Documents about Herpes Simplex Virus
L4Herpes
Allan Hancock College, BIO 3305
Excerpt: ... Virology Lecture 4 The Herpesviruses Dr Mike Kotiw Ref: Sherris p503-518 Lecture aims To be aware of the members of the herpesviridae To be able to describe the general structure of Herpes Simplex virus es To be able to describe how Herpes Simplex virus es are classified To be able to describe how a Herpes Simplex virus may be diagnosed To understand the pathogenesis of Herpes Simplex virus es The herpesviruses Name from the Greek word Herpein meaning `to creep' 1950s, Burnet demonstrated HSV latency following a primary infection Weller (1954) found VZV from chicken pox and zoster were the same causal agent. ~ Over 100 Herpesviruses have been isolated There is at least one for most animal species There are 8 known human Herpesviruses The herpesviridae family is divided into 3 sub-families based on host range, cell tropism and growth rates The Herpesvirinae Alphaherpesvirinae may grow in a number of cell types, rapid and commonly destroy host cells Simplexvirus Varicellovirus ...
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Btech quiz 3 Spring 2006 samples only
Kennesaw, BTECH 3100
Excerpt: ... BTEC 3301 Quiz 3 samples only Check the answers from testbk & lectures 1. Retrovirus-mediated transgenics is accomplished by infectiong mouse embryo with retrovirus before the embryo is implanted A. True B. False 2. The OncoMouse or the Harvard mouse, carrying a gene that promotes the development of various human cancers A. True B. False 3. A transgenic bull carries a human gene for Lactoferrin (gene responsible for higher iron content) A. True B. False 4. The Foot and Mouth disease in England in - led to destruction of herds of cattle, sheep and goat. A. 2000 B. 2001 C. 1999 D. 2002 5. The Human immunodeficiency virus (HIV) is-. A. adenoviruses B. adeno-associated viruses and C. herpes simplex virus es D. retroviruses. 6. Dolly who became the first famous adult cloned sheep was successfully cloned in 1996. A. True B. False 7. Embyro twinning is the process of splitting the embryo in half. A.True B.False 8. In the embryo stem cells, embryonic cells are collected from any part of the ...
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lecture26_07
Berkeley, MCB 250
Excerpt: ... /Trif dependent while by poly(IC) is Trif-dependent Hoebe, K. et al. Nature 424, 743-748 (2003). Approaches to the studies of TLR and pathogens: Infection studies with: 1. DNA viruses [MCMV (cytomegalovirus), EMCV (encephalomyocarditis virus), HSV ( herpes simplex virus )]. 2. RNA viruses [Influenza, VSV (vesicular stomatatis virus), SeV sendai virus, NDV, Newcastle Disease Virus ]. In vivo: Infect mice and measure serum cytokine levels and mouse lethality In vitro by infecting different cell populations (eg. PDC, cDC, macrophages) and measure IFN production. MCMV: Initial phase of defense: Plasmacytoid dendritic cells (=PDC=IPC) produce IL-12, which induces NK cells to produce -IFN. Activated NK cells can lyse viral infected cells. Type I IFNs produced by PDC are also crucial in providing resistance to viral replication. Recognized by TLR9 Differential host response to MCMV by DC in vitro: Wild-type but not TLR9-/DC cells respond to MCMV Splenic DC were cultured with MCMV at MOI 1 (moi= ...
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Characteristics of a Cancer cell
Penn State, BI SC 001
Excerpt: ... growth or regulatory genes. They have variable activity (ability to transform cells): a.src transforms almost all cells. b. SV40 transforms 1 in 10,000. Proto-oncogenes can be changed into oncogenes by radiation or chemical carcinogens. Oncogenes can transform cells by "expressing" its products too much or inappropriately Viral Oncogenes and Cancer Known: Epstein-Barr virus can cause Burkitt's Lymphoma (a cancer of the jaw in children in Africa - something else is involved,too) HTLV-1 causes a rare leukemia "Suspected": Hepatitis B - liver cnacer Papilloma virus - penile and cervical cancers Herpes Simplex virus - cervical cancer ...
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stmicro06_lecture
Columbus State Community College, BIO 215
Excerpt: ... each type of virus few to hundreds 14 Nucleic Acids DNA viruses usually double stranded (ds) but may be single stranded (ss) circular or linear RNA viruses usually _ stranded, may be double stranded, may be segmented into separate RNA pieces ssRNA genomes ready for immediate _ are positive-sense RNA. ssRNA genomes that must be _ into proper form are negative-sense RNA. 15 General Structure Pre-formed enzymes may be present. polymerases DNA or RNA replicases copy DNA reverse transcriptase synthesis of DNA from RNA (AIDS virus) 16 How Viruses are Classified Main criteria presently used are _, chemical composition, and genetic makeup. No taxa above Family (no kingdom, phylum, etc.) Currently recognized: 3 orders, 63 families, and 263 genera of viruses Family name ends in -_, i.e.Herpesviridae Genus name ends in -_, Simplexvirus Herpes simplex virus I (HSV-I) 17 Modes of Viral ...
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FS2006-Review_exam4-Lec31-37
Michigan State University, MMG 301
Excerpt: ... ver disease and cirrhosis; Michigan prison problem Neisseria gonorrhoeae: gonorrhea; sexually transmitted, antibiotic resistance a problem Treponema pallidum: causes syphilis, sexually transmitted, initial infection causes chancre, eventually infects nervous system Chlamydia trachomatis: most prevalent sexually transmitted disease in US, intracellular parasite Herpes: herpes simplex virus ; HSV-1: cold sores; HSV-2: genital herpes review how CD4, CCR5, and gp120 is involved in HIV life cycle ...
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Virology Case Study Evaluation, 2007
CSU LA, MICRO 401
Excerpt: ... Herpes Simplex Virus _ _ Case Study #16: Smallpox Virus _ _ Case Study #17: Prions _ _ _ _ _ _ _ _ Student Evaluator _ Please comment on the relative contributions of the members of your group to your PowerPoint presentation and written report. ...
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Ovarian Cancer Case Study
JMU, BIO 430
Excerpt: ... Ovarian Cancer Case Study Leila and Mindy This study involves using the adenovirus modified herpes simplex virus thymidine kinase gene followed by chemotherapy to fight ovarian cancer. Permission of 10 suffers of this disease was gained to attempt this suicide gene study. The procedure was done after the tumor was removed and the patients were treated with acyclovir and topotecan. Two patients were given dose level 1, dose level 2, dose level 3 of the adenovirus and four of the patients were treated with dose level 4. Dose level 4 is 100 times higher than any dose used in humans to this point. The two drugs acyclovir and topotecan were administered 24 hours after the vector was injected. The results were as follows: Five patients underwent second-look exploration within one month after vector delivery to study morphological changes and vector expression in the tissue. The most common adverse events after gene therapy and TP was myelosuppression. Grade 3 and 4 thrombocytopenia and anemia were seen in two pati ...
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Quiz 3 Samples only
Kennesaw, BTECH 3100
Excerpt: ... Sample quiz 3 : Btech 330,1Fall 2005 *Check Answers before the Quiz date* 1. Several products for prevention and gene therapy go for human species. They range between A. 70-75% B. 70-80% C. 60-70% D. 80-90% 2. Hemophilia A is due to -. A. absence of clotting factor VIII B. absence of clotting factor IX C. defective protein defective beta globin D. defective muscle protein. 3. Sickle-cell disease is due to a defective beta globin. A. True. B. False. 4. In US any clinical trial for human gene therapy must be approved by A. the RAC committee B. EPA committee C. Biotechnology committee D. Ethic clearance committee. 5. The Human immunodeficiency virus (HIV) is A. adenoviruses B. adeno-associated viruses and C. herpes simplex virus es D. retroviruses. 6. The virus that causes the common cold is an adenovirus. A. True B. False 7. One way to move a gene copy into a cell is through the use of: A. viruses B. lasers C. DNA markers D. transporter genes E. none of the above 8. One example of a condition wh ...
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Quiz 3 Samples
Kennesaw, BTECH 3100
Excerpt: ... Sample quiz 3 *Check Answers before the Quiz date* 1. Several products for prevention and gene therapy go for human species. They range between A. 70-75% B. 70-80% C. 60-70% D. 80-90% 2. Hemophilia A is due to -. A. absence of clotting factor VIII B. absence of clotting factor IX C. defective protein defective beta globin D. defective muscle protein. 3. Sickle-cell disease is due to a defective beta globin. A. True. B. False. 4. In US any clinical trial for human gene therapy must be approved by A. the RAC committee B. EPA committee C. Biotechnology committee D. Ethic clearance committee. 5. The Human immunodeficiency virus (HIV) is A. adenoviruses B. adeno-associated viruses and C. herpes simplex virus es D. retroviruses. 6. The virus that causes the common cold is an adenovirus. A. True B. False 7. One way to move a gene copy into a cell is through the use of: A. viruses B. lasers C. DNA markers D. transporter genes E. none of the above 8. One example of a condition which gene therapy WON'T ...
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lecture4
N. Illinois, BIOS 423
Excerpt: ... Lecture 4 Structure 1. Virion structure 2. Packaging the nucleic acid 3. Enveloped virions 1. Virion structure Protein structure 1 Cryo-electron microscopy: image reconstruction X-ray diffraction Structure of HIV 2 Building a protective coat Capsids with icosahedral symmetry T=4 triangulation of icosahedral face Triangulation number T 3 T, cont. Simple capsid: poliovirus Poliovirus capsid, cont., protein interactions 4 SV-40 polyomavirus Adenovirus capsid Complex icosahedral capsids 5 Packaging the Nucleic Acid Genome Direct contact of NA with the shell: Reoviridae Bluetongue virus Human reovirus Double RNA within rotavirus shell 6 More about retrovirus capsid HIV Viruses with envelopes 7 Structure of a typical glycoprotein Herpes Simplex Virus type 1 virion proteins Sindbis virus 8 Herpesvirus Nucleocapsid Simian cytomegalovirus Single portal and model Other virion components Homework for this week: Read and understand Chapter 4 in the book. Pay special attention ...
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sun_lec1
UCLA, OLD 229
Excerpt: ... ticle is composed of an icosahedral capsid, containing a large linear double-stranded DNA genome. 2. Viral genome is a double-stranded DNA (150 kb to 250 kb), encoding about 100 genes. Only 40-60% of the genes are essential for viral replication in tissue culture. 3. The capsid is surrounded by a tegument and wrapped in a lipid envelope. The tegument, which consists of viral proteins, is unique to herpesviruses. 4. The particle is about 200 to 300 nm with 100 nm capsid. Herpesviruses Large genome, complex gene expression and regulation Ubiquitous infections, primary infections usually in-apparent in childhood latent/persistent/recurrent infections Transition between lytic and latent replication Associated with acute and chronic/malignant diseases Human herpesviruses Name Common name associated diseases subfamily size 150kb 150kb 130kb 170kb 230kb 160kb 160kb 140kb HHV-1 Herpes Simplex Virus 1 (HVS-1) Oral, ocular lesions; encephalitis HHV-2 Herpes Simplex Virus 2 (HSV-2) Genital ...
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Deis
Caltech, JOURNAL 03
Excerpt: ... Final Draft Word count: 3480 Robin Deis 23 May 2003 Mentor: Pamela Bjorkman Editor: Karen Hurst Core 1a The Guerillas Inside: Understanding the War Against the Herpes Simplex Virus The battle was fought over the course of almost three weeks. Casualty rates were high and the damage was extensive. In the end, the invaders were vanquished and seemingly eradicated, but as the homeland protectors began the long process of repairing the destruction left in the wake of the war, none of the defenders noticed a tiny invader sleeper cell establishing itself deep within their territory, waiting opportunistically for any sign of weakness and another chance to strike. Falling into a state of hibernation, the tiny group of invaders lay dormant for several months until one day that opportunity presented itself, and the war began anew. This narrative might sound like the introduction to a war movie or spy novel, but in fact it is the beginning of the story of the human body's response to invasion by the herpes simplex v ...
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TEXT-HERPESVIRUSES-LECT-6
LSU, BIOL 4190
Excerpt: ... s simplex virus type 1 Herpes simplex virus type 2 Varicella zoster virus Epstein-Barr virus Cytomegalovirus HHV-6 Human herpesvirus 6 ~160 HHV-7 HHV-8 Human herpesvirus 7 Human herpesvirus 8 / (rhad) ~140 ~150 Grouping of herpesviruses on the basis of biological properties With respect to biological properties, the herpesviruses that have been studied in some detail can be clustered into three subfamilies on the basis of host range ( ability to infect different cells), duration of reproductive cycle (time it takes to form new progeny viruses) and characteristics of latent infection (type of cell and other). Group Alphaherpesviruses (wide host range, short growth cycle) Member Host human rhesus cow cow pig catfish human monkey mouse guinea pig human monkey chicken HSV-1, HSV-2 Monkey B virus Bovine mammilitis virus IBR(BHV-1) Pseudorabies Channel catfish herpesvirus Betaherpesviruses Human CMV (restricted host range, Simian CMV long growth cycle) Murine CMV Guinea pig CMV gammaherpesviruses ...
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MMG 301 Study Guide L35.36
Michigan State University, MMG 301
Excerpt: ... tissues causing characteristic skin rash; a latent stage, not infectious, can last years, lesions eventually form on skin, bone and nervous system (causes blindness, insanity). Chlamydia trachomatis: causes Chlamydia; the most prevalent sexually transmitted disease in the U.S. o Stages in life cycle (life cycle results in destruction of host cell): The extracellular elementary body attaches to a specific host cell receptor. Elementary body undergoes parasite-specified endocytosis. It differentiates to the metabolically active reticulate bodies. In the next 20 hours the reticulate bodies multiply. Reticulate bodies differentiate into more elementary bodies. These are then released from the cell either by exocytosis or cytolysis. Herpes: caused by Herpesvirus, herpes simplex virus o HSV-1: causes cold sores, fever blisters; transmitted by direct contact; latent and recurrent infections common. o HSV-2: causes genital herpes; transmitted by sexual contact; latent infection occurs between active blister per ...
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01-Meeting_Program_Only
UC Davis, LOG 0001
Excerpt: ... Membrane Arrays for In Situ Cell Signaling Applications Jwa-Min Nam (UC Berkeley) Human Hair Proteomics: Analysis of Human Hair Protein Composition by Mudpit Young Jin Lee (UC Davis) Biophysical Studies on Self-propulsion Mechanism in Cell Migration: Role of Intercellular Water Transport Jung Kyung Kim (UCSF) P-13 P-14 P-15 ~ P-19 P-15 Neuroscience Effect of nuclear factor- B on cell survival and COX-2 expression in SOD1 Tg astrocytes after oxygen glucose deprivation Yong-Sun Lee (Stanford) Mechanism of Neuronal Latency of Herpes Simplex Virus Type 1 Chi-Yong Eom (Stanford) Signaling from Roundabout (ROBO), a repulsive axon guidance receptor, inhibits Ncadherin-mediated intercellular adhesion Jinseol Rhee (UCSF) Glucose deprivation/reperfusion induces neuronal NADPH oxidase activation, superoxide production and neuronal death. Sang Won Suh (UCSF) Neuronal activity regulates GIRK channel trafficking Hee Jung Chung (UCSF) P-16 P-17 P-18 P-19 3 ...
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2-19-08 notes
Michigan State University, FCE 145
Excerpt: ... tation Secondary infection STDS Pubic lice Trichomoniasis Scabies o Viral Swollen Glands Diarrhea STDS HIV o AIDS HBV o HPV o o o HSV o o o o Human Immunodeficiency Virus Hepatitis B Virus Human papilloma Virus Genital Warts Condyloma Herpes Simplex Virus es Herpes 1-oral Herpes 2- Genital Herpes zoster Shingles Chicken Pox Varicella ...
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21
MCPHS, BIO 152
Excerpt: ... ubal ligation (close what) or vasectomy (close what?) o Rhythm method (natural family planning) Track Ovulation o Barrier methods: condoms. Diagphragm o Spermicide o Oral contraceptives o Prevent ovulation - Morning after pills o Can prevent ovulation, fertilization, or implantation 27.7 Sexual transmitted diseases (STDs) - Viruses, bacteria, parasites enter and leave the body through the reproductive tract o Bacteria can be killed with antibiotics (for now.) o Viruses can be controlled, but not killed. o Can cause long-term problems, infertility, death o A recent report on teenagers and STDs - CDC study March 2008 - One in four (26 percent) women age 14-19 is infected with at least one STD - Human papillomavirus (HPV), Chlamydia, herpes simplex virus , and trichomoniasis. - ...
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public
Maryville MO, JORGENSONR 120905
Excerpt: ... n mucosal tissues lining the body cavities such as the respiratory tract, the gastrointestinal tract, or the reproductive tract. These surfaces are composed of epithelial cells that act as a barrier to pathogen entry into the body and act as sentinel cells, alerting the immune system to the presence of an invading pathogen by initiating innate immune responses to pathogen. The human reproductive tract is exposed to a variety of sexually transmitted pathogens including Human Immunodeficiency Virus (HIV), Herpes Simplex Virus (HSV), and Human Papilloma Virus (HPV). These viruses are the cause of vast global human health and reproductive problems. Currently, there is a need to develop vaccines and treatment strategies to prevent transmission of these viruses. This study examines a cellular protein known as Toll-like receptor 3 (TLR3) that is involved in detecting viral pathogens and initiating innate antiviral immune responses to these viral pathogens. We have found that TLR3 is expressed by endometrial epitheli ...
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BIOL440_S09_Lecture20-DiseasesOfSkin
CSU Sacramento, BIOL 440
Excerpt: ... BIOL440GeneralMicrobiology Spring2009Telleen Lecture20Outline MicrobialDiseasesontheSkin I.Structureoftheskin A.Epidermisthinouterportion,composedofseverallayersofepithelialcells 1.Outermostlayersconsistsofdeadcellscontainingkeratin B.DermisInner,thi ...
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ANSWERS-STUDY-GUIDE-II
LSU, BIOL 4190
Excerpt: ... HERPESVIRUSES 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. Which is the greek word that herpesviruses derived their name from? erpein What does latency mean? There are no infectious virion produced What does persistence mean? Low amounts of virions are produced What are primary and secondary infections by herpesviruses? Primary is the first time, secondary is anytime after the first time. What happens during the process of herpesvirus reactivation? The virus goes into lytic phase produces all genes and infectious virions Which are the major subfamilies of herpesviruses on the basis of their biological properties? Alpha (simplex), beta (CMV), gamma (EBV) Is EBV an alpha, beta or gamma herpesvirus? gamma Is chickenpox caused by herpesviruses or coronaviruses? herpesviruses Is roseola caused by a herpesvirus or measles? herpesvirus Name some alphaherpesviruses of animals other than herpes simplex virus . bovine herpes, canine herpes, etc. How are herpes simplex 1 and simplex 2 related to each other? 50% ...
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