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Mitosis Class Notes

Mitosis Class Notes - Genetics and Evolution Pamela...

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Genetics and Evolution Pamela Diggle ( [email protected]) Office: Ramaley C287 Office hours: Thursday and Friday 1-2 or by appointment INTRODUCTORY MATERIAL An example of the genetics and evolution of two inter-related diseases Sickle cell disease is a form of anemia It is the most common inherited blood disorder in the US It affects 72,000 Americans It affects 1 in 500 African Americans Fig 5.21 Sickle-cell disease. These sickled cells become stuck in small blood vessels, causing a "crisis" of pain, fever, swelling, and tissue damage that can lead to death. Capillary with red blood cells: www.tigr.org/tdb/ edb/pfdb/disease.html Fig 5.21 Sickle-cell disease and hemoglobin structure Single amino acid substitution in one protein of hemoglobin Causes cell to “sickle” and reduces oxygen carrying capacity Fig 17.23 Sickle-cell disease is caused by a single mutation Why does sickle cell persist in human populations? The distribution of the sickle cell gene coincides with the distribution of malaria Malaria is caused by a plasmodium parasite The parasite is carried by the female anopheles mosquito Each year 400 million people contract malaria About 2-3 million of these die from the disease
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