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Wake Forest | CHM 765
21 sample documents related to CHM 765
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Wake Forest CHM 765
O2, a toxic waste product two billion years ago Passive regulation: 4Fe2+ + O2 + 2H2O + 8OH- 4Fe(OH)3 2Fe2O3 + 6H2O In an oxygen-rich atmosphere, evolution developed organisms that use reverse photosynthesis (respiration) for the controlled combust -
Wake Forest CHM 765
RNR (E. coli) diphos 5\' 4\' R1 2 2 radical transfer O 1\' bas e + 2 e - diphos O bas e 3\' 2\' HO OH NDP HO d NDP H SH SH -2 e - S S R2 ribonucleotide reductases are essential for DNA synthesis 2 Fe2+ + Tyr-122 + O2 + e Fe3+-O-Fe3+ + T -
Wake Forest CHM 765
Mssbauer spectra of (a) 2Fe ferredoxin model, reduced (b) 2Fe ferredoxin model, oxidized [Fe4S4]2+ core in [Fe4S4(SCH2Ph)4]2(solid state structure) -
Wake Forest CHM 765
Protein Structure two-fold symmetry (point group C2) alpha helix domains hemerythrin antiparallel beta sheets alpha/beta barrel open twisted alpha/beta domain -
Wake Forest CHM 765
microbial phosphorylation/respiration The active site of D. gigas hydrogenase Proposed Mechanism of Nitrogenase -
Wake Forest CHM 765
Metal Toxicity Pb contained in solders, alloys, pigments usually passive: PbSO4, PbCO3 form protective layer Historical cases of lead poisoning Roman Empire: consumption of wine stored in Pb vessels Medieval mining: inhalation of volatile PbO dur -
Wake Forest CHM 765
Inorganic Chemistry and the Origin of Life in a Prebiotic Broth Waechtershaeuser Theory (PNAS, 1992, 89, 8117) 2 FeS + H2S + CO2 2 FeS2 + HCOOH 2 FeS + H2O + CO2 2 FeO + 1/n (CHOH)n + 2 S Cody et al.; Science 25 August 2000: Vol. 289. no. 5483, pp -
Wake Forest CHM 765
Paramagnetic NMR Spectroscopy Isotropic shifts resulting from dipolar and contact mechanisms in FeII TPA complexes p m o N N N S Fe N [Fe(TPA)SPh]+ -
Wake Forest CHM 765
Watson-Crick Hydrogen Bonding DNA CONFORMATION backbone parameters base orientation sugar pucker base pair and base step parameters The 7 \"Degrees of Freedom\" of the DNA Backbone The Sugar Pucker tan P = P = 0 - 360 ( 1+ 4 ) - ( 0 + 3) 2 -
Wake Forest CHM 765
Metal Toxicity Pb contained in solders, alloys, pigments usually passive: PbSO4, PbCO3 form protective layer Historical cases of lead poisoning Roman Empire: consumption of wine stored in Pb vessels Medieval mining: inhalation of volatile PbO dur -
Wake Forest CHM 765
\".the goal is.to find chemical substances that have special affinities for pathogenic organisms and that, like magic bullets, go straight to the organisms that they are aimed at.\" Paul Ehrlich (18541915) Inorganic Compounds in Medicine 3000 BC 25 -
Wake Forest CHM 765
Mapping of cisplatin binding sites on DNA using plasmids and restriction endonucleases Maxam-Gilbert Sequencing Maxam-Gilbert sequencing ladder PAGE electrophoresis recognition of the 1,2-intrastrand xlink formed by cisplatin by high mobility gro -
Wake Forest CHM 765
Metallo-Cofactors and Their Redox Potentials in the Respiratory Chain Cytochromes (a, b, c) are high-potential electron-transfer proteins that operate at the Fe2+/Fe3+ level Electron transfer is favored by the entatic state of the protein, which re -
Wake Forest CHM 765
Metallo-Cofactors and Their Redox Potentials in the Respiratory Chain Cytochromes (a, b, c.) are high-potential electron-transfer proteins that operate at the Fe2+/Fe3+ level Electron transfer is favored by the entatic state of the protein, which r -
Wake Forest CHM 765
Metalloproteins Functions Uptake, transport, and activation of small molecules Lewis-acid catalysis e. g., hemoglobin, myoglobin, non-heme O2 transporters (Fe, Cu), methane monooxygenase, P450 e. g., carbonic anhydrase (Zn), Urease (Ni) e. g., iron -
Wake Forest CHM 765
Iron bleomycin in cancer treatment Erika Klorig Julie Reisz November 13, 2007 Overview Bleomycin compounds Development side effects RNA, dsDNA Bleomycins Antineoplastic = an -
Wake Forest CHM 765
Iron Regulatory Proteins and Disease Bioinorganic Chemistry 11.15.07 Jenna DuMond Lindsey Oliver Iron Regulatory Protein 1 Is structurally very similar to aconitase (from TCA cycle) Has a completely different function without the FeS cluster tha -
Wake Forest CHM 765
Inhibition of Ribonucleotide Reductase as a Chemotherapeutic Route by Leigh Ann Graham and Chris Junker Ribonucleotide Reductase Tetramer (22) resulting from the association of two catalytically inactive homodimers (R1 and R2) Catalyzes the co -
Wake Forest CHM 765
1-Aminocyclopropane-1-Carboxylic Acid Oxidase (ACCO) Leigh Ann Graham and Chris Junker Ethylene Biosynthesis ACCO catalyzes two-electron oxidation of ACC in the final step in ethylene biosynthesis in plants Zhang, A.; Ren, J.; Clifton, I. J.; Scho -
Wake Forest CHM 765
Human Telomerase Lu Rao Montserrat Vasquez Telomeres Cech, T. R. Angew. Chem. Int. Ed., 2000, 39, 34-43 Blackburn, E. H. Cell, 2001, 106, 661-673 2 Telomerase and cancer Jerry W. Shay & Woodring E. Wright, Nature Reviews Drug Discovery, 2006, 5, -
Wake Forest CHM 765
Alcohol Dehydrogenase Lindsey Oliver & Jenna DuMond October 23, 2007 Alcohol Dehydrogenase O O NH2 H N H H O OH + + NH2 + H+ PDB 1acd PDB 1acd active site Zn2+ tetrahedral coordination Zn2+ coordinated to 2 Cys, His, and water After NAD+
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