BIO 1A Berkeley

Bio 1A Lecture 1 January 23, 2008 Professor Schlissel Introduction to Bio 1A 1. Goals of course: To understand how living organisms are built and function; to understand life processes in chemical terms; to understand the structure and function of

Bio 1A Lecture 2 January 25, 2008 Professor Schlissel Storage, retrieval, and transmission of information 1) DNA is the genetic material-Avery, McCarty, McLeod experiment. Bacterial transfomation. Bacteriophage. Hershey & Chase experiment. 2) Wats

Bio 1A Lecture 3 January 28, 2008 Professor Schlissel Biological Polymers 1. Review of basic chemistry. Chemical interactions: covalent, ionic, \"weak\", hydrogen bonding, hydrophobic. Polar compounds or groups. Water and its unique properties. 2. R

Bio 1A Lecture 4 January 30, 2008 Professor Schlissel Amino Acids, Proteins and Protein Structure 1. Proteins are polymers of amino acid building blocks. Sizes range from ~10 to greater than ~30,000 amino acids in length. By first the most diverse

Bio 1A Lecture 5 Biological Membranes February 1, 2008 Professor Schlissel 1. Why do cells have membranes and what do they do? Localization of molecules and functions; control intracellular composition. Receiving and sending information. Interacti

Bio 1A Lecture 6 February 4, 2008 Professor Schlissel Cells and Organelles I 1. Limits to cell size based on surface area to volume ratio. 2. Prokaryotic cells. Nucleoid, ribosomes, cell wall, capsule, plasma membrane. No membrane-bound organelles

Bio 1A Lecture 7 February 6, 2008 Professor Schlissel Cells and Organelles II 1. Vesicular transport. How proteins travel from the RER and cell membrane to other locations in cells. Budding and fusion. Donor and targets. Endosome-vesicle generated

Bio 1A Lecture 8 Energy degradation, cell growth & division, pumping molecules across membranes, sending signals, etc., etc. 2. Types of

Bio 1A Lecture 9 Enzymes: Mechanism & Regulation Prof. Schlissel Feb 11, 2008 Enzyme Mechanisms and Regulation 1. Acid-base catalysis. Requires R-groups with hydrogen donors or acceptors (know these). Example of lysozyme using Glu and Asp residues