8 sample documents related to CHEM 5

• 
  2.pdf

  Caltech CHEM 5
  

  TABLE OF CONTENTS Syllabus Basics of Laboratory Technique Notebook Laboratory Regulations and Safety Introduction: Synthesis of ()-Estrone Step 1: 1-Hydroxy-1-vinyl-6-methoxy tetralin Step 2: 3-Methoxy-1,3,5(10),8(9),14(15)-estrapentaene-17-one Step
   
• 
  12.pdf

  Caltech CHEM 5
  

  STEP 5: ESTRONE-3-METHYL ETHER-17-ETHYLENE KETAL H3 C O O H3 C O O Li / NH3 (l) H CH3 O CH3 O H H H 1. Procedure At least 24 hours in advance: Fill a 250-mL, 3-necked round-bottomed flask equipped with a stirbar with 50 mL acetone. Mark the
   
• 
  6.pdf

  Caltech CHEM 5
  

  Basics of Laboratory Safety: Chem 5a Lab 2003 LABORATORY RULES AND REGULATIONS 1. Safety glasses, goggles, face shield, and shoes (no sandals) must be worn at all times. Normal prescription lenses are insufficient! Violations will not be tolerated. T
   
• 
  11.pdf

  Caltech CHEM 5
  

  STEP 4: 3-METHOXY-1,3,5(10),8(9)-ESTRATETRAENE-17-ETHYLENE KETAL CH3 O OH H3 C O O + H CH3 O OH p-TsOH H CH3 O 1. Procedure In a 100-mL, three-necked, round-bottomed flask equipped with a stirbar, prepare a solution (~ 0.1 M) of the starting
   
• 
  10.pdf

  Caltech CHEM 5
  

  STEP 3: 3-METHOXY-1,3,5(10),8(9)-ESTRATETRAENE-17-ONE CH3 O CH3 O + H2 CH3 O Pd/CaCO3 H CH3 O 1. Procedure Dissolve the starting material, 3-methoxy-1,3,5(10),8(9),14(15)-estrapentaene-17one in toluene (~ 0.05 M) in a 500-mL, three-necked, round-
   
• 
  8.pdf

  Caltech CHEM 5
  

  STEP 1: 1-HYDROXY-1-VINYL-6-METHOXY TETRALIN MgBr O OH CH3 O THF / Et2O CH3 O 1. Procedure Equip a 500-mL, three-necked round-bottomed flask with a reflux condenser, a 250-mL dropping addition funnel, a magnetic stirbar, and a vacuum adapter (no
   
• 
  13.pdf

  Caltech CHEM 5
  

  STEP 6: ESTRONE METHYL ETHER H3 C H H CH3 O H O O CH3 O H+ H CH3 O H H 1. Procedure Prepare a solution of the starting material, estrone-3-methyl ether-17-ethylene ketal in THF (~ 0.05 M) in a 100-mL round-bottomed flask equipped with a stir
   
• 
  3.pdf

  Caltech CHEM 5
  

  Chemistry 5a: Advanced Techniques of Synthesis and Analysis Spring 2003 Brian M. Stoltz office: 352 Crellin lab: 262 Crellin/204 Church phone: (626) 395-6064 office hours: any time by appointment email: stoltz@caltech.edu web: http:/Chemistry.caltech