Lecture 04 - Tubular Function

Lecture 04 - Tubular Function - Renal handling of Na K Cl...

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Renal handling of Na+, K+, & Cl- and Glucose Lecture 4 I. Intro a. 180 L/day enter glomerulus 120 L/day reabsorbed in Proximal Tubule 35 L reabsorbed in Loop of henle of remaining 18L, concentrated to 1-2L of urine in Distal tubule & collecting duct II. Epithelia a. 180 L/day enter glomerulus 120 L/day reabsorbed in Proximal Tubule 35 L reabsorbed in Loop of henle of remaining 18L, concentrated to 1-2L of urine in Distal tubule & collecting duct b. Structural Polarity i. Epithelia is made of polar cells => different components on apical and basolateral surfaces! ii. Occluding zone (= “ tight jxn ”) between cells fxns as a barrier to prevent passage of plasma membrane proteins iii. Specialized extracellular compartments ( microvilli , etc) concentrate solutes iv. Key components 1. substances move across cell in 1 main direction 2. transport proteins different on apical & basal membranes 3. must sort transporters to proper membrane 4. must maintain transporters in proper place c. Functional Polarity (absorption—to blood/body vs. secretion—out of bl./body) i. Ions enter via channels or carrier-mediated transport systems ii. Na-K pump —creates Na gradient which supplies energy for transport 1. usually located on blood (basal) side 2. Fxn: 1) exit step for Na+, 2) generator of ion gradient essential for solute entry mechanism iii. Eg: Absorption of Na
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