Lecture8_ExtensionsToMendel

Lecture8_ExtensionsToMendel - Extensions to Mendel II I....

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Extensions to Mendel II I. Quantitative traits Another key exception to Mendel’s results A. Variation in many traits tends to be normally distributed Discrete traits: Quantitative traits: When crosses are made between individuals with different values of quantitative traits, offspring tend to be Nilsson-Ehle experiment: Parental pure line white X pure line red F 1 s: F 2 s: Hypothesis: The model: 1) Instead of one gene coding for a trait, 2) Each gene involved adds a 3) Genes involved assort independently Predictions made by the model: Parentals aa bb cc x AA BB CC F 1 genotype: F 1 phenotypes F 1 gametes F 2 genotypes:
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II. A laundry list of other exceptions to Mendel • Multiple allelism • Incomplete dominance • Co-dominance • Pleiotropy • Gene x gene interactions (epistasis) • Gene x environment interactions • Multiple allelism Definition: In the population in question, more than two alleles are present at the locus of interest. Example: CFTR (cystic fibrosis transmembrane regulator) gene in humans
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This note was uploaded on 04/10/2008 for the course BIOL 180 taught by Professor Freeman during the Fall '07 term at University of Washington.

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Lecture8_ExtensionsToMendel - Extensions to Mendel II I....

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