5 - 6 - 45. Bipolar Disorder (8-47)

5 - 6 - 45. Bipolar Disorder (8-47) - This is the first of...

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This is the first of three lectures on Bipolar Disease. Many students have asked to learn more about Bipolar Disease in order to be able to help friends or relatives who seem to have a disorder somewhere on the Bipolar spectrum. Unfortunately it's rather frustrating to discuss Bipolar Disease. Because we know so little about it's pathophysiology, about it's genetics. Or about the way that drugs act. Which gives some, but not complete relief for Bipolar Disorder. As usual, we'll begin with a clinical description. We'll talk about the genetics of Bipolar Disease, about possible causes, about a heterozygote advantage in which people with. Just a few of the genes predisposing to Bipolar Disorder might have an advantage. And about drug or other therapeutic approaches. first we begin with a clinical description based on DSM-IV. Bipolar Disorder affects between one and 1.5 percent of the population in most modern societies. It was formerly called, Manic Depressive disorder. Because patients have one or more manic or nearly manic, hypomanic episodes alternating with major depressive episodes. The first episode is often in the mid-20s, which is a bit later than major depressive disorder and a bit later than schizophrenia, but this is quite variable. And Bipolar disorder, unfortunately often leads to suicide. I base a lot of my description on a major shcolarly work. By Fred Goodwin and Kay Redfield Jamison called Manic-Depressive Illness. It's now in its
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  • Winter '15

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