2. A reaction w
UCSD - BIOLGY - BICD 110
Summary 1. 2. 3. 4. 5. Cell doctrine; Two major types of microscopes: light and electron; Limitation of resolution: wavelength of radiation; Advantage and disadvantage of light and electron MS Different types of light microscopes: bright field, phase cont
UCSD - BIOLGY - BICD 110
Summary 1. 2. 3. 4. 5. 6. 7. Membranes are made of lipids and proteins; Lipid bilayer is a energetically favored structure; Fluidity, permeability and asymmetry of lipid bilayer Membrane proteins and transmembrane domains; Membrane protein modifications a
UCSD - BIOLGY - BICD 110
Summary 1. Ions and larger polar molecules cannot cross the lipid bilayer; 2. Two types of transport proteins: carriers (transporters) and channels; 3. Passive and active transport; 4. Three types of active transport; 5. Mechanisms of cotransport; 6. Na+-
UCSD - BIOLGY - BICD 110
Summary 1. Cells are highly compartmentalized; proteins are sorted to different compartments; 1. Nuclear transport, nuclear pore, nucleoporins, NLS; 2. Ran GTPase control direction; 3. Nuclear lamina, nuclear lamins; 4. Mitochondria transport, signal sequ
UCSD - BIOLGY - BICD 110
Summary 1. 2. 3. 4. 5. 6. Rough ER and smooth ER; Signal hypothesis, translocation into ER; Single-span and multi-span membrane proteins; Glycosylation; Protein folding; Lipid synthesisLecture 8 Vesicular trafficking from ER to GolgiEndocytic and biosyn
UCSD - BIOLGY - BICD 110
Summary 1. Vesicular transport, biosynthetic-secretory and endocytic pathways; 2. Coated vesicles; 1. Coat assembly and disassembly, budding, dynamin, coat-recruitment GTPases; 1. Targeting and fusion by Rab GTPases, SNAREs; 2. ER to Golgi: COPII, folding
UCSD - BIOLGY - BICD 110
Lecture 10 Energy Conversion: Mitochondria and ChloroplastsChemiosmotic coupling:the common pathway used by mito, chloroplasts and procaryotes ATP (chemi) membrane transport (osmotic)electrochemical proton gradientLarge amount of internal membrane in
UCSD - BIOLGY - BICD 110
Summary 1. 2. 3. 4. 5. 6. 7. Chemiosmotic coupling and electron transport Mitochondria are plastic and can be motile Oxidative phosphorylation and ATP synthase Plastids and chloroplasts Photosynthesis, antenna and reaction center Mitochondrial and chlorop
UCSD - BIOLGY - BICD 110
Summary 1. Cell communication is essential for both mutlicellular organism and unicellular organisms; 1. Different forms of signaling, different signal molecules, receptors; 2. Switches, intracellular signaling proteins, complexes, integration 3. Non-line
UCSD - BIOLGY - BICD 110
Summary 1. Three types of cytoskeletal filaments, protofilaments; 2. Subunits, polymerization, treadmilling, dynamic instability; 1. Intermediate filaments, cell integrity, diseases caused by mutations in the intermediate filament genes 4. Natural toxins
UCSD - BIOLGY - BICD 110
Lecture 1 (September 28): Introduction 1 (Genetics and Cell Nucleus) - Chapters 1, 4, 5, 6. 7 Chapter 1 The single cell vehicle for the hereditary information that defines the species specified by this information, the cell includes the machinery to gathe
UCSD - BIOLGY - BICD 110
Lecture 2 - Chapters 2, 3 Chapter 2 Water accounts for about 70% of a cells weight & most intracellular reactions occur in an aqueous environment life on earth began in the ocean In each water molecule the 2 H atoms are linked to the O atom by covalent bo
UCSD - BIOLGY - BICD 110
Lecture 3 Chapter 9 Chapter 9 Series of images illustrate an imaginary progression from a thumb to a cluster of atoms each successive image represents a tenfold increase in magnification the naked eye could see features in the first 2 panels, the resoluti
UCSD - BIOLGY - BICD 110
Lecture 4 - Chapter 10 Chapter 10 All biological membranes have a common general structure: each is a very thin film of lipid (fatty) and protein molecules, held together mainly by noncovalent interactions cell membranes are dynamic, fluid structures, and
UCSD - BIOLGY - BICD 110
Lecture 5 Notes Chapter 11 Chapter 11 Given enough time, virtually any molecule will diffuse across a protein-free lipid bilayer down its concentration gradient. The rate of diffusion, however, varies enormously, depending partly on the size of the molecu
UCSD - BIOLGY - BICD 110
Lecture 10 Notes Slide 2 Mitochondria uses oxygen to oxidate foodstuffs get energy in the form of high energy electrons usable energy for the cell Plant cells chloroplasts can use light energy sunlight has photons which has energy high energy electrons ar
UCSD - BIOLGY - BICD 110
Lecture 11 11/4/10 Slide 1 Mitochondria & chloroplasts both use chemiosmotic coupling & electron transport mitochondria converts energy from food while chloroplast from light Mitochondria are very plastic (structure) & motile some dont move but most do &
Adelphi - HISTORY - HIST201
201992 202028 202030Napo o Bo le n naparteDis us thec e o Napo o Bo cs are r f le n naparte .11/22/10 re What we hisac ve e and failure ? hie m nts sClick to edit Master subtitle styleCareerAll abo thebac ro o Napo o until hebe am an ut kg und f le
University of Toronto - UT - CHM138
What is a reaction paper? Reaction or response papers are designed so that you'll consider carefully what you think or feel about something you've read or seen. Instructions Read or view whatever you've been asked to respond to read or view. While reading
Korea University - CAC - BSA
PROBLEM NO. 1 - Conviction Corporation Question Nos. 1, 3 to 5 - B Authorized common stock Unissued common stock Common stock issued Subscribed common stock Subscriptions receivable Additional paid-in capital Donated capital Gain on sale of treasury stock
Korea University - CAC - BSA
Page 1 of 5CPA REVIEW SCHOOL OF THE PHILIPPINESManilaAUDITING PROBLEMS AUDIT OF STOCKHOLDERS EQUITY - QUIZZERS PROBLEM NO. 1 Resolve Corporation began operations on January 1, 2005. The company was authorized to issue 60,000 shares of P10 par value com
Korea University - CAC - BSA
PROBLEM NO. 1 - Resolve Corporation Date Preferred stock Common stock1/31 8/30 1/1 2/20 8/30 8/30 11/07 5/30 11/07 5/30 11/07 1/31 1/31 8/30 1/1 2/20 2/20 5/30 8/30 8/30 12/01 12/31Particulars (Debit) Credit 3,000,000 420,000 15,000 90,000 18,000 21,000
Korea University - CAC - BSA
Page 1 of 10CPA REVIEW SCHOOL OF THE PHILIPPINESManilaAUDITING PROBLEMS AUDIT OF LIABILITIES PROBLEM NO. 1 In the audit of the Heats Corporation's financial statements at December 31, 2005, the chief accountant of the said corporation provided the foll
Korea University - CAC - BSA
PROBLEM NO. 1 - Heats Corporation Requirement no. 1 Notes payable: Arising from purchase of goods Arising from bank loans, on which marketable securities valued at P600,000 have pledged as security, due Dec. 31, 2005 Arising from advances by officers, due
Korea University - CAC - BSA
Page 1 of 4CPA REVIEW SCHOOL OF THE PHILIPPINESManilaAUDITING PROBLEMS AUDIT OF LIABILITIES QUIZZERS PROBLEM NO. 1 Cavaliers Corporation is selling audio and video appliances. The company's fiscal year ends on March 31. The following information relate
Korea University - CAC - BSA
PROBLEM NO. 1 - Cavaliers Corporation 1 Warranty payable, 3/31/04 Add warranty expense accrued during 2004-2005 Total Less payments during 2004-2005 Warranty payable, 3/31/05 2 Bond discount, 10/1/99 (P5,000,000 x .04) Discount amortization, 10/1/99 to 3/
Korea University - CAC - BSA
Page 1 of 10CPA REVIEW SCHOOL OF THE PHILIPPINESManilaAUDITING PROBLEMS AUDIT OF PROPERTY, PLANT & EQUIPMENT AND INTANGIBLE ASSETS PROBLEM NO. 1 The property, plant and equipment section of White Corporations balance sheet at December 31, 2004 included