Glycoside Coupling Notes - GlycosideCoupling...

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Glycoside Coupling Oligosaccharides are of central importance in the development and maintenance of  biological systems. They are found free in solution and as constituents of proteins  (glycoproteins) and lipids (glycolipids) on the cell surface, and have been implicated in  the mechanisms of action of diverse cellular processes such as inflammation, cell-cell  recognition and adhesion, protein turnover, and bacterial infection. Oligosaccharides, or  molecular mimics thereof, are becoming more frequent targets in drug design for the  treatment of human illness and disease.  The cellular functions of oligosaccharides are intimately related to their three- dimensional shapes or conformations; knowledge of these 3D structures, both free in  solution and in the bound state, is essential to deciphering the underlying factors that  control recognition between oligosaccharides and specific cellular receptors. This  proposal aims to develop new probes of oligosaccharide conformation based on nuclear  magne tic resonance (NMR) spin-couplings involving 13C. Major objectives are to refine
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  • Fall '12
  • AnnelieseSchultz
  • Organic chemistry, Lipids, Oligosaccharides, Glycoside Coupling Oligosaccharides, bacterial infection. Oligosaccharides

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