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FINAL KEY - BIMM118 WI'07 Final NOTE WRONG answers on...

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BIMM118 – WI’07 Final NOTE : WRONG answers on multiple choice questions will result in the DEDUCTION of the points !!!!! 1) Which of the following conditions can be treated with Dopamine receptor anta gonists? (5 ea) a) Epilepsy b) Parkinson’s Disease c) Schizophrenia (Phenothiazines; Butyrophenones) d) Angina pectoris e) Nausea/Vomiting (Metoclopramide) f) Diarrhea 2) Which anti-diabetic drug group acts via the nuclear receptor PPAR γ ? Can these drugs be used for type I diabetes (explain!)? (10) Glitazones: Upregulate signaling molecules downstream of the insulin receptor. Useless for type I diabetes due to a complete lack of insulin production! 3) What is the “Minimal Alveolar Concentration (MAC)”? How does the MAC relate to the lipophilicity of the drug? (10) The MAC is the concentration of the anesthetic at 1 atm that prevents a reaction to a painful stimulus in 50% of subjects. MAC decreases with increased lipophilicity. 4) Aspirin is contraindicated in which of the following conditions (5 ea) a) Angina pectoris b) Bronchial asthma c) Hypertension d) Arthritis e) Gastritic ulcers f) Bradycardia 5)
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