FinalExamKey(AnswersBolded)

FinalExamKey(AnswersBolded) - Biochemistry 415/515 Final...

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Biochemistry 415/515 Final Exam December 20, 2006 Multiple Choice Questions (2 points each). Choose the most appropriate answer. 1. Aspartate Transcarbamoylase is: a) an allosterically regulated enzyme b) a key enzyme in the citric acid cycle c) inhibited by a bisubstrate analog denoted PALA d) a and c above e) all of the above 2. The hydrophobic effect is best explained by: a) a decrease in entropy of water molecules b) an increase in the entropy of hydrophobic residues within proteins c) an increase in the entropy of water molecules d) a decrease in the entropy of hydrophilic residues within proteins e) b and d above 3. The side chain of the amino acid shown at right: a) is likely to be positively charged at a pH of 3.0 or lower b) could be involved in an electrostatic bond with an Arg sidechains at pH 7.0 c) is most likely to be found in the interior of a globular protein d) a and c above e) b anc c above 4. The experiments performed by Christian Anfinsen showed: a) all proteins contain at least one disulfide bond b) most proteins fold cooperatively c) the lowest energy conformation of a protein is it’s active conformation d) diagonal gel electrophoresis can be used to identify disulfide bonded Cys residues e) b and d above 5. The allosteric regulation of hemoglobin is: a) demonstrated by the inhibition of oxygen binding in the presence of 2,3- bisphosphoglycerate b) not seen for myoglobin because does not contain a heme group c) demonstrated by the inhibition of oxygen binding at pH values lower than 7 d) a and c above e) a, b and c above 6. For an enzyme that obeys Michaelis-Menten kinetics: a) the concentration of substrate that give a half-maximal reaction velocity is the Km b) the Km represents the rates of dissociation of the ES complex over the rate of association c) the formation of product from the ES complex is assumed to be irreversible d) a and b above e) a, b and c above Page 1
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Biochemistry 415/515 Final Exam December 20, 2006 7. Penicillin is: a) an example of a suicide inhibitor b) an inhibitor of the enzyme glycopeptide transpeptidase c) used in the Ames test for mutagens d) a and b above e) a and c above 8. The intermediate in both ketone body formation and cholesterol synthesis is a) Mevalonic acid b) Malonyl CoA c) HMG-CoA d) dihydroxybenzoate e) squalene 9. The electron carrier(s) in beta-oxidation is (are): a) NAD/NADH b) NADP/NADPH c) FAD/FADH 2 d) a and c e) b and c 10. The compound(s) that is (are) esterified to fatty acids at some point in synthesis or degradation are a) Coenzyme A b) Carnitine c) Acyl carrier protein d) All of the above e) a and c 11. Biological membranes a) Allow easy transverse (flip-flop) mobility b) Contain channels, antiporters and pumps c) Are asymmetric d) All of the above e) b and c 12. The key enzyme that determines whether a cell (or tissue) can contribute to the body’s glucose homeostasis is a) Hexokinase b) Glucose-6-phosphatase c) Pyruvate kinase d) phosphofructokinase e) phosphoglucomutase
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FinalExamKey(AnswersBolded) - Biochemistry 415/515 Final...

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