bios 213 lecture 12 - Disorders Associated with the Immune...

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    Disorders Associated  with the Immune System Infection  and  immunosuppression   are failures of the immune system. Superantigens  cause release of  cytokines that cause adverse host  responses. Allergies  and  transplant rejection   are harmful immune reactions
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    Response to antigens (allergens) leading to  damage Require sensitizing dose(s) Hypersensitivity Reactions Type I
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    Involve IgE  antibodies Localized: Hives  or asthma from  contact or  inhaled antigens Systemic: Shock  from ingested or  injected antigens Type I (Anaphylactic) Reactions Figure 19.1a
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    Figure 19.1
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    Skin testing Desensitization   - small doses  administered to  stimulate  production of IgG  as a blocking  antibody Type I (Anaphylactic) Reactions Figure 19.3
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    Involve IgG or IgM antibodies and  complement Complement activation causes cell lysis or  damage by macrophages Type II (Cytotoxic) Reactions
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    ABO Blood Group System Table 19.2
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    Drug-induced Thrombocytopenic Purpura Figure 19.5 1. Drug coats platelets 2. Coated platelets      are antigenic 3. Complement and      antibody lyse platelets 4. Platelets loss causes      hemorrhages on skin
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    IgG antibodies and antigens form complexes  that lodge in basement membranes. Type III (Immune Complex) Reactions Figure 19.6
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    Delayed-type  hypersensitivities  due to T D  cells Cytokines attract  macrophages and  initiate tissue  damage Type IV (Cell-Mediated) Reactions Figure 19.8
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    Clonal deletion during fetal development  ensures self-tolerance Autoimmunity is loss of self-tolerance Autoimmune Diseases
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This note was uploaded on 04/09/2008 for the course BIOS 231 taught by Professor Hill during the Spring '08 term at Northern Illinois University.

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bios 213 lecture 12 - Disorders Associated with the Immune...

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