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Week_9_Section_Handout - Benjamin Yip [email protected] Section...

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Benjamin Yip [email protected] Section Wednesday 1:00p.m. WLH 2114 Handout Week 9: Enzymes/Membranes Methods of Enzyme Regulation o Allosteric Control o Reversible Covalent Modification o Proteolytic Activation Allosteric Control: o Allostery: Ligand binding to an allosteric site induces a conformational change that stimulates or inhibits enzyme activity. o Protein Kinase A Tetramer of 2 regulatory and 2 catalytic subunits. ATP ___________ binds to the ____________ subunits on the ___________ site conformational change so the regulatory subunits dissociate, thus uncovering the _____________ site on the _______________ subunits. These will go off to phosphorylate other targets downstream. Enzyme Pathways and Negative Feedback o Ile will bind to the regulatory site of Thr Dehydratase, thus inactivating it. o If there is a ↑ [Ile], then ↓ Thr dehyratase and no Δ in [Thr] o If there is a ↓ [Ile], then ↑ Thr dehyratase and ↓ [Thr] o Why would you have feedback inhibition on this enzyme when Ile is high? Lipids o Composed of a polar head and a nonpolar tail. o The hydrophobic tails force water to be ________________ ordered, which is energetically ____________. o If hydrophobic portions of the lipids cluster into _______________, _____________________, or______________________, they will prevent the ordering of water, which is energetically favorable.
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