Week_8_Section_Handout

Week_8_Section_Handout - Benjamin Yip byip@ucsd.edu Section...

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Benjamin Yip byip@ucsd.edu Section Wednesday 1:00p.m. WLH 2114 Handout Week 8: Enzymes/Transition State Analogs Enzymes binding to substrates o Transition state is very unstable o Catalysts are: A substance that lowers the activation energy of a reaction withotu being consumed within the reaction. o Why don’t enzymes have a complementary shape to the enzyme substrate complex? Because it impedes the desired reaction for the product because it stabilizes the substrate Lowest energy is in the substrate form, so it won’t want to form a product. o Enzyme is actually complementary to the transition state. Stabilizes the high energy transition state and lowers the activation energy so the reaction may occur at a more favorable rate. Enzymes usually function by: o Lowering the activation energy by stabilizing the transition state. o Bringing the substrate into optimal conformations/locations for interaction. Eg. Bringing the reaction sites closer to each other or orienting the angles properly. o Providing a hydrophobic environment so water’s polar groups don’t interfere with the substrate. Reactions rates may increase by:
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Week_8_Section_Handout - Benjamin Yip byip@ucsd.edu Section...

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