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Pharmacology: Antibiotic Chart Antibiotic Spectrum Toxicity Suicide inhibitor Mechanism Beta-Lactams Penicillins Natural PCN Gram + Bactericidal PCNase-resistant Gram + & PCNase resistant Bactericidal AminoPCN Gram + and Gram - Sulbactam (Unasyn) Clavulanic acid (Augmentin) Bactericidal Antipseudomonal PCN Potent against Pseudomonas (part of Gram -) Clavulanate (timentin) Tazobactam (zosyn) Bactericidal Cephalosporins 1 st generation Gm + (except methicillin resistant staph) Gm- (klebsiella and E. Coli) MOST anaerobic Gm + and (not b. fragilis) Bactericidal 2 nd generation 1 st + aerobic more Gm (H. Bactericidal Influenza) 3 rd generation Less Gm + More Gm - Parenteral only Carbapenems Wide spectrum, powerful None listed Bactericidal Monobactams Powerful Gm-activity None listed Bactericidal Glycopeptides Vancomycin Teicoplanin Powerful Gm+ None listed ? Aminoglycosides Gentamycin Tobramycin Amikacin Neomycin Powerful Gm- Renally toxic and can destroy inner ear ? Fluoroquinolones UTI Norfloxacin Enoxacin Systemic Infections-Floxacin Gm+ (good staph, moderate strep) Gm- Excellent activity against shigella and salmonella Bactericidal Macrolides Erythromycin (bad on gut) Clarithromycin (BEST for AIDS and H. Pylori) Azithromycin Gm+ Gm- Genital pathogens (broad spectrum: Bacteriostatic, bacteriocidal at high doses (conc dependent: low con=inhibitory (best for mycoplasma pneumonia) *all for legionella part of rape kit to prevent STD) and high con= lethal) Tetracyclines-cycline Gm+ Gm- Bacteriostatic Misc. Agents Metronidazole Gram + Gram (anaerobes) None listed Bactericidal Clindamycin Gram + Gram- (aerobes and anaerobes) Protozoa: toxoplasma and plasmodium B. fragilis Acne vulgaris Toxoplasmosis Bacteriostatic SMX-TMP Gram + Gram (aerobic) Chlamydia Protoza UTI URI/LRI Salmonella, shigella Travelers diarrhea Bactericidal... View Full Document

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