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Lecture 02 - Renal Histology

Lecture 02 - Renal Histology - Renal Histology Lecture 2...

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Renal Histology Lecture 2 GROSS ANATOMY - Kidney cortex : contains distinctive glomeruli, convoluted tubules, parts of collecting ducts - Kidney medulla : below the cortex, contains limbs of Henle & collecting ducts - Medullary ray : groups of collecting ducts that extend from cortex to medulla - Calyx : terminal expansions of ureter in the kidney, minor calyces meet up with papilla (papilla minor calyx major calyx pelvis ureter) - Papilla : termination of collecting duct into a minor calyx - Lobe : a medullary pyramid and the overlying cortex - Lobule : lateral borders marked by medullary rays - Arteries in order: abdominal aorta, renal artery, interlobar, arcuate, interlobular, intralobular, afferent arteriole, glomerulus, efferent arteriole, vasa recta RENAL CORPUSCLE - Renal corpuscle : glomerulus + Bowman’s capsule - Glomerulus : tufts of capillaries with fenestrated (“holey”) endothelium - Parietal Epithelium : squamous pariental epithelium of Bowman’s capsule that’s continuous w/ epithelium of proximal tubule - Visceral Epithelium : composed of podocytes - Podocytes : easily seen at border of glomerulus, obvious under EM, have filtration slits that act as filtration barrier; Fxn: manufacture basement membrane, provide filtration support - Mesangial cells : produce & breakdown basement membrane; uptake macromolecules; can respond to local injury; embedded in mesangial substance (stains bright purple/blue—PAS-positive) - Basement membrane : very thick (3500A), PAS-positive, trilaminar (lamina rara interna, lamina densa, lamina rara externa), primary glomerular filtration barrier o Contains type IV collagen, glycoproteins, & proteoglycans
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