5 - 13 - 52. Overview, Summary, Prospects (9-09)

5 - 13 - 52. Overview, Summary, Prospects (9-09) - Here is...

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Here is the Atheneum from the southwest, as it might be viewed from one of the student's residences. This is our final lecture and it gives us a chance to wrap up some of the concepts we've introduced to show you where we need a lot more data. And to introduce, reintroduce really my own ideas about the difference between Outside-In and inside-out pharmacology, to thank several very key people, including yourselves who've helped to make the course smooth and lively and accurate, and to tell you about the next steps in your career. During the first three weeks, we introduced the concept and tools. We talked about an introduction to neuroscience. We told you about drugs as chemicals with access to the brain, about receptors as protein, about protein as a possible drugs. We introduce the study of the nervous system, those response relations and electrophysiology. Then we went on to talk about drugs as activators and blockers of ion channels, especially at synapses, but also in axons. We also discussed drugs and their actions on G protein pathways, both immediate and long term, several G protein pathways. We discussed that drugs act on neurotransmitter transporters as well. And we wrap this up by giving you a feeling for how drugs act recreationally in various parts of the brain, various types of drugs, then we moved to the intellectually incomplete parts of the course. Neural scientist have been willing to admit that we don't understand the causes of many neural diseases. I think we have been less willing to admit than we should, that we don't understand basic mechanism of important neural drugs. And
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