A 1. man has a balanced reciprocal translocation between one copy of chromosome 1 and one copy of chromosome 3, in which large portions of the q arms of chromosomes 1 and 3 are involved. A position effect occurs as a result of the translocation, so that individuals with the translocation have an increased risk of leukemia. If each of the two possible separations of chromosomes 1 and 3 during meiosis (as shown in Figure 8-23 of your book) is equally likely, fraction what of the man's gametes would be expected to be viable? Of his offspring, what fraction would be expected to have an increased risk for leukemia?
If each of the two possible separations of chromosomes 1 and 3 are possible then half of the man's gametes would be expected to be viable. One gamete would be normal and the other would be balanced. The other two are duplicated and deficient and therefore have a chance of causing lethality.