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bios213lecture 14 - Antimicrobial Drugs Chemotherapy The...

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Antimicrobial Drugs
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Chemotherapy The use of drugs to treat a disease Antimicrobial drugs Interfere with the growth of microbes within a host Antibiotic Substance produced by a microbe that, in small amounts,inhibits another microbe Selective toxicity A drug that kills harmful microbes without damaging the host
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1928 – Fleming discovered penicillin, produced by Penicillium . 1940 – Howard Florey and Ernst Chain performed first clinical trials of penicillin. Figure 20.1
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Table 20.1
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Table 20.2
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The Action of Antimicrobial Drugs Broad-spectrum - may kill normal microbiota Superinfection - opportunistic infections Bactericidal Bacteriostatic
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Figure 20.2
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Penicillin Natural penicillins Semisynthetic penicillins Antibacterial Antibiotics Inhibitors of Cell Wall Synthesis
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Penicillins Figure 20.6
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Penicillin derivatives Penicilinase-resistant penicillins Extended-spectrum penicillins Penicillins + β -lactamase inhibitors Carbapenems Monobactam Antibacterial Antibiotics Inhibitors of Cell Wall Synthesis
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Figure 20.8 Penicillinase or beta-lactamase
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