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14 Chapter Mendel and the Gene Idea Genes: heritable units, specific location on chromosomes (locus) Alleles: alt versions of genes Characters: heritable feature that varies among individuals Trait: each variant of a character Each Reproductive Event: Parental Generation (P Generation) F1 generation (Offspring) F2 generation (Offspring of F1 Generation) Gregor Mendel Revolutionized the field of genetics Pre-Mendel: variation from blending once blended, can't unblend offspring are intermediates eventually offspring are identical once blended, original trait can't reappear Mendel Carefully planned experiments on pea plants in monastery garden Quantitative, experimental methods , large sample sizes Mendel worked on garden peas because: Available in easily distinguishable varieties Strict control over mating possible petals cover the carpel (female) and stamen (male) normally self-fertilize remove stamen and dust with pollen know both parents in cross (hybridization) Mendel worked on peas because: Peas have 2 alternate forms of each of the 7 characters he examined: flower color (purple vs. white) flower position (on stem vs. on tip of plant) seed color (yellow vs. green) seed shape (smooth vs. wrinkled) pod shape (smooth vs. lumpy) pod color (green vs. yellow) stem length (tall vs. short) CHARACTER! TRAITS! Before starting experimental cross: Followed plants through many self-fertilization generations These were true-breeding individuals Experimental design: Crossed two true-breeding individuals with alternate forms of the character Example: purple X white flowers Called: Monohybrid cross Purple X White flower cross: P1 generation F1 generation: all purple F2 generation: 705 purple, 224 white ratio = 3:1 Mendel's theories from these results: Alternate forms of genes responsible for variation in inherited characters (alleles) For each character, organism inherits 2 alleles, one from each parent If 2 alleles differ, one is dominant and other is recessive 2 alleles for each character segregate during gamete production More useful vocabulary: Homozygous: identical alleles for a trait; PP or pp; all gametes carry th3 Allele; true-breeding Heterozygous: 2 different alleles for a trait; Pp; gametes carry each allele; not truebreeding Still more Vocabulary: Phenotype: organisms expressed traits; purple or white flower Genotype: genetic make-up of an organism; PP, Pp, pp Test-Cross: If organism's appearance does not reveal its genetic composition (PP or Pp), determine with test crosses Dihybrid Cross Cross 2 parents that are heterozygous for 2 characters Example from Mendel: Mendel's Law of Independent Assortment each allele pair segregates independently of other pairs during gamete formation Mendel's experiments worked because: Plants and characters had simple genetic basis 1 gene each gene had 2 alleles one allele completely dominant genotype/phenotype relationship straightforward Incomplete dominance: One allele not dominant over the other Heterozygote has phenotype intermediate between phenotypes of the parents Example: snapdragons Flower colors: red, white and pink Red(RR), white(ww), pink(Rw) Codominance: Both alleles dominant equally - NOT intermediate Full expression of both alleles in heterozygote Example: Homozygote:DD Homozygote:RR Heterozygote:DR 3 genotypes, 3 phenotypes Dominance/recessive relationships vary along a continuum: Complete dominance to incomplete dominance to codominance If complete, AA and Aa same phenotype If incomplete then Aa is intermediate If codominance, then Aa alleles expressed equally- new phenotype Don't confuse: Dominant/recessive does not refer to relative abundances in population Recessive trait may be more abundant Example: Polydactyly is rare (1/400 births), but dominant allele Multiple Alleles: Some genes exist in more than 2 alternate forms, each person carries only 2 Examples: eye color, blood types Blood groups: 3 alleles=A, B, 0 A, B are polysaccharides on surface of RBC and o is absence of these Inject wrong type, antibodies clot, kill person Pleiotropy: The ability of a single gene to have multiple phenotypic effects Example: Siamese cats and tigers Fur pigmentation gene also controls eye-brain connections(abnormal pigmentation, cross eyed) Example: Sickle cell disease: RBC produce abnormal hemoglobin and cells deform Huge set of symptoms, multiple phenotypic effects E.g. anemia, heart failure, spleen damage, etc Epistasis: Gene at one locus alters phenotypic expression of a second gene No 9:3:3:1 ratio Example: albino condition Rodents have 2 genes that control fur color Presence/absence of pigment (C or c) Pigment color (B or b) The C genes is epistatic to B, in other words it controls B, he determiner of color Albino genes: Must have one dominant pigment allele (C) present for color to be expressed Pigment gene: dominant/recessive: CC, Cc = expressed, cc = albino No pigment, then albino and color (Black vs. Brown) does not matter If not albino: color is dominant/recessive, black over brown (B vs. b) Polygenic Inheritance: Quantitative characters, vary along a continuum not either/ NOT DISCRETE like Mendel's work Continuous variation determined by many segregating loci Additive effect of 2 or more genes determines 1 phenotypic character Polygenic Inheritance: Example Skin color 3 genes, all incompletely dominant AABBCC= darkest aabbcc=lightest sum up to get intermediate combinations AAbbcc=aaBBCc Pedigree (Family Tree): Use with human phenotypes because: Long generation time Few offspring No breeding experiments Pedigree: Need generations of information Predict past, future Conventions: Square=male, circle = female Horizontal line=mating occurred Offspring below line in order of birth Shaded: has trait A man has A blood and a woman has B blood and their first baby has O blood. 1) What must be the genotype of each parent? AO and BO 2) What other possible blood types can there be for 3 future children? AB, AO, BO, OO 3) What is the probability their 2nd child will have O blood? 25% A couple is planning on having a baby. The father has a recessive disorder that causes him to hiccup when he eats sugar. The mother is a normal carrier. 1) What is the probability the 1st child will have the disorder? 50% 2) What is the probability any other offspring will have the disease? 50%
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Path: UCF >> BSC >> 2010c Spring, 2007
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Path: UCF >> BSC >> 2010c Spring, 2007
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Path: UCF >> BSC >> 2010c Spring, 2007
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Path: UCF >> AMH >> 2020 Fall, 2006
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Path: UMass (Amherst) >> ENGLISH >> 112 Spring, 2006
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Path: UCSB >> WRIT >> 2 Winter, 2008
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Path: Toledo >> BIOL >> 2180 Spring, 2008
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Path: UConn >> PHRM >> 234 Spring, 2008
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Path: UConn >> PHRM >> 242 Fall, 2004
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Path: UConn >> PHRM >> 223 Fall, 2005
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Path: Toledo >> BIOL >> 2180 Spring, 2008
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Path: UCSB >> MUS >> 15 Fall, 2007
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Path: SUNY Albany >> AANT >> 104 Spring, 2008
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Path: UMiami >> GEOGRAPHY >> 564 Spring, 2008
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Path: Arkansas >> ENGL >> 1013 Spring, 2008
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Path: Arkansas >> ENGL >> 1013 Spring, 2008
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Path: Colorado College >> BY >> 207 Spring, 2008
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Path: Truman State >> BIO >> 100 Spring, 2008
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Path: Maryland >> ENGL >> 223 Spring, 2005
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Path: Truman State >> BIO >> 100 Spring, 2008
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Path: Truman State >> BIO >> 100 Spring, 2008
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Path: Truman State >> BIO >> 100 Spring, 2008
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Path: Truman State >> BIO >> 100 Spring, 2008
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Path: Truman State >> BIO >> 100 Spring, 2008
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Path: Truman State >> BIO >> 100 Spring, 2008
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Path: Minnesota >> ECON >> 1102 Spring, 2008
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Path: CofC >> ITAL >> 201 Spring, 2008
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Path: CofC >> ITAL >> 201 Spring, 2008
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Path: CofC >> ITAL >> 201 Spring, 2008
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Path: CofC >> ITAL >> 201 Spring, 2008
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Path: Arizona >> CHEM >> 103a Spring, 2008
Description: Question 1 (1 point) Problem 1(a) Which of the following is not possible for a spontaneous process? deltaSsyst > 0 and deltaSsurr > 0 deltaSsyst < 0 and deltaSsurr > 0 deltaSsyst < 0 and deltaSsurr < 0 deltaSsyst > 0 and deltaSsurr < 0 Question 2 (1 ...
answer to problem set 5
Path: Arizona >> CHEM >> 103a Spring, 2008
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Path: Morgan >> ENG >> 111 Fall, 2008
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Path: UC Riverside >> ECON >> 103a Winter, 2008
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Path: UC Riverside >> ECON >> 103a Winter, 2008
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Path: UC Riverside >> ECON >> 103a Winter, 2008
Description: Chapter 3 Productivity, Output and Employment 1 Introduction In this chapter, we will discuss the factors that determine an economy\'s productive capacity (i.e. the quantity of goods and services an economy can produce). Other things being equal, t...
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Path: UC Riverside >> ECON >> 103a Winter, 2008
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Path: Western Michigan >> MKTG >> 2500 Spring, 2008
Description: 1. In 2006, Atlanta once again hosted the Peachtree Road Race, a running event that attracts many worldcalibre racers. This year race officials also sanctioned a race conducted in Iraq so that soldiers from the state would not have to miss the annua...
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Path: Wisconsin Milwaukee >> ATM >> 100 Fall, 2006
Description: Meteorology 4/8/2008 1:09:00 AM Pressure Gradient [continued] in upper air, net force will change either speed or direction; this net force is centripetal force. friction plays a role further down in the atmosphere; friction is directed opposite to...
