HST527-Lecture 14
MIT, HST 527
Excerpt: ... Lecture 14 CARDIAC ENDOTHELIUM AND CORONARY ARTERY DISEASE GOALS 1. Describe the major pathologies that affect the coronary circulation. 2. Identify the risk factors for the development of coronary artery disease , and the current approaches for its prevention, detection and treatment. READING Required reading: 1. Hansson GK.Inflammation, atherosclerosis and coronary artery disease . N. Engl. J. Med. 2005; 352: 1685-1695. Suggested reading: 1. Hambrecht R, Wolf A, Gielen S, Linke A, Hofer J, Erbs S, Schoene N, Schuler G. Effect of exercise on coronary endothelial function in patients with coronary artery disease . N. Engl. J. Med. 2000; 342:454-460. SUMMARY The coronary arteries supply blood to the myocardium and their normal function is required for the optimal performance of the heart. Because of the crucial role of the coronaries arteries in human physiology and the frequency of their dysfunction, the pathophysiology of these vessels has been extensively studied (i.e., CAD and atherosclerosis). These studies ...
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What is Coronary Artery Disease.html
Slippery Rock, PETE 7507
Excerpt: ... What is Coronary Artery Disease (Heart Disease)? Coronary Artery Disease is a chronic disease in which the coronary arteries have hardened and narrowed, leaving less room for blood to flow through. Go Back to Main Page ...
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HW2
USC, BME 423
Excerpt: ... ggest any relationship between alcohol consumption and nose-bleeding? If a difference is found, do not isolate which groups are different. 5. In an experimental study conducted in rats, the potential link between amount of fats consumed everyday and incidence of coronary artery disease was investigated. This study found plaques representative of coronary artery disease in 0.45% of the rats which were not given any fatty food, in 0.65% of the rats given light amount of fatty food daily, and 0.95% of the rats given heavy fatty foods daily. The results of this animal study led to an investigation of the effects of fatty food consumption in people. A study of people aged 40-50 years came up with the following results: # people w/ CAD Total # studied Fatty Food Consumption Level None Light 40 54 5432 5691 Heavy 83 6781 Based on the statistical evidence available, determine whether the results of the clinical study on humans are consistent with the linkage between fatty food consumption and coronary artery di ...
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11-27-06
Georgia Tech, HPS 1040
Excerpt: ... Toward the heart Capillaries Heart Consists of four chambers Upper atria Lower ventricles Heart has two circulatory systems Pulmonary circulation Systematic circulation Major Forms of Cardiovascular Disease CAD ( Coronary Artery Disease ) Atherosclerosis: build up of plaque on the arteries. A form of arteriosclerosis (hardening of the arteries) Arteries become narrow due to plaque buildup. This process deprives blood and vital oxygen to specific organs, such as the heart, brain, etc. Results in the following: Coronary Heart Disease Stroke Peripheral Arterial Disease Hypertension Stroke Congestive Heart Failure Disease Process Coronary artery disease is the most common form of cardiovascular disease. This process involves the slow gradual buildup of plaque within the arteries. Over many years, plaque reduces the blood supply to the heart tissue. This may result in either the onset of symptoms or a heart attack. In this heart (picture in slides), a blockage has completely cut off the blood supply in the left ...
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Heart Disease Quiz.html
Slippery Rock, PETE 7507
Excerpt: ... Heart Disease Quiz Test your knowledge on Heart Disease. Answer the following questions. This quiz is brought to you by Heart Center Online. For more quizzes and information visit www.heartcenteronline.com then click on patients. As you may know, the coronary arteries are the blood vessels that supply oxygen-rich blood to the heart. Which of the following is the best description of coronary artery disease (CAD)? A chronic disease in which the coronary arteries have hardened and narrowed, leaving less room for blood to flow through A chronic disease in which the coronary arteries have gradually shortened over time, so that they no longer reach the heart A chronic disease in which fatty cholesterol has softened the coronary arteries, causing chest pain A chronic disease in which high-fat foods have eroded the coronary arteries so that blood is leaking from them and causing chest pain According to the American Heart Association, coronary artery disease is: The #1 killer of both men and women in the United State ...
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Final Exam Review - Fall 03
N. Arizona, EXS 460
Excerpt: ... resting levels to and exercising heart rate of 100 btsmin -1 is primarily due to Ejection fraction is equal to , Forces that effect contractility can best be explain by just before contraction is best explained by Increases in VO2 max that occur with aerobic training are mo st likely due to increases in in a healthy person Increases in VO2 max that occur with aerobic training in those with severe cardiovascular disease (i.e. congestive heart failure) are most likely due to increases in During an acute, dynamic exercise bout, total peripheral resistance Compared to dynamic exercise systolic and diastolic blood pressure tend to during static exercise Compared to leg exercise, at any one workload, arm exercise is characterized by (i.e. differences in responses) With cardiorespiratory training all but which of the following tend to increase after a training (i.e. 3 months of aerobic exercise training)? Coronary artery disease patients can generally reach approximately for their peak MET capaci ...
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lecture11
Allan Hancock College, STAT 175
Excerpt: ... Gambling,Sport andMedicine Lecture11 Whatyoudidinthelastfew weeks (Thismaynotbecomprehensive) Leanedaboutnormaldistributions Calculatingzscores Findingprobabilitiesfromnormaltables Whatyoudidinthelastfew weeks Comparingtwoindependentmeans ...
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vitamin_E_benefits_unproven
Yale, LR 288
Excerpt: ... Benefits of Vitamin E in Coronary Artery Disease "Far From Proven" June 29, 1999 - The jury is still out on the benefits of vitamin E supplements to prevent or treat coronary artery disease (CAD), according to a comprehensive review published in the June 28th Archives of Internal Medicine. "Despite some data supporting the use of vitamin E, findings of controlled trials are limited and inconclusive," Dr. Anne Spencer say in the report. While studies "suggest" that supplemental vitamin E may ward off CAD, several questions have yet to be answered, such as the best dose, how long to take it and method of consumption. In the absence of conclusive data, supplemental vitamin E "may be considered" in CAD patients or those at high risk of developing CAD, ".but the potential benefits should be weighed against possible unknown long-term adverse effects." Editorialist Dr. Gordon Ewy says there are 3 reasons why it might be wise right now to hold off on prescribing vitamin E and other antioxidants. The first is th ...
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chap1-eg-E
UWO, SS 357
Excerpt: ... Coronary Artery Example Example E, page 20 Rice. Diagnosis of coronary artery disease . The disease is either present (D+ ) or not present (D- ) A screening test results in 4 categories, T0 , T1 , T2 and T3 , where Tk means the screening test detected k calcified arteries. The test result depends on the actual presence or absence of the disease. The following table is based on detailed empirical medical studies. i 0 1 2 3 P (Tk |D+ ) P (Ti |D- ) .42 .96 .24 .02 .20 .02 .15 .00 Suppose that for a patient in the 30-39 age group who suffers from non-anginal chest pains, the change thaty they have the arterial disease is .05, that is P (D+ ) = .05. A patient suffering from non-anginal chest pains undergoes the medical diagnostic test. If they fall into category i what is the chance they have the coronary artery disease ? Bayes rule gives P (D+ |Ti ) = P (Ti |D+ ) P (Ti |D+ )P (D+ ) + P (Ti |D- )P (D- ) (1) Using (1) we then calculate for example P (D+ |T0 ) P (D+ |T0 ) Remarks If someone tests 0 there is only ...
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Cardiovascular_Disease_Lecture_Fall08_WebCT
UGA, HPBR 1710
Excerpt: ... Cardiovascular Disease Dr. Elizabeth Mendell HPRB 1710 Wed, Sept 17 2008 Lecture Overview (CVD=Cardiovascular Disease) CVD background Website: www.goredforwomen.org Women and CVD facts Part I: Cardiovascular System Overview Heart facts; heart structure and function The blood vessels The cardiovascular system (the heart + blood vessels) Part II: Cardiovascular Disease (CVD) CVD definition CVDs we will be covering in this lecture: coronary artery disease , heart attack, stroke You are responsible for reading Ch 21 (the entire chapter). Cardiovascular Disease Background CVD disease includes heart attack, stroke, peripheral artery disease, congestive heart failure, and other conditions. The disease process underlying many (but not all!) forms of CVD is atherosclerosis (hardening of the arteries). CVD is the #1 killer of men and women worldwide. Has been the leading cause of death in the US every year since 1900except 1918, when there was a ...
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HeartDiseaseChap15_webct
Georgia Tech, HPS 1040
Excerpt: ... c Fever/Rheumatic Heart Failure High Blood Pressure Diseases of the Arteries Rheumatic Fever/Rheumatic Heart Disease Source: CDC/NCHS and NHLBI. *Preliminary Congenital Cardiovascular Defects Other Prevalence of Cardiovascular Diseases in Americans Age 20 and Older by Age and Sex NHANES: 1999-2002 100 90 80 70 60 50 40 30 20 10 0 Percent of Population 86.4 75.0 68.5 52.9 36.2 36.6 22.9 11.2 6.2 17.6 56.5 77.8 Males Females 20-34 35-44 45-54 55-64 65-74 75+ Ages Source: CDC/NCHS and NHLBI. These data include coronary heart disease, heart failure, stroke and hypertension. Estimated Direct and Indirect Costs of Major Cardiovascular Diseases and Stroke United States: 2006 160 140 120 100 80 60 40 20 0 Billions of Dollars 142.5 57.9 63.5 29.6 Source: Heart Disease and Stroke Statistics 2006 Update. Normal Heart Diseased Heart Disease Process Coronary artery disease is the most common form of cardiovascular disease. This pro ...
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Cardiovascular disease -- fall 07
Georgia Tech, HPS 1040
Excerpt: ... Cardiovascular Disease (CVD) Statistics Coronary heart disease is the # 1 cause of death in the U.S., accounting over 40% of deaths annually. It is also the leading cause of death in 35-44 yr old males. Over 1.5 million Americans experience a heart attack per year. For 25% of these people, cardiac arrest will be their first symptom. Cardiovascular Disease (CVD) Statistics (cont.) Women are 5 times more likely to develop cardiovascular disease than breast cancer. It has been estimated that cardiovascular disease costs our economy over $400 billion annually. Major Forms of Cardiovascular Disease CAD ( coronary artery disease ) Atherosclerosis: build up of plaque on the arteries Hypertension Stroke Congestive heart failure Atherosclerosis Atherosclerosis is a form of arteriosclerosis (hardening of the arteries) Arteries become narrow due to plaque buildup This process deprives blood and vital oxygen to specific organs, such as the heart, brain, etc. Results in the following: ...
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epid758_schedule
UNC, EPID 758
Excerpt: ... ses (3 weeks) Start Date (Sunday) Independence Day Lectures 3 July, 2006 4 July, 2006 Immunity, Vaccine and Drug Treatment and Prophylaxis Disease Elimination and Eradication Host Defenses and Infection Case Study Case Study Due Date Group Discussion Dates Group Project Group Project Due Date End Date (Saturday) 21 July, 2006 5 21 July 21 July, 2006 22 July, 2006 Immunity, Vaccine and Drug Treatment and Prophylaxis Disease Elimination and Eradication Host Defenses and Infection Immunity, Vaccine and Drug Treatment and Prophylaxis Disease Elimination and Eradication Host Defenses and Infection TOPIC: Special Topics in Infectious Disease Epidemiology (2 weeks) Start Date (Sunday) Lectures 23 July, 2006 Bioterrorism, ID as a cause of chronic conditions: Infection as a Risk Factor for Coronary Artery Disease 23 July, 2006 4 August, 2006 None None None 5 August, 2006 TBA Capstone Project available Capstone Project Due Date Group Discussion Dates Group Project Group Project Due Date End Date (Saturday) ...
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Angiogenesis_1
Yale, LR 288
Excerpt: ... American College of Cardiology 48th Annual Scientific Session March 7-10, 1999 Does Angiogenesis Promote Perfusion or Encourage Plaque Growth (help or hurt)? Angiogenesis is the process whereby new blood vessels are grown to service specific areas in the body, like the heart. Many proteins either inhibit or stimulate angiogenesis. Dr. Judah Folkman delivered the lecture: "Angiogenic Therapy for the Heart." Stimulators of Angiogenesis Angiogenic stimulation in patients with coronary artery disease (CAD) may have risks. Some data suggest that artherosclerotic plaque growth may depend on angiogenesis. New, growing micro-blood-vessels have been seen growing in plaques. In other words, causing angiogenesis, we may also be building up the very same plaque that caused clogged arteries in the first place. The search for stimulators of angiogenesis began recently. Dr. Jeffrey Isner presented data in 1997 showing that injection of VEGF - vascular endothelial growth factor - into the legs of patients with ...
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PastMedicalHistory_JohnGazewood_2006
UVA, POM 1
Excerpt: ... majority of the information needed to diagnose and manage a patients problem(s) is obtained during the history of present illness. The information obtained during the latter portions of the interview provides a complete database of the patients medical, personal and family history needed to provide optimal management of a patients problems. Frequently, information contained in the past history is asked about and reported in the history of present illness. For example, in interviewing a patient with chest pain that is suspicious for angina, a physician would query the patient about health habits (for example smoking), past history (hypertension, diabetes, hyperlipidemia), and family history (of early coronary artery disease ) that would affect the patients probability of having coronary artery disease . Balance The physician must often strike a balance between the need to obtain certain information, the health of the patient, and the time available and the setting. Portions of the past medi ...
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THEPASTMEDICALHISTORY_HO
UVA, POM 1
Excerpt: ... lem(s) is obtained during the history of present illness. The information obtained during the latter portions of the interview provides a complete database of the patients medical, personal and family history needed to provide optimal management of a patients problems. Frequently, information contained in the past history is asked about and reported in the history of present illness. For example, in interviewing a patient with chest pain that is suspicious for angina, a physician would query the patient about health habits (for example smoking), past history (hypertension, diabetes, hyperlipidemia), and family history (of early coronary artery disease ) that would affect the patients probability of having coronary artery disease . Balance The physician must often strike a balance between the need to obtain certain information, the health of the patient, and the time available and the setting. Portions of the past medical history are frequently not needed to address the problem at hand. Elemen ...
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EP_guided_therapy_and_SCD
Yale, LR 288
Excerpt: ... 3/8/99 - PRNewswire - Results from the Multicenter Unsustained Tachycardia Trial (MUSTT) show that when an electrophysiologist (cardiologist who specializes in heart rhythm) uses electrophysiology (EP) testing to guide therapy in high risk patients, arrhythmic death is reduced by 27%. Also, when this group was treated with an ICD, the risk of arrhythmic death was reduced by more than 50% when compared to those patients who did not receive ICD therapy. 300,000 - 400,000 people in the USA die from sudden cardiac death each year. "The preliminary results of MUSTT show a need for EP-guided therapy for high risk patients with coronary artery disease which. This can reduce the number of sudden cardiac deaths in these patients," said Alfred Buxton, MD, Temple University School of Medicine, lead investigator for MUSTT. "The study has defined the risk for sudden death in this study population, which was found to be 32% at 5 years." One of the most tightly-controlled studies of its kind, the MUSTT trial included pa ...
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spchte_chlyd_rick_05
UCSD, BIMM 124
Excerpt: ... d by C. trachomatis is the number one STD. Clinical spectrum like gonorrhea. 1. Chlamydia pneumoniae-cause walking pneumonia; endocarditis; coronary artery disease Chlamydiae and Heart Disease (Background) Indirect Evidence Chlamydiae pneumoniae first came under suspicion as a cause of heart attacks in 1988 when doctors in Helinski reported that people with coronary artery disease were more likely than healthy control subjects to have antibodies to the organism in their blood. A second study showed unusually high antibody levels in the heart attack victims. Most experts dismssed the studies as a statistical oddity. Later, Dr. Thomas Grayston, an epidemiologist at UW, repeated and confirmed the studies. Direct evidence 1993, South African Reseacher found C pneumoniae in tissue during autopsies. These findings were confirmed by the Seattle researchers and other laboratories. Few experts paid attention until 1995 when a team at University of Louisville recovered the live organism from blood vessels of a pati ...
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Lecture 9 - Alcohol no liver trans
UCSB, PHIL 7
Excerpt: ... it is a disease. But alcoholics are responsible for seeking out effective and available treatment and continuously pursuing it their entire lives 2. ARESLD is caused by 10-20 years of heavy drinking; they have time, then, to seek help 3. They could have prevented their failed liver in that they didn't seek (or continuously seek) treatment for their disease V. Another Objection A. There are people who are responsible for their medical conditions (ie: coronary artery disease , lung cancer) that compete equally (for treatments) with others who have the same conditions but through no fault of their own B. Their Reply: 1. But the medical resources needed to treat these conditions (ie: lung cancer, coronary artery disease ) are only relatively or moderately scarce 2. See Side Bar * 3. Absent extreme scarcity, alcoholics should compete equally with other ESLD patients a) There are other medical resources that alcoholics should (and do) compete equally for (ie: hospital beds) 4. When it's impossible for all to be sa ...
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5230-7-BBB
N.E. Illinois, UX 5250
Excerpt: ... Ventricular Conduction Disturbances Chapter 7 Bundle Branches Normal conduction speed through the bundles is about 0.1 seconds. Bundle Branch Block Consider a blocked or slowed branch or bundle Right Bundle Branch Block Right Bundle Branch Block First Phase Normal Second Phase Normal Third Phase ? Right Bundle Branch Block V1 = rSR' V6 = qRS Right Bundle Branch Block V1 = rSR'? V6 = qRS Right Bundle Branch Block V1 or V2= rSR' M or rabbit ear shape V5 or V6 = qRS Right chest leads: T wave inversion ("secondary changes" since they reflect a delay in depolarization not an actual change in depolarization). Complete RBBB: QRS > 0.12 sec. Incomplete RBBB: QRS = 0.10 to 0.12 sec. Right Bundle Branch Block Clinical Significance Normal Organic heart disease atrial septal defect pulmonary disease valvular lesions degenerative changes in conduction system chronic coronary artery disease Left Bundle Branch Block RBBB affects mainly the terminal phase of depolari ...
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Panel4_SilverthornSp07
Western Washington, BIOL 349
Excerpt: ... s symptom with the fewest possible side effects (e.g. cholinergic, sympathomimetic, parasympatholytic, or?) 3. You meet Dom after he returns from his hike to the top of Mt. St. Helens. He trained on a stair climber for weeks to get into shape, and says that he had no trouble on his hike up the mountain, but he had some muscle pain while coming down. However, the pain went away as soon as he stopped hiking, and he remembers feeling pleased that his training paid off. However, when you meet up with him a few days later, he complains of increasing muscle pain that began one day after his return. Explain the possible mechanisms responsible for this delayed muscle pain, related to the type of exercise required in his hike. 4. Gloria has coronary artery disease and experiences angina with exertion, so her mobility is limited and she is becoming increasingly unsteady on her feet (with an increased risk for falls). In addition, she was recently diagnosed with osteopenia, so her doctor recommended increasing her le ...
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