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Unformatted text preview: BIMM118 – Midterm ’08 NOTE : WRONG answers on multiple choice questions will result in the DEDUCTION of the points !!!!! 1) A drug that is a partial agonist a) binds to the same site on the receptor as the natural ligand b) binds the receptor irreversibly c) does not elicit a response from the receptor d) shifts the dose-response curve of the natural ligand to the right e) shifts the dose-response curve of the natural ligand to the right AND down (5 pts each) 2) What are the V d and t 1/2 ? How are they interconnected (explain the underlying concept!)? V d = volume of distribution; t 1/2 = half-life. Typically, drugs with a large V d are highly protein bound, and their metabolism/excretion is therefore attenuated. Consequently, drugs with a large V d have usually a longer half-life than drugs with small V d . (10 pts) 3) According to the diagram a) Both drugs have the same efficacy b) Drug B has higher efficacy c) The drugs have different potency d) Drug B has the lower potency e) Drug A is a partial agonist (5 pts each) 4) Provide an example of a food-drug interaction! Explain the underlying mechanism! (10 pts) *) Grapefruit juice contains a CYP3A4 inhibitor, thereby preventing oxidative metabolism of drugs such as acetaminophen, codeine, warfarin, erythromycin etc....
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This test prep was uploaded on 04/11/2008 for the course BIMM 118 taught by Professor Michael during the Winter '08 term at UCSD.
- Winter '08