limb development F07

limb development F07 - Development of Vertebrate Limbs The...

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1 Development of Vertebrate Limbs The models Chick Mouse Skeletal Pattern of the Chick Wing
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2 Limb Bud Formation Martin, IJDB , 34:323-336. Outgrowth and patterning of mouse limb buds Introduction • Limb buds develop from lateral plate mesoderm (somatic layer) 3 developmental axes: • proximo-distal, • antero-posterior, • dorso-ventral Pattern is organized by: • progress zone • apical ectodermal ridge • polarizing region, • dorsal ectoderm. Posterior Anterior Proximal Distal Dorsal ventral
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3 Limbs have three signaling centers AER: Apical Ectodermal Ridge (the AER overlies progress zone @ distal tip of bud ZPA: Zone of Polarizing Activity The proximodistal axis Apical Ectodermal Ridge (AER) maintains proximo-distal outgrowth of limb bud.
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4 The Apical Ectodermal Ridge (AER) develops along the distal margin of the limb bud AER Removal of AER causes stage-dependent loss of distal structures Effect of the AER on the underlying mesenchyme
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5 Removal of the AER at different time points results in stage-dependent truncation of the limb skeleton early late FGF8 is expressed in the Apical Ectodermal Ridge (other Fgfs in the AER are Fgf4, Fgf9 and Fgf17) Chick
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6 What does the AER removal tell us about specification of proximodistal pattern? Proximal skeletal elements are specified before distal
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This note was uploaded on 04/11/2008 for the course ZOO 3003C taught by Professor Cohn during the Spring '08 term at University of Florida.

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limb development F07 - Development of Vertebrate Limbs The...

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