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sk NEURO DAY2
Course: NEURO 4340, Spring 2012School: Georgia State
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Word Count: 239
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Mircoanatomy Objectives: 1. 2. 3. 4. 5. 6. Understand Muscle the basic organization of a myofiber. Know the basic anatomy and function of the basement membrane. Know the basic anatomy and function of the following organelles: nuclei, ER, mitochondria, and myofibrils. Know the detailed anatomy of the sarcomere (i.e., bands) Know the different myosin heavy chain isoforms and their functional differences....
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Mircoanatomy
Objectives:
1.
2.
3.
4.
5.
6.
Understand Muscle the basic organization of a myofiber.
Know the basic anatomy and function of the basement
membrane.
Know the basic anatomy and function of the following
organelles: nuclei, ER, mitochondria, and myofibrils.
Know the detailed anatomy of the sarcomere (i.e., bands)
Know the different myosin heavy chain isoforms and their
functional differences.
Understand the basic anatomy and function of the
plasmalemma, T-tubule system and sarcoplasmic reticulum
(SR).
Myofiber
Myofiber
Definition:
Diameter and length
Organelles
Connective tissue(basement membrane)
Sarcolemma & Basement Membrane
Basement Membrane
Anatomy
Functions:
Development (embryonic)
Regeneration
Attachment and force transmission
Terminates synaptic transmission via acetylcholinesterase
Plasmalemma and Cytosol
Plasmalemma and Cytosol
Plasmalemma
Anatomy
Function
Cytosol
Composition
Function
Nuclei and Satellite Cells
Nuclei Satellite and Cells
Definition (nucleus):
Genes
http://www.youtube.com/watch?v=OEWOZS_JTgk&featu
DNA
mRNA
Endoplasmic reticulum and ribosomes
Amino acids and proteins
Nuclear domain
Satellite cells
Mitochondria
Mitochondria
Definition
Location
Membranes, cristae(folds), matrix(fluid)
Kreb cycle, electron transport
chain(innermembrane), O2, ATP
Plasticity
Programmed cell death (apoptosis)
Neuromuscular control
http://www.youtube.com/watch?v=ytU1O7ZeNCA
Myofibril
Myofibril
Myofilaments
Myosin ATPase and Shortening Velocity
YouTube - Muscle contraction
Myofibril
Myofiber
Myofibril
Myofilaments
Sarcomere
A-band, I-band, Z-line, H-zone, M-band
Thin filament: actin, troponin, tropomyosin
Thick filament: myosin
Myosin heavy chain isoforms(type 1, 2a2b2x
T-Tubule and SR Systems
T-Tubule and SR Systems
T-tubule
Function
Dihydropyridine receptor
SR
Function
Ryanodine receptor
Triad
YouTube - sacroplasmic reticulum
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