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Cornell | CHEM 288
Intro Physical Chem
Professors
- Lee
15 sample documents related to CHEM 288
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Cornell CHEM 288
REVIEW 2005 Nature Publishing Group http:/www.nature.com/naturebiotechnology Monoclonal antibody therapy of cancer Gregory P Adams & Louis M Weiner The most significant recent advances in the application of monoclonal antibodies (mAbs) to oncology -
Cornell CHEM 288
research focus REVIEWS The cell cycle and drug discovery: the promise and the hope Gavin Brooks and Nicholas B. La Thangue In recent years, there have been major developments in the understanding of the cell cycle. It is now known that normal cellu -
Cornell CHEM 288
insight review articles Life in extreme environments Lynn J. Rothschild rmancinelli@mail.arc.nasa.gov) Each recent re -
Cornell CHEM 288
Questions Group 1: ALL Why is there a gym and cafeteria for a company of only 60 employees? Why did you determine that there would be an 8-week treatment program? How reliable are hollow fiber bioreactors? Why did you make the distinction that you wo -
Cornell CHEM 288
Questions Group 2: Lung Why did you choose to use one large bioreactor instead of multiple smaller bioreactors? How did you determine that a 25% market share was reasonable? Can you control the temp/pH of an airlift bioreactor? Why did you choose San -
Cornell CHEM 288
Questions Group 3: Liver How did you determine a 10-month treatment program? Why so long compared to other antibody cancer therapies? How many 5L reactors will you need? Is this feasible? What is a double-blind randomized clinical trial? Are all clin -
Cornell CHEM 288
Questions Group 4: Liver Why would you culture CHO cells rather than testing the supernatants of the original spleen cell line to isolate function mAbs? Will you license the HuMAB technology from the parent company (which will incur a large cost) or -
Cornell CHEM 288
Questions Group 5: Liver How can pH be sterilely monitored in a fed-batch process? Is it ethical to sell a drug to Americans for $20,000 and only $500 to other parts of the world when less fortunate Americans may not have the means to afford the drug -
Cornell CHEM 288
Questions Group 6: Breast You stated that 8 SH groups were detected per mAb, what does that mean? How does it impact your process? How can you separate conjugated mAbs from those that remain unattached? Why did you specify a ROI of 15%? How often wil -
Cornell CHEM 288
Questions Group 7: Colon What role does the recycle in your process design play and can your stream be safely recycled? Why is affinity chromatography advantageous over other purification methods? What happens to MMAE after apoptosis? How many biorea -
Cornell CHEM 288
QUIZ 9 Wed. Feb. 15 1. Bacteria and viruses are not eukaryotes. 2. Phospholipids form the cell membrane. 4. Vm = k 2 [ E o ] [ E ][ S ] Km \'= [ ES ] V [S ] v= m K m \'+[ S ] 5. CORRECTION FROM CLASS: Technically, the process does not consume oxygen. -
Cornell CHEM 288
Quiz #10 Fri. Feb. 17 1. At high substrate concentrations, [S] exerts little effect on the velocity of reaction, i.e. the enzyme is saturated with substrate, creating a zero-order reaction. This is subtly different from the Rapid Equilibrium Assumpti -
Cornell CHEM 288
Quiz #11 Mon. Feb. 20 1. To receive credit you must draw the correct structure and then label the three groups. Study your notes if you got this one wrong because it is an important part of biology. 2 biopolymer substrate.\" This sh -
Cornell CHEM 288
QUIZ #12 Wed. Feb. 22 3. Think about the peptide bond formation reaction, the end product is a polymerized molecule and water (i.e. \"the other chemical species\"). 4. 686 kcal/mol glucose with 38-40% efficiency at standard conditions and 60% efficienc -
Cornell CHEM 288
QUIZ 13 Fri. Feb. 24 2. The key assumption in the Monod equation is that there is substrate limited growth. If not then growth rate would not be a function of [S]. 3. Taq polymerase is a DNA polymerase used in PCR. 5. Mammalian cells do not like cont
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