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01 Biomolecules NARRATED 2011 renumb

Course: BIO 205, Spring 2011
School: SUNY Buffalo
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1 Lecture : Biomolecules Figures in this presentation appear in Biological Chemistry, Bio 205 Classnotes, 5th Edition, published (2009) by the Custom Services division of John Wiley and Sons, Inc. (Hoboken, NJ). Some figures might be taken from the textbooks listed below. This material is used by permission of John Wiley & Sons, Inc. Fundamentals of Biochemistry, 1st and 2nd editions (1999 and 2006, Wiley) D. Voet, J.G. Voet, & C.W. Pratt Biochemistry, 3rd edition ( 2004, Wiley) D. Voet & J.G. Voet Principles of Anatomy and Physiology, 10th edition ( 2003, Wiley) G.J. Tortora & S.R. Grabowski Essential Biochemistry, 3rd edition ( 2004, Wiley) C.W. Pratt & K. Cornely Cell Biology, 4th edition ( 2005, Wiley) Karp Fig-01 N1 4 classes of biomolecules : Proteins Nucleic acids Carbohydrates Lipids Proteins Fig 2 N-02 household appliances protein functions : hemoglobin trypsin insulin immunoglobulin myosin keratin opsin transporter enzyme hormone defense motility structure vision carries oxygen digests food proteins regulates metabolism recognizes bacteria muscle contraction hair binds retinal pigment Fig-03 N3 Fig 4A V-01A Nonpolar sidechains alkane aromatic Based on Tbl 4-1, p. 78-79, Voet Voet & Pratt (2nd Ed.), Wiley (2006) Fig 4B V-01B alcohol amide Fig 4C V-01C amine carboxylic acid ENSATION reaction V-02 carboxylic acid + amine -> amide Based on Fig 4-3, p. 81, Voet Voet & Pratt (2nd Ed.), Wiley (2006) Fig V-03 6. HETERO-polymer HETERO = different HOMO = same Based on insert (Ch 4), p. 85, Voet Voet & Pratt (2nd Ed.), Wiley (2006) Fig V-04 7. Protein folding N end helices sheet Based on Fig 6-28, p. 151, Voet Voet & Pratt (2nd Ed.), Wiley (2006) Nucleic acids Fig 8 N-04 Nucleic acid functions DNA messenger RNA ATP genetics genetics energy replication when cells divide DNA -> mRNA -> proteins high-energy currency VFig -05 9. Nucleotides acid ribose deoxy RNA = Ribo Nucleic Acid DNA = Deoxy ribo Nucleic Acid Based on Fig 3-1, p. 43, Voet Voet & Pratt (2nd Ed.), Wiley (2006) ig -06 Polynucleotide chain V 10. Based on Fig 3-3, p. 45, Voet Voet & Pratt (2nd Ed.), Wiley (2006) V-07 ig 11. Base pairs V-07 far apart Based on insert (Ch 3), p. 57, Pratt & Cornely, Wiley (2004) Fig-05 N 12. V 13. Fig -09 Replication on function Based Fig 3-11, p. 50, Voet, Voet & Pratt (2nd Edit), Wiley (2006) Fig -10 Converting DNA into proteins 14. V Transcription Translation Based on Fig 3-11, p. 50, Voet, Voet & Pratt (2nd Edit), Wiley (2006) Fig-11 V 15. ATP (adenoside triphosphate = base-sugar-phos-phos-phos) ADP (base-sugar-phos-phos) + phos Based on Fig 13-4, p.407, Voet, Voet & Pratt (2nd Edit), Wiley (2006) Carbohydrates Fig 16. N-06 Carbohydrate function : cellulose chitin starch glucose type A antigen structure structure energy energy marker plant cell walls insect exoskeleton storage in plants food storage blood group V-12 Fig 17. Aldoses aldehyde 3C 4C 5C 6C Based on Fig 8-1, p. 208, Voet, Voet & Pratt (2nd Edit), Wiley (2006) V-13 Ketoses (ketone) 3C 4C 5C 6C Based on Fig 8-2, p. 209, Voet, Voet & Pratt (2nd Edit), Wiley (2006) N-07 Fig 19 ig 20. Blood group antigens : short heteropolymers V-14 Based on Fig 4-11, p. 130, Karp (4th Edit), Wiley (2005) omopolymer of glucose V-15 Based on Fig 15-2, p. 474, Voet, Voet & Pratt (2nd Edit), Wiley (2006) homopolymer of glucose V-16 two strands in the upper sheet lower sheet Based on Fig 8-9, p. 217, Voet, Voet & Pratt (2nd Edit), Wiley (2006) Lipids Fig 23 N-08 Lipid functions : fatty acid phospholipid bees wax testosterone retinal energy structure structure hormone pigments metabolic fuel animal cell membrane honey comb male sex traits vision N-09 Fig 24 N-10 Fig 25 Fig 26 V-17 FA (fatty acid) FA small polar alcohol glycerol cartoon Based on Tbl 9-2, p. 237, Voet, Voet & Pratt (2nd Edit), Wiley (2006) N-11* Fig 27 Based on Fig 9-15, p. 249, Voet, Voet & Pratt (2nd Edit), Wiley (2006) ig -18 V28 Isoprene unit : 5 Cs, C=C, branch Based on insert (Ch 9), p. 246, Voet, Voet & Pratt (2nd Edit), Wiley (2006) Summary Fig 29 Class Proteins Structural feature Many types of amino acids Functional consequence Many useful appliances Negative phosphates Small/large bases : donors/acceptors Instability (high energy) of ATP Base pairing : genetic replication Lipids Many nonpolar CH2 Polar head / nonpolar tail Fuel : oxidation -> heat Membrane bilayer (phospholipids) Carbohydrates Many OH H-bonds : rigid cellulose Soluble in H2O : easy transport in blood Nucleic acids

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02 Stereochemistry NARRATED v6 renumb

SUNY Buffalo - BIO - 205

Lecture 2 : StereochemistryFigures in this presentation appear in Biological Chemistry, Bio 205 Classnotes, 5thEdition, published (2009) by the Custom Services division of John Wiley and Sons, Inc.(Hoboken, NJ). Some figures might be taken from the tex

03 Acids NARRATED v7 renumb

SUNY Buffalo - BIO - 205

Lecture 3 : Weak acids and basesFigures in this presentation appear in Biological Chemistry, Bio 205 Classnotes, 5thEdition, published (2009) by the Custom Services division of John Wiley and Sons, Inc.(Hoboken, NJ). Some figures might be taken from th

04 Thermo NARRATED v5 renumb

SUNY Buffalo - BIO - 205

Lecture 4 : ThermodynamicsFigures in this presentation appear in Biological Chemistry, Bio 205 Classnotes, 5thEdition, published (2009) by the Custom Services division of John Wiley and Sons, Inc.(Hoboken, NJ). Some figures might be taken from the text

05 Polar NARRATED v9 renumb

SUNY Buffalo - BIO - 205

Lecture 5 : Polar / nonpolarFigures in this presentation appear in Biological Chemistry, Bio 205 Classnotes, 5thEdition, published (2009) by the Custom Services division of John Wiley and Sons, Inc.(Hoboken, NJ). Some figures might be taken from the te

06 Kinetics NARRATED v4 renumb

SUNY Buffalo - BIO - 205

Lecture 6 : Kinetics / equilibriumFigures in this presentation appear in Biological Chemistry, Bio 205 Classnotes, 5thEdition, published (2009) by the Custom Services division of John Wiley and Sons, Inc.(Hoboken, NJ). Some figures might be taken from

07 Oxid-reduct NARRATED v5 renumb

SUNY Buffalo - BIO - 205

Lecture 7 : Oxidation / reductionFigures in this presentation appear in Biological Chemistry, Bio 205 Classnotes, 5thEdition, published (2009) by the Custom Services division of John Wiley and Sons, Inc.(Hoboken, NJ). Some figures might be taken from t

08 Amino acids NARRATED v5

SUNY Buffalo - BIO - 205

Lecture 8 : Amino acidsFigures in this presentation appear in Biological Chemistry, Bio 205 Classnotes, 5thEdition, published (2009) by the Custom Services division of John Wiley and Sons, Inc.(Hoboken, NJ). Some figures might be taken from the textboo

09 Molecular evolution NARRATED v6

SUNY Buffalo - BIO - 205

Lecture 9 : Molecular evolutionFigures in this presentation appear in Biological Chemistry, Bio 205 Classnotes, 5thEdition, published (2009) by the Custom Services division of John Wiley and Sons, Inc.(Hoboken, NJ). Some figures might be taken from the

10 Helices NARRATED v6

SUNY Buffalo - BIO - 205

Lecture 10 : Protein folding - helicesFigures in this presentation appear in Biological Chemistry, Bio 205 Classnotes, 5thEdition, published (2009) by the Custom Services division of John Wiley and Sons, Inc.(Hoboken, NJ). Some figures might be taken f

11 Sheets NARRATED v3

SUNY Buffalo - BIO - 205

Lecture 11 : Protein folding - sheetsFigures in this presentation appear in Biological Chemistry, Bio 205 Classnotes, 5thEdition, published (2009) by the Custom Services division of John Wiley and Sons, Inc.(Hoboken, NJ). Some figures might be taken fr

12 Hb coop NARRATED v5

SUNY Buffalo - BIO - 205

Lecture 12 : Hb / positive cooperativityFigures in this presentation appear in Biological Chemistry, Bio 205 Classnotes, 5thEdition, published (2009) by the Custom Services division of John Wiley and Sons, Inc.(Hoboken, NJ). Some figures might be taken

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SUNY Buffalo - BIO - 205

Lecture 13 : Hb / pH, DPG, mutationsFigures in this presentation appear in Biological Chemistry, Bio 205 Classnotes, 5thEdition, published (2009) by the Custom Services division of John Wiley and Sons, Inc.(Hoboken, NJ). Some figures might be taken fro

14 Enzyme mech NARRATED v5

SUNY Buffalo - BIO - 205

Lecture 14: Enzyme mechanisms and regulationFigures in this presentation appear in Biological Chemistry, Bio 205 Classnotes, 5thEdition, published (2009) by the Custom Services division of John Wiley and Sons, Inc.(Hoboken, NJ). Some figures might be t

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SUNY Buffalo - BIO - 205

Lecture 15 : Enzyme kineticsRaw dataN-01N-02N-03N-04N-05N-06Simple system of 3 ksN-07N-08N-09k-cat = k2N-10Michaelis-Menten variationsN-11N-12N-13N-14N-17Effects of inhibitorsN-18N-19S-initN-20N-21

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SUNY Buffalo - BIO - 205

Lecture 16 : MonosaccharidesFigures in this presentation appear in Biological Chemistry, Bio 205 Classnotes, 5thEdition, published (2009) by the Custom Services division of John Wiley and Sons, Inc.(Hoboken, NJ). Some figures might be taken from the te

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SUNY Buffalo - BIO - 205

Lecture 17 : PolysaccharidesFigures in this presentation appear in Biological Chemistry, Bio 205 Classnotes, 5thEdition, published (2009) by the Custom Services division of John Wiley and Sons, Inc.(Hoboken, NJ). Some figures might be taken from the te

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SUNY Buffalo - BIO - 205

Lecture 18 : Nucleic acids monomers / chainsFigures in this presentation appear in Biological Chemistry, Bio 205 Classnotes, 5thEdition, published (2009) by the Custom Services division of John Wiley and Sons, Inc.(Hoboken, NJ). Some figures might be t

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SUNY Buffalo - BIO - 205

Lecture 19 : PolynucleotidesFigures in this presentation appear in Biological Chemistry, Bio 205 Classnotes, 5thEdition, published (2009) by the Custom Services division of John Wiley and Sons, Inc.(Hoboken, NJ). Some figures might be taken from the te

20 DNA-protein NARRATED v4

SUNY Buffalo - BIO - 205

Lecture 20 : DNA / protein relationshipsFigures in this presentation appear in Biological Chemistry, Bio 205 Classnotes, 5thEdition, published (2009) by the Custom Services division of John Wiley and Sons, Inc.(Hoboken, NJ). Some figures might be taken

21 Fatty NARRATED v5

SUNY Buffalo - BIO - 205

Lecture 21 : Lipids based on fatty acidsFigures in this presentation appear in Biological Chemistry, Bio 205 Classnotes, 5thEdition, published (2009) by the Custom Services division of John Wiley and Sons, Inc.(Hoboken, NJ). Some figures might be taken

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SUNY Buffalo - BIO - 205

Lecture 22 : Isoprene lipids , membranesFigures in this presentation appear in Biological Chemistry, Bio 205 Classnotes, 5thEdition, published (2009) by the Custom Services division of John Wiley and Sons, Inc.(Hoboken, NJ). Some figures might be taken

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SUNY Buffalo - BIO - 205

Lecture 23 : Introduction to metabolismFigures in this presentation appear in Biological Chemistry, Bio 205 Classnotes, 4thEdition, published by the Custom Services division of John Wiley and Sons, Inc.(Hoboken, NJ). Some figures were taken from the te

24 Glycolysis 10 steps NARRATED v3B

SUNY Buffalo - BIO - 205

Lecture 24 : Glycolysis 10 stepsFigures in this presentation appear in Biological Chemistry, Bio 205 Classnotes, 4thEdition, published by the Custom Services division of John Wiley and Sons, Inc.(Hoboken, NJ). Some figures were taken from the textbook

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SUNY Buffalo - BIO - 205

Lecture 25 : Glycolysis energeticsPlot : delta-G vs. step #N-1N-2N-2Hexokinase : couplingN-3N-4N-4N-5Paying for ATP and NADHsynthesisN-6N-6Products of steps 6and 7 combined :G3P (GAP)3PGReactant atbeginning ofstep 6Product atend ofs

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SUNY Buffalo - BIO - 205

Lecture 26 : GluconeogenesisFigures in this presentation appear in Biological Chemistry, Bio 205 Classnotes, 4thEdition, published by the Custom Services division of John Wiley and Sons, Inc.(Hoboken, NJ). Some figures were taken from the textbook list

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SUNY Buffalo - BIO - 205

Lecture 27 : G6P fatesFigures in this presentation appear in Biological Chemistry, Bio 205 Classnotes, 4thEdition, published by the Custom Services division of John Wiley and Sons, Inc.(Hoboken, NJ). Some figures were taken from the textbooks listed be

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SUNY Buffalo - BIO - 205

Lecture 28 : Hormone regulation byphosphorylation / dephosphorylationFigures in this presentation appear in Biological Chemistry, Bio 205 Classnotes, 4thEdition, published by the Custom Services division of John Wiley and Sons, Inc.(Hoboken, NJ). Some

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SUNY Buffalo - BIO - 205

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SUNY Buffalo - BIO - 205

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SUNY Buffalo - BIO - 205

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SUNY Buffalo - BIO - 205

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SUNY Buffalo - BIO - 205

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SUNY Buffalo - BIO - 205

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