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Lehigh - FIN - 323
BOND PRICING I. Bond Pricing on Coupon dates Take the present value of all cash flows (i.e., the present value of an annuity of the coupon payments plus the present value of bond's face value) Example 1: Treasury Note; Maturity 2/15/2016; Coupon 4.50
Vanderbilt - BSCI - 110B
CH 14 Mendel and the Gene Idea Character a heritable feature (color) that varies among individuals Trait each variant for a character (purple, green, orange) The Law of Segregation 1. Alternative versions of genes account for variations in inherit
Georgia Tech - POL - 1101
1 Pol 1101 4/11/2007 Road Construction in National Forests"There is nothing in which the birds differ more from man than the way in which they can build and yet leave a landscape as it was before." Robert Lynd. Building is something our society is
Vanderbilt - AMER - 100W
Constructing a Strong Thesis The difference between a weak and strong thesis has a lot to do with your willingness to engage with your subject manner. Rather than just reporting and summarizing, let your stance be an interactive one one in which you
Vanderbilt - BSCI - 110A
The Basic ProblemDNA Damage S phaseG1G2MitosisDNA DamageMagnitude of Mutation ProblemSpontaneous mutation rate = 1 per 10 9 bases per cell division Number of bases in mammalian genome = > 10 9 Number of mutations = 1 per genome per cell d
Vanderbilt - BSCI - 110A
Genome Organization and SizeKingdom Organism Haploid Chromosome Organization Number 1 1 1 1 1 1 1 1 1 1 8 1 16 6 25 5 50 39 10 23 ssDNA, circular dsDNA ssRNA dsDNA, circular dsDNA, circular dsDNA, circular dsDNA, circular dsDNA, circular dsDNA ssRNA
Vanderbilt - BSCI - 110A
Eukaryotic Transcription ControlFigure 12.32Figure 12.33Figure 12.36The cluster of globin genes in humanSuper-enhancerThis globin cluster is located on chromosome 11. The - and -globin genes are located on chromosome 16. Upstream of each
Vanderbilt - BSCI - 110A
Table 11. Genome overview. -Size of the genome (including gaps) Size of the genome (excluding gaps) Longest contig Longest scaffold Percent of A+T in the genome Percent of G+C in the genome Percent of undetermined bases in the genome Most GC-rich 50
Vanderbilt - BSCI - 110A
Figure 13.12aFigure 13.13Figure 13.21Figure 13.22QuickTimeTM and a Animation decompressor are needed to see this picture.Telomere RepeatsTetrahymena Oxytricha Trypanosomes Dictyostelium Yeast Plant HumanGGGGTT GGGGTTTT GGGAT GGGAT G2-3T
Vanderbilt - BSCI - 110A
Growth Hormone DeficiencyQuickTimeTM and a Animation decompressor are needed to see this picture.QuickTimeTM and a Animation decompressor are needed to see this picture.
Vanderbilt - BSCI - 110A
Transcription Termination: Rho IndependentRho DependentEukaryotic TranscriptionRNA Pol I RNA Pol II RNA Pol IIIRNA Pol II InitiationEukaryotic RNA PolymerasesPol I: rRNAPol II: mRNA and some snRNAsPol III: tRNA, 5S rRNA, and some snRNA
Vanderbilt - BSCI - 110A
Mitosis: DNA replicated to produce twoidentical copies of each chromosome prior to cell divisionmetaphasecytokinesisDNA replication (S-Phase)Metaphase ChromosomeTightly wound complex of DNA and protein (chromatin) DNA content of each sister
Vanderbilt - BSCI - 110A
Copyright, , 2002, John Wiley & Sons, Inc.,Karp/CELL & MOLECULAR BIOLOGY 3EFigure 12.24Copyright, , 2002, John Wiley & Sons, Inc.,Karp/CELL & MOLECULAR BIOLOGY 3EFigure 12.26
Vanderbilt - BSCI - 110A
Overview of TranslationGenetic CodeUniversal Codons Read 5'-3' Nonoverlapping (no punctuation or gaps) Unambiguous (1 codon=1 amino acid) Degenerate (more than 1 codon/amino acid 3 Stop codons (UAA, UAG, UGA) 1 Start codon (AUG)Degeneracy of th
Vanderbilt - BSCI - 110A
Ribosome nomenclature3-D Structure of Active RibosomeProkaryotic mRNASummary of Prokaryotic initiationProkaryotic Initiation Factors Initiator tRNA with formyl-Met IF1, IF2, IF3Positioning the 30S at the start siteElongationTranslatio
Vanderbilt - BSCI - 110A
Control of Eukaryotic Gene ExpressionEukaryotic Translational Control MechanismsEukaryotic: -Secondary structure of mRNA -multiple AUG codons in 5' UTR -protein binding sites in 5'UTR and 3'UTR -*phosphorylation of eIF-4E and eIF-4EBP -*phosphoryl
Vanderbilt - BSCI - 110A
BSCI 110A Introduction to Biological ScienceInstructor: First Half Dr. Kendal Broadie Professor of Biological Sciences Office: 6270A BSB/MRB III Telephone: 6-3937 kendal.broadie@vanderbilt.edu Office Hours: Friday 2-4 (must schedule at any other tim
Vanderbilt - BSCI - 110B
Biological Sciences 110A: Introduction to BiologyKendal BroadieLecture 2. The chemistry and composition of cells:elements, bonds, and water Primary elemental composition of cells Brief review of atomic structure: electron shells Covalent b
Vanderbilt - BSCI - 110B
Biological Sciences 110A: Introduction to BiologyKendal BroadieLecture 3: Biological Macromolecules Classes of macromolecules Polymer formation Carbohydrates (polysaccharides) Classes and structure of lipids Composition of proteins (polypep
Vanderbilt - BSCI - 110B
Biological Sciences 110A: Introduction to BiologyKendal BroadieLecture 4: Protein Structure, Folding & Function Primary amino acid sequence Secondary protein structure: -helix and -sheet Domain and subunit structure of proteins Higher order
Vanderbilt - BSCI - 110B
Biological Sciences 110A: Introduction to BiologyKendal BroadieLecture 5: Enzymatic function and catalyzed reactions The laws of thermodynamics Free energy change (G) in chemical reactions ATP: The energy currency of cells Coupled reactions
Vanderbilt - BSCI - 110B
Biological Sciences 110A: Introduction to BiologyKendal BroadieLecture 6: Membrane structure & membrane proteins Plasma and organelle membranes Structure and properties of phospholipids Properties of the membrane lipid bilayer Structure and
Vanderbilt - BSCI - 110B
Biological Sciences 110A: Introduction to BiologyKendal BroadieLecture 7: Membrane properties and membrane transport Regulation of membrane fluidity Diffusion of proteins in the membrane Passive diffusion vs. facilitated transport Ion chann
Vanderbilt - BSCI - 110B
Biological Sciences 110A: Introduction to BiologyKendal BroadieLecture 8: Electrochemical gradients & signaling Electrochemical gradients and membrane potential Voltage- and ligand-gated ion channels Structure and functional properties of ion
Vanderbilt - BSCI - 110B
Biological Sciences 110A: Introduction to BiologyKendal BroadieLecture 9: Types of organelles & biochemical compartments Overview of the endomembrane organelles Membrane and protein trafficking (secretion) Signal Hypothesis: cytosol to ER Me
Vanderbilt - BSCI - 110B
Biological Sciences 110A: Introduction to BiologyKendal BroadieLecture 10: Protein transport between organelles Transport vesicles move membrane and protein Vesicle coat proteins (COPs, Clathrin) Vesicle trafficking specificity (SNARE protein
Vanderbilt - BSCI - 110B
Biological Sciences 110A: Introduction to BiologyKendal BroadieLecture 11: Overview of metabolism Introduction to metabolism Review of oxidation (redox potential) Convergent catabolic pathways Glycolysis & ATP production Feedback regulation
Vanderbilt - BSCI - 110B
Biological Sciences 110A: Introduction to BiologyKendal BroadieLecture 12: Glycolysis & TCA cycle Summary overview of glycolysis Anaerobic processes; fermentation Evolution of oxidative respiration Mitochondrion (pyruvate to acetyl-CoA) Cit
Vanderbilt - BSCI - 110B
Biological Sciences 110A: Introduction to BiologyKendal BroadieLecture 13: Electron transport & oxidative phosphorylation Structure of the mitochondrion Electron transport; electron carriers Proton pumps in the inner mitochondrial membrane R
Vanderbilt - BSCI - 110B
Biological Sciences 110A: Introduction to BiologyKendal BroadieLecture 14: Chloroplasts and Photosynthesis Structure of the chloroplast "Light" reactions vs. "dark" reactions Pigments capture light energy Photosystems in the thylakoid membr
Vanderbilt - BSCI - 110B
Biological Sciences 110A: Introduction to BiologyKendal BroadieLecture 15: Microtubule Structure & Function Overview of the cytoskeleton Microtubules are polymers of tubulin dimers The centrosome: the microtubule organizing center Microtubu
Vanderbilt - BSCI - 110B
Biological Sciences 110A: Introduction to BiologyKendal BroadieLecture 16: Intermediate and Actin Filaments The "rope-like" intermediate filaments (IF) Cell-type specific IF families IF structure and function Actin forms microfilaments Act
Vanderbilt - BSCI - 110B
Biological Sciences 110A: Introduction to BiologyKendal BroadieLecture 17: Muscle and non-muscle motility Myosins: actin-binding ATPase motors Roles for non-muscle myosins Structure and function of muscle Structure of the muscle sarcomere
Vanderbilt - BSCI - 110B
Biological Sciences 110A: Introduction to BiologyKendal BroadieLecture 18: The intercellular environment From cell to tissue to organism The extracellular matrix (ECM) in animals The cell wall in plants Collagen, fibronectins and glycoamino
Vanderbilt - BSCI - 110B
Biological Sciences 110A: Introduction to BiologyKendal BroadieLecture 19: Intercellular interactions Overview of types of cell-cell junctions Cadherins: homophilic adhesion molecules Adherens junctions: adhesion belts Desmosomes: "spot-weld
Vanderbilt - BSCI - 110B
Alternate hypotheses for sex determination XX XY #X's determines gender? Presence or absence of Y determines gender? Other modes of sex determinationSex determination (environmental)ReptilesThe X and Y chromosomesHow did the Y become red
Vanderbilt - BSCI - 110B
Voyage of the HMS BeagleDescent with Modification?Glyptodont fossil ancestor toarmadilloAdaptation of Galapagos Tortoisesvaried adaptations to varied environmentDarwin's Observations and DeductionsPopulations have the potential to incre
Vanderbilt - BSCI - 110B
EXAM #3 - KEY BSCI 110B Section 2 Intro to Biological Science Spring 2008 26 March 2008 Denise Due-GoodwinMultiple Choice: 1. d 2. e 3. d 4. c 5. c 6. c 7. d 8. d 9. b 10. b 11. a 12. d 13. d 14. d 15. c 16. d 17. b 18. a 19. b 20. c 21. b 22. c
Vanderbilt - BSCI - 110B
Deriving Hardy-Weinberg Equilibrium p2 + 2pq + q2Predictive value of Hardy-Weinberg Genetic diseases Can determine frequency of carriers (heterozygotes) which "keep" lethal alleles in the population e.g. PKU and Cystic fibrosis Predicting frequ
Vanderbilt - BSCI - 110B
PKU-Cystic Fibrosis PKU Autosomal recessive 1/10,000 aa = q2 = 0.0001 q = 0.01, so p = 0.99 2pq = 0.0198 = 1/50 Cystic fibrosisAutosomal recessive 1/1800 aa = q2 = 0.00056 q = 0.024, p = 0.976 2pq = 0.047 = 1/21 Consider CF to be lethal;
Vanderbilt - BSCI - 110B
The connection between genetics and evolution population genetics The Modern Synthesis "It is now possible.to redescribe the evolutionary process in the language of modern genetics. Evolution can be broadly defined as a change in the heredity of a
Vanderbilt - BSCI - 110B
And finally-natural selection as an adaptive mechanism of microevolutionVoyage of the HMS BeagleDarwin's Observations and DeductionsPopulations have the potential to increase exponentially Variation within a species and variation is inherited Th
Vanderbilt - BSCI - 110B
Sickle Cell the heterozygote advantage the stable polymorphismSelection against two homozygotes 2 selection coefficients (S1 and S2)Calculating allele frequencies with stable polymorphism (equilibrium)Change in selection pressure change in p
Vanderbilt - BSCI - 110B
Podos, J. 2001. Correlated evolution of morphology and vocal signal structure in Darwin's finches. Nature 409, 185-188Natural selection DOES NOT OPTIMIZE ALL OF THE TRAITS (trade-offs) Natural selection results in overall adaptation, not perfection
Vanderbilt - BSCI - 110B
Population Genetics Problems 1. In a population that is in Hardy-Weinberg equilibrium, the frequency of the allele "a" is 0.3. What is the percentage of the population that is homozygous for this allele? 2. In the foregoing population, what is the pe
Vanderbilt - BSCI - 110B
NameScore Multiple Choice. #1-23. Mark the letter of the best answer to each of the following questions on the scantron sheet. Read the question and each choice carefully before making your selection. Erase changes completely and indicate your final
Vanderbilt - BSCI - 110B
NameScore Multiple Choice. #1-23. Mark the letter of the best answer to each of the following questions on the scantron sheet. Read the question and each choice carefully before making your selection. Erase changes completely and indicate your final
Vanderbilt - BSCI - 110B
Mechanisms of reproductive isolation reducing gene flow between populations Allopatric speciation (= other homeland) geographic isolation in situ separation (water, mountain-building, etc.) long-distance dispersalFollowed by genetic drift and l
Vanderbilt - BSCI - 110B
7 traits All ~3:1 ratio?Mendel's Experiments: Monohybrid CrossWere Mendel's ratios too perfect?Phenotype vs. GenotypePP or Pp?Monohybrid Test CrossMendel's Experiments: Dihybrid Cross See all possible combinations of traits, not just
Vanderbilt - BSCI - 110B
Predictions of Mendelian Genetics are based on rules of probabilityMultiplication rule Chance of getting this AND this Addition rule Chance of getting this OR thisIncomplete Dominance F1 exhibits unexpected phenotype (intermediate to both parent
Vanderbilt - BSCI - 110B
SO FAR-Single gene 2 or more alleles complete dominance incomplete dominance codominance multiple alleles pleiotropyWhat about traits controlled by more than one gene (polygenic) and environmental influence? epistasis (modified 9:3:3:1 rati
Vanderbilt - PSY - 101
A Review the concepts that gave you trouble on Exams 1-2. Looking back at the keys, why did you make the mistakes you made?A James-Lange Perception of stimulus -> Physiological Change -> Perception of Physiological Change -> Emotion.The per
Vanderbilt - PSY - 101
Chapter 1 Extension / ClarificationIn question 2, in order to match the structure drawn in the answer key with that in the original problem set replace the H of both N-H bonds with a CH3. This does not change any of the bond orders or geometry sinc
Georgia Tech - POL - 1101
3/7/2007 Pol Sci-1101-JWFlorida Senator Bill Nelson Bill Nelson was born in 1942, in Miami, Florida. He went to the University of Florida, before finishing his bachelors at Yale University. After graduation, he went into the U.S. Reserves for 6 yea
Temple - RELIGION - 1902
I. ConfucianismA. Confucius1. Founder of the religion 2. Political leader, big nameB. Analects1. Collection of writings from Confucius 2. Written by his disciples 3. Has contradictory responsesC. Confucius as a tutor:1. Works with individuals
Cornell - ECON - 1120
Professor Kyle Warren Hall 249 5-2104 - email sck5@cornell.edu Economics 102 Introduction to MacroeconomicsSpring 2008 Tue./Thurs 9:051. There are two lectures each week, from 9:05 to 9:55 on Tuesdays and Thursdays. There is one section per week.
St. Johns - PAS - 3301
Chapter 16Alternative MedicineAllopathic Medicinethe conventional practice of medicine we see today, i.e. doctor, pharmacist, nurse, drugs, surgery, etc.;it is the system of treating symptoms of disease (mostly with medication/drugs); physicia
Cornell - ECON - 1120
Paper Assignment Spring 2008 Economics 102 1. A short paper is required of ALL students. This paper will be due on May 1 in class. There will be a box for each section. You may submit your paper directly to your TA if you want to hand it in early. Yo
Cornell - ECON - 1120
Economics 102 Course Outline and Reading List Spring 2008Lecture 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12.Date Jan. 22 Jan. 24 Jan. 29 Jan. 31 Feb. 5 Feb. 7 Feb. 12 Feb. 14 Feb. 19 Feb. 21 Feb. 26 Feb. 28Topic Introduction: What is Economics? The