5B nus 210 - Patients with Malignant Disorders Leukemia A...

This preview shows page 1 - 4 out of 25 pages.

Patients with Malignant Disorders Leukemia •A group of malignant disorders affecting the blood and blood-forming tissues of –Bone marrowa –Lymph system –Spleen Can’t give us hemoglobin, WBC or platelets •Accumulation of dysfunctional cells due to loss of regulation in cell division •Fatal if untreated Leukemia •Occurs in all age groups •Often thought of as a childhood disease •The number of adults affected is 10 times that of children Leukemia Etiology and Pathophysiology (often a 2 nd cancer) •No single causative agent –Combination of genetic and environmental (triggers) influences •Associated with development –Chemical agents –Chemotherapeutic agents –Viruses (abtenebar virus, HIV) –Radiation –Immunologic deficiencies Increased risk for children with downs syndrome Leukemia Classification Cell type Acute Chronic Myelogenous Acute Myelogenous Leukemia (AML) Chronic Myelogenous Leukemia (CML) Lymphocytic Acute Lymphocytic Leukemia (ALL) Chronic Lymphocytic Leukemia (CLL) Young cells Mature cells Leukemia Classification •Acute versus Chronic–Cell maturity and nature of disease onset •Acute: Clonal proliferation of immature hematopoietic cells •Chronic: Mature forms of WBC and onset is more gradual Leukemia Classification
Image of page 1
•Based on type of WBC –Acute lymphocytic leukemia (ALL)—More often in children –Acute myelogenous leukemia (AML)- more often in adults •Also called acute nonlymphoblastic leukemia (ANLL) –Chronic myelogenous leukemia (CML) –Chronic lymphocytic leukemia (CLL) Acute Myelogenous Leukemia (AML) •Uncontrolled proliferation of myeloblasts in bone marrow –Hyperplasia of bone marrow and spleen •25% of all leukemias –85% of the acute leukemias in adults\ - 35% survivial rate •Abrupt, dramatic onset –Serious infections or abnormal bleeding - Admitted & receive high dose chemotherapy (wiping out marrow) - 3 drug treatment - Risk for infection r/t disease or treatment - Need transplant Acute Lymphocytic Leukemia (ALL) •Most common type of leukemia in children •15% of acute leukemia in adults •Immature lymphocytes proliferate in the bone marrow - High survival rate 80-90% - Can affect nerurosytem – and require radiation •Signs and symptoms may appear abruptly –Fever –Bleeding --s/s related to bone marrow •Fever, infection, lymphadenopathy •Bleeding, bruising •Bone Pain •Insidious with progressive weakness and fatigue •CNS manifestations Chronic Myelogenous Leukemia (CML)--- (not in children) •Excessive mature neoplastic granulocytes in bone marrow –Move into peripheral blood in massive numbers –Ultimately infiltrate liver and spleen •Philadelphia chromosome (discovered in philly)
Image of page 2
–Genetic marker –Present in >90-95% CML patients •Chronic, stable phase –(symptoms may not seem present) –Followed by acute, aggressive (blastic) phase •Treatment: GLEEVEC® (imatinib )- PO 1/d @ home - Biologic therapy- targets receptors inside of cell Chronic Lymphocytic Leukemia (CLL) •Most common leukemia in adults (older adults)
Image of page 3

Want to read all 25 pages?

Image of page 4

Want to read all 25 pages?

You've reached the end of your free preview.

Want to read all 25 pages?

  • Fall '12
  • Dr.McGinley
  • Module V-B

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern