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HKUST - SOSC - 111
SOSC 111SOSC 111Science, Technology & SocietyL21The global and the localOverviewOverviewI. Impact of global technologies (and cultures)on the local technologies (and cultures)1. English in programmingII. The interaction between global and local
HKUST - SOSC - 111
SOSC111Science, Technology & SocietyL22Ethics ()EthicsWhy act ethically?Perhaps because you believe there arenormative () standardsPerhaps because you believe it is part of asocial obligation ()Perhaps because you believe it will furtheryour ow
HKUST - SOSC - 111
SOSC111Science, Technology & SocietyL23Ethics and SafetyHow safe does it have to be?Safety is at the center ofmany ethical engineeringconsiderations (though wecan think of other issues,such as protection of theenvironment).What standard of safe
HKUST - SOSC - 111
SOSC111Science, Technology & SocietyL24Organizing to Avoid FailureOverviewHonest ErrorsParallel systems that reduce the risk oferrorsSerial Independent system (special case)Pitfalls () for parallel systemsScience and ReliabilityHonest ErrorsFa
HKUST - SOSC - 111
SOSC111Science, Technology & SocietyL25Technology Assessment& GovernanceGovernanceOverviewOverviewTechnology AssessmentAssessmentSteps of Technology AssessmentExample: Technology Assessment of wind energy(Optional video: Wind Turbine technolog
Wisconsin - BIOCHEM - 501
Biochemistry 501Chapter 1: Cellular basics!Professor ButcherOffice hours: MWF 11 am-12 pm or by appointmentOffice: 141E Biochemistry AdditionEmail: butcher@biochem.wisc.eduLectures, previous exam, problem sets with answers availablefor free downloa
Wisconsin - BIOCHEM - 501
Lecture 3!Amino Acids, Peptides, and Primary Structure of Proteins!!Proteins are the most abundant macromolecules in cells.They play a central role in all aspects of cell metabolism,structure and replication. Cells contains thousands ofdifferent typ
Wisconsin - BIOCHEM - 501
Lecture 2: WaterWater has a high melting point and boiling pointrelative to other liquids. "Main Points Weak interactions between molecules in aqueoussolvent Hydrogen bonds Ionic interactions The hydrophobic effect Ionization of water, weak acids
Wisconsin - BIOCHEM - 501
Electron Transport and ATP production ! Oxidative phosphorylation: redox reactions for ATPproduction. Electrons from NADH & FADH2 (reducing power)transported via electron transport chain to O2 &some energy stored in ATP.Energy Benets of Oxidative Ph
Wisconsin - BIOCHEM - 501
Lecture 4: Properties of Proteins:!Protein purication, Characterization!Proteins have a unique amino acid sequence specied by thegenetic code. This sequence dictates the function of theprotein. Thus it is vital to know the sequence.!Although most p
Wisconsin - BIOCHEM - 501
Lecture 5: Three-Dimensional Structure of Proteins!1. Most proteins have a well dened three-dimensional structure.More than 50,000 protein structures have been determined(atomic coordinates available from the protein data bank,www.rcsb.org).!Levels o
Wisconsin - BIOCHEM - 501
Lecture 6: Protein Function!Protein-protein and protein-ligand interactions are of centralimportance in Biochemistry.!These interactions are intimately associated with threedimensional structure.!The study of protein-ligand interactions is vital for
Wisconsin - BIOCHEM - 501
Lecture 7: Enzymes: General Properties!Enzymes are essential for life1. Almost exclusively proteins !!exception: Ribozymes!2. Incredible catalysts!!Increase rates of reaction under very mild conditionsin aqueous solution.!3. Enormously specic.!5.
Wisconsin - BIOCHEM - 501
Lecture 8: Enzyme structure, function and regulationSmall changes in substrate structure have large"effects on enzymatic parameters"Main points:! Chymotrypsin mechanism: example of a serine proteaseenzyme Atomic-level view of the active site Speci
Wisconsin - BIOCHEM - 501
Lecture 9: Structure and Property of Lipids!Fatty Acid Structure:!Biological Lipids:!A diverse class of organic molecules that share thecommon feature of insolubility in water!Functions:!Principal forms of energy stores in many organisms!Biological
Wisconsin - BIOCHEM - 501
Lecture 10: Membrane Structure and Function!Major components of plasma membranes of different speciesMembranes are critical for cell function (life)!They provide compartments and allow redirection of theenergy ow into useful metabolic processes!Stero
Wisconsin - BIOCHEM - 501
Bioenergetics: Energy Transformationsin Living Systems!Part II!Biosynthesis(Anabolism) Part III!LightATPMembrane Transport"Food" (Catabolism)MotionPart I!(Today a combination of Chapter 1 (Section 1.3) and Chapter 13 !(13.1 & 13.3) and is a r
Wisconsin - BIOCHEM - 501
Catabolism (slow combustion) overview:!CarbohydratesProteinsFatsGlycolysis!Hexoses Ubiquitous: carbohydrates are an ancient methodof energy storage and source of precursors forbiosynthetic pathways.!Amino acidsFatty acidsPyruvate!-keto acids
Wisconsin - BIOCHEM - 501
After Glycolysis: Fermentation or Citric Acid Cycle (in yeastor humans)!GlucoseFates of Pyruvate!2 ATPGlucose2 ADPFructose-1,6-bisphosphateGlycolysis(anaerobic)2 Triose phosphate2 NAD+More energy in NADH than ATP!2 Pyruvate(aerobic)O22 N
Wisconsin - BIOCHEM - 501
Citric Acid Cycle!(aka Krebs and TCA)!Figure 16-7"Aerobic Fate of Pyruvate:!Acetyl-CoACO2"Fig 16 - 1"Citric Acid Cycle Summary"Importance of Citric Acid Cycle" Central energy-yielding path (generates NADH)" Point of convergence of catabolism o
Wisconsin - BIOCHEM - 501
Energy from Lipids!Lipids: general term which includes membrane components, hormones,vitamins, etc. Triacylglycerols (triglycerides): type of lipid used forenergy storage. With hydration, ~ 6.75X more energy per gram of fatrelative to carbohydrate.!
Wisconsin - BIOCHEM - 501
Nitrogen Utilization: Amino Acid Oxidation! Source of metabolicenergy when aminoacids in excess orcarbohydratesunavailable.! Focus on problem ofhow to deal with NH4+!Carbohydrates!The 20 aas are ultimately converted to 6 products!Proteins!Fats
Wisconsin - BIOCHEM - 501
Path of Energy Flow to ATP (1 to 2 5) ; Fig. 19-17 4e, 19-19 5e! Chemiosmotic theory - historical term - Peter Mitchell, 1961: electron flow (3)coupled to formation of a gradient of H+ (4) across the mitochondrial inner membranewhich is used for ATP (5
Wisconsin - BIOCHEM - 501
History: Joseph Priestly 1772from 1948 Scientific American,Rabinowitch The Physics and Chemistry of LifeCarbon cycle of our planet!H2O + CO2 !Respiration!Energy !ATP/NADH!Low energy!Light!Energy!High energy!Similar Figures 19-36, 37 4e, 19-43,
Wisconsin - BIOCHEM - 501
There are many ways for living systems to obtainenergy other than O2-based respiration, and allhave common features.! The earth has undergone many huge changes inclimate, and metabolic evolution has often been amajor contributing factor.!C!O!S!N
Wisconsin - BIOCHEM - 501
Synthesis of Fatty Acids andPhospholipidsIntracellular Localization of Fat Synthesis-Synthesis of Fatty Acids(and Sterols)Acetate (Acetyl-CoA) is precursorRepetitive condensationsEndergonic- ATPReductive- NADPHMalonyl-CoA Synthesis- Rate-limi
Wisconsin - BIOCHEM - 501
Synthesis of Ketones,Sterols and IsoprenoidsPhysiological Conditions thatPromote KetogenesisFasting - starvationDiabetesKetogenic dietHigh fatNewbornKetogenesis-hydroxybutyrateAcetoacetateThe final product from the breakdown of fatty acids is
Wisconsin - BIOCHEM - 501
Cholesterol Regulation, LipoproteinsCholesterol vs. Coronary Heart DiseaseCholesterol Regulation, LipoproteinsThe LDL receptor is a transmembrane protein spanningthe plasma membrane of cells, binds LDL and mediatesits entry into cells. Absence of LDL
Wisconsin - BIOCHEM - 501
Regulation of blood glucose I:Gluconeogenesis Blood glucose levels must be controlled within very tight limits. The process of glucose homeostasis is related to the fact thatthe brain requires glucose. A level of glucose below about 1.5 mM results in
Wisconsin - BIOCHEM - 501
Regulation of blood glucose II:Glycogen metabolismRegulation of Blood Glucose:Glycogen Metabolism Glycogen synthesis occurs virtually in all animal tissues,but is especially prominent in liver and skeletal muscle. In liver glycogen serves as a reser
Wisconsin - BIOCHEM - 501
15Glucose Tolerance Test10Normal4523Hour(s)DiabeticRegulation of blood glucose III:Hormonal controlBloodglucose(mM)1180-120 mg100 ml= ~ 1 g/l5 mMRegulation of Blood GlucoseNormal level :Humans have about 5 liters of bloodsoTotal g
Wisconsin - BIOCHEM - 501
R1R2Biosynthesis of AminoAcids and PorphyrinsCOOCOOPLPR1Aminotransferase( transaminase)R2OCCHCOOCOONH3+Transamination: General Reaction+NH3CHOCPLP = Pyridoxal phosphate, from vitamin B6Biosynthesis of Amino Acidsand Porphyrins
Wisconsin - BIOCHEM - 501
Integration of MetabolismAvailable FuelsSources of Glucose during FastingFuel Levels in Plasma during FastingEnd Product InhibitionDEFAllosteric regulation : non-covalent binding of regulator to enzymeCExamples : Phosphofructokinase, Aspartate T
Wisconsin - BIOCHEM - 501
Bile acids:WaxesPigmentsScentsand moreFor digestionBiological activities of lipidsStorage Lipids:Neutral fat:TriacylglycerolsTypes of LipidsMembrane Lipids:A, D, and KSteroidsProstaglandinsPolar lipids:PhospholipidsGlycolipidsSphingolipi
Wisconsin - BIOCHEM - 501
Information Transfer: Four Basic Themes!Introduction to BiochemistryFall 2010- Part IVInformation TransferThe 11 lectures in this portion of Biochemistry 501 will describethe basic biochemistry involved in the transfer of geneticinformation. This wi
Wisconsin - BIOCHEM - 501
Summary:DNA denaturation (melting) measures the stability of double stranded polynucleotides.The stability is determined by:Solution conditions, Base pairing, Base stacking, Charge shieldingLecture 2DNA and ChromosomeStructure(see Nelson & Cox, Cha
Wisconsin - BIOCHEM - 501
Summary:DNA replication is a semi conservative process in which informationtransfer occurs through base pairing.!Lecture 3DNA Replication(see Nelson and Cox,Chapter 25)DNA polymeraseSubstrate = dNTPsTemplate = DNA strand that provides base pair i
Wisconsin - BIOCHEM - 501
Summary:Lecture 4Mutagenesis: Repair andHomologous Recombination(see Nelson and Cox, Chapters 8 and 25)Point mutationsTransitionsTransversionsSmall deletions and insertionsFrame shift mutationsCauses of mutationsReplication errorsDNA damage (c
Wisconsin - BIOCHEM - 501
Summary:Lecture 5Large Scale Genome Instability(see Nelson and Cox, chapter 25) Programmed Large Scale Changes an important process inevolution, genetic diseases such as cancer and AIDS,and in gene formationNecessary for normal processes Site Spec
Wisconsin - BIOCHEM - 501
Summary:Overall processInitiationElongationTerminationRNA polymerasesLecture 6Biochemical activitySubunit structureTranscriptionTranscription initiation is a multi step processBinding to form a closed complexIsomerization to form an open compl
Wisconsin - BIOCHEM - 501
Summary PhysiologyLecture 7Gene Regulation(see Nelson and Cox, Chapter 28)Adaptive Enzyme SynthesisSome genes are regulatedin a reversible fashion inresponse to environmentalcues. For instance a cell mayor may not synthesize largeamounts of a g
Wisconsin - BIOCHEM - 501
Summary:Lecture 8RNA Processing(see Nelson and Cox, Chapter 26)OverviewThe study of RNA processing has led to three of the mostimportant discoveries in biology: Eukaryotic genes are interrupted by substantial amountsof extra DNA (introns) of unkno
Wisconsin - BIOCHEM - 501
Summary:Lecture 9TranslationDecoding the Message(see Nelson and Cox, Chapter 27)Colinearity of mRNA and ProteinProductionGenes encodeproteins in acolinear fashionwith theorientation of theencoding processbeing 5 to3 (mRNA) relatedto the N (
Wisconsin - BIOCHEM - 501
Summary:Lecture 10TranslationBiochemistry and Regulation(see Nelson and Cox, Chapter 27)InitiationThe initiating amino acid isN-formylmethionine. Thismakes sense because proteinsynthesis involves sequentialcondensation reactions ofcarboxyl to a
Wisconsin - BIOCHEM - 501
Summary:Lecture 11Modern Techniquesfor Studying Gene Structure(see Nelson and Cox, Chapters 9 & 28)DNA SequencingDNA sequencing allows us to determine the precise structure of genes.The techniques used involve the generation of nested families ofm
University of Guelph - PSYC - 2310
Jan 10, 2012Introducing Social PsychologyMan is by nature a social animal Aristotle. We are a social animals; we crave other people. Our lives areconnected by thousands of threads. We make it our business to talk about other peoples lives; what they do
University of Guelph - PSYC - 2310
The Self in the Social WorldHow did you become the person you are? Parents FriendsWho I am because of who she was Eva Tihanyi, says who she is based on her grandmother.The Nature of SelfWilliam James (184-1910) described the basic duality of our per
University of Guelph - PSYC - 2310
Self & CultureAn English princess with an Egyptian boyfriend crashes in a French tunnel, driving a German carw ith a Dutch engine, driven by a Belgian who was high on Scotch Whiskey, followed closely byI talian Paparazzi on Japanese motorcycles, and ge
University of Guelph - PSYC - 2310
AttributionAttribution is when we try to make inferences about other peoples behaviour. Why do people do the things theydo, and why are they the way that they are?The Heart and Soul of Attribution 3 DimensionsQuote of the day: No man really knows abou
University of Guelph - PSYC - 2310
Lecture 6: Attitudes One of the most researched topics within contemporary Social PsychologyWhat is attitude? What is it made of? How can we measure attitude? How can you change attitude (persuasion)? We have attitudes towards exotic food Prejudice is
University of Guelph - PSYC - 2310
Attitudes & Attribution Across CulturesMaking Attributions in Intercultural InteractionsIts already difficult to make attributions in our own culture, let alone other cultures.Types of Explanations for making attributions:1. Ability Im in University b
University of Guelph - PSYC - 2310
Review Session40 from textbook40 from lecture materials(When theres overlap, the likelihood the questions will be from overlap materials is high)Chapters 1,3,4,6 = 10 questions per chapter6 lectures = Lecture 2 & 3, 4, 5, 6 (7 questions/lecture)Lect
University of Guelph - PSYC - 2310
Chapter 1: Introducing SocialPsychologyWhat is Social Psychology?Social psychology is the scientific study of how peoples thoughts, feelings andbehaviour are influenced by factors in the social world.Social psychologists study how people explain thei
University of Guelph - PSYC - 2310
Chapter 3: The Self: Self Perception AndSelf-PresentationWhat are the Self-Concept and Self-Awareness?Three functions of the self:1. Interpersonal tool2. Decision Maker3. Regulatory SystemSelf-Concept: Your overall beliefs about your own attitudes.
University of Guelph - PSYC - 2310
Chapter 4: Social PerceptionSocial Perception: How people form impressions and make inferences about other people. It isimportant to note that we arent always very accurate in assessing the cause of another personsbehaviour.How Do We Think About Why O
University of Guelph - PSYC - 2310
Chapter 6: Attitude Formation and ChangeAttitudes: Positive and negative evaluations of people, objects, events and ideas3 components of attitudes:1. Affect2. Cognition3. Behavioural tendencyIt is not the behaviour itself, but the tendency toward it
University of Guelph - PSYC - 2310
Chapter 7: PersuasionPersuasion: Communications that are designed to influence peoples attitudes and behaviour.How Do We Process Persuasive Messages?The faster delivery is more amenable to peripheral than central processing as it gives you (the audienc
University of Guelph - PSYC - 2310
Chapter 8: Social Influence: Norms, Conformity,Compliance, and ObedienceSocial Norms: Unspoken but shared rules of conduct within a particular formal or informal groupConformity: Changing our opinions or behaviours to meet perceived group norms, can oc
University of Guelph - PSYC - 2310
Chapter 9: Group ProcessesHow Do Groups Influence Behaviour?Intragroup Processes: Processes that happen within a group.Intergroup Processes: Processes that occur between groups of people.What is a group?: A group exists when two or more people define
University of Guelph - PSYC - 2310
Chapter 10: P. 320-332 Intergroup RelationsIntergroup Relations: The way in which people in groups perceive, think about, feel about, and act toward peoplein other groups.Early Research and Theories of Crowd BehaviourAccording to Gustav Le Bon, when p
University of Guelph - PSYC - 2310
Lecture 7: Conformity, ObedienceConfromity: When people are free to do as they please, they usually imitate each other.We always conform the way we dress, talk (slang), the way you do your hair, we are always conforming.DefinitionsConformity: A change