4 - 4 - 35. Parkinson's Disease. Clinical picture; genetics (12-07)

4 - 4 - 35. Parkinson's Disease. Clinical picture; genetics (12-07)

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Hello. The next few lectures we are going to be discussing Parkinson's Disease. This is an active and vibrant area in modern research, especially on the translational front. We can't cover all aspects but, as usual I'm gonna try to give you a flavor of the research that may develop new drugs and new treatments for Parkinson's Disease. As usual we will begin. With the clinical picture and with the genetics. and then in the following lectures, we will talk about patho-physiology, about bio-markers and non-human models for the disease. That there won't be a heterozygote advantage. And then we will talk about therapeutic approaches. Interestingly enough. For Parkinson's Disease, there are two therapeutic approaches being considered. One is symptomatic relief for people who clearly have the symptoms of Parkinson. And the other is protection against further degeneration. The story begins with James Parkinson who was an apothecary surgeon. In 1817, he described in an essay, a paralysis agitans, an agitated paralysis. These were not patients of his. These were individuals he observed during his daily walks in London. the, the disease includes tremor and rest, three to five hertz, a hertz is a cycle per second. The kind of pill rolling motion. like this. Slow movements, particularly when starting, and short rapid steps. These days, however, most Parkinson's patients are either medicated or electrically stimulated, and so one does not see a complete set of Parkinsonian symptoms. Here's an excellent Youtube video. This gait is the gait that is hypokinetic gait the prototype is Parkinson's or Parkinsonian type of gait, in which the patient will have a posture which will be stooped over, being forward, and then will have difficulty as far as initiating gait. When the gait is initiated, there are small steps. Often times there's a, there's a tremor associated with this. And as the gait progresses there may be a picking up of speed or what's called a fenestrated gait, and then a turning. Instead of having the normal turning, t he patient will turn on blot, which means they'll turn, almost. As a statue moving around and then again, having difficulty starting in the Mosh Pit IPA. I apologize for not knowing the name
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