LS2 - Lecture 4 Endocrine System 2013 (1) - CELL SIGNALING AND THE ENDOCRINE SYSTEM transducer PITUITARY Prof Peter Ellison ofce hours TU 1-2 or by appt

LS2 - Lecture 4 Endocrine System 2013 (1) - CELL SIGNALING...

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CELL SIGNALING AND THE ENDOCRINE SYSTEM Prof. Peter Ellison, office hours TU 1-2 or by appt., Peabody Museum 51F “transducer” PITUITARY
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THE ENDOCRINE SYSTEM LECTURE OUTLINE 1. Case study: Death in bereavement 2. Types of hormones and receptors 3. Feedback control 4. Hypothalamus and pituitary 5. Example: HPA axis
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DEATH IN BEREAVEMENT CASE STUDY: Williams JR, 2005. Southwest Med J 98:90-95.
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β - adrenergic receptor The “sensory organs” of single celled organisms provided the foundation for cellular integration in multicellular organisms.
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THREE MAJOR SYSTEMS OF INTEGRATION NERVOUS SYSTEM Point-to-point, fast, sensory information, muscle control, cognition ENDOCRINE SYSTEM Broadcast, fixed source to dispersed targets, coordination of physiology, integration of physiology and behavior, regulation of gene expression IMMUNE SYSTEM Broadcast, mobile sources and targets, detection of “non-self” indicators, coordination of mobile defenses, “search and destroy”, rapid clonal expansion
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THREE MAJOR SYSTEMS OF INTEGRATION NERVOUS SYSTEM Point-to-point, fast, sensory information, muscle control, cognition ENDOCRINE SYSTEM Broadcast, fixed source to dispersed targets, coordination of physiology, integration of physiology and behavior, regulation of gene expression IMMUNE SYSTEM Broadcast, mobile sources and targets, detection of “non-self” indicators, coordination of mobile defenses, “search and destroy”, rapid clonal expansion
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KINDS OF HORMONES short amino acid chains neurosecretion long amino acid chains glandular secretion BOTH coded in genome membrane receptors PEPTIDES oxytocin PROTEINS prolactin
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KINDS OF HORMONES Human (left) and pig (right) insulin molecules differ by a single amino acid.
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  • Fall '10
  • AndrewA.Biewener,PeterT.Ellison,andDanielE.Lieberman
  • posterior pituitary, membrane¬†receptors

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