CNS lecture copy - Development of the Central Nervous...

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1 Development of the Central Nervous System Epithelial cells are tightly connected to one another in a contiguous sheet or tube. They rest on an extracellular matrix layer called a basement membrane. Epithelial cells are polarized. The side in contact with the basement membrane is “basal”and the opposite side is “apical”. They are connected to one another through tight junctions, anchoring junctions and gap junctions. Mesenchymal cells are sparsely connected (or unconnected) to one another and are surrounded on all sides by extracellular matrix. Cell-cell contact is via gap junctions. They are generally unpolarized, although migratory mesenchymal cells have a leading edge and a trailing edge. Some key definitions…. Major Derivatives of the Ectodermal Germ Layer
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2 Primary Neurulation: Neural Tube Formation in the Chick Embryo Failure of neurulation can result in neural tube defects Spina Bifida open neural tube Occlusion of the Neural Tube Allows Expansion of the Future Brain Region
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3 Dorsoventral Patterning of CNS Dorsoventral organization of neurons in the CNS Dorsal : Sensory neurons (neural crest) Commissural neurons Ventral : Motor neurons Middle : Interneurons
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4 Extrinsic dorsal and ventral signals
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This note was uploaded on 04/11/2008 for the course ZOO 3003C taught by Professor Cohn during the Spring '08 term at University of Florida.

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CNS lecture copy - Development of the Central Nervous...

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